Amino acid dipepetide frequency for Erwinia phage vB_EamM_Caitlin

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.792AlaAla: 7.792 ± 0.397
0.659AlaCys: 0.659 ± 0.098
5.142AlaAsp: 5.142 ± 0.251
4.536AlaGlu: 4.536 ± 0.276
3.665AlaPhe: 3.665 ± 0.174
5.234AlaGly: 5.234 ± 0.322
1.543AlaHis: 1.543 ± 0.133
4.575AlaIle: 4.575 ± 0.258
4.588AlaLys: 4.588 ± 0.267
7.964AlaLeu: 7.964 ± 0.308
2.808AlaMet: 2.808 ± 0.208
3.626AlaAsn: 3.626 ± 0.232
2.914AlaPro: 2.914 ± 0.27
2.769AlaGln: 2.769 ± 0.189
4.14AlaArg: 4.14 ± 0.23
3.969AlaSer: 3.969 ± 0.265
4.852AlaThr: 4.852 ± 0.283
5.59AlaVal: 5.59 ± 0.288
1.094AlaTrp: 1.094 ± 0.11
3.323AlaTyr: 3.323 ± 0.21
0.0AlaXaa: 0.0 ± 0.0
Cys
0.712CysAla: 0.712 ± 0.098
0.132CysCys: 0.132 ± 0.047
0.501CysAsp: 0.501 ± 0.084
0.633CysGlu: 0.633 ± 0.099
0.277CysPhe: 0.277 ± 0.074
0.58CysGly: 0.58 ± 0.077
0.29CysHis: 0.29 ± 0.051
0.461CysIle: 0.461 ± 0.08
0.422CysLys: 0.422 ± 0.089
0.646CysLeu: 0.646 ± 0.1
0.277CysMet: 0.277 ± 0.06
0.369CysAsn: 0.369 ± 0.073
0.369CysPro: 0.369 ± 0.081
0.435CysGln: 0.435 ± 0.07
0.488CysArg: 0.488 ± 0.077
0.58CysSer: 0.58 ± 0.103
0.554CysThr: 0.554 ± 0.09
0.699CysVal: 0.699 ± 0.105
0.079CysTrp: 0.079 ± 0.037
0.409CysTyr: 0.409 ± 0.083
0.0CysXaa: 0.0 ± 0.0
Asp
5.063AspAla: 5.063 ± 0.251
0.58AspCys: 0.58 ± 0.084
4.272AspAsp: 4.272 ± 0.362
4.272AspGlu: 4.272 ± 0.255
2.545AspPhe: 2.545 ± 0.147
4.654AspGly: 4.654 ± 0.274
1.398AspHis: 1.398 ± 0.148
3.903AspIle: 3.903 ± 0.242
3.468AspLys: 3.468 ± 0.28
5.63AspLeu: 5.63 ± 0.269
1.82AspMet: 1.82 ± 0.167
3.046AspAsn: 3.046 ± 0.209
3.125AspPro: 3.125 ± 0.211
1.714AspGln: 1.714 ± 0.142
2.901AspArg: 2.901 ± 0.209
3.046AspSer: 3.046 ± 0.199
3.692AspThr: 3.692 ± 0.236
5.103AspVal: 5.103 ± 0.259
0.989AspTrp: 0.989 ± 0.111
2.466AspTyr: 2.466 ± 0.181
0.0AspXaa: 0.0 ± 0.0
Glu
4.76GluAla: 4.76 ± 0.285
0.607GluCys: 0.607 ± 0.081
3.692GluAsp: 3.692 ± 0.234
4.074GluGlu: 4.074 ± 0.263
2.532GluPhe: 2.532 ± 0.19
3.362GluGly: 3.362 ± 0.177
1.345GluHis: 1.345 ± 0.142
4.074GluIle: 4.074 ± 0.235
3.323GluLys: 3.323 ± 0.281
6.988GluLeu: 6.988 ± 0.344
1.793GluMet: 1.793 ± 0.148
2.479GluAsn: 2.479 ± 0.173
2.07GluPro: 2.07 ± 0.166
2.558GluGln: 2.558 ± 0.184
3.415GluArg: 3.415 ± 0.205
3.112GluSer: 3.112 ± 0.204
3.613GluThr: 3.613 ± 0.237
4.377GluVal: 4.377 ± 0.212
1.147GluTrp: 1.147 ± 0.122
2.532GluTyr: 2.532 ± 0.187
0.0GluXaa: 0.0 ± 0.0
Phe
2.822PheAla: 2.822 ± 0.22
0.369PheCys: 0.369 ± 0.072
3.151PheAsp: 3.151 ± 0.214
1.938PheGlu: 1.938 ± 0.166
1.846PhePhe: 1.846 ± 0.162
2.861PheGly: 2.861 ± 0.189
0.844PheHis: 0.844 ± 0.102
1.885PheIle: 1.885 ± 0.141
1.793PheLys: 1.793 ± 0.149
2.584PheLeu: 2.584 ± 0.199
1.332PheMet: 1.332 ± 0.128
2.558PheAsn: 2.558 ± 0.187
1.503PhePro: 1.503 ± 0.14
1.45PheGln: 1.45 ± 0.134
2.136PheArg: 2.136 ± 0.184
2.4PheSer: 2.4 ± 0.157
2.993PheThr: 2.993 ± 0.186
2.69PheVal: 2.69 ± 0.21
0.541PheTrp: 0.541 ± 0.076
1.767PheTyr: 1.767 ± 0.152
0.0PheXaa: 0.0 ± 0.0
Gly
4.035GlyAla: 4.035 ± 0.269
0.58GlyCys: 0.58 ± 0.093
3.837GlyAsp: 3.837 ± 0.272
4.694GlyGlu: 4.694 ± 0.227
2.808GlyPhe: 2.808 ± 0.194
4.799GlyGly: 4.799 ± 0.601
1.121GlyHis: 1.121 ± 0.129
3.876GlyIle: 3.876 ± 0.229
4.588GlyLys: 4.588 ± 0.262
5.538GlyLeu: 5.538 ± 0.269
2.083GlyMet: 2.083 ± 0.149
3.468GlyAsn: 3.468 ± 0.25
1.688GlyPro: 1.688 ± 0.162
2.452GlyGln: 2.452 ± 0.169
3.758GlyArg: 3.758 ± 0.242
3.639GlySer: 3.639 ± 0.238
4.206GlyThr: 4.206 ± 0.28
4.918GlyVal: 4.918 ± 0.238
1.266GlyTrp: 1.266 ± 0.142
2.466GlyTyr: 2.466 ± 0.17
0.0GlyXaa: 0.0 ± 0.0
His
1.45HisAla: 1.45 ± 0.149
0.251HisCys: 0.251 ± 0.054
1.292HisAsp: 1.292 ± 0.146
1.279HisGlu: 1.279 ± 0.136
0.844HisPhe: 0.844 ± 0.11
1.411HisGly: 1.411 ± 0.136
0.738HisHis: 0.738 ± 0.098
1.279HisIle: 1.279 ± 0.133
0.831HisLys: 0.831 ± 0.103
2.083HisLeu: 2.083 ± 0.179
0.738HisMet: 0.738 ± 0.093
0.804HisAsn: 0.804 ± 0.105
1.173HisPro: 1.173 ± 0.135
0.725HisGln: 0.725 ± 0.104
1.305HisArg: 1.305 ± 0.14
0.91HisSer: 0.91 ± 0.106
1.398HisThr: 1.398 ± 0.146
1.345HisVal: 1.345 ± 0.119
0.277HisTrp: 0.277 ± 0.062
1.094HisTyr: 1.094 ± 0.11
0.0HisXaa: 0.0 ± 0.0
Ile
4.799IleAla: 4.799 ± 0.241
0.58IleCys: 0.58 ± 0.091
4.114IleAsp: 4.114 ± 0.247
3.573IleGlu: 3.573 ± 0.259
1.701IlePhe: 1.701 ± 0.169
3.362IleGly: 3.362 ± 0.187
1.371IleHis: 1.371 ± 0.134
2.677IleIle: 2.677 ± 0.22
2.597IleLys: 2.597 ± 0.178
4.311IleLeu: 4.311 ± 0.296
1.318IleMet: 1.318 ± 0.122
3.323IleAsn: 3.323 ± 0.197
2.861IlePro: 2.861 ± 0.205
1.833IleGln: 1.833 ± 0.146
3.534IleArg: 3.534 ± 0.209
3.046IleSer: 3.046 ± 0.206
3.613IleThr: 3.613 ± 0.24
3.679IleVal: 3.679 ± 0.23
0.514IleTrp: 0.514 ± 0.075
2.07IleTyr: 2.07 ± 0.18
0.0IleXaa: 0.0 ± 0.0
Lys
4.813LysAla: 4.813 ± 0.268
0.316LysCys: 0.316 ± 0.061
2.927LysAsp: 2.927 ± 0.243
3.705LysGlu: 3.705 ± 0.258
2.162LysPhe: 2.162 ± 0.172
3.098LysGly: 3.098 ± 0.199
1.16LysHis: 1.16 ± 0.114
2.597LysIle: 2.597 ± 0.176
2.993LysLys: 2.993 ± 0.225
5.234LysLeu: 5.234 ± 0.245
1.846LysMet: 1.846 ± 0.147
2.479LysAsn: 2.479 ± 0.174
2.07LysPro: 2.07 ± 0.176
2.07LysGln: 2.07 ± 0.165
2.927LysArg: 2.927 ± 0.198
2.69LysSer: 2.69 ± 0.189
3.098LysThr: 3.098 ± 0.216
4.087LysVal: 4.087 ± 0.222
0.778LysTrp: 0.778 ± 0.098
1.727LysTyr: 1.727 ± 0.153
0.0LysXaa: 0.0 ± 0.0
Leu
7.568LeuAla: 7.568 ± 0.329
0.804LeuCys: 0.804 ± 0.103
5.92LeuAsp: 5.92 ± 0.269
5.617LeuGlu: 5.617 ± 0.289
3.072LeuPhe: 3.072 ± 0.183
5.656LeuGly: 5.656 ± 0.274
1.793LeuHis: 1.793 ± 0.182
4.391LeuIle: 4.391 ± 0.232
4.707LeuLys: 4.707 ± 0.262
7.713LeuLeu: 7.713 ± 0.35
2.769LeuMet: 2.769 ± 0.206
4.865LeuAsn: 4.865 ± 0.266
5.129LeuPro: 5.129 ± 0.245
3.151LeuGln: 3.151 ± 0.204
5.379LeuArg: 5.379 ± 0.263
5.933LeuSer: 5.933 ± 0.297
6.223LeuThr: 6.223 ± 0.263
5.894LeuVal: 5.894 ± 0.317
0.963LeuTrp: 0.963 ± 0.118
3.296LeuTyr: 3.296 ± 0.177
0.0LeuXaa: 0.0 ± 0.0
Met
2.677MetAla: 2.677 ± 0.177
0.316MetCys: 0.316 ± 0.056
1.411MetAsp: 1.411 ± 0.143
2.03MetGlu: 2.03 ± 0.18
1.292MetPhe: 1.292 ± 0.131
1.872MetGly: 1.872 ± 0.197
0.607MetHis: 0.607 ± 0.085
1.345MetIle: 1.345 ± 0.165
1.358MetLys: 1.358 ± 0.137
2.386MetLeu: 2.386 ± 0.195
0.857MetMet: 0.857 ± 0.103
1.556MetAsn: 1.556 ± 0.183
1.108MetPro: 1.108 ± 0.11
1.055MetGln: 1.055 ± 0.114
2.004MetArg: 2.004 ± 0.171
2.189MetSer: 2.189 ± 0.139
1.912MetThr: 1.912 ± 0.157
2.004MetVal: 2.004 ± 0.163
0.396MetTrp: 0.396 ± 0.068
1.108MetTyr: 1.108 ± 0.115
0.0MetXaa: 0.0 ± 0.0
Asn
4.206AsnAla: 4.206 ± 0.248
0.303AsnCys: 0.303 ± 0.062
3.098AsnAsp: 3.098 ± 0.203
2.65AsnGlu: 2.65 ± 0.182
1.595AsnPhe: 1.595 ± 0.148
4.048AsnGly: 4.048 ± 0.259
1.134AsnHis: 1.134 ± 0.115
2.65AsnIle: 2.65 ± 0.156
2.439AsnLys: 2.439 ± 0.209
4.048AsnLeu: 4.048 ± 0.254
0.976AsnMet: 0.976 ± 0.108
2.584AsnAsn: 2.584 ± 0.216
2.874AsnPro: 2.874 ± 0.209
1.872AsnGln: 1.872 ± 0.149
2.861AsnArg: 2.861 ± 0.207
2.492AsnSer: 2.492 ± 0.174
3.362AsnThr: 3.362 ± 0.255
3.362AsnVal: 3.362 ± 0.185
0.897AsnTrp: 0.897 ± 0.103
1.806AsnTyr: 1.806 ± 0.178
0.0AsnXaa: 0.0 ± 0.0
Pro
3.296ProAla: 3.296 ± 0.255
