Amino acid dipepetide frequency for Oerskovia sp. Root918

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.871AlaAla: 20.871 ± 0.201	0.792AlaCys: 0.792 ± 0.029	8.112AlaAsp: 8.112 ± 0.084	7.855AlaGlu: 7.855 ± 0.096	3.581AlaPhe: 3.581 ± 0.059	13.599AlaGly: 13.599 ± 0.127	2.648AlaHis: 2.648 ± 0.064	4.452AlaIle: 4.452 ± 0.076	2.219AlaLys: 2.219 ± 0.054	14.305AlaLeu: 14.305 ± 0.15	2.458AlaMet: 2.458 ± 0.047	2.075AlaAsn: 2.075 ± 0.048	8.026AlaPro: 8.026 ± 0.129	4.186AlaGln: 4.186 ± 0.071	10.053AlaArg: 10.053 ± 0.131	7.425AlaSer: 7.425 ± 0.087	8.335AlaThr: 8.335 ± 0.094	12.736AlaVal: 12.736 ± 0.124	2.031AlaTrp: 2.031 ± 0.043	2.412AlaTyr: 2.412 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.735CysAla: 0.735 ± 0.026	0.062CysCys: 0.062 ± 0.008	0.309CysAsp: 0.309 ± 0.017	0.278CysGlu: 0.278 ± 0.016	0.156CysPhe: 0.156 ± 0.012	0.641CysGly: 0.641 ± 0.022	0.118CysHis: 0.118 ± 0.01	0.145CysIle: 0.145 ± 0.011	0.059CysLys: 0.059 ± 0.007	0.484CysLeu: 0.484 ± 0.022	0.084CysMet: 0.084 ± 0.009	0.087CysAsn: 0.087 ± 0.009	0.342CysPro: 0.342 ± 0.019	0.12CysGln: 0.12 ± 0.011	0.312CysArg: 0.312 ± 0.016	0.383CysSer: 0.383 ± 0.02	0.404CysThr: 0.404 ± 0.018	0.488CysVal: 0.488 ± 0.019	0.086CysTrp: 0.086 ± 0.011	0.09CysTyr: 0.09 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.818AspAla: 8.818 ± 0.096	0.257AspCys: 0.257 ± 0.015	4.324AspAsp: 4.324 ± 0.074	4.362AspGlu: 4.362 ± 0.068	1.402AspPhe: 1.402 ± 0.038	6.905AspGly: 6.905 ± 0.097	1.264AspHis: 1.264 ± 0.032	1.556AspIle: 1.556 ± 0.04	1.009AspLys: 1.009 ± 0.032	7.152AspLeu: 7.152 ± 0.09	0.81AspMet: 0.81 ± 0.025	0.749AspAsn: 0.749 ± 0.026	4.57AspPro: 4.57 ± 0.063	1.663AspGln: 1.663 ± 0.038	4.291AspArg: 4.291 ± 0.067	2.311AspSer: 2.311 ± 0.048	2.717AspThr: 2.717 ± 0.051	6.653AspVal: 6.653 ± 0.082	0.879AspTrp: 0.879 ± 0.03	1.06AspTyr: 1.06 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.274GluAla: 7.274 ± 0.106	0.243GluCys: 0.243 ± 0.016	3.118GluAsp: 3.118 ± 0.051	2.945GluGlu: 2.945 ± 0.065	1.253GluPhe: 1.253 ± 0.034	4.47GluGly: 4.47 ± 0.056	1.65GluHis: 1.65 ± 0.038	2.447GluIle: 2.447 ± 0.048	1.258GluLys: 1.258 ± 0.036	6.146GluLeu: 6.146 ± 0.081	0.847GluMet: 0.847 ± 0.032	1.068GluAsn: 1.068 ± 0.034	3.217GluPro: 3.217 ± 0.064	2.144GluGln: 2.144 ± 0.047	4.898GluArg: 4.898 ± 0.089	2.658GluSer: 2.658 ± 0.048	2.966GluThr: 2.966 ± 0.055	5.353GluVal: 5.353 ± 0.075	0.773GluTrp: 0.773 ± 0.026	1.037GluTyr: 1.037 ± 0.031	0.001GluXaa: 0.001 ± 0.001
Phe	3.81PheAla: 3.81 ± 0.066	0.182PheCys: 0.182 ± 0.012	1.977PheAsp: 1.977 ± 0.042	1.551PheGlu: 1.551 ± 0.039	0.877PhePhe: 0.877 ± 0.028	2.841PheGly: 2.841 ± 0.055	0.526PheHis: 0.526 ± 0.021	0.722PheIle: 0.722 ± 0.026	0.394PheLys: 0.394 ± 0.019	2.643PheLeu: 2.643 ± 0.056	0.358PheMet: 0.358 ± 0.018	0.536PheAsn: 0.536 ± 0.023	1.323PhePro: 1.323 ± 0.036	0.667PheGln: 0.667 ± 0.022	1.595PheArg: 1.595 ± 0.041	1.599PheSer: 1.599 ± 0.042	1.864PheThr: 1.864 ± 0.049	2.835PheVal: 2.835 ± 0.054	0.434PheTrp: 0.434 ± 0.02	0.601PheTyr: 0.601 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	12.549GlyAla: 12.549 ± 0.13	0.566GlyCys: 0.566 ± 0.023	5.322GlyAsp: 5.322 ± 0.087	5.151GlyGlu: 5.151 ± 0.075	2.866GlyPhe: 2.866 ± 0.057	8.462GlyGly: 8.462 ± 0.118	1.872GlyHis: 1.872 ± 0.044	3.792GlyIle: 3.792 ± 0.065	2.017GlyLys: 2.017 ± 0.044	9.498GlyLeu: 9.498 ± 0.1	1.908GlyMet: 1.908 ± 0.041	1.587GlyAsn: 1.587 ± 0.047	5.051GlyPro: 5.051 ± 0.081	2.638GlyGln: 2.638 ± 0.05	6.681GlyArg: 6.681 ± 0.083	5.817GlySer: 5.817 ± 0.074	6.756GlyThr: 6.756 ± 0.105	8.381GlyVal: 8.381 ± 0.114	1.719GlyTrp: 1.719 ± 0.046	2.188GlyTyr: 2.188 ± 0.045	0.002GlyXaa: 0.002 ± 0.001
His	2.449HisAla: 2.449 ± 0.043	0.102HisCys: 0.102 ± 0.01	1.361HisAsp: 1.361 ± 0.035	1.234HisGlu: 1.234 ± 0.031	0.498HisPhe: 0.498 ± 0.022	2.128HisGly: 2.128 ± 0.047	0.54HisHis: 0.54 ± 0.024	0.432HisIle: 0.432 ± 0.02	0.241HisLys: 0.241 ± 0.016	2.363HisLeu: 2.363 ± 0.046	0.269HisMet: 0.269 ± 0.014	0.304HisAsn: 0.304 ± 0.017	1.467HisPro: 1.467 ± 0.039	0.539HisGln: 0.539 ± 0.022	1.695HisArg: 1.695 ± 0.036	0.811HisSer: 0.811 ± 0.031	0.966HisThr: 0.966 ± 0.027	1.955HisVal: 1.955 ± 0.042	0.286HisTrp: 0.286 ± 0.015	0.364HisTyr: 0.364 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.721IleAla: 4.721 ± 0.064	0.199IleCys: 0.199 ± 0.014	2.643IleAsp: 2.643 ± 0.047	2.224IleGlu: 2.224 ± 0.048	0.864IlePhe: 0.864 ± 0.031	3.463IleGly: 3.463 ± 0.061	0.545IleHis: 0.545 ± 0.023	1.04IleIle: 1.04 ± 0.039	0.625IleLys: 0.625 ± 0.026	2.862IleLeu: 2.862 ± 0.064	0.495IleMet: 0.495 ± 0.02	0.677IleAsn: 0.677 ± 0.024	1.733IlePro: 1.733 ± 0.035	0.717IleGln: 0.717 ± 0.028	1.782IleArg: 1.782 ± 0.042	1.756IleSer: 1.756 ± 0.044	2.23IleThr: 2.23 ± 0.043	3.427IleVal: 3.427 ± 0.065	0.355IleTrp: 0.355 ± 0.017	0.56IleTyr: 0.56 ± 0.021	0.001IleXaa: 0.001 ± 0.001
Lys	2.206LysAla: 2.206 ± 0.053	0.07LysCys: 0.07 ± 0.009	1.107LysAsp: 1.107 ± 0.035	0.886LysGlu: 0.886 ± 0.035	0.389LysPhe: 0.389 ± 0.02	1.459LysGly: 1.459 ± 0.035	0.375LysHis: 0.375 ± 0.018	0.791LysIle: 0.791 ± 0.025	0.577LysLys: 0.577 ± 0.028	1.424LysLeu: 1.424 ± 0.043	0.295LysMet: 0.295 ± 0.017	0.437LysAsn: 0.437 ± 0.022	0.946LysPro: 0.946 ± 0.032	0.487LysGln: 0.487 ± 0.021	1.126LysArg: 1.126 ± 0.035	0.994LysSer: 0.994 ± 0.033	0.994LysThr: 0.994 ± 0.028	1.782LysVal: 1.782 ± 0.041	0.179LysTrp: 0.179 ± 0.013	0.383LysTyr: 0.383 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.844LeuAla: 15.844 ± 0.152	0.551LeuCys: 0.551 ± 0.022	7.399LeuAsp: 7.399 ± 0.083	4.997LeuGlu: 4.997 ± 0.08	2.529LeuPhe: 2.529 ± 0.053	9.63LeuGly: 9.63 ± 0.098	1.846LeuHis: 1.846 ± 0.034	2.651LeuIle: 2.651 ± 0.064	1.409LeuLys: 1.409 ± 0.041	10.671LeuLeu: 10.671 ± 0.122	1.417LeuMet: 1.417 ± 0.044	1.471LeuAsn: 1.471 ± 0.041	5.927LeuPro: 5.927 ± 0.078	2.165LeuGln: 2.165 ± 0.038	7.594LeuArg: 7.594 ± 0.09	5.352LeuSer: 5.352 ± 0.07	6.804LeuThr: 6.804 ± 0.083	11.364LeuVal: 11.364 ± 0.12	1.256LeuTrp: 1.256 ± 0.034	1.503LeuTyr: 1.503 ± 0.038	0.001LeuXaa: 0.001 ± 0.001
Met	1.92MetAla: 1.92 ± 0.044	0.1MetCys: 0.1 ± 0.009	0.819MetAsp: 0.819 ± 0.026	0.584MetGlu: 0.584 ± 0.02	0.488MetPhe: 0.488 ± 0.021	1.205MetGly: 1.205 ± 0.038	0.324MetHis: 0.324 ± 0.018	0.698MetIle: 0.698 ± 0.023	0.304MetLys: 0.304 ± 0.017	1.722MetLeu: 1.722 ± 0.039	0.238MetMet: 0.238 ± 0.014	0.351MetAsn: 0.351 ± 0.018	0.988MetPro: 0.988 ± 0.026	0.361MetGln: 0.361 ± 0.017	1.234MetArg: 1.234 ± 0.036	1.28MetSer: 1.28 ± 0.031	1.608MetThr: 1.608 ± 0.038	1.316MetVal: 1.316 ± 0.034	0.189MetTrp: 0.189 ± 0.012	0.264MetTyr: 0.264 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.0AsnAla: 2.0 ± 0.046	0.099AsnCys: 0.099 ± 0.008	0.986AsnAsp: 0.986 ± 0.034	0.853AsnGlu: 0.853 ± 0.031	0.531AsnPhe: 0.531 ± 0.021	1.656AsnGly: 1.656 ± 0.044	0.359AsnHis: 0.359 ± 0.018	0.588AsnIle: 0.588 ± 0.02	0.343AsnLys: 0.343 ± 0.018	1.702AsnLeu: 1.702 ± 0.041	0.265AsnMet: 0.265 ± 0.015	0.391AsnAsn: 0.391 ± 0.021	1.369AsnPro: 1.369 ± 0.039	0.482AsnGln: 0.482 ± 0.02	1.008AsnArg: 1.008 ± 0.03	0.734AsnSer: 0.734 ± 0.027	0.956AsnThr: 0.956 ± 0.038	1.556AsnVal: 1.556 ± 0.038	0.239AsnTrp: 0.239 ± 0.014	0.426AsnTyr: 0.426 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.707ProAla: 8.707 ± 0.124	0.199ProCys: 0.199 ± 0.014	4.474ProAsp: 4.474 ± 0.068	3.868ProGlu: 3.868 ± 0.056	1.644ProPhe: 1.644 ± 0.038	6.383ProGly: 6.383 ± 0.101	1.145ProHis: 1.145 ± 0.03	1.329ProIle: 1.329 ± 0.033	0.734ProLys: 0.734 ± 0.027	5.129ProLeu: 5.129 ± 0.076	0.784ProMet: 0.784 ± 0.025	0.766ProAsn: 0.766 ± 0.024	2.844ProPro: 2.844 ± 0.073	1.618ProGln: 1.618 ± 0.037	3.62ProArg: 3.62 ± 0.071	3.544ProSer: 3.544 ± 0.057	3.959ProThr: 3.959 ± 0.054	6.034ProVal: 6.034 ± 0.087	0.929ProTrp: 0.929 ± 0.032	1.054ProTyr: 1.054 ± 0.034	0.001ProXaa: 0.001 ± 0.001
Gln	3.69GlnAla: 3.69 ± 0.062	0.132GlnCys: 0.132 ± 0.011	1.522GlnAsp: 1.522 ± 0.036	1.414GlnGlu: 1.414 ± 0.04	0.678GlnPhe: 0.678 ± 0.024	2.318GlnGly: 2.318 ± 0.05	0.658GlnHis: 0.658 ± 0.022	1.174GlnIle: 1.174 ± 0.032	0.524GlnLys: 0.524 ± 0.023	2.603GlnLeu: 2.603 ± 0.051	0.47GlnMet: 0.47 ± 0.02	0.496GlnAsn: 0.496 ± 0.021	1.439GlnPro: 1.439 ± 0.051	1.002GlnGln: 1.002 ± 0.038	2.089GlnArg: 2.089 ± 0.042	1.251GlnSer: 1.251 ± 0.032	1.395GlnThr: 1.395 ± 0.038	3.153GlnVal: 3.153 ± 0.051	0.423GlnTrp: 0.423 ± 0.018	0.579GlnTyr: 0.579 ± 0.024	0.001GlnXaa: 0.001 ± 0.001
Arg	9.403ArgAla: 9.403 ± 0.115	0.366ArgCys: 0.366 ± 0.021	4.138ArgAsp: 4.138 ± 0.071	4.294ArgGlu: 4.294 ± 0.074	2.059ArgPhe: 2.059 ± 0.038	5.467ArgGly: 5.467 ± 0.072	1.528ArgHis: 1.528 ± 0.033	2.696ArgIle: 2.696 ± 0.049	1.296ArgLys: 1.296 ± 0.035	7.405ArgLeu: 7.405 ± 0.093	1.383ArgMet: 1.383 ± 0.033	1.162ArgAsn: 1.162 ± 0.034	4.112ArgPro: 4.112 ± 0.068	1.793ArgGln: 1.793 ± 0.043	6.696ArgArg: 6.696 ± 0.098	4.308ArgSer: 4.308 ± 0.066	5.044ArgThr: 5.044 ± 0.069	6.048ArgVal: 6.048 ± 0.077	1.372ArgTrp: 1.372 ± 0.036	1.537ArgTyr: 1.537 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	7.252SerAla: 7.252 ± 0.09	0.317SerCys: 0.317 ± 0.018	2.959SerAsp: 2.959 ± 0.047	2.48SerGlu: 2.48 ± 0.053	1.726SerPhe: 1.726 ± 0.041	5.987SerGly: 5.987 ± 0.094	0.975SerHis: 0.975 ± 0.031	1.976SerIle: 1.976 ± 0.047	0.87SerLys: 0.87 ± 0.028	5.26SerLeu: 5.26 ± 0.063	1.108SerMet: 1.108 ± 0.029	0.909SerAsn: 0.909 ± 0.03	3.463SerPro: 3.463 ± 0.055	1.363SerGln: 1.363 ± 0.035	3.838SerArg: 3.838 ± 0.061	3.531SerSer: 3.531 ± 0.071	4.077SerThr: 4.077 ± 0.068	4.804SerVal: 4.804 ± 0.063	0.996SerTrp: 0.996 ± 0.032	1.138SerTyr: 1.138 ± 0.033	0.002SerXaa: 0.002 ± 0.001
Thr	8.147ThrAla: 8.147 ± 0.088	0.351ThrCys: 0.351 ± 0.016	3.794ThrAsp: 3.794 ± 0.056	3.184ThrGlu: 3.184 ± 0.057	2.109ThrPhe: 2.109 ± 0.051	6.662ThrGly: 6.662 ± 0.096	1.13ThrHis: 1.13 ± 0.029	2.375ThrIle: 2.375 ± 0.054	0.99ThrLys: 0.99 ± 0.03	6.182ThrLeu: 6.182 ± 0.085	0.889ThrMet: 0.889 ± 0.025	1.149ThrAsn: 1.149 ± 0.038	4.338ThrPro: 4.338 ± 0.069	1.593ThrGln: 1.593 ± 0.038	3.8ThrArg: 3.8 ± 0.059	4.143ThrSer: 4.143 ± 0.065	4.73ThrThr: 4.73 ± 0.08	6.581ThrVal: 6.581 ± 0.086	1.131ThrTrp: 1.131 ± 0.034	1.365ThrTyr: 1.365 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	13.726ValAla: 13.726 ± 0.12	0.564ValCys: 0.564 ± 0.024	6.157ValAsp: 6.157 ± 0.079	5.842ValGlu: 5.842 ± 0.083	2.449ValPhe: 2.449 ± 0.051	8.52ValGly: 8.52 ± 0.098	1.901ValHis: 1.901 ± 0.044	3.05ValIle: 3.05 ± 0.058	1.427ValLys: 1.427 ± 0.041	11.149ValLeu: 11.149 ± 0.122	1.407ValMet: 1.407 ± 0.035	1.579ValAsn: 1.579 ± 0.037	5.831ValPro: 5.831 ± 0.084	2.359ValGln: 2.359 ± 0.045	7.049ValArg: 7.049 ± 0.088	5.051ValSer: 5.051 ± 0.066	6.668ValThr: 6.668 ± 0.099	11.798ValVal: 11.798 ± 0.142	1.258ValTrp: 1.258 ± 0.031	1.555ValTyr: 1.555 ± 0.042	0.001ValXaa: 0.001 ± 0.001
Trp	1.69TrpAla: 1.69 ± 0.042	0.112TrpCys: 0.112 ± 0.011	0.932TrpAsp: 0.932 ± 0.031	0.691TrpGlu: 0.691 ± 0.025	0.605TrpPhe: 0.605 ± 0.023	1.149TrpGly: 1.149 ± 0.035	0.31TrpHis: 0.31 ± 0.014	0.551TrpIle: 0.551 ± 0.023	0.29TrpLys: 0.29 ± 0.014	1.587TrpLