Amino acid dipepetide frequency for Erythrobacter mangrovi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.652AlaAla: 16.652 ± 0.209	1.096AlaCys: 1.096 ± 0.046	6.972AlaAsp: 6.972 ± 0.091	8.294AlaGlu: 8.294 ± 0.113	4.227AlaPhe: 4.227 ± 0.067	10.534AlaGly: 10.534 ± 0.115	2.26AlaHis: 2.26 ± 0.049	6.648AlaIle: 6.648 ± 0.094	4.383AlaLys: 4.383 ± 0.079	13.63AlaLeu: 13.63 ± 0.168	3.918AlaMet: 3.918 ± 0.076	3.236AlaAsn: 3.236 ± 0.071	5.545AlaPro: 5.545 ± 0.091	4.399AlaGln: 4.399 ± 0.082	9.106AlaArg: 9.106 ± 0.127	6.624AlaSer: 6.624 ± 0.089	6.215AlaThr: 6.215 ± 0.083	8.152AlaVal: 8.152 ± 0.096	1.596AlaTrp: 1.596 ± 0.046	2.582AlaTyr: 2.582 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.011CysAla: 1.011 ± 0.037	0.079CysCys: 0.079 ± 0.011	0.569CysAsp: 0.569 ± 0.027	0.511CysGlu: 0.511 ± 0.024	0.289CysPhe: 0.289 ± 0.019	0.911CysGly: 0.911 ± 0.036	0.243CysHis: 0.243 ± 0.022	0.349CysIle: 0.349 ± 0.018	0.193CysLys: 0.193 ± 0.016	0.709CysLeu: 0.709 ± 0.03	0.164CysMet: 0.164 ± 0.015	0.253CysAsn: 0.253 ± 0.018	0.45CysPro: 0.45 ± 0.022	0.234CysGln: 0.234 ± 0.016	0.551CysArg: 0.551 ± 0.028	0.501CysSer: 0.501 ± 0.022	0.43CysThr: 0.43 ± 0.025	0.542CysVal: 0.542 ± 0.027	0.104CysTrp: 0.104 ± 0.011	0.174CysTyr: 0.174 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.282AspAla: 7.282 ± 0.088	0.534AspCys: 0.534 ± 0.026	3.359AspAsp: 3.359 ± 0.07	4.062AspGlu: 4.062 ± 0.074	2.368AspPhe: 2.368 ± 0.055	5.769AspGly: 5.769 ± 0.097	1.322AspHis: 1.322 ± 0.045	2.918AspIle: 2.918 ± 0.069	1.868AspLys: 1.868 ± 0.057	5.755AspLeu: 5.755 ± 0.081	1.454AspMet: 1.454 ± 0.041	1.445AspAsn: 1.445 ± 0.041	3.928AspPro: 3.928 ± 0.074	1.724AspGln: 1.724 ± 0.045	4.625AspArg: 4.625 ± 0.075	2.515AspSer: 2.515 ± 0.052	2.844AspThr: 2.844 ± 0.065	3.853AspVal: 3.853 ± 0.063	1.211AspTrp: 1.211 ± 0.043	1.603AspTyr: 1.603 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.562GluAla: 8.562 ± 0.115	0.388GluCys: 0.388 ± 0.02	3.465GluAsp: 3.465 ± 0.072	4.074GluGlu: 4.074 ± 0.085	2.043GluPhe: 2.043 ± 0.052	5.291GluGly: 5.291 ± 0.075	1.311GluHis: 1.311 ± 0.035	3.3GluIle: 3.3 ± 0.065	2.273GluLys: 2.273 ± 0.057	6.134GluLeu: 6.134 ± 0.084	1.642GluMet: 1.642 ± 0.046	1.661GluAsn: 1.661 ± 0.046	2.912GluPro: 2.912 ± 0.054	2.456GluGln: 2.456 ± 0.048	5.376GluArg: 5.376 ± 0.094	2.603GluSer: 2.603 ± 0.057	3.323GluThr: 3.323 ± 0.058	4.24GluVal: 4.24 ± 0.076	0.936GluTrp: 0.936 ± 0.032	