Amino acid dipepetide frequency for Fonticula alba (Slime mold)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.561AlaAla: 23.561 ± 0.222	2.578AlaCys: 2.578 ± 0.09	6.806AlaAsp: 6.806 ± 0.062	6.042AlaGlu: 6.042 ± 0.066	3.196AlaPhe: 3.196 ± 0.033	14.768AlaGly: 14.768 ± 0.132	2.669AlaHis: 2.669 ± 0.03	3.563AlaIle: 3.563 ± 0.033	2.233AlaLys: 2.233 ± 0.032	11.333AlaLeu: 11.333 ± 0.097	2.204AlaMet: 2.204 ± 0.022	2.225AlaAsn: 2.225 ± 0.027	11.279AlaPro: 11.279 ± 0.086	3.633AlaGln: 3.633 ± 0.035	7.771AlaArg: 7.771 ± 0.067	12.048AlaSer: 12.048 ± 0.091	7.593AlaThr: 7.593 ± 0.053	6.591AlaVal: 6.591 ± 0.046	1.1AlaTrp: 1.1 ± 0.017	1.531AlaTyr: 1.531 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	2.009CysAla: 2.009 ± 0.063	0.2CysCys: 0.2 ± 0.009	0.902CysAsp: 0.902 ± 0.026	0.645CysGlu: 0.645 ± 0.016	0.499CysPhe: 0.499 ± 0.012	1.065CysGly: 1.065 ± 0.024	0.644CysHis: 0.644 ± 0.025	0.498CysIle: 0.498 ± 0.011	0.267CysLys: 0.267 ± 0.01	1.999CysLeu: 1.999 ± 0.04	0.308CysMet: 0.308 ± 0.01	0.305CysAsn: 0.305 ± 0.009	1.887CysPro: 1.887 ± 0.063	0.752CysGln: 0.752 ± 0.024	1.187CysArg: 1.187 ± 0.025	1.329CysSer: 1.329 ± 0.033	1.141CysThr: 1.141 ± 0.048	1.18CysVal: 1.18 ± 0.038	0.187CysTrp: 0.187 ± 0.007	0.229CysTyr: 0.229 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.06AspAla: 6.06 ± 0.048	0.759AspCys: 0.759 ± 0.023	3.69AspAsp: 3.69 ± 0.061	2.828AspGlu: 2.828 ± 0.036	1.999AspPhe: 1.999 ± 0.025	4.081AspGly: 4.081 ± 0.043	1.239AspHis: 1.239 ± 0.02	2.091AspIle: 2.091 ± 0.026	0.955AspLys: 0.955 ± 0.02	5.533AspLeu: 5.533 ± 0.047	1.185AspMet: 1.185 ± 0.017	1.06AspAsn: 1.06 ± 0.016	4.384AspPro: 4.384 ± 0.04	1.724AspGln: 1.724 ± 0.019	3.524AspArg: 3.524 ± 0.04	4.165AspSer: 4.165 ± 0.043	2.638AspThr: 2.638 ± 0.029	2.967AspVal: 2.967 ± 0.034	0.535AspTrp: 0.535 ± 0.012	0.968AspTyr: 0.968 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	6.176GluAla: 6.176 ± 0.058	0.879GluCys: 0.879 ± 0.028	2.986GluAsp: 2.986 ± 0.037	3.193GluGlu: 3.193 ± 0.053	1.249GluPhe: 1.249 ± 0.02	2.888GluGly: 2.888 ± 0.031	1.287GluHis: 1.287 ± 0.017	1.52GluIle: 1.52 ± 0.025	1.208GluLys: 1.208 ± 0.021	4.384GluLeu: 4.384 ± 0.043	0.892GluMet: 0.892 ± 0.018	0.957GluAsn: 0.957 ± 0.019	2.918GluPro: 2.918 ± 0.04	1.952GluGln: 1.952 ± 0.028	3.201GluArg: 3.201 ± 0.04	3.215GluSer: 3.215 ± 0.034	1.961GluThr: 1.961 ± 0.032	2.579GluVal: 2.579 ± 0.031	0.447GluTrp: 0.447 ± 0.012	1.006GluTyr: 1.006 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.186PheAla: 3.186 ± 0.031	0.535PheCys: 0.535 ± 0.012	2.026PheAsp: 2.026 ± 0.026	1.509PheGlu: 1.509 ± 0.022	1.441PhePhe: 1.441 ± 0.023	2.61PheGly: 2.61 ± 0.037	0.924PheHis: 0.924 ± 0.017	1.155PheIle: 1.155 ± 0.019	0.625PheLys: 0.625 ± 0.015	3.452PheLeu: 3.452 ± 0.035	0.594PheMet: 0.594 ± 0.013	0.859PheAsn: 0.859 ± 0.018	1.948PhePro: 1.948 ± 0.023	1.078PheGln: 1.078 ± 0.014	2.099PheArg: 2.099 ± 0.026	2.937PheSer: 2.937 ± 0.032	1.462PheThr: 1.462 ± 0.021	1.946PheVal: 1.946 ± 0.025	0.347PheTrp: 0.347 ± 0.01	0.708PheTyr: 0.708 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.244GlyAla: 11.244 ± 0.099	1.298GlyCys: 1.298 ± 0.034	4.238GlyAsp: 4.238 ± 0.041	2.903GlyGlu: 2.903 ± 0.029	2.452GlyPhe: 2.452 ± 0.026	10.524GlyGly: 10.524 ± 0.163	2.507GlyHis: 2.507 ± 0.034	2.259GlyIle: 2.259 ± 0.026	1.483GlyLys: 1.483 ± 0.022	7.728GlyLeu: 7.728 ± 0.057	1.524GlyMet: 1.524 ± 0.022	1.529GlyAsn: 1.529 ± 0.022	9.231GlyPro: 9.231 ± 0.108	3.067GlyGln: 3.067 ± 0.033	5.825GlyArg: 5.825 ± 0.054	8.933GlySer: 8.933 ± 0.107	4.659GlyThr: 4.659 ± 0.047	4.324GlyVal: 4.324 ± 0.042	0.8GlyTrp: 0.8 ± 0.013	1.314GlyTyr: 1.314 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.786HisAla: 2.786 ± 0.033	0.475HisCys: 0.475 ± 0.016	1.067HisAsp: 1.067 ± 0.019	0.967HisGlu: 0.967 ± 0.017	1.11HisPhe: 1.11 ± 0.018	2.071HisGly: 2.071 ± 0.032	1.738HisHis: 1.738 ± 0.068	0.955HisIle: 0.955 ± 0.017	0.386HisLys: 0.386 ± 0.011	3.041HisLeu: 3.041 ± 0.03	0.609HisMet: 0.609 ± 0.013	0.506HisAsn: 0.506 ± 0.012	2.372HisPro: 2.372 ± 0.038	1.295HisGln: 1.295 ± 0.03	1.826HisArg: 1.826 ± 0.022	2.129HisSer: 2.129 ± 0.03	1.182HisThr: 1.182 ± 0.021	1.418HisVal: 1.418 ± 0.022	0.278HisTrp: 0.278 ± 0.008	0.616HisTyr: 0.616 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	2.932IleAla: 2.932 ± 0.032	0.574IleCys: 0.574 ± 0.013	1.9IleAsp: 1.9 ± 0.026	1.641IleGlu: 1.641 ± 0.025	1.263IlePhe: 1.263 ± 0.023	2.313IleGly: 2.313 ± 0.027	0.855IleHis: 0.855 ± 0.015	1.355IleIle: 1.355 ± 0.023	0.819IleLys: 0.819 ± 0.017	3.229IleLeu: 3.229 ± 0.036	0.606IleMet: 0.606 ± 0.013	0.97IleAsn: 0.97 ± 0.018	2.113IlePro: 2.113 ± 0.024	1.147IleGln: 1.147 ± 0.019	2.359IleArg: 2.359 ± 0.03	2.603IleSer: 2.603 ± 0.029	1.594IleThr: 1.594 ± 0.021	1.937IleVal: 1.937 ± 0.028	0.323IleTrp: 0.323 ± 0.01	0.732IleTyr: 0.732 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.212LysAla: 2.212 ± 0.031	0.313LysCys: 0.313 ± 0.012	0.96LysAsp: 0.96 ± 0.019	0.992LysGlu: 0.992 ± 0.022	0.643LysPhe: 0.643 ± 0.015	1.042LysGly: 1.042 ± 0.017	0.528LysHis: 0.528 ± 0.011	0.887LysIle: 0.887 ± 0.018	1.109LysLys: 1.109 ± 0.03	1.804LysLeu: 1.804 ± 0.028	0.493LysMet: 0.493 ± 0.012	0.654LysAsn: 0.654 ± 0.016	1.378LysPro: 1.378 ± 0.027	0.789LysGln: 0.789 ± 0.017	1.61LysArg: 1.61 ± 0.025	1.575LysSer: 1.575 ± 0.026	1.141LysThr: 1.141 ± 0.02	1.116LysVal: 1.116 ± 0.02	0.187LysTrp: 0.187 ± 0.007	0.572LysTyr: 0.572 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.543LeuAla: 13.543 ± 0.108	1.495LeuCys: 1.495 ± 0.024	5.387LeuAsp: 5.387 ± 0.041	4.631LeuGlu: 4.631 ± 0.043	3.484LeuPhe: 3.484 ± 0.038	6.975LeuGly: 6.975 ± 0.052	2.543LeuHis: 2.543 ± 0.028	2.739LeuIle: 2.739 ± 0.037	1.924LeuLys: 1.924 ± 0.029	11.964LeuLeu: 11.964 ± 0.102	1.702LeuMet: 1.702 ± 0.023	2.189LeuAsn: 2.189 ± 0.025	7.985LeuPro: 7.985 ± 0.056	3.463LeuGln: 3.463 ± 0.037	6.991LeuArg: 6.991 ± 0.06	8.681LeuSer: 8.681 ± 0.069	4.547LeuThr: 4.547 ± 0.041	6.267LeuVal: 6.267 ± 0.048	0.906LeuTrp: 0.906 ± 0.018	1.63LeuTyr: 1.63 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.691MetAla: 2.691 ± 0.027	0.294MetCys: 0.294 ± 0.009	1.03MetAsp: 1.03 ± 0.015	0.801MetGlu: 0.801 ± 0.014	0.544MetPhe: 0.544 ± 0.012	1.139MetGly: 1.139 ± 0.017	0.538MetHis: 0.538 ± 0.012	0.611MetIle: 0.611 ± 0.013	0.415MetLys: 0.415 ± 0.011	1.949MetLeu: 1.949 ± 0.021	0.477MetMet: 0.477 ± 0.013	0.46MetAsn: 0.46 ± 0.011	1.511MetPro: 1.511 ± 0.022	0.633MetGln: 0.633 ± 0.013	1.221MetArg: 1.221 ± 0.017	1.931MetSer: 1.931 ± 0.025	1.014MetThr: 1.014 ± 0.015	1.258MetVal: 1.258 ± 0.018	0.162MetTrp: 0.162 ± 0.006	0.37MetTyr: 0.37 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.195AsnAla: 2.195 ± 0.02	0.333AsnCys: 0.333 ± 0.012	1.003AsnAsp: 1.003 ± 0.016	0.894AsnGlu: 0.894 ± 0.016	0.846AsnPhe: 0.846 ± 0.015	1.441AsnGly: 1.441 ± 0.024	0.52AsnHis: 0.52 ± 0.011	1.043AsnIle: 1.043 ± 0.021	0.587AsnLys: 0.587 ± 0.016	1.998AsnLeu: 1.998 ± 0.025	0.533AsnMet: 0.533 ± 0.013	0.688AsnAsn: 0.688 ± 0.017	1.644AsnPro: 1.644 ± 0.021	0.726AsnGln: 0.726 ± 0.015	1.369AsnArg: 1.369 ± 0.02	1.603AsnSer: 1.603 ± 0.022	1.136AsnThr: 1.136 ± 0.02	1.346AsnVal: 1.346 ± 0.02	0.252AsnTrp: 0.252 ± 0.008	0.526AsnTyr: 0.526 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	14.16ProAla: 14.16 ± 0.116	1.114ProCys: 1.114 ± 0.027	4.049ProAsp: 4.049 ± 0.039	4.2ProGlu: 4.2 ± 0.044	2.049ProPhe: 2.049 ± 0.025	11.593ProGly: 11.593 ± 0.123	1.878ProHis: 1.878 ± 0.033	1.824ProIle: 1.824 ± 0.023	1.293ProLys: 1.293 ± 0.025	6.811ProLeu: 6.811 ± 0.05	1.449ProMet: 1.449 ± 0.022	1.385ProAsn: 1.385 ± 0.02	9.098ProPro: 9.098 ± 0.123	2.16ProGln: 2.16 ± 0.036	4.343ProArg: 4.343 ± 0.044	7.893ProSer: 7.893 ± 0.083	4.388ProThr: 4.388 ± 0.047	5.433ProVal: 5.433 ± 0.046	0.624ProTrp: 0.624 ± 0.014	1.01ProTyr: 1.01 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.632GlnAla: 4.632 ± 0.04	0.714GlnCys: 0.714 ± 0.027	1.387GlnAsp: 1.387 ± 0.02	1.522GlnGlu: 1.522 ± 0.026	0.97GlnPhe: 0.97 ± 0.016	1.871GlnGly: 1.871 ± 0.024	1.377GlnHis: 1.377 ± 0.034	1.106GlnIle: 1.106 ± 0.019	0.805GlnLys: 0.805 ± 0.016	3.872GlnLeu: 3.872 ± 0.037	0.773GlnMet: 0.773 ± 0.013	0.67GlnAsn: 0.67 ± 0.013	3.116GlnPro: 3.116 ± 0.043	4.187GlnGln: 4.187 ± 0.169	2.459GlnArg: 2.459 ± 0.027	2.534GlnSer: 2.534 ± 0.027	1.596GlnThr: 1.596 ± 0.026	2.002GlnVal: 2.002 ± 0.024	0.328GlnTrp: 0.328 ± 0.009	0.759GlnTyr: 0.759 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.686ArgAla: 7.686 ± 0.06	1.261ArgCys: 1.261 ± 0.038	3.073ArgAsp: 3.073 ± 0.038	2.902ArgGlu: 2.902 ± 0.04	2.09ArgPhe: 2.09 ± 0.026	4.207ArgGly: 4.207 ± 0.04	1.99ArgHis: 1.99 ± 0.024	2.101ArgIle: 2.101 ± 0.024	1.527ArgLys: 1.527 ± 0.024	7.639ArgLeu: 7.639 ± 0.062	1.401ArgMet: 1.401 ± 0.02	1.339ArgAsn: 1.339 ± 0.021	5.644ArgPro: 5.644 ± 0.048	2.937ArgGln: 2.937 ± 0.029	6.55ArgArg: 6.55 ± 0.067	5.574ArgSer: 5.574 ± 0.062	2.947ArgThr: 2.947 ± 0.029	3.885ArgVal: 3.885 ± 0.034	0.73ArgTrp: 0.73 ± 0.015	1.167ArgTyr: 1.167 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	10.853SerAla: 10.853 ± 0.091	1.56SerCys: 1.56 ± 0.051	4.484SerAsp: 4.484 ± 0.05	3.341SerGlu: 3.341 ± 0.037	2.714SerPhe: 2.714 ± 0.032	8.291SerGly: 8.291 ± 0.092	2.094SerHis: 2.094 ± 0.029	2.801SerIle: 2.801 ± 0.029	1.687SerLys: 1.687 ± 0.028	8.57SerLeu: 8.57 ± 0.069	1.755SerMet: 1.755 ± 0.022	1.77SerAsn: 1.77 ± 0.028	8.961SerPro: 8.961 ± 0.098	2.928SerGln: 2.928 ± 0.034	5.576SerArg: 5.576 ± 0.064	11.86SerSer: 11.86 ± 0.164	5.179SerThr: 5.179 ± 0.049	4.586SerVal: 4.586 ± 0.04	0.751SerTrp: 0.751 ± 0.014	1.248SerTyr: 1.248 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	6.501ThrAla: 6.501 ± 0.049	1.244ThrCys: 1.244 ± 0.054	2.483ThrAsp: 2.483 ± 0.025	2.167ThrGlu: 2.167 ± 0.033	1.647ThrPhe: 1.647 ± 0.024	5.328ThrGly: 5.328 ± 0.049	1.167ThrHis: 1.167 ± 0.02	1.764ThrIle: 1.764 ± 0.029	1.003ThrLys: 1.003 ± 0.019	4.653ThrLeu: 4.653 ± 0.042	0.978ThrMet: 0.978 ± 0.016	1.049ThrAsn: 1.049 ± 0.02	4.989ThrPro: 4.989 ± 0.05	1.394ThrGln: 1.394 ± 0.021	3.01ThrArg: 3.01 ± 0.027	4.827ThrSer: 4.827 ± 0.044	3.282ThrThr: 3.282 ± 0.047	2.953ThrVal: 2.953 ± 0.032	0.466ThrTrp: 0.466 ± 0.012	0.868ThrTyr: 0.868 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	7.802ValAla: 7.802 ± 0.054	1.138ValCys: 1.138 ± 0.023	3.466ValAsp: 3.466 ± 0.032	2.642ValGlu: 2.642 ± 0.032	2.04ValPhe: 2.04 ± 0.024	3.987ValGly: 3.987 ± 0.037	1.428ValHis: 1.428 ± 0.019	1.929ValIle: 1.929 ± 0.026	1.102ValLys: 1.102 ± 0.022	5.942ValLeu: 5.942 ± 0.048	0.973ValMet: 0.973 ± 0.016	1.319ValAsn: 1.319 ± 0.021	4.582ValPro: 4.582 ± 0.036	1.72ValGln: 1.72 ± 0.021	3.698ValArg: 3.698 ± 0.035	4.902ValSer: 4.902 ± 0.042	2.949ValThr: 2.949 ± 0.032	3.915ValVal: 3.915 ± 0.037	0.576ValTrp: 0.576 ± 0.014	1.122ValTyr: 1.122 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.972TrpAla: 0.972 ± 0.019	0.169TrpCys: 0.169 ± 0.006	0.51TrpAsp: 0.51 ± 0.012	0.348TrpGlu: 0.348 ± 0.01	0.337TrpPhe: 0.337 ± 0.011	0.461TrpGly: 0.461 ± 0.011	0.275TrpHis: 0.275 ± 0.009	0.321TrpIle: 0.321 ± 0.009	0.204TrpLys: 0.204 ± 0.007	1.219TrpLeu: 1.219 ± 0.019	0.193TrpMet: 0.193 ± 0.006	0.239TrpAsn: 0.239 ± 0.008	0.731TrpPro: 0.731 ± 0.016	0.366TrpGln: 0.366 ± 0.009	0.838TrpArg: 0.838 ± 0.016	0.784TrpSer: 0.784 ± 0.014	0.521TrpThr: 0.521 ± 0.012	0.524TrpVal: 0.524 ± 0.013	0.17TrpTrp: 0.17 ± 0.008	0.192TrpTyr: 0.192 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.525TyrAla: 1.525 ± 0.023	0.302TyrCys: 0.302 ± 0.009	0.938TyrAsp: 0.938 ± 0.018	0.73TyrGlu: 0.73 ± 0.016	0.866TyrPhe: 0.866 ± 0.016	1.188TyrGly: 1.188 ± 0.023	0.627TyrHis: 0.627 ± 0.014	0.741TyrIle: 0.741 ± 0.014	0.372TyrLys: 0.372 ± 0.012	1.926TyrLeu: 1.926 ± 0.027	0.401TyrMet: 0.401 ± 0.012	0.512TyrAsn: 0.512 ± 0.012	0.98TyrPro: 0.98 ± 0.018	0.727TyrGln: 0.727 ± 0.015	1.188TyrArg: 1.188 ± 0.018	1.492TyrSer: 1.492 ± 0.02	0.842TyrThr: 0.842 ± 0.018	1.005TyrVal: 1.005 ± 0.019	0.202TyrTrp: 0.202 ± 0.007	0.556TyrTyr: 0.556 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6244 proteins (4258807 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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