0.224ProCys: 0.224 ± 0.055
3.085ProAsp: 3.085 ± 0.211
3.296ProGlu: 3.296 ± 0.201
1.714ProPhe: 1.714 ± 0.149
2.967ProGly: 2.967 ± 0.184
1.108ProHis: 1.108 ± 0.143
2.268ProIle: 2.268 ± 0.196
2.479ProLys: 2.479 ± 0.188
3.903ProLeu: 3.903 ± 0.224
1.226ProMet: 1.226 ± 0.134
1.938ProAsn: 1.938 ± 0.192
1.45ProPro: 1.45 ± 0.14
1.859ProGln: 1.859 ± 0.181
1.833ProArg: 1.833 ± 0.186
2.65ProSer: 2.65 ± 0.191
2.927ProThr: 2.927 ± 0.233
3.758ProVal: 3.758 ± 0.252
0.435ProTrp: 0.435 ± 0.07
1.569ProTyr: 1.569 ± 0.173
0.0ProXaa: 0.0 ± 0.0
Gln
3.23GlnAla: 3.23 ± 0.229
0.422GlnCys: 0.422 ± 0.089
1.754GlnAsp: 1.754 ± 0.151
2.03GlnGlu: 2.03 ± 0.171
1.556GlnPhe: 1.556 ± 0.126
2.255GlnGly: 2.255 ± 0.183
0.699GlnHis: 0.699 ± 0.096
1.938GlnIle: 1.938 ± 0.167
1.74GlnLys: 1.74 ± 0.161
3.784GlnLeu: 3.784 ± 0.228
1.305GlnMet: 1.305 ± 0.162
1.701GlnAsn: 1.701 ± 0.161
1.648GlnPro: 1.648 ± 0.163
1.951GlnGln: 1.951 ± 0.188
2.36GlnArg: 2.36 ± 0.19
2.281GlnSer: 2.281 ± 0.175
1.925GlnThr: 1.925 ± 0.196
2.466GlnVal: 2.466 ± 0.184
0.593GlnTrp: 0.593 ± 0.094
1.622GlnTyr: 1.622 ± 0.15
0.0GlnXaa: 0.0 ± 0.0
Arg
3.837ArgAla: 3.837 ± 0.255
0.514ArgCys: 0.514 ± 0.071
3.547ArgAsp: 3.547 ± 0.276
3.389ArgGlu: 3.389 ± 0.239
2.281ArgPhe: 2.281 ± 0.202
3.375ArgGly: 3.375 ± 0.241
1.292ArgHis: 1.292 ± 0.118
3.52ArgIle: 3.52 ± 0.197
2.901ArgLys: 2.901 ± 0.243
5.208ArgLeu: 5.208 ± 0.284
2.03ArgMet: 2.03 ± 0.162
2.914ArgAsn: 2.914 ± 0.186
1.846ArgPro: 1.846 ± 0.158
2.123ArgGln: 2.123 ± 0.191
3.362ArgArg: 3.362 ± 0.237
2.888ArgSer: 2.888 ± 0.197
3.257ArgThr: 3.257 ± 0.225
3.85ArgVal: 3.85 ± 0.233
0.857ArgTrp: 0.857 ± 0.104
2.677ArgTyr: 2.677 ± 0.18
0.0ArgXaa: 0.0 ± 0.0
Ser
4.298SerAla: 4.298 ± 0.2
0.475SerCys: 0.475 ± 0.088
3.375SerAsp: 3.375 ± 0.232
3.178SerGlu: 3.178 ± 0.215
2.321SerPhe: 2.321 ± 0.176
4.377SerGly: 4.377 ± 0.299
0.923SerHis: 0.923 ± 0.127
3.27SerIle: 3.27 ± 0.198
2.729SerLys: 2.729 ± 0.205
5.353SerLeu: 5.353 ± 0.307
1.688SerMet: 1.688 ± 0.118
2.558SerAsn: 2.558 ± 0.192
2.703SerPro: 2.703 ± 0.221
2.057SerGln: 2.057 ± 0.155
3.019SerArg: 3.019 ± 0.211
2.967SerSer: 2.967 ± 0.254
3.454SerThr: 3.454 ± 0.246
4.021SerVal: 4.021 ± 0.24
0.791SerTrp: 0.791 ± 0.096
2.123SerTyr: 2.123 ± 0.176
0.0SerXaa: 0.0 ± 0.0
Thr
5.696ThrAla: 5.696 ± 0.431
0.448ThrCys: 0.448 ± 0.084
3.837ThrAsp: 3.837 ± 0.204
3.639ThrGlu: 3.639 ± 0.219
2.518ThrPhe: 2.518 ± 0.219
4.351ThrGly: 4.351 ± 0.271
1.253ThrHis: 1.253 ± 0.121
3.573ThrIle: 3.573 ± 0.228
3.125ThrLys: 3.125 ± 0.213
6.263ThrLeu: 6.263 ± 0.346
1.371ThrMet: 1.371 ± 0.142
2.65ThrAsn: 2.65 ± 0.19
3.745ThrPro: 3.745 ± 0.258
2.228ThrGln: 2.228 ± 0.148
2.848ThrArg: 2.848 ± 0.19
3.389ThrSer: 3.389 ± 0.222
4.14ThrThr: 4.14 ± 0.259
5.155ThrVal: 5.155 ± 0.281
0.91ThrTrp: 0.91 ± 0.097
2.07ThrTyr: 2.07 ± 0.17
0.0ThrXaa: 0.0 ± 0.0
Val
5.907ValAla: 5.907 ± 0.317
0.844ValCys: 0.844 ± 0.1
4.813ValAsp: 4.813 ± 0.278
4.654ValGlu: 4.654 ± 0.244
2.597ValPhe: 2.597 ± 0.177
4.127ValGly: 4.127 ± 0.234
1.121ValHis: 1.121 ± 0.127
3.929ValIle: 3.929 ± 0.244
4.087ValLys: 4.087 ± 0.29
6.026ValLeu: 6.026 ± 0.312
1.622ValMet: 1.622 ± 0.157
3.415ValAsn: 3.415 ± 0.23
3.375ValPro: 3.375 ± 0.24
2.637ValGln: 2.637 ± 0.176
3.916ValArg: 3.916 ± 0.24
4.588ValSer: 4.588 ± 0.253
4.76ValThr: 4.76 ± 0.227
5.182ValVal: 5.182 ± 0.274
1.042ValTrp: 1.042 ± 0.113
2.953ValTyr: 2.953 ± 0.205
0.0ValXaa: 0.0 ± 0.0
Trp
0.949TrpAla: 0.949 ± 0.102
0.119TrpCys: 0.119 ± 0.039
1.055TrpAsp: 1.055 ± 0.122
0.765TrpGlu: 0.765 ± 0.089
0.646TrpPhe: 0.646 ± 0.117
0.659TrpGly: 0.659 ± 0.085
0.343TrpHis: 0.343 ± 0.066
0.725TrpIle: 0.725 ± 0.09
0.91TrpLys: 0.91 ± 0.104
1.464TrpLeu: 1.464 ± 0.159
0.593TrpMet: 0.593 ± 0.078
0.712TrpAsn: 0.712 ± 0.087
0.514TrpPro: 0.514 ± 0.075
0.659TrpGln: 0.659 ± 0.101
1.002TrpArg: 1.002 ± 0.108
0.883TrpSer: 0.883 ± 0.108
0.699TrpThr: 0.699 ± 0.097
0.963TrpVal: 0.963 ± 0.125
0.251TrpTrp: 0.251 ± 0.061
0.448TrpTyr: 0.448 ± 0.079
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.874TyrAla: 2.874 ± 0.23
0.369TyrCys: 0.369 ± 0.069
2.861TyrAsp: 2.861 ± 0.198
1.899TyrGlu: 1.899 ± 0.191
1.49TyrPhe: 1.49 ± 0.14
2.769TyrGly: 2.769 ± 0.178
1.147TyrHis: 1.147 ± 0.132
1.938TyrIle: 1.938 ± 0.149
1.701TyrLys: 1.701 ± 0.165
3.718TyrLeu: 3.718 ± 0.213
1.015TyrMet: 1.015 ± 0.092
2.215TyrAsn: 2.215 ± 0.173
1.82TyrPro: 1.82 ± 0.158
1.661TyrGln: 1.661 ± 0.153
2.479TyrArg: 2.479 ± 0.186
2.03TyrSer: 2.03 ± 0.166
2.545TyrThr: 2.545 ± 0.171
2.452TyrVal: 2.452 ± 0.181
0.541TyrTrp: 0.541 ± 0.078
1.74TyrTyr: 1.74 ± 0.16
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 271 proteins (75845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski