Amino acid dipepetide frequency for Salinibacter phage M8CC-19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.426AlaAla: 5.426 ± 0.934
0.192AlaCys: 0.192 ± 0.125
6.639AlaAsp: 6.639 ± 0.711
6.703AlaGlu: 6.703 ± 0.944
3.447AlaPhe: 3.447 ± 0.653
4.277AlaGly: 4.277 ± 0.555
1.277AlaHis: 1.277 ± 0.258
2.873AlaIle: 2.873 ± 0.44
4.277AlaLys: 4.277 ± 0.53
5.299AlaLeu: 5.299 ± 0.728
1.915AlaMet: 1.915 ± 0.365
3.958AlaAsn: 3.958 ± 0.561
2.554AlaPro: 2.554 ± 0.382
2.873AlaGln: 2.873 ± 0.689
5.937AlaArg: 5.937 ± 0.715
4.277AlaSer: 4.277 ± 0.676
3.575AlaThr: 3.575 ± 0.647
5.107AlaVal: 5.107 ± 0.782
1.085AlaTrp: 1.085 ± 0.245
3.256AlaTyr: 3.256 ± 0.475
0.0AlaXaa: 0.0 ± 0.0
Cys
0.383CysAla: 0.383 ± 0.136
0.0CysCys: 0.0 ± 0.0
0.128CysAsp: 0.128 ± 0.097
0.319CysGlu: 0.319 ± 0.129
0.128CysPhe: 0.128 ± 0.088
0.192CysGly: 0.192 ± 0.101
0.064CysHis: 0.064 ± 0.055
0.192CysIle: 0.192 ± 0.136
0.255CysLys: 0.255 ± 0.123
0.383CysLeu: 0.383 ± 0.175
0.064CysMet: 0.064 ± 0.066
0.064CysAsn: 0.064 ± 0.063
0.192CysPro: 0.192 ± 0.091
0.064CysGln: 0.064 ± 0.077
0.255CysArg: 0.255 ± 0.176
0.447CysSer: 0.447 ± 0.168
0.383CysThr: 0.383 ± 0.198
0.638CysVal: 0.638 ± 0.195
0.064CysTrp: 0.064 ± 0.063
0.192CysTyr: 0.192 ± 0.127
0.0CysXaa: 0.0 ± 0.0
Asp
6.193AspAla: 6.193 ± 0.634
0.319AspCys: 0.319 ± 0.137
3.83AspAsp: 3.83 ± 0.659
5.299AspGlu: 5.299 ± 0.714
3.447AspPhe: 3.447 ± 0.535
7.725AspGly: 7.725 ± 1.016
1.341AspHis: 1.341 ± 0.277
3.639AspIle: 3.639 ± 0.415
3.703AspLys: 3.703 ± 0.433
5.554AspLeu: 5.554 ± 0.622
1.532AspMet: 1.532 ± 0.453
3.767AspAsn: 3.767 ± 0.603
2.937AspPro: 2.937 ± 0.414
1.277AspGln: 1.277 ± 0.302
3.894AspArg: 3.894 ± 0.515
3.958AspSer: 3.958 ± 0.709
5.299AspThr: 5.299 ± 0.551
6.959AspVal: 6.959 ± 0.902
0.958AspTrp: 0.958 ± 0.274
3.511AspTyr: 3.511 ± 0.462
0.0AspXaa: 0.0 ± 0.0
Glu
6.831GluAla: 6.831 ± 0.817
0.319GluCys: 0.319 ± 0.107
6.001GluAsp: 6.001 ± 0.927
7.406GluGlu: 7.406 ± 0.969
4.277GluPhe: 4.277 ± 0.599
5.49GluGly: 5.49 ± 0.572
1.085GluHis: 1.085 ± 0.21
4.788GluIle: 4.788 ± 0.483
4.533GluLys: 4.533 ± 0.835
4.98GluLeu: 4.98 ± 0.66
2.617GluMet: 2.617 ± 0.453
2.937GluAsn: 2.937 ± 0.325
2.554GluPro: 2.554 ± 0.602
2.234GluGln: 2.234 ± 0.351
5.426GluArg: 5.426 ± 0.772
4.66GluSer: 4.66 ± 0.479
5.682GluThr: 5.682 ± 0.735
5.49GluVal: 5.49 ± 0.58
1.341GluTrp: 1.341 ± 0.276
3.064GluTyr: 3.064 ± 0.569
0.0GluXaa: 0.0 ± 0.0
Phe
2.937PheAla: 2.937 ± 0.438
0.128PheCys: 0.128 ± 0.101
3.894PheAsp: 3.894 ± 0.479
4.341PheGlu: 4.341 ± 0.671
1.979PhePhe: 1.979 ± 0.465
3.575PheGly: 3.575 ± 0.507
0.638PheHis: 0.638 ± 0.18
1.596PheIle: 1.596 ± 0.41
1.915PheLys: 1.915 ± 0.37
2.617PheLeu: 2.617 ± 0.493
1.213PheMet: 1.213 ± 0.334
1.788PheAsn: 1.788 ± 0.31
1.66PhePro: 1.66 ± 0.28
0.638PheGln: 0.638 ± 0.212
3.001PheArg: 3.001 ± 0.521
2.681PheSer: 2.681 ± 0.606
2.554PheThr: 2.554 ± 0.482
3.703PheVal: 3.703 ± 0.512
0.319PheTrp: 0.319 ± 0.155
1.468PheTyr: 1.468 ± 0.427
0.0PheXaa: 0.0 ± 0.0
Gly
3.958GlyAla: 3.958 ± 0.507
0.511GlyCys: 0.511 ± 0.191
6.193GlyAsp: 6.193 ± 1.114
5.426GlyGlu: 5.426 ± 0.604
2.745GlyPhe: 2.745 ± 0.489
7.086GlyGly: 7.086 ± 0.899
1.404GlyHis: 1.404 ± 0.33
3.384GlyIle: 3.384 ± 0.461
3.767GlyLys: 3.767 ± 0.662
4.852GlyLeu: 4.852 ± 0.762
1.724GlyMet: 1.724 ± 0.439
3.447GlyAsn: 3.447 ± 1.166
2.362GlyPro: 2.362 ± 0.419
2.298GlyGln: 2.298 ± 0.488
5.682GlyArg: 5.682 ± 0.664
4.916GlySer: 4.916 ± 1.206
5.363GlyThr: 5.363 ± 0.743
5.937GlyVal: 5.937 ± 0.511
1.66GlyTrp: 1.66 ± 0.528
3.32GlyTyr: 3.32 ± 0.451
0.0GlyXaa: 0.0 ± 0.0
His
2.043HisAla: 2.043 ± 0.396
0.064HisCys: 0.064 ± 0.075
1.341HisAsp: 1.341 ± 0.323
1.277HisGlu: 1.277 ± 0.335
0.83HisPhe: 0.83 ± 0.274
1.915HisGly: 1.915 ± 0.373
0.511HisHis: 0.511 ± 0.155
1.404HisIle: 1.404 ± 0.28
0.702HisLys: 0.702 ± 0.202
1.66HisLeu: 1.66 ± 0.501
0.319HisMet: 0.319 ± 0.168
0.894HisAsn: 0.894 ± 0.241
0.766HisPro: 0.766 ± 0.239
0.064HisGln: 0.064 ± 0.046
1.341HisArg: 1.341 ± 0.301
1.213HisSer: 1.213 ± 0.288
1.021HisThr: 1.021 ± 0.223
1.277HisVal: 1.277 ± 0.257
0.192HisTrp: 0.192 ± 0.112
0.511HisTyr: 0.511 ± 0.163
0.0HisXaa: 0.0 ± 0.0
Ile
3.575IleAla: 3.575 ± 0.388
0.255IleCys: 0.255 ± 0.125
4.469IleAsp: 4.469 ± 0.602
5.171IleGlu: 5.171 ± 0.645
1.851IlePhe: 1.851 ± 0.426
3.575IleGly: 3.575 ± 0.391
1.021IleHis: 1.021 ± 0.269
2.426IleIle: 2.426 ± 0.506
1.851IleLys: 1.851 ± 0.391
2.617IleLeu: 2.617 ± 0.406
1.085IleMet: 1.085 ± 0.312
1.979IleAsn: 1.979 ± 0.494
2.298IlePro: 2.298 ± 0.38
2.107IleGln: 2.107 ± 0.462
3.447IleArg: 3.447 ± 0.405
3.767IleSer: 3.767 ± 0.702
3.384IleThr: 3.384 ± 0.496
3.384IleVal: 3.384 ± 0.454
0.383IleTrp: 0.383 ± 0.173
1.915IleTyr: 1.915 ± 0.415
0.0IleXaa: 0.0 ± 0.0
Lys
4.916LysAla: 4.916 ± 0.639
0.064LysCys: 0.064 ± 0.063
3.192LysAsp: 3.192 ± 0.47
3.256LysGlu: 3.256 ± 0.469
1.724LysPhe: 1.724 ± 0.368
3.511LysGly: 3.511 ± 0.485
0.511LysHis: 0.511 ± 0.19
3.192LysIle: 3.192 ± 0.354
3.703LysLys: 3.703 ± 0.655
2.873LysLeu: 2.873 ± 0.405
1.468LysMet: 1.468 ± 0.272
2.298LysAsn: 2.298 ± 0.359
1.788LysPro: 1.788 ± 0.301
2.171LysGln: 2.171 ± 0.638
3.32LysArg: 3.32 ± 0.662
2.043LysSer: 2.043 ± 0.392
2.681LysThr: 2.681 ± 0.369
3.767LysVal: 3.767 ± 0.552
0.702LysTrp: 0.702 ± 0.193
1.724LysTyr: 1.724 ± 0.279
0.0LysXaa: 0.0 ± 0.0
Leu
6.001LeuAla: 6.001 ± 0.849
0.447LeuCys: 0.447 ± 0.186
5.363LeuAsp: 5.363 ± 0.523
5.426LeuGlu: 5.426 ± 0.737
2.554LeuPhe: 2.554 ± 0.466
3.958LeuGly: 3.958 ± 0.486
1.149LeuHis: 1.149 ± 0.269
3.703LeuIle: 3.703 ± 0.543
3.83LeuLys: 3.83 ± 0.504
4.724LeuLeu: 4.724 ± 0.543
1.532LeuMet: 1.532 ± 0.353
4.213LeuAsn: 4.213 ± 0.539
3.767LeuPro: 3.767 ± 0.638
2.617LeuGln: 2.617 ± 0.494
4.597LeuArg: 4.597 ± 0.691
5.426LeuSer: 5.426 ± 0.671
4.98LeuThr: 4.98 ± 0.51
3.767LeuVal: 3.767 ± 0.462
0.319LeuTrp: 0.319 ± 0.167
2.873LeuTyr: 2.873 ± 0.395
0.0LeuXaa: 0.0 ± 0.0
Met
1.724MetAla: 1.724 ± 0.36
0.0MetCys: 0.0 ± 0.0
1.596MetAsp: 1.596 ± 0.358
1.66MetGlu: 1.66 ± 0.417
0.958MetPhe: 0.958 ± 0.251
1.277MetGly: 1.277 ± 0.301
0.383MetHis: 0.383 ± 0.178
1.213MetIle: 1.213 ± 0.304
1.341MetLys: 1.341 ± 0.334
1.788MetLeu: 1.788 ± 0.38
0.766MetMet: 0.766 ± 0.3
1.404MetAsn: 1.404 ± 0.365
1.788MetPro: 1.788 ± 0.361
1.149MetGln: 1.149 ± 0.316
1.532MetArg: 1.532 ± 0.4
1.468MetSer: 1.468 ± 0.343
1.149MetThr: 1.149 ± 0.278
1.404MetVal: 1.404 ± 0.341
0.192MetTrp: 0.192 ± 0.108
0.894MetTyr: 0.894 ± 0.232
0.0MetXaa: 0.0 ± 0.0
Asn
3.703AsnAla: 3.703 ± 0.6
0.128AsnCys: 0.128 ± 0.09
3.384AsnAsp: 3.384 ± 0.486
3.128AsnGlu: 3.128 ± 0.433
2.171AsnPhe: 2.171 ± 0.307
4.086AsnGly: 4.086 ± 0.673
1.468AsnHis: 1.468 ± 0.256
1.788AsnIle: 1.788 ± 0.371
2.362AsnLys: 2.362 ± 0.285
3.703AsnLeu: 3.703 ± 0.491
1.277AsnMet: 1.277 ± 0.282
2.49AsnAsn: 2.49 ± 0.707
2.873AsnPro: 2.873 ± 0.357
1.021AsnGln: 1.021 ± 0.242
3.192AsnArg: 3.192 ± 0.438
3.511AsnSer: 3.511 ± 0.746
2.809AsnThr: 2.809 ± 0.629
3.384AsnVal: 3.384 ± 0.55
0.638AsnTrp: 0.638 ± 0.202
1.213AsnTyr: 1.213 ± 0.289
0.0AsnXaa: 0.0 ± 0.0
Pro
2.49ProAla: 2.49 ± 0.435
0.255ProCys: 0.255 ± 0.113
3.384ProAsp: 3.384 ± 0.447
3.256ProGlu: 3.256 ± 0.583
1.788ProPhe: 1.788 ± 0.366
2.809ProGly: 2.809 ± 0.499
0.958ProHis: 0.958 ± 0.283
1.979ProIle: 1.979 ± 0.331
2.362ProLys: 2.362 ± 0.39
3.32ProLeu: 3.32 ± 0.502
1.149ProMet: 1.149 ± 0.344
2.298ProAsn: 2.298 ± 0.333
1.149ProPro: 1.149 ± 0.348
1.213ProGln: 1.213 ± 0.243
2.171ProArg: 2.171 ± 0.408
2.809ProSer: 2.809 ± 0.496
2.617ProThr: 2.617 ± 0.427
3.384ProVal: 3.384 ± 0.493
0.511ProTrp: 0.511 ± 0.208
1.341ProTyr: 1.341 ± 0.236
0.0ProXaa: 0.0 ± 0.0
Gln
1.979GlnAla: 1.979 ± 0.389
0.128GlnCys: 0.128 ± 0.092
1.724GlnAsp: 1.724 ± 0.329
2.937GlnGlu: 2.937 ± 0.461
1.213GlnPhe: 1.213 ± 0.273
2.809GlnGly: 2.809 ± 0.412
0.447GlnHis: 0.447 ± 0.146
2.554GlnIle: 2.554 ± 0.346
2.043GlnLys: 2.043 ± 0.396
2.234GlnLeu: 2.234 ± 0.447
0.894GlnMet: 0.894 ± 0.229
2.043GlnAsn: 2.043 ± 0.438
0.894GlnPro: 0.894 ± 0.238
1.213GlnGln: 1.213 ± 0.295
2.298GlnArg: 2.298 ± 0.447
1.851GlnSer: 1.851 ± 0.268
1.66GlnThr: 1.66 ± 0.351
1.724GlnVal: 1.724 ± 0.329
0.319GlnTrp: 0.319 ± 0.156
1.085GlnTyr: 1.085 ± 0.271
0.0GlnXaa: 0.0 ± 0.0
Arg
4.469ArgAla: 4.469 ± 0.747
0.383ArgCys: 0.383 ± 0.184
4.66ArgAsp: 4.66 ± 0.564
4.788ArgGlu: 4.788 ± 0.759
3.511ArgPhe: 3.511 ± 0.398
4.086ArgGly: 4.086 ± 0.449
2.362ArgHis: 2.362 ± 0.462
4.277ArgIle: 4.277 ± 0.4
3.511ArgLys: 3.511 ± 0.577
5.873ArgLeu: 5.873 ± 0.684
1.66ArgMet: 1.66 ± 0.408
2.873ArgAsn: 2.873 ± 0.428
2.426ArgPro: 2.426 ± 0.523
2.171ArgGln: 2.171 ± 0.535
4.277ArgArg: 4.277 ± 0.705
4.086ArgSer: 4.086 ± 0.488
3.256ArgThr: 3.256 ± 0.487
4.086ArgVal: 4.086 ± 0.597
1.021ArgTrp: 1.021 ± 0.276
2.362ArgTyr: 2.362 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
4.405SerAla: 4.405 ± 0.663
0.255SerCys: 0.255 ± 0.134
4.469SerAsp: 4.469 ± 0.487
4.66SerGlu: 4.66 ± 0.523
2.49SerPhe: 2.49 ± 0.38
6.448SerGly: 6.448 ± 1.368
0.702SerHis: 0.702 ± 0.235
3.128SerIle: 3.128 ± 0.6
1.404SerLys: 1.404 ± 0.335
4.533SerLeu: 4.533 ± 0.49
1.085SerMet: 1.085 ± 0.282
3.384SerAsn: 3.384 ± 0.679
2.809SerPro: 2.809 ± 0.424
1.915SerGln: 1.915 ± 0.324
4.277SerArg: 4.277 ± 0.421
2.745SerSer: 2.745 ± 0.681
3.703SerThr: 3.703 ± 0.65
4.022SerVal: 4.022 ± 0.869
1.149SerTrp: 1.149 ± 0.254
1.979SerTyr: 1.979 ± 0.426
0.0SerXaa: 0.0 ± 0.0
Thr
4.341ThrAla: 4.341 ± 0.487
0.192ThrCys: 0.192 ± 0.119
5.043ThrAsp: 5.043 ± 0.667
5.235ThrGlu: 5.235 ± 0.567
2.937ThrPhe: 2.937 ± 0.507
4.597ThrGly: 4.597 ± 0.744
1.213ThrHis: 1.213 ± 0.251
3.575ThrIle: 3.575 ± 0.699
2.107ThrLys: 2.107 ± 0.333
6.065ThrLeu: 6.065 ± 0.624
1.213ThrMet: 1.213 ± 0.292
2.617ThrAsn: 2.617 ± 0.503
3.256ThrPro: 3.256 ± 0.558
1.788ThrGln: 1.788 ± 0.344
3.192ThrArg: 3.192 ± 0.547
2.809ThrSer: 2.809 ± 0.535
3.575ThrThr: 3.575 ± 0.576
4.086ThrVal: 4.086 ± 0.542
0.638ThrTrp: 0.638 ± 0.212
2.745ThrTyr: 2.745 ± 0.371
0.0ThrXaa: 0.0 ± 0.0
Val
5.235ValAla: 5.235 ± 0.702
0.447ValCys: 0.447 ± 0.137
5.426ValAsp: 5.426 ± 0.625
6.32ValGlu: 6.32 ± 0.72
3.001ValPhe: 3.001 ± 0.549
4.533ValGly: 4.533 ± 0.656
1.532ValHis: 1.532 ± 0.301
2.681ValIle: 2.681 ± 0.409
2.873ValLys: 2.873 ± 0.434
4.277ValLeu: 4.277 ± 0.535
1.404ValMet: 1.404 ± 0.341
2.809ValAsn: 2.809 ± 0.534
3.256ValPro: 3.256 ± 0.445
3.384ValGln: 3.384 ± 0.483
5.618ValArg: 5.618 ± 0.632
4.277ValSer: 4.277 ± 0.742
4.724ValThr: 4.724 ± 0.581
4.533ValVal: 4.533 ± 0.543
1.596ValTrp: 1.596 ± 0.273
3.128ValTyr: 3.128 ± 0.373
0.0ValXaa: 0.0 ± 0.0
Trp
1.213TrpAla: 1.213 ± 0.325
0.128TrpCys: 0.128 ± 0.087
1.085TrpAsp: 1.085 ± 0.287
1.021TrpGlu: 1.021 ± 0.22
0.319TrpPhe: 0.319 ± 0.16
0.894TrpGly: 0.894 ± 0.326
0.192TrpHis: 0.192 ± 0.105
0.638TrpIle: 0.638 ± 0.298
0.766TrpLys: 0.766 ± 0.221
1.213TrpLeu: 1.213 ± 0.306
0.255TrpMet: 0.255 ± 0.147
0.702TrpAsn: 0.702 ± 0.281
0.383TrpPro: 0.383 ± 0.168
0.702TrpGln: 0.702 ± 0.299
0.638TrpArg: 0.638 ± 0.161
0.958TrpSer: 0.958 ± 0.275
0.958TrpThr: 0.958 ± 0.253
0.766TrpVal: 0.766 ± 0.261
0.192TrpTrp: 0.192 ± 0.109
0.638TrpTyr: 0.638 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.128TyrAla: 3.128 ± 0.474
0.192TyrCys: 0.192 ± 0.106
3.32TyrAsp: 3.32 ± 0.353
4.086TyrGlu: 4.086 ± 0.645
1.277TyrPhe: 1.277 ± 0.32
3.192TyrGly: 3.192 ± 0.674
1.085TyrHis: 1.085 ± 0.276
1.596TyrIle: 1.596 ± 0.306
1.596TyrLys: 1.596 ± 0.266
2.681TyrLeu: 2.681 ± 0.487
0.447TyrMet: 0.447 ± 0.214
2.362TyrAsn: 2.362 ± 0.336
1.532TyrPro: 1.532 ± 0.273
1.149TyrGln: 1.149 ± 0.256
2.043TyrArg: 2.043 ± 0.37
1.66TyrSer: 1.66 ± 0.286
1.851TyrThr: 1.851 ± 0.351
3.639TyrVal: 3.639 ± 0.57
0.383TyrTrp: 0.383 ± 0.144
0.894TyrTyr: 0.894 ± 0.285
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (15665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski