Amino acid dipepetide frequency for Human papillomavirus 52

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.773AlaAla: 1.773 ± 1.096
0.887AlaCys: 0.887 ± 0.491
3.103AlaAsp: 3.103 ± 0.561
3.546AlaGlu: 3.546 ± 0.644
2.216AlaPhe: 2.216 ± 0.965
4.433AlaGly: 4.433 ± 1.68
0.887AlaHis: 0.887 ± 0.475
1.773AlaIle: 1.773 ± 0.319
3.103AlaLys: 3.103 ± 1.746
3.546AlaLeu: 3.546 ± 1.387
0.443AlaMet: 0.443 ± 0.361
1.33AlaAsn: 1.33 ± 0.639
3.546AlaPro: 3.546 ± 2.251
2.216AlaGln: 2.216 ± 0.939
2.216AlaArg: 2.216 ± 0.522
3.989AlaSer: 3.989 ± 1.377
6.206AlaThr: 6.206 ± 1.97
2.66AlaVal: 2.66 ± 1.674
0.0AlaTrp: 0.0 ± 0.0
1.33AlaTyr: 1.33 ± 1.176
0.0AlaXaa: 0.0 ± 0.0
Cys
1.773CysAla: 1.773 ± 0.797
0.0CysCys: 0.0 ± 0.0
1.773CysAsp: 1.773 ± 0.837
1.33CysGlu: 1.33 ± 0.729
0.0CysPhe: 0.0 ± 0.0
0.443CysGly: 0.443 ± 0.392
0.887CysHis: 0.887 ± 0.651
2.216CysIle: 2.216 ± 1.646
2.66CysLys: 2.66 ± 1.032
2.216CysLeu: 2.216 ± 0.664
0.443CysMet: 0.443 ± 0.404
0.443CysAsn: 0.443 ± 0.404
2.66CysPro: 2.66 ± 0.925
1.33CysGln: 1.33 ± 0.791
0.443CysArg: 0.443 ± 0.392
1.33CysSer: 1.33 ± 0.659
3.989CysThr: 3.989 ± 1.915
2.66CysVal: 2.66 ± 1.187
1.33CysTrp: 1.33 ± 0.659
0.443CysTyr: 0.443 ± 0.649
0.0CysXaa: 0.0 ± 0.0
Asp
1.773AspAla: 1.773 ± 0.6
0.887AspCys: 0.887 ± 0.446
3.103AspAsp: 3.103 ± 2.235
3.103AspGlu: 3.103 ± 0.695
2.66AspPhe: 2.66 ± 0.985
5.319AspGly: 5.319 ± 1.35
0.443AspHis: 0.443 ± 0.392
3.989AspIle: 3.989 ± 1.559
1.33AspLys: 1.33 ± 0.723
5.762AspLeu: 5.762 ± 2.217
0.443AspMet: 0.443 ± 0.404
2.66AspAsn: 2.66 ± 0.9
3.989AspPro: 3.989 ± 0.605
1.33AspGln: 1.33 ± 0.396
1.773AspArg: 1.773 ± 0.749
5.319AspSer: 5.319 ± 1.325
4.433AspThr: 4.433 ± 1.618
4.876AspVal: 4.876 ± 1.247
1.773AspTrp: 1.773 ± 1.093
3.103AspTyr: 3.103 ± 1.146
0.0AspXaa: 0.0 ± 0.0
Glu
3.103GluAla: 3.103 ± 0.839
3.546GluCys: 3.546 ± 2.051
5.762GluAsp: 5.762 ± 2.093
3.989GluGlu: 3.989 ± 2.051
0.887GluPhe: 0.887 ± 0.446
3.546GluGly: 3.546 ± 1.696
1.33GluHis: 1.33 ± 0.383
2.66GluIle: 2.66 ± 1.143
2.66GluLys: 2.66 ± 0.813
2.66GluLeu: 2.66 ± 1.443
0.887GluMet: 0.887 ± 0.475
3.103GluAsn: 3.103 ± 2.235
2.66GluPro: 2.66 ± 0.948
2.216GluGln: 2.216 ± 1.252
1.773GluArg: 1.773 ± 1.358
3.546GluSer: 3.546 ± 0.892
4.433GluThr: 4.433 ± 0.923
4.433GluVal: 4.433 ± 0.98
0.443GluTrp: 0.443 ± 0.392
1.33GluTyr: 1.33 ± 0.983
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
3.103PheAsp: 3.103 ± 0.97
1.33PheGlu: 1.33 ± 0.639
3.103PhePhe: 3.103 ± 1.421
2.66PheGly: 2.66 ± 1.031
1.773PheHis: 1.773 ± 0.549
1.773PheIle: 1.773 ± 0.64
3.989PheLys: 3.989 ± 2.457
5.762PheLeu: 5.762 ± 1.117
0.887PheMet: 0.887 ± 0.437
1.773PheAsn: 1.773 ± 1.126
2.216PhePro: 2.216 ± 1.032
0.443PheGln: 0.443 ± 0.404
0.443PheArg: 0.443 ± 0.404
2.66PheSer: 2.66 ± 0.663
2.66PheThr: 2.66 ± 1.08
3.103PheVal: 3.103 ± 1.377
0.887PheTrp: 0.887 ± 0.446
1.773PheTyr: 1.773 ± 1.138
0.0PheXaa: 0.0 ± 0.0
Gly
2.216GlyAla: 2.216 ± 1.104
2.216GlyCys: 2.216 ± 0.929
4.876GlyAsp: 4.876 ± 1.858
3.546GlyGlu: 3.546 ± 0.715
1.33GlyPhe: 1.33 ± 0.799
1.773GlyGly: 1.773 ± 0.769
2.216GlyHis: 2.216 ± 1.095
3.546GlyIle: 3.546 ± 0.975
3.989GlyLys: 3.989 ± 1.304
4.876GlyLeu: 4.876 ± 1.126
1.33GlyMet: 1.33 ± 1.176
3.546GlyAsn: 3.546 ± 1.442
1.33GlyPro: 1.33 ± 0.724
3.546GlyGln: 3.546 ± 1.22
2.66GlyArg: 2.66 ± 1.398
3.103GlySer: 3.103 ± 1.243
5.762GlyThr: 5.762 ± 1.603
6.206GlyVal: 6.206 ± 1.198
0.887GlyTrp: 0.887 ± 0.475
1.33GlyTyr: 1.33 ± 0.51
0.0GlyXaa: 0.0 ± 0.0
His
0.443HisAla: 0.443 ± 0.392
0.443HisCys: 0.443 ± 0.649
0.887HisAsp: 0.887 ± 0.437
1.33HisGlu: 1.33 ± 1.299
1.33HisPhe: 1.33 ± 0.737
1.33HisGly: 1.33 ± 0.383
0.0HisHis: 0.0 ± 0.0
1.33HisIle: 1.33 ± 0.383
1.33HisLys: 1.33 ± 0.553
2.66HisLeu: 2.66 ± 1.392
0.887HisMet: 0.887 ± 0.784
1.33HisAsn: 1.33 ± 0.726
1.33HisPro: 1.33 ± 0.799
0.443HisGln: 0.443 ± 0.45
0.887HisArg: 0.887 ± 0.437
1.773HisSer: 1.773 ± 1.301
1.33HisThr: 1.33 ± 0.888
1.773HisVal: 1.773 ± 0.69
1.33HisTrp: 1.33 ± 0.85
1.33HisTyr: 1.33 ± 0.639
0.0HisXaa: 0.0 ± 0.0
Ile
1.773IleAla: 1.773 ± 1.074
2.216IleCys: 2.216 ± 0.899
3.546IleAsp: 3.546 ± 1.661
4.876IleGlu: 4.876 ± 1.867
2.216IlePhe: 2.216 ± 1.032
3.989IleGly: 3.989 ± 1.15
1.33IleHis: 1.33 ± 0.814
3.989IleIle: 3.989 ± 1.685
2.216IleLys: 2.216 ± 0.929
3.989IleLeu: 3.989 ± 1.127
1.33IleMet: 1.33 ± 1.299
2.66IleAsn: 2.66 ± 0.985
3.989IlePro: 3.989 ± 1.863
3.989IleGln: 3.989 ± 0.994
2.66IleArg: 2.66 ± 1.395
3.989IleSer: 3.989 ± 0.922
3.546IleThr: 3.546 ± 1.091
3.989IleVal: 3.989 ± 1.483
0.0IleTrp: 0.0 ± 0.0
2.216IleTyr: 2.216 ± 0.762
0.0IleXaa: 0.0 ± 0.0
Lys
2.66LysAla: 2.66 ± 1.644
1.773LysCys: 1.773 ± 1.093
1.773LysAsp: 1.773 ± 0.646
4.433LysGlu: 4.433 ± 1.489
3.989LysPhe: 3.989 ± 1.268
2.216LysGly: 2.216 ± 0.788
2.216LysHis: 2.216 ± 1.463
2.66LysIle: 2.66 ± 1.218
4.433LysLys: 4.433 ± 1.826
3.546LysLeu: 3.546 ± 0.715
0.443LysMet: 0.443 ± 0.404
3.546LysAsn: 3.546 ± 1.351
2.216LysPro: 2.216 ± 1.165
1.773LysGln: 1.773 ± 0.319
3.989LysArg: 3.989 ± 0.417
3.546LysSer: 3.546 ± 2.071
2.66LysThr: 2.66 ± 1.78
3.546LysVal: 3.546 ± 1.338
0.0LysTrp: 0.0 ± 0.0
2.66LysTyr: 2.66 ± 0.703
0.0LysXaa: 0.0 ± 0.0
Leu
0.887LeuAla: 0.887 ± 0.475
3.103LeuCys: 3.103 ± 1.986
3.103LeuAsp: 3.103 ± 0.695
3.546LeuGlu: 3.546 ± 1.627
3.989LeuPhe: 3.989 ± 1.051
5.762LeuGly: 5.762 ± 2.198
2.66LeuHis: 2.66 ± 1.048
3.546LeuIle: 3.546 ± 2.622
4.876LeuLys: 4.876 ± 1.054
5.762LeuLeu: 5.762 ± 0.824
1.33LeuMet: 1.33 ± 0.599
2.66LeuAsn: 2.66 ± 1.097
3.546LeuPro: 3.546 ± 1.706
9.752LeuGln: 9.752 ± 3.228
5.319LeuArg: 5.319 ± 1.85
3.103LeuSer: 3.103 ± 1.121
3.989LeuThr: 3.989 ± 1.135
3.989LeuVal: 3.989 ± 1.135
0.0LeuTrp: 0.0 ± 0.0
4.433LeuTyr: 4.433 ± 1.193
0.0LeuXaa: 0.0 ± 0.0
Met
1.33MetAla: 1.33 ± 0.383
1.33MetCys: 1.33 ± 0.878
2.216MetAsp: 2.216 ± 1.095
1.773MetGlu: 1.773 ± 0.949
1.33MetPhe: 1.33 ± 0.983
0.887MetGly: 0.887 ± 0.679
0.0MetHis: 0.0 ± 0.0
0.887MetIle: 0.887 ± 0.437
0.0MetLys: 0.0 ± 0.0
0.443MetLeu: 0.443 ± 0.649
0.0MetMet: 0.0 ± 0.0
0.443MetAsn: 0.443 ± 0.392
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.33MetArg: 1.33 ± 0.601
2.66MetSer: 2.66 ± 0.588
0.887MetThr: 0.887 ± 0.807
2.216MetVal: 2.216 ± 1.174
0.443MetTrp: 0.443 ± 0.45
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.546AsnAla: 3.546 ± 1.744
0.443AsnCys: 0.443 ± 0.392
2.66AsnAsp: 2.66 ± 1.253
2.66AsnGlu: 2.66 ± 0.985
0.443AsnPhe: 0.443 ± 0.404
1.773AsnGly: 1.773 ± 0.893
0.0AsnHis: 0.0 ± 0.0
3.103AsnIle: 3.103 ± 2.254
3.989AsnLys: 3.989 ± 1.682
0.443AsnLeu: 0.443 ± 0.45
0.443AsnMet: 0.443 ± 0.404
5.319AsnAsn: 5.319 ± 0.941
3.103AsnPro: 3.103 ± 0.675
0.443AsnGln: 0.443 ± 0.404
2.216AsnArg: 2.216 ± 1.154
6.206AsnSer: 6.206 ± 2.884
5.762AsnThr: 5.762 ± 1.002
0.887AsnVal: 0.887 ± 0.48
0.887AsnTrp: 0.887 ± 0.475
0.443AsnTyr: 0.443 ± 0.649
0.0AsnXaa: 0.0 ± 0.0
Pro
5.762ProAla: 5.762 ± 2.812
0.887ProCys: 0.887 ± 0.446
3.989ProAsp: 3.989 ± 1.631
3.103ProGlu: 3.103 ± 1.47
1.773ProPhe: 1.773 ± 1.096
2.216ProGly: 2.216 ± 1.271
0.0ProHis: 0.0 ± 0.0
4.876ProIle: 4.876 ± 1.456
3.103ProLys: 3.103 ± 1.171
5.762ProLeu: 5.762 ± 1.782
0.887ProMet: 0.887 ± 0.59
1.773ProAsn: 1.773 ± 1.268
6.206ProPro: 6.206 ± 1.846
1.773ProGln: 1.773 ± 1.179
2.216ProArg: 2.216 ± 1.276
5.319ProSer: 5.319 ± 2.814
3.989ProThr: 3.989 ± 2.996
2.66ProVal: 2.66 ± 1.28
0.0ProTrp: 0.0 ± 0.0
3.546ProTyr: 3.546 ± 0.896
0.0ProXaa: 0.0 ± 0.0
Gln
3.546GlnAla: 3.546 ± 1.385
1.33GlnCys: 1.33 ± 1.299
1.33GlnAsp: 1.33 ± 0.737
1.773GlnGlu: 1.773 ± 0.693
1.773GlnPhe: 1.773 ± 1.138
1.33GlnGly: 1.33 ± 0.778
0.443GlnHis: 0.443 ± 0.392
2.216GlnIle: 2.216 ± 0.672
1.773GlnLys: 1.773 ± 0.887
5.319GlnLeu: 5.319 ± 1.417
2.216GlnMet: 2.216 ± 1.207
0.887GlnAsn: 0.887 ± 0.784
4.433GlnPro: 4.433 ± 1.47
3.546GlnGln: 3.546 ± 1.338
1.773GlnArg: 1.773 ± 0.958
2.66GlnSer: 2.66 ± 0.588
2.66GlnThr: 2.66 ± 0.443
3.546GlnVal: 3.546 ± 1.956
0.887GlnTrp: 0.887 ± 0.784
2.66GlnTyr: 2.66 ± 1.218
0.0GlnXaa: 0.0 ± 0.0
Arg
4.433ArgAla: 4.433 ± 1.06
1.33ArgCys: 1.33 ± 1.299
0.443ArgAsp: 0.443 ± 0.678
1.773ArgGlu: 1.773 ± 0.856
3.546ArgPhe: 3.546 ± 1.176
2.66ArgGly: 2.66 ± 0.806
2.66ArgHis: 2.66 ± 1.229
1.33ArgIle: 1.33 ± 0.659
2.216ArgLys: 2.216 ± 0.965
4.433ArgLeu: 4.433 ± 1.285
0.443ArgMet: 0.443 ± 0.487
0.887ArgAsn: 0.887 ± 0.475
6.206ArgPro: 6.206 ± 1.982
0.443ArgGln: 0.443 ± 0.45
3.989ArgArg: 3.989 ± 1.982
3.546ArgSer: 3.546 ± 1.385
3.546ArgThr: 3.546 ± 1.005
2.66ArgVal: 2.66 ± 1.161
0.887ArgTrp: 0.887 ± 0.679
1.33ArgTyr: 1.33 ± 0.51
0.0ArgXaa: 0.0 ± 0.0
Ser
5.319SerAla: 5.319 ± 1.187
1.33SerCys: 1.33 ± 0.856
2.216SerAsp: 2.216 ± 0.692
3.989SerGlu: 3.989 ± 1.977
1.773SerPhe: 1.773 ± 1.093
7.535SerGly: 7.535 ± 2.509
0.443SerHis: 0.443 ± 0.392
7.092SerIle: 7.092 ± 2.328
3.103SerLys: 3.103 ± 0.77
4.876SerLeu: 4.876 ± 1.633
1.773SerMet: 1.773 ± 0.684
6.649SerAsn: 6.649 ± 2.437
2.66SerPro: 2.66 ± 1.448
2.216SerGln: 2.216 ± 0.965
3.989SerArg: 3.989 ± 1.15
8.422SerSer: 8.422 ± 1.751
9.309SerThr: 9.309 ± 3.893
5.762SerVal: 5.762 ± 1.167
0.0SerTrp: 0.0 ± 0.0
1.33SerTyr: 1.33 ± 0.736
0.0SerXaa: 0.0 ± 0.0
Thr
3.989ThrAla: 3.989 ± 1.241
2.66ThrCys: 2.66 ± 0.588
7.092ThrAsp: 7.092 ± 1.867
3.103ThrGlu: 3.103 ± 1.023
2.66ThrPhe: 2.66 ± 1.816
4.876ThrGly: 4.876 ± 1.076
3.546ThrHis: 3.546 ± 1.865
4.876ThrIle: 4.876 ± 2.285
0.887ThrLys: 0.887 ± 0.491
5.762ThrLeu: 5.762 ± 2.705
1.33ThrMet: 1.33 ± 0.51
2.66ThrAsn: 2.66 ± 1.098
4.876ThrPro: 4.876 ± 1.183
3.103ThrGln: 3.103 ± 1.165
3.989ThrArg: 3.989 ± 1.398
9.752ThrSer: 9.752 ± 2.836
5.762ThrThr: 5.762 ± 1.612
5.762ThrVal: 5.762 ± 1.044
0.887ThrTrp: 0.887 ± 0.475
3.989ThrTyr: 3.989 ± 0.691
0.0ThrXaa: 0.0 ± 0.0
Val
1.773ValAla: 1.773 ± 0.319
1.773ValCys: 1.773 ± 1.22
5.319ValAsp: 5.319 ± 0.566
3.103ValGlu: 3.103 ± 1.358
2.216ValPhe: 2.216 ± 0.788
2.66ValGly: 2.66 ± 0.766
1.773ValHis: 1.773 ± 1.148
3.103ValIle: 3.103 ± 0.591
4.433ValLys: 4.433 ± 0.802
4.433ValLeu: 4.433 ± 1.753
1.33ValMet: 1.33 ± 0.77
2.216ValAsn: 2.216 ± 1.061
3.546ValPro: 3.546 ± 1.635
4.876ValGln: 4.876 ± 1.276
2.216ValArg: 2.216 ± 0.73
6.649ValSer: 6.649 ± 1.168
7.535ValThr: 7.535 ± 1.99
2.66ValVal: 2.66 ± 0.643
1.33ValTrp: 1.33 ± 0.778
2.66ValTyr: 2.66 ± 1.199
0.0ValXaa: 0.0 ± 0.0
Trp
0.887TrpAla: 0.887 ± 0.446
1.33TrpCys: 1.33 ± 0.746
0.0TrpAsp: 0.0 ± 0.0
0.887TrpGlu: 0.887 ± 0.491
0.443TrpPhe: 0.443 ± 0.392
0.887TrpGly: 0.887 ± 0.807
0.443TrpHis: 0.443 ± 0.45
0.887TrpIle: 0.887 ± 0.784
1.33TrpLys: 1.33 ± 0.837
0.887TrpLeu: 0.887 ± 0.446
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.443TrpPro: 0.443 ± 0.392
0.887TrpGln: 0.887 ± 0.446
1.773TrpArg: 1.773 ± 0.616
0.0TrpSer: 0.0 ± 0.0
1.773TrpThr: 1.773 ± 1.003
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.443TrpTyr: 0.443 ± 0.392
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.216TyrAla: 2.216 ± 0.751
0.887TyrCys: 0.887 ± 0.806
1.773TyrAsp: 1.773 ± 0.693
1.773TyrGlu: 1.773 ± 0.677
2.66TyrPhe: 2.66 ± 0.836
3.989TyrGly: 3.989 ± 1.275
0.443TyrHis: 0.443 ± 0.384
2.66TyrIle: 2.66 ± 1.578
2.66TyrLys: 2.66 ± 0.706
2.216TyrLeu: 2.216 ± 0.983
0.887TyrMet: 0.887 ± 0.446
0.887TyrAsn: 0.887 ± 0.48
0.887TyrPro: 0.887 ± 0.491
1.773TyrGln: 1.773 ± 0.807
3.546TyrArg: 3.546 ± 1.005
2.216TyrSer: 2.216 ± 0.974
1.33TyrThr: 1.33 ± 0.976
2.216TyrVal: 2.216 ± 0.518
1.33TyrTrp: 1.33 ± 0.383
3.103TyrTyr: 3.103 ± 1.315
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2257 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski