Amino acid dipepetide frequency for Lysinibacillus yapensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.211AlaAla: 6.211 ± 0.105	0.591AlaCys: 0.591 ± 0.026	3.334AlaAsp: 3.334 ± 0.072	5.044AlaGlu: 5.044 ± 0.092	3.489AlaPhe: 3.489 ± 0.061	5.23AlaGly: 5.23 ± 0.089	1.318AlaHis: 1.318 ± 0.041	6.61AlaIle: 6.61 ± 0.087	4.943AlaLys: 4.943 ± 0.072	7.463AlaLeu: 7.463 ± 0.09	2.022AlaMet: 2.022 ± 0.051	3.197AlaAsn: 3.197 ± 0.056	2.179AlaPro: 2.179 ± 0.057	2.592AlaGln: 2.592 ± 0.051	2.671AlaArg: 2.671 ± 0.056	4.239AlaSer: 4.239 ± 0.065	3.819AlaThr: 3.819 ± 0.062	5.456AlaVal: 5.456 ± 0.075	0.593AlaTrp: 0.593 ± 0.026	2.262AlaTyr: 2.262 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	0.443CysAla: 0.443 ± 0.021	0.097CysCys: 0.097 ± 0.01	0.366CysAsp: 0.366 ± 0.02	0.461CysGlu: 0.461 ± 0.025	0.312CysPhe: 0.312 ± 0.017	0.642CysGly: 0.642 ± 0.026	0.178CysHis: 0.178 ± 0.013	0.565CysIle: 0.565 ± 0.026	0.32CysLys: 0.32 ± 0.019	0.627CysLeu: 0.627 ± 0.025	0.168CysMet: 0.168 ± 0.012	0.284CysAsn: 0.284 ± 0.019	0.329CysPro: 0.329 ± 0.019	0.2CysGln: 0.2 ± 0.014	0.258CysArg: 0.258 ± 0.016	0.471CysSer: 0.471 ± 0.023	0.376CysThr: 0.376 ± 0.019	0.368CysVal: 0.368 ± 0.02	0.069CysTrp: 0.069 ± 0.009	0.231CysTyr: 0.231 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.459AspAla: 3.459 ± 0.066	0.35AspCys: 0.35 ± 0.017	2.233AspAsp: 2.233 ± 0.052	4.535AspGlu: 4.535 ± 0.073	2.512AspPhe: 2.512 ± 0.049	3.287AspGly: 3.287 ± 0.06	1.059AspHis: 1.059 ± 0.028	3.846AspIle: 3.846 ± 0.067	2.605AspLys: 2.605 ± 0.058	4.821AspLeu: 4.821 ± 0.064	1.179AspMet: 1.179 ± 0.033	1.71AspAsn: 1.71 ± 0.042	1.802AspPro: 1.802 ± 0.047	1.803AspGln: 1.803 ± 0.043	2.056AspArg: 2.056 ± 0.043	2.705AspSer: 2.705 ± 0.047	2.278AspThr: 2.278 ± 0.049	3.715AspVal: 3.715 ± 0.068	0.547AspTrp: 0.547 ± 0.024	2.159AspTyr: 2.159 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.705GluAla: 5.705 ± 0.082	0.383GluCys: 0.383 ± 0.022	3.708GluAsp: 3.708 ± 0.064	7.721GluGlu: 7.721 ± 0.123	2.7GluPhe: 2.7 ± 0.056	4.497GluGly: 4.497 ± 0.08	1.539GluHis: 1.539 ± 0.036	6.056GluIle: 6.056 ± 0.098	6.489GluLys: 6.489 ± 0.089	7.327GluLeu: 7.327 ± 0.1	2.393GluMet: 2.393 ± 0.045	4.104GluAsn: 4.104 ± 0.06	2.014GluPro: 2.014 ± 0.049	3.793GluGln: 3.793 ± 0.078	3.407GluArg: 3.407 ± 0.054	3.9GluSer: 3.9 ± 0.067	3.954GluThr: 3.954 ± 0.07	5.457GluVal: 5.457 ± 0.073	0.798GluTrp: 0.798 ± 0.029	2.167GluTyr: 2.167 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.334PheAla: 3.334 ± 0.067	0.331PheCys: 0.331 ± 0.018	2.418PheAsp: 2.418 ± 0.046	3.249PheGlu: 3.249 ± 0.055	2.313PhePhe: 2.313 ± 0.055	3.439PheGly: 3.439 ± 0.066	0.986PheHis: 0.986 ± 0.032	4.066PheIle: 4.066 ± 0.074	2.55PheLys: 2.55 ± 0.052	4.469PheLeu: 4.469 ± 0.078	1.206PheMet: 1.206 ± 0.034	2.056PheAsn: 2.056 ± 0.044	1.597PhePro: 1.597 ± 0.039	1.513PheGln: 1.513 ± 0.04	1.485PheArg: 1.485 ± 0.038	3.144PheSer: 3.144 ± 0.059	2.592PheThr: 2.592 ± 0.062	3.28PheVal: 3.28 ± 0.056	0.471PheTrp: 0.471 ± 0.024	1.752PheTyr: 1.752 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.912GlyAla: 4.912 ± 0.085	0.545GlyCys: 0.545 ± 0.024	3.093GlyAsp: 3.093 ± 0.058	4.686GlyGlu: 4.686 ± 0.074	3.365GlyPhe: 3.365 ± 0.06	4.821GlyGly: 4.821 ± 0.086	1.36GlyHis: 1.36 ± 0.04	6.007GlyIle: 6.007 ± 0.086	4.793GlyLys: 4.793 ± 0.068	6.386GlyLeu: 6.386 ± 0.09	1.991GlyMet: 1.991 ± 0.052	2.786GlyAsn: 2.786 ± 0.054	1.682GlyPro: 1.682 ± 0.045	2.308GlyGln: 2.308 ± 0.051	2.627GlyArg: 2.627 ± 0.059	3.872GlySer: 3.872 ± 0.065	4.054GlyThr: 4.054 ± 0.068	4.901GlyVal: 4.901 ± 0.078	0.785GlyTrp: 0.785 ± 0.028	2.825GlyTyr: 2.825 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.348HisAla: 1.348 ± 0.038	0.185HisCys: 0.185 ± 0.014	0.964HisAsp: 0.964 ± 0.031	1.381HisGlu: 1.381 ± 0.037	1.048HisPhe: 1.048 ± 0.029	1.375HisGly: 1.375 ± 0.04	0.638HisHis: 0.638 ± 0.029	1.494HisIle: 1.494 ± 0.043	1.038HisLys: 1.038 ± 0.026	2.051HisLeu: 2.051 ± 0.046	0.474HisMet: 0.474 ± 0.023	0.79HisAsn: 0.79 ± 0.025	1.162HisPro: 1.162 ± 0.035	0.807HisGln: 0.807 ± 0.029	0.801HisArg: 0.801 ± 0.028	1.182HisSer: 1.182 ± 0.034	0.969HisThr: 0.969 ± 0.031	1.342HisVal: 1.342 ± 0.034	0.2HisTrp: 0.2 ± 0.014	0.901HisTyr: 0.901 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.712IleAla: 6.712 ± 0.087	0.592IleCys: 0.592 ± 0.024	4.362IleAsp: 4.362 ± 0.069	6.267IleGlu: 6.267 ± 0.09	3.502IlePhe: 3.502 ± 0.067	6.077IleGly: 6.077 ± 0.083	1.615IleHis: 1.615 ± 0.043	6.182IleIle: 6.182 ± 0.097	4.262IleLys: 4.262 ± 0.061	7.694IleLeu: 7.694 ± 0.12	1.911IleMet: 1.911 ± 0.042	3.153IleAsn: 3.153 ± 0.06	3.373IlePro: 3.373 ± 0.058	3.06IleGln: 3.06 ± 0.055	3.127IleArg: 3.127 ± 0.059	5.177IleSer: 5.177 ± 0.076	4.307IleThr: 4.307 ± 0.066	5.968IleVal: 5.968 ± 0.081	0.602IleTrp: 0.602 ± 0.024	2.626IleTyr: 2.626 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.586LysAla: 4.586 ± 0.074	0.305LysCys: 0.305 ± 0.018	3.24LysAsp: 3.24 ± 0.057	6.574LysGlu: 6.574 ± 0.1	2.113LysPhe: 2.113 ± 0.044	4.126LysGly: 4.126 ± 0.07	1.217LysHis: 1.217 ± 0.039	4.861LysIle: 4.861 ± 0.072	5.323LysLys: 5.323 ± 0.081	5.881LysLeu: 5.881 ± 0.088	2.177LysMet: 2.177 ± 0.045	3.432LysAsn: 3.432 ± 0.052	2.23LysPro: 2.23 ± 0.051	2.878LysGln: 2.878 ± 0.064	2.993LysArg: 2.993 ± 0.056	3.457LysSer: 3.457 ± 0.062	3.466LysThr: 3.466 ± 0.064	4.67LysVal: 4.67 ± 0.064	0.792LysTrp: 0.792 ± 0.028	2.07LysTyr: 2.07 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	7.517LeuAla: 7.517 ± 0.092	0.625LeuCys: 0.625 ± 0.025	4.638LeuAsp: 4.638 ± 0.066	6.896LeuGlu: 6.896 ± 0.1	4.846LeuPhe: 4.846 ± 0.083	6.379LeuGly: 6.379 ± 0.098	1.94LeuHis: 1.94 ± 0.041	7.422LeuIle: 7.422 ± 0.107	6.581LeuLys: 6.581 ± 0.096	10.139LeuLeu: 10.139 ± 0.134	2.547LeuMet: 2.547 ± 0.058	4.663LeuAsn: 4.663 ± 0.07	3.96LeuPro: 3.96 ± 0.069	3.727LeuGln: 3.727 ± 0.071	3.547LeuArg: 3.547 ± 0.064	6.669LeuSer: 6.669 ± 0.082	5.533LeuThr: 5.533 ± 0.079	6.394LeuVal: 6.394 ± 0.094	0.792LeuTrp: 0.792 ± 0.03	3.069LeuTyr: 3.069 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.007MetAla: 2.007 ± 0.045	0.148MetCys: 0.148 ± 0.013	1.476MetAsp: 1.476 ± 0.038	1.973MetGlu: 1.973 ± 0.043	1.039MetPhe: 1.039 ± 0.034	1.792MetGly: 1.792 ± 0.046	0.489MetHis: 0.489 ± 0.02	2.121MetIle: 2.121 ± 0.049	2.356MetLys: 2.356 ± 0.054	2.533MetLeu: 2.533 ± 0.054	0.807MetMet: 0.807 ± 0.03	1.558MetAsn: 1.558 ± 0.041	1.077MetPro: 1.077 ± 0.032	1.033MetGln: 1.033 ± 0.032	1.097MetArg: 1.097 ± 0.037	1.548MetSer: 1.548 ± 0.04	1.599MetThr: 1.599 ± 0.039	1.692MetVal: 1.692 ± 0.04	0.164MetTrp: 0.164 ± 0.014	0.71MetTyr: 0.71 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.206AsnAla: 3.206 ± 0.057	0.322AsnCys: 0.322 ± 0.018	2.199AsnAsp: 2.199 ± 0.045	3.842AsnGlu: 3.842 ± 0.067	1.878AsnPhe: 1.878 ± 0.043	3.488AsnGly: 3.488 ± 0.058	0.998AsnHis: 0.998 ± 0.028	3.488AsnIle: 3.488 ± 0.061	2.811AsnLys: 2.811 ± 0.054	4.139AsnLeu: 4.139 ± 0.062	1.165AsnMet: 1.165 ± 0.031	2.214AsnAsn: 2.214 ± 0.06	2.244AsnPro: 2.244 ± 0.054	1.863AsnGln: 1.863 ± 0.058	2.058AsnArg: 2.058 ± 0.047	2.596AsnSer: 2.596 ± 0.056	2.093AsnThr: 2.093 ± 0.049	3.118AsnVal: 3.118 ± 0.052	0.505AsnTrp: 0.505 ± 0.019	1.729AsnTyr: 1.729 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.354ProAla: 2.354 ± 0.05	0.218ProCys: 0.218 ± 0.017	1.896ProAsp: 1.896 ± 0.046	3.008ProGlu: 3.008 ± 0.053	2.046ProPhe: 2.046 ± 0.044	2.192ProGly: 2.192 ± 0.053	0.761ProHis: 0.761 ± 0.024	3.025ProIle: 3.025 ± 0.053	2.186ProLys: 2.186 ± 0.048	3.4ProLeu: 3.4 ± 0.064	0.845ProMet: 0.845 ± 0.031	1.737ProAsn: 1.737 ± 0.039	0.967ProPro: 0.967 ± 0.032	1.25ProGln: 1.25 ± 0.036	1.063ProArg: 1.063 ± 0.037	2.28ProSer: 2.28 ± 0.046	2.109ProThr: 2.109 ± 0.047	2.754ProVal: 2.754 ± 0.053	0.317ProTrp: 0.317 ± 0.017	1.406ProTyr: 1.406 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.755GlnAla: 2.755 ± 0.054	0.207GlnCys: 0.207 ± 0.013	1.617GlnAsp: 1.617 ± 0.042	2.9GlnGlu: 2.9 ± 0.057	1.729GlnPhe: 1.729 ± 0.041	2.11GlnGly: 2.11 ± 0.046	0.797GlnHis: 0.797 ± 0.027	2.731GlnIle: 2.731 ± 0.057	2.641GlnLys: 2.641 ± 0.056	4.273GlnLeu: 4.273 ± 0.076	1.161GlnMet: 1.161 ± 0.034	1.832GlnAsn: 1.832 ± 0.056	1.298GlnPro: 1.298 ± 0.035	1.999GlnGln: 1.999 ± 0.066	1.418GlnArg: 1.418 ± 0.043	2.318GlnSer: 2.318 ± 0.048	2.034GlnThr: 2.034 ± 0.042	2.3GlnVal: 2.3 ± 0.051	0.386GlnTrp: 0.386 ± 0.019	1.461GlnTyr: 1.461 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.525ArgAla: 2.525 ± 0.054	0.258ArgCys: 0.258 ± 0.015	1.899ArgAsp: 1.899 ± 0.047	3.193ArgGlu: 3.193 ± 0.068	1.922ArgPhe: 1.922 ± 0.049	2.226ArgGly: 2.226 ± 0.049	0.762ArgHis: 0.762 ± 0.029	3.116ArgIle: 3.116 ± 0.054	3.03ArgLys: 3.03 ± 0.053	3.785ArgLeu: 3.785 ± 0.07	1.206ArgMet: 1.206 ± 0.035	1.9ArgAsn: 1.9 ± 0.041	1.263ArgPro: 1.263 ± 0.039	1.507ArgGln: 1.507 ± 0.042	1.691ArgArg: 1.691 ± 0.048	2.063ArgSer: 2.063 ± 0.046	1.941ArgThr: 1.941 ± 0.048	2.654ArgVal: 2.654 ± 0.063	0.353ArgTrp: 0.353 ± 0.019	1.443ArgTyr: 1.443 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.888SerAla: 3.888 ± 0.065	0.372SerCys: 0.372 ± 0.019	2.645SerAsp: 2.645 ± 0.049	4.125SerGlu: 4.125 ± 0.065	3.335SerPhe: 3.335 ± 0.059	4.27SerGly: 4.27 ± 0.063	1.163SerHis: 1.163 ± 0.037	5.354SerIle: 5.354 ± 0.09	3.91SerLys: 3.91 ± 0.057	6.061SerLeu: 6.061 ± 0.078	1.673SerMet: 1.673 ± 0.04	2.796SerAsn: 2.796 ± 0.057	2.052SerPro: 2.052 ± 0.045	2.014SerGln: 2.014 ± 0.048	2.195SerArg: 2.195 ± 0.046	4.04SerSer: 4.04 ± 0.076	3.253SerThr: 3.253 ± 0.057	4.043SerVal: 4.043 ± 0.069	0.545SerTrp: 0.545 ± 0.024	2.219SerTyr: 2.219 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.024ThrAla: 4.024 ± 0.067	0.339ThrCys: 0.339 ± 0.017	2.573ThrAsp: 2.573 ± 0.048	3.743ThrGlu: 3.743 ± 0.064	2.549ThrPhe: 2.549 ± 0.051	4.016ThrGly: 4.016 ± 0.065	1.035ThrHis: 1.035 ± 0.031	4.785ThrIle: 4.785 ± 0.075	3.338ThrLys: 3.338 ± 0.059	5.201ThrLeu: 5.201 ± 0.08	1.296ThrMet: 1.296 ± 0.039	2.44ThrAsn: 2.44 ± 0.045	2.258ThrPro: 2.258 ± 0.048	1.513ThrGln: 1.513 ± 0.033	1.69ThrArg: 1.69 ± 0.044	3.211ThrSer: 3.211 ± 0.058	3.078ThrThr: 3.078 ± 0.061	4.294ThrVal: 4.294 ± 0.067	0.466ThrTrp: 0.466 ± 0.022	1.905ThrTyr: 1.905 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.435ValAla: 5.435 ± 0.082	0.541ValCys: 0.541 ± 0.027	3.677ValAsp: 3.677 ± 0.066	5.31ValGlu: 5.31 ± 0.088	3.12ValPhe: 3.12 ± 0.06	4.78ValGly: 4.78 ± 0.076	1.323ValHis: 1.323 ± 0.035	5.524ValIle: 5.524 ± 0.079	4.536ValLys: 4.536 ± 0.069	7.017ValLeu: 7.017 ± 0.094	1.844ValMet: 1.844 ± 0.046	3.283ValAsn: 3.283 ± 0.063	2.68ValPro: 2.68 ± 0.049	2.436ValGln: 2.436 ± 0.05	2.631ValArg: 2.631 ± 0.057	4.339ValSer: 4.339 ± 0.069	3.907ValThr: 3.907 ± 0.058	5.253ValVal: 5.253 ± 0.076	0.579ValTrp: 0.579 ± 0.024	2.261ValTyr: 2.261 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.577TrpAla: 0.577 ± 0.024	0.065TrpCys: 0.065 ± 0.009	0.459TrpAsp: 0.459 ± 0.024	0.585TrpGlu: 0.585 ± 0.024	0.539TrpPhe: 0.539 ± 0.024	0.644TrpGly: 0.644 ± 0.026	0.215TrpHis: 0.215 ± 0.014	0.793TrpIle: 0.793 ± 0.028	0.619TrpLys: 0.619 ± 0.022	1.065TrpLeu: 1.065 ± 0.032	0.312TrpMet: 0.312 ± 0.016	0.482TrpAsn: 0.482 ± 0.019	0.243TrpPro: 0.243 ± 0.016	0.358TrpGln: 0.358 ± 0.019	0.393TrpArg: 0.393 ± 0.019	0.547TrpSer: 0.547 ± 0.026	0.499TrpThr: 0.499 ± 0.022	0.648TrpVal: 0.648 ± 0.024	0.127TrpTrp: 0.127 ± 0.013	0.275TrpTyr: 0.275 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.265TyrAla: 2.265 ± 0.046	0.291TyrCys: 0.291 ± 0.017	1.864TyrAsp: 1.864 ± 0.049	2.62TyrGlu: 2.62 ± 0.056	1.893TyrPhe: 1.893 ± 0.046	2.409TyrGly: 2.409 ± 0.043	0.761TyrHis: 0.761 ± 0.031	2.522TyrIle: 2.522 ± 0.049	2.059TyrLys: 2.059 ± 0.045	3.551TyrLeu: 3.551 ± 0.065	0.839TyrMet: 0.839 ± 0.025	1.538TyrAsn: 1.538 ± 0.043	1.403TyrPro: 1.403 ± 0.039	1.309TyrGln: 1.309 ± 0.033	1.53TyrArg: 1.53 ± 0.04	2.196TyrSer: 2.196 ± 0.051	1.895TyrThr: 1.895 ± 0.043	2.169TyrVal: 2.169 ± 0.042	0.354TyrTrp: 0.354 ± 0.02	1.368TyrTyr: 1.368 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3570 proteins (1043971 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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