1.249GluTyr: 1.249 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	5.022PheAla: 5.022 ± 0.072	0.328PheCys: 0.328 ± 0.021	2.876PheAsp: 2.876 ± 0.06	2.302PheGlu: 2.302 ± 0.055	1.353PhePhe: 1.353 ± 0.042	3.851PheGly: 3.851 ± 0.067	0.717PheHis: 0.717 ± 0.027	1.538PheIle: 1.538 ± 0.048	0.934PheLys: 0.934 ± 0.033	3.218PheLeu: 3.218 ± 0.071	0.756PheMet: 0.756 ± 0.034	0.989PheAsn: 0.989 ± 0.037	1.547PhePro: 1.547 ± 0.043	0.89PheGln: 0.89 ± 0.033	2.174PheArg: 2.174 ± 0.044	2.074PheSer: 2.074 ± 0.046	2.076PheThr: 2.076 ± 0.051	2.788PheVal: 2.788 ± 0.063	0.57PheTrp: 0.57 ± 0.026	0.945PheTyr: 0.945 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.289GlyAla: 9.289 ± 0.114	0.862GlyCys: 0.862 ± 0.033	5.093GlyAsp: 5.093 ± 0.066	5.703GlyGlu: 5.703 ± 0.088	3.849GlyPhe: 3.849 ± 0.064	7.776GlyGly: 7.776 ± 0.131	1.91GlyHis: 1.91 ± 0.049	4.642GlyIle: 4.642 ± 0.065	3.557GlyLys: 3.557 ± 0.071	8.595GlyLeu: 8.595 ± 0.11	2.46GlyMet: 2.46 ± 0.053	2.347GlyAsn: 2.347 ± 0.055	3.59GlyPro: 3.59 ± 0.064	2.945GlyGln: 2.945 ± 0.054	5.85GlyArg: 5.85 ± 0.075	5.115GlySer: 5.115 ± 0.076	4.972GlyThr: 4.972 ± 0.08	6.097GlyVal: 6.097 ± 0.083	1.626GlyTrp: 1.626 ± 0.044	2.281GlyTyr: 2.281 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.368HisAla: 2.368 ± 0.05	0.254HisCys: 0.254 ± 0.017	1.101HisAsp: 1.101 ± 0.033	1.171HisGlu: 1.171 ± 0.032	0.89HisPhe: 0.89 ± 0.034	2.037HisGly: 2.037 ± 0.053	0.573HisHis: 0.573 ± 0.027	0.912HisIle: 0.912 ± 0.031	0.504HisLys: 0.504 ± 0.026	1.823HisLeu: 1.823 ± 0.045	0.459HisMet: 0.459 ± 0.024	0.487HisAsn: 0.487 ± 0.023	1.32HisPro: 1.32 ± 0.039	0.527HisGln: 0.527 ± 0.022	1.471HisArg: 1.471 ± 0.039	1.035HisSer: 1.035 ± 0.027	0.762HisThr: 0.762 ± 0.032	1.452HisVal: 1.452 ± 0.038	0.359HisTrp: 0.359 ± 0.021	0.561HisTyr: 0.561 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.705IleAla: 7.705 ± 0.103	0.462IleCys: 0.462 ± 0.024	3.877IleAsp: 3.877 ± 0.066	4.002IleGlu: 4.002 ± 0.07	1.637IlePhe: 1.637 ± 0.047	5.037IleGly: 5.037 ± 0.076	0.931IleHis: 0.931 ± 0.032	2.01IleIle: 2.01 ± 0.048	1.299IleLys: 1.299 ± 0.035	3.868IleLeu: 3.868 ± 0.074	0.958IleMet: 0.958 ± 0.034	1.295IleAsn: 1.295 ± 0.039	2.348IlePro: 2.348 ± 0.052	1.052IleGln: 1.052 ± 0.038	3.022IleArg: 3.022 ± 0.058	2.523IleSer: 2.523 ± 0.056	2.543IleThr: 2.543 ± 0.057	3.935IleVal: 3.935 ± 0.073	0.592IleTrp: 0.592 ± 0.024	1.062IleTyr: 1.062 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.185LysAla: 4.185 ± 0.071	0.182LysCys: 0.182 ± 0.014	1.768LysAsp: 1.768 ± 0.055	1.579LysGlu: 1.579 ± 0.05	0.959LysPhe: 0.959 ± 0.034	2.774LysGly: 2.774 ± 0.066	0.598LysHis: 0.598 ± 0.03	1.489LysIle: 1.489 ± 0.042	1.187LysLys: 1.187 ± 0.045	3.447LysLeu: 3.447 ± 0.069	0.728LysMet: 0.728 ± 0.032	0.733LysAsn: 0.733 ± 0.029	1.975LysPro: 1.975 ± 0.056	1.03LysGln: 1.03 ± 0.034	2.41LysArg: 2.41 ± 0.049	1.557LysSer: 1.557 ± 0.042	1.622LysThr: 1.622 ± 0.041	2.388LysVal: 2.388 ± 0.048	0.412LysTrp: 0.412 ± 0.021	0.65LysTyr: 0.65 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.8LeuAla: 14.8 ± 0.169	0.756LeuCys: 0.756 ± 0.028	6.332LeuAsp: 6.332 ± 0.087	5.78LeuGlu: 5.78 ± 0.085	3.572LeuPhe: 3.572 ± 0.073	8.522LeuGly: 8.522 ± 0.093	1.751LeuHis: 1.751 ± 0.048	4.377LeuIle: 4.377 ± 0.067	2.964LeuLys: 2.964 ± 0.062	9.365LeuLeu: 9.365 ± 0.139	2.042LeuMet: 2.042 ± 0.044	2.241LeuAsn: 2.241 ± 0.05	5.512LeuPro: 5.512 ± 0.076	2.555LeuGln: 2.555 ± 0.056	6.577LeuArg: 6.577 ± 0.099	5.643LeuSer: 5.643 ± 0.07	5.258LeuThr: 5.258 ± 0.069	7.865LeuVal: 7.865 ± 0.103	1.237LeuTrp: 1.237 ± 0.038	1.883LeuTyr: 1.883 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.323MetAla: 3.323 ± 0.071	0.16MetCys: 0.16 ± 0.013	1.207MetAsp: 1.207 ± 0.039	1.288MetGlu: 1.288 ± 0.038	0.662MetPhe: 0.662 ± 0.03	1.945MetGly: 1.945 ± 0.046	0.5MetHis: 0.5 ± 0.027	1.32MetIle: 1.32 ± 0.044	0.938MetLys: 0.938 ± 0.03	2.645MetLeu: 2.645 ± 0.056	0.641MetMet: 0.641 ± 0.031	0.696MetAsn: 0.696 ± 0.027	1.441MetPro: 1.441 ± 0.042	0.829MetGln: 0.829 ± 0.025	1.824MetArg: 1.824 ± 0.042	1.487MetSer: 1.487 ± 0.046	1.656MetThr: 1.656 ± 0.044	1.668MetVal: 1.668 ± 0.047	0.254MetTrp: 0.254 ± 0.017	0.277MetTyr: 0.277 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.098AsnAla: 3.098 ± 0.06	0.29AsnCys: 0.29 ± 0.021	1.383AsnAsp: 1.383 ± 0.046	1.356AsnGlu: 1.356 ± 0.042	1.04AsnPhe: 1.04 ± 0.034	2.387AsnGly: 2.387 ± 0.062	0.494AsnHis: 0.494 ± 0.021	1.268AsnIle: 1.268 ± 0.041	0.633AsnLys: 0.633 ± 0.03	2.45AsnLeu: 2.45 ± 0.059	0.582AsnMet: 0.582 ± 0.025	0.614AsnAsn: 0.614 ± 0.025	1.837AsnPro: 1.837 ± 0.051	0.757AsnGln: 0.757 ± 0.028	1.867AsnArg: 1.867 ± 0.042	1.294AsnSer: 1.294 ± 0.044	1.184AsnThr: 1.184 ± 0.037	1.764AsnVal: 1.764 ± 0.041	0.436AsnTrp: 0.436 ± 0.023	0.705AsnTyr: 0.705 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.968ProAla: 5.968 ± 0.086	0.315ProCys: 0.315 ± 0.019	3.746ProAsp: 3.746 ± 0.07	4.048ProGlu: 4.048 ± 0.074	1.932ProPhe: 1.932 ± 0.039	4.622ProGly: 4.622 ± 0.072	1.026ProHis: 1.026 ± 0.031	2.485ProIle: 2.485 ± 0.058	1.596ProLys: 1.596 ± 0.048	4.883ProLeu: 4.883 ± 0.08	1.141ProMet: 1.141 ± 0.037	1.296ProAsn: 1.296 ± 0.041	2.507ProPro: 2.507 ± 0.081	1.794ProGln: 1.794 ± 0.051	2.942ProArg: 2.942 ± 0.061	2.668ProSer: 2.668 ± 0.064	2.581ProThr: 2.581 ± 0.057	4.024ProVal: 4.024 ± 0.061	0.67ProTrp: 0.67 ± 0.027	1.151ProTyr: 1.151 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.077GlnAla: 4.077 ± 0.074	0.244GlnCys: 0.244 ± 0.015	1.55GlnAsp: 1.55 ± 0.043	1.497GlnGlu: 1.497 ± 0.043	1.154GlnPhe: 1.154 ± 0.037	2.493GlnGly: 2.493 ± 0.057	0.632GlnHis: 0.632 ± 0.024	1.664GlnIle: 1.664 ± 0.045	0.891GlnLys: 0.891 ± 0.034	3.287GlnLeu: 3.287 ± 0.065	0.836GlnMet: 0.836 ± 0.03	0.704GlnAsn: 0.704 ± 0.029	1.713GlnPro: 1.713 ± 0.045	1.223GlnGln: 1.223 ± 0.051	2.514GlnArg: 2.514 ± 0.056	1.65GlnSer: 1.65 ± 0.043	1.508GlnThr: 1.508 ± 0.044	2.492GlnVal: 2.492 ± 0.056	0.468GlnTrp: 0.468 ± 0.025	0.632GlnTyr: 0.632 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.903ArgAla: 7.903 ± 0.119	0.477ArgCys: 0.477 ± 0.028	4.293ArgAsp: 4.293 ± 0.077	4.721ArgGlu: 4.721 ± 0.078	2.983ArgPhe: 2.983 ± 0.052	5.038ArgGly: 5.038 ± 0.076	1.542ArgHis: 1.542 ± 0.046	4.149ArgIle: 4.149 ± 0.071	2.375ArgLys: 2.375 ± 0.049	7.646ArgLeu: 7.646 ± 0.126	2.012ArgMet: 2.012 ± 0.047	1.847ArgAsn: 1.847 ± 0.049	3.247ArgPro: 3.247 ± 0.058	2.386ArgGln: 2.386 ± 0.055	5.186ArgArg: 5.186 ± 0.098	3.589ArgSer: 3.589 ± 0.075	3.23ArgThr: 3.23 ± 0.066	4.67ArgVal: 4.67 ± 0.064	1.18ArgTrp: 1.18 ± 0.037	1.76ArgTyr: 1.76 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.88SerAla: 5.88 ± 0.077	0.475SerCys: 0.475 ± 0.025	3.195SerAsp: 3.195 ± 0.053	3.092SerGlu: 3.092 ± 0.069	2.185SerPhe: 2.185 ± 0.052	5.498SerGly: 5.498 ± 0.077	1.033SerHis: 1.033 ± 0.031	2.738SerIle: 2.738 ± 0.051	1.532SerLys: 1.532 ± 0.045	5.11SerLeu: 5.11 ± 0.079	1.304SerMet: 1.304 ± 0.038	1.373SerAsn: 1.373 ± 0.041	2.748SerPro: 2.748 ± 0.051	1.714SerGln: 1.714 ± 0.043	3.499SerArg: 3.499 ± 0.067	2.775SerSer: 2.775 ± 0.061	2.626SerThr: 2.626 ± 0.057	3.492SerVal: 3.492 ± 0.064	0.842SerTrp: 0.842 ± 0.03	1.358SerTyr: 1.358 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.829ThrAla: 5.829 ± 0.08	0.44ThrCys: 0.44 ± 0.024	2.931ThrAsp: 2.931 ± 0.06	2.759ThrGlu: 2.759 ± 0.059	1.847ThrPhe: 1.847 ± 0.047	5.179ThrGly: 5.179 ± 0.086	1.05ThrHis: 1.05 ± 0.034	2.927ThrIle: 2.927 ± 0.066	1.428ThrLys: 1.428 ± 0.041	5.451ThrLeu: 5.451 ± 0.072	1.196ThrMet: 1.196 ± 0.035	1.274ThrAsn: 1.274 ± 0.037	3.099ThrPro: 3.099 ± 0.061	1.452ThrGln: 1.452 ± 0.039	3.455ThrArg: 3.455 ± 0.062	2.73ThrSer: 2.73 ± 0.063	2.608ThrThr: 2.608 ± 0.059	4.123ThrVal: 4.123 ± 0.076	0.634ThrTrp: 0.634 ± 0.026	1.218ThrTyr: 1.218 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.081ValAla: 9.081 ± 0.102	0.547ValCys: 0.547 ± 0.023	4.381ValAsp: 4.381 ± 0.071	5.037ValGlu: 5.037 ± 0.079	2.401ValPhe: 2.401 ± 0.054	5.715ValGly: 5.715 ± 0.084	1.302ValHis: 1.302 ± 0.038	3.819ValIle: 3.819 ± 0.08	2.026ValLys: 2.026 ± 0.05	6.988ValLeu: 6.988 ± 0.09	1.668ValMet: 1.668 ± 0.042	1.918ValAsn: 1.918 ± 0.057	3.913ValPro: 3.913 ± 0.066	1.942ValGln: 1.942 ± 0.048	4.668ValArg: 4.668 ± 0.078	3.948ValSer: 3.948 ± 0.062	4.33ValThr: 4.33 ± 0.073	5.439ValVal: 5.439 ± 0.094	0.921ValTrp: 0.921 ± 0.037	1.318ValTyr: 1.318 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.38TrpAla: 1.38 ± 0.041	0.125TrpCys: 0.125 ± 0.012	0.798TrpAsp: 0.798 ± 0.033	0.689TrpGlu: 0.689 ± 0.028	0.632TrpPhe: 0.632 ± 0.028	1.071TrpGly: 1.071 ± 0.034	0.388TrpHis: 0.388 ± 0.021	0.708TrpIle: 0.708 ± 0.029	0.51TrpLys: 0.51 ± 0.023	1.848TrpLeu: 1.848 ± 0.047	0.377TrpMet: 0.377 ± 0.023	0.406TrpAsn: 0.406 ± 0.02	0.69TrpPro: 0.69 ± 0.03	0.671TrpGln: 0.671 ± 0.023	1.271TrpArg: 1.271 ± 0.037	0.881TrpSer: 0.881 ± 0.035	0.797TrpThr: 0.797 ± 0.029	0.899TrpVal: 0.899 ± 0.033	0.253TrpTrp: 0.253 ± 0.019	0.297TrpTyr: 0.297 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.654TyrAla: 2.654 ± 0.053	0.252TyrCys: 0.252 ± 0.017	1.543TyrAsp: 1.543 ± 0.047	1.275TyrGlu: 1.275 ± 0.041	0.927TyrPhe: 0.927 ± 0.038	2.109TyrGly: 2.109 ± 0.049	0.482TyrHis: 0.482 ± 0.023	0.897TyrIle: 0.897 ± 0.028	0.581TyrLys: 0.581 ± 0.029	2.179TyrLeu: 2.179 ± 0.048	0.426TyrMet: 0.426 ± 0.024	0.626TyrAsn: 0.626 ± 0.029	1.071TyrPro: 1.071 ± 0.033	0.649TyrGln: 0.649 ± 0.025	1.845TyrArg: 1.845 ± 0.046	1.26TyrSer: 1.26 ± 0.037	1.064TyrThr: 1.064 ± 0.036	1.479TyrVal: 1.479 ± 0.044	0.388TyrTrp: 0.388 ± 0.021	0.631TyrTyr: 0.631 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2957 proteins (933445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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