Amino acid dipepetide frequency for Paracandidimonas soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.974AlaAla: 14.974 ± 0.168
1.33AlaCys: 1.33 ± 0.035
6.06AlaAsp: 6.06 ± 0.081
6.058AlaGlu: 6.058 ± 0.072
3.92AlaPhe: 3.92 ± 0.048
10.366AlaGly: 10.366 ± 0.098
2.503AlaHis: 2.503 ± 0.051
5.863AlaIle: 5.863 ± 0.077
3.276AlaLys: 3.276 ± 0.063
13.69AlaLeu: 13.69 ± 0.142
3.504AlaMet: 3.504 ± 0.059
2.796AlaAsn: 2.796 ± 0.052
5.195AlaPro: 5.195 ± 0.075
5.621AlaGln: 5.621 ± 0.07
8.145AlaArg: 8.145 ± 0.096
7.069AlaSer: 7.069 ± 0.091
5.061AlaThr: 5.061 ± 0.077
8.151AlaVal: 8.151 ± 0.1
1.815AlaTrp: 1.815 ± 0.046
2.561AlaTyr: 2.561 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.106CysAla: 1.106 ± 0.033
0.135CysCys: 0.135 ± 0.011
0.503CysAsp: 0.503 ± 0.023
0.458CysGlu: 0.458 ± 0.021
0.314CysPhe: 0.314 ± 0.017
0.989CysGly: 0.989 ± 0.034
0.264CysHis: 0.264 ± 0.015
0.446CysIle: 0.446 ± 0.02
0.22CysLys: 0.22 ± 0.013
0.968CysLeu: 0.968 ± 0.027
0.251CysMet: 0.251 ± 0.016
0.241CysAsn: 0.241 ± 0.016
0.493CysPro: 0.493 ± 0.023
0.279CysGln: 0.279 ± 0.014
0.65CysArg: 0.65 ± 0.026
0.54CysSer: 0.54 ± 0.023
0.479CysThr: 0.479 ± 0.022
0.697CysVal: 0.697 ± 0.025
0.136CysTrp: 0.136 ± 0.01
0.215CysTyr: 0.215 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.612AspAla: 6.612 ± 0.075
0.493AspCys: 0.493 ± 0.02
2.858AspAsp: 2.858 ± 0.058
3.13AspGlu: 3.13 ± 0.054
2.049AspPhe: 2.049 ± 0.042
4.57AspGly: 4.57 ± 0.076
1.059AspHis: 1.059 ± 0.035
3.229AspIle: 3.229 ± 0.059
1.683AspLys: 1.683 ± 0.039
5.447AspLeu: 5.447 ± 0.073
1.491AspMet: 1.491 ± 0.033
1.29AspAsn: 1.29 ± 0.035
3.015AspPro: 3.015 ± 0.056
1.725AspGln: 1.725 ± 0.037
3.262AspArg: 3.262 ± 0.059
2.654AspSer: 2.654 ± 0.045
2.824AspThr: 2.824 ± 0.057
3.948AspVal: 3.948 ± 0.066
0.925AspTrp: 0.925 ± 0.027
1.531AspTyr: 1.531 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.395GluAla: 6.395 ± 0.071
0.381GluCys: 0.381 ± 0.019
2.668GluAsp: 2.668 ± 0.045
2.745GluGlu: 2.745 ± 0.058
1.746GluPhe: 1.746 ± 0.045
3.677GluGly: 3.677 ± 0.065
1.428GluHis: 1.428 ± 0.037
2.955GluIle: 2.955 ± 0.053
2.039GluLys: 2.039 ± 0.045
5.762GluLeu: 5.762 ± 0.07
1.358GluMet: 1.358 ± 0.033
1.709GluAsn: 1.709 ± 0.04
2.636GluPro: 2.636 ± 0.05
3.028GluGln: 3.028 ± 0.052
4.552GluArg: 4.552 ± 0.069
2.99GluSer: 2.99 ± 0.06
2.893GluThr: 2.893 ± 0.05
3.534GluVal: 3.534 ± 0.056
0.727GluTrp: 0.727 ± 0.026
1.28GluTyr: 1.28 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.732PheAla: 3.732 ± 0.06
0.392PheCys: 0.392 ± 0.019
2.279PheAsp: 2.279 ± 0.053
1.928PheGlu: 1.928 ± 0.038
1.233PhePhe: 1.233 ± 0.035
3.252PheGly: 3.252 ± 0.053
0.792PheHis: 0.792 ± 0.028
1.743PheIle: 1.743 ± 0.043
0.947PheLys: 0.947 ± 0.032
3.325PheLeu: 3.325 ± 0.065
0.811PheMet: 0.811 ± 0.028
1.051PheAsn: 1.051 ± 0.028
1.625PhePro: 1.625 ± 0.035
1.131PheGln: 1.131 ± 0.032
2.084PheArg: 2.084 ± 0.042
2.467PheSer: 2.467 ± 0.052
1.796PheThr: 1.796 ± 0.042
2.387PheVal: 2.387 ± 0.043
0.548PheTrp: 0.548 ± 0.026
0.85PheTyr: 0.85 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.427GlyAla: 8.427 ± 0.096
0.854GlyCys: 0.854 ± 0.029
3.837GlyAsp: 3.837 ± 0.065
4.271GlyGlu: 4.271 ± 0.06
3.157GlyPhe: 3.157 ± 0.05
6.75GlyGly: 6.75 ± 0.086
1.865GlyHis: 1.865 ± 0.046
4.857GlyIle: 4.857 ± 0.072
3.584GlyLys: 3.584 ± 0.058
8.893GlyLeu: 8.893 ± 0.095
2.687GlyMet: 2.687 ± 0.054
2.392GlyAsn: 2.392 ± 0.053
2.8GlyPro: 2.8 ± 0.052
3.378GlyGln: 3.378 ± 0.054
5.577GlyArg: 5.577 ± 0.072
5.063GlySer: 5.063 ± 0.07
4.104GlyThr: 4.104 ± 0.065
6.257GlyVal: 6.257 ± 0.086
1.427GlyTrp: 1.427 ± 0.038
2.446GlyTyr: 2.446 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.902HisAla: 2.902 ± 0.052
0.265HisCys: 0.265 ± 0.016
1.211HisAsp: 1.211 ± 0.035
1.194HisGlu: 1.194 ± 0.036
0.777HisPhe: 0.777 ± 0.026
2.126HisGly: 2.126 ± 0.045
0.6HisHis: 0.6 ± 0.023
1.22HisIle: 1.22 ± 0.035
0.575HisLys: 0.575 ± 0.022
2.287HisLeu: 2.287 ± 0.05
0.548HisMet: 0.548 ± 0.021
0.534HisAsn: 0.534 ± 0.021
1.519HisPro: 1.519 ± 0.037
0.74HisGln: 0.74 ± 0.025
1.464HisArg: 1.464 ± 0.039
1.118HisSer: 1.118 ± 0.032
1.067HisThr: 1.067 ± 0.036
1.628HisVal: 1.628 ± 0.036
0.366HisTrp: 0.366 ± 0.02
0.614HisTyr: 0.614 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.5IleAla: 6.5 ± 0.078
0.479IleCys: 0.479 ± 0.019
3.309IleAsp: 3.309 ± 0.057
3.271IleGlu: 3.271 ± 0.054
1.47IlePhe: 1.47 ± 0.039
4.679IleGly: 4.679 ± 0.067
1.048IleHis: 1.048 ± 0.03
2.235IleIle: 2.235 ± 0.044
1.502IleLys: 1.502 ± 0.043
4.553IleLeu: 4.553 ± 0.074
1.091IleMet: 1.091 ± 0.03
1.503IleAsn: 1.503 ± 0.037
2.55IlePro: 2.55 ± 0.05
1.726IleGln: 1.726 ± 0.04
3.379IleArg: 3.379 ± 0.057
3.138IleSer: 3.138 ± 0.048
2.513IleThr: 2.513 ± 0.05
4.098IleVal: 4.098 ± 0.066
0.569IleTrp: 0.569 ± 0.019
1.089IleTyr: 1.089 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.863LysAla: 3.863 ± 0.067
0.153LysCys: 0.153 ± 0.013
1.65LysAsp: 1.65 ± 0.04
1.743LysGlu: 1.743 ± 0.047
0.804LysPhe: 0.804 ± 0.028
2.529LysGly: 2.529 ± 0.058
0.693LysHis: 0.693 ± 0.025
1.458LysIle: 1.458 ± 0.042
1.176LysLys: 1.176 ± 0.048
3.134LysLeu: 3.134 ± 0.057
0.727LysMet: 0.727 ± 0.027
0.917LysAsn: 0.917 ± 0.025
1.941LysPro: 1.941 ± 0.043
1.287LysGln: 1.287 ± 0.035
2.23LysArg: 2.23 ± 0.049
1.762LysSer: 1.762 ± 0.039
1.871LysThr: 1.871 ± 0.045
2.209LysVal: 2.209 ± 0.048
0.358LysTrp: 0.358 ± 0.017
0.678LysTyr: 0.678 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
14.106LeuAla: 14.106 ± 0.146
1.055LeuCys: 1.055 ± 0.034
6.068LeuAsp: 6.068 ± 0.077
5.76LeuGlu: 5.76 ± 0.08
3.658LeuPhe: 3.658 ± 0.071
8.571LeuGly: 8.571 ± 0.093
2.342LeuHis: 2.342 ± 0.041
4.913LeuIle: 4.913 ± 0.076
3.377LeuLys: 3.377 ± 0.062
11.757LeuLeu: 11.757 ± 0.164
2.598LeuMet: 2.598 ± 0.048
2.954LeuAsn: 2.954 ± 0.048
6.182LeuPro: 6.182 ± 0.072
4.202LeuGln: 4.202 ± 0.065
7.756LeuArg: 7.756 ± 0.09
7.143LeuSer: 7.143 ± 0.087
5.194LeuThr: 5.194 ± 0.075
7.086LeuVal: 7.086 ± 0.097
1.223LeuTrp: 1.223 ± 0.033
2.261LeuTyr: 2.261 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
3.123MetAla: 3.123 ± 0.053
0.189MetCys: 0.189 ± 0.014
1.218MetAsp: 1.218 ± 0.033
1.219MetGlu: 1.219 ± 0.033
0.79MetPhe: 0.79 ± 0.028
1.907MetGly: 1.907 ± 0.045
0.643MetHis: 0.643 ± 0.022
1.154MetIle: 1.154 ± 0.029
0.999MetLys: 0.999 ± 0.024
3.021MetLeu: 3.021 ± 0.055
0.684MetMet: 0.684 ± 0.023
0.858MetAsn: 0.858 ± 0.027
1.626MetPro: 1.626 ± 0.041
1.269MetGln: 1.269 ± 0.031
1.978MetArg: 1.978 ± 0.039
1.86MetSer: 1.86 ± 0.038
1.628MetThr: 1.628 ± 0.038
1.685MetVal: 1.685 ± 0.037
0.215MetTrp: 0.215 ± 0.013
0.386MetTyr: 0.386 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.207AsnAla: 3.207 ± 0.058
0.225AsnCys: 0.225 ± 0.014
1.402AsnAsp: 1.402 ± 0.03
1.314AsnGlu: 1.314 ± 0.035
0.912AsnPhe: 0.912 ± 0.029
2.279AsnGly: 2.279 ± 0.044
0.546AsnHis: 0.546 ± 0.022
1.5AsnIle: 1.5 ± 0.041
0.827AsnLys: 0.827 ± 0.031
2.719AsnLeu: 2.719 ± 0.055
0.713AsnMet: 0.713 ± 0.023
0.811AsnAsn: 0.811 ± 0.029
2.01AsnPro: 2.01 ± 0.041
0.918AsnGln: 0.918 ± 0.032
1.885AsnArg: 1.885 ± 0.046
1.277AsnSer: 1.277 ± 0.039
1.537AsnThr: 1.537 ± 0.037
1.986AsnVal: 1.986 ± 0.045
0.392AsnTrp: 0.392 ± 0.019
0.751AsnTyr: 0.751 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.231ProAla: 6.231 ± 0.087
0.394ProCys: 0.394 ± 0.022
3.688ProAsp: 3.688 ± 0.063
3.816ProGlu: 3.816 ± 0.062
1.853ProPhe: 1.853 ± 0.039
4.692ProGly: 4.692 ± 0.065
1.113ProHis: 1.113 ± 0.035
2.192ProIle: 2.192 ± 0.041
1.327ProLys: 1.327 ± 0.034
5.017ProLeu: 5.017 ± 0.063
1.28ProMet: 1.28 ± 0.033
1.259ProAsn: 1.259 ± 0.035
2.164ProPro: 2.164 ± 0.048
1.991ProGln: 1.991 ± 0.036
2.692ProArg: 2.692 ± 0.047
3.069ProSer: 3.069 ± 0.048
2.111ProThr: 2.111 ± 0.041
4.313ProVal: 4.313 ± 0.06
0.73ProTrp: 0.73 ± 0.024
1.357ProTyr: 1.357 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
6.229GlnAla: 6.229 ± 0.095
0.302GlnCys: 0.302 ± 0.017
2.015GlnAsp: 2.015 ± 0.045
2.296GlnGlu: 2.296 ± 0.044
1.189GlnPhe: 1.189 ± 0.036
3.284GlnGly: 3.284 ± 0.055
0.926GlnHis: 0.926 ± 0.028
1.896GlnIle: 1.896 ± 0.041
1.164GlnLys: 1.164 ± 0.037
3.942GlnLeu: 3.942 ± 0.058
1.036GlnMet: 1.036 ± 0.033
0.919GlnAsn: 0.919 ± 0.028
2.198GlnPro: 2.198 ± 0.046
2.034GlnGln: 2.034 ± 0.047
3.182GlnArg: 3.182 ± 0.055
2.22GlnSer: 2.22 ± 0.043
2.045GlnThr: 2.045 ± 0.045
2.904GlnVal: 2.904 ± 0.048
0.7GlnTrp: 0.7 ± 0.027
0.919GlnTyr: 0.919 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.594ArgAla: 6.594 ± 0.077
0.579ArgCys: 0.579 ± 0.026
3.549ArgAsp: 3.549 ± 0.064
4.181ArgGlu: 4.181 ± 0.068
2.524ArgPhe: 2.524 ± 0.041
4.398ArgGly: 4.398 ± 0.061
1.987ArgHis: 1.987 ± 0.044
4.19ArgIle: 4.19 ± 0.06
2.543ArgLys: 2.543 ± 0.047
8.171ArgLeu: 8.171 ± 0.097
2.01ArgMet: 2.01 ± 0.044
2.152ArgAsn: 2.152 ± 0.047
3.181ArgPro: 3.181 ± 0.056
3.545ArgGln: 3.545 ± 0.072
5.215ArgArg: 5.215 ± 0.076
3.841ArgSer: 3.841 ± 0.061
3.238ArgThr: 3.238 ± 0.05
4.511ArgVal: 4.511 ± 0.068
1.081ArgTrp: 1.081 ± 0.031
2.04ArgTyr: 2.04 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.418SerAla: 6.418 ± 0.079
0.536SerCys: 0.536 ± 0.024
2.976SerAsp: 2.976 ± 0.054
2.85SerGlu: 2.85 ± 0.044
2.165SerPhe: 2.165 ± 0.043
5.867SerGly: 5.867 ± 0.079
1.404SerHis: 1.404 ± 0.035
2.981SerIle: 2.981 ± 0.051
1.524SerLys: 1.524 ± 0.035
6.764SerLeu: 6.764 ± 0.085
1.729SerMet: 1.729 ± 0.035
1.555SerAsn: 1.555 ± 0.038
3.028SerPro: 3.028 ± 0.055
2.243SerGln: 2.243 ± 0.045
4.154SerArg: 4.154 ± 0.056
3.682SerSer: 3.682 ± 0.061
2.911SerThr: 2.911 ± 0.047
4.313SerVal: 4.313 ± 0.059
0.817SerTrp: 0.817 ± 0.028
1.405SerTyr: 1.405 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.339ThrAla: 5.339 ± 0.076
0.432ThrCys: 0.432 ± 0.019
2.603ThrAsp: 2.603 ± 0.048
2.409ThrGlu: 2.409 ± 0.043
1.628ThrPhe: 1.628 ± 0.039
4.605ThrGly: 4.605 ± 0.062
1.19ThrHis: 1.19 ± 0.032
2.446ThrIle: 2.446 ± 0.049
1.069ThrLys: 1.069 ± 0.03
6.191ThrLeu: 6.191 ± 0.073
1.115ThrMet: 1.115 ± 0.029
1.187ThrAsn: 1.187 ± 0.031
3.34ThrPro: 3.34 ± 0.051
2.042ThrGln: 2.042 ± 0.042
3.13ThrArg: 3.13 ± 0.05
2.689ThrSer: 2.689 ± 0.051
2.438ThrThr: 2.438 ± 0.047
3.885ThrVal: 3.885 ± 0.065
0.602ThrTrp: 0.602 ± 0.024
1.047ThrTyr: 1.047 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.206ValAla: 8.206 ± 0.098
0.751ValCys: 0.751 ± 0.026
3.873ValAsp: 3.873 ± 0.064
4.002ValGlu: 4.002 ± 0.058
2.735ValPhe: 2.735 ± 0.05
5.009ValGly: 5.009 ± 0.08
1.481ValHis: 1.481 ± 0.037
3.714ValIle: 3.714 ± 0.06
2.183ValLys: 2.183 ± 0.05
7.984ValLeu: 7.984 ± 0.098
1.905ValMet: 1.905 ± 0.038
2.031ValAsn: 2.031 ± 0.042
3.785ValPro: 3.785 ± 0.056
2.637ValGln: 2.637 ± 0.053
5.075ValArg: 5.075 ± 0.076
4.672ValSer: 4.672 ± 0.071
3.707ValThr: 3.707 ± 0.058
5.729ValVal: 5.729 ± 0.083
0.903ValTrp: 0.903 ± 0.028
1.541ValTyr: 1.541 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.206TrpAla: 1.206 ± 0.031
0.155TrpCys: 0.155 ± 0.011
0.573TrpAsp: 0.573 ± 0.022
0.613TrpGlu: 0.613 ± 0.024
0.562TrpPhe: 0.562 ± 0.025
0.892TrpGly: 0.892 ± 0.031
0.369TrpHis: 0.369 ± 0.019
0.733TrpIle: 0.733 ± 0.025
0.485TrpLys: 0.485 ± 0.02
2.126TrpLeu: 2.126 ± 0.057
0.45TrpMet: 0.45 ± 0.017
0.457TrpAsn: 0.457 ± 0.02
0.654TrpPro: 0.654 ± 0.023
0.721TrpGln: 0.721 ± 0.028
1.23TrpArg: 1.23 ± 0.034
0.783TrpSer: 0.783 ± 0.026
0.647TrpThr: 0.647 ± 0.024
0.913TrpVal: 0.913 ± 0.028
0.244TrpTrp: 0.244 ± 0.015
0.316TrpTyr: 0.316 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.787TyrAla: 2.787 ± 0.053
0.284TyrCys: 0.284 ± 0.015
1.453TyrAsp: 1.453 ± 0.038
1.248TyrGlu: 1.248 ± 0.034
0.886TyrPhe: 0.886 ± 0.026
2.183TyrGly: 2.183 ± 0.044
0.503TyrHis: 0.503 ± 0.022
0.977TyrIle: 0.977 ± 0.029
0.68TyrLys: 0.68 ± 0.025
2.452TyrLeu: 2.452 ± 0.049
0.465TyrMet: 0.465 ± 0.022
0.599TyrAsn: 0.599 ± 0.024
1.348TyrPro: 1.348 ± 0.034
0.885TyrGln: 0.885 ± 0.028
1.89TyrArg: 1.89 ± 0.04
1.287TyrSer: 1.287 ± 0.041
1.323TyrThr: 1.323 ± 0.034
1.69TyrVal: 1.69 ± 0.036
0.349TyrTrp: 0.349 ± 0.019
0.574TyrTyr: 0.574 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3626 proteins (1167027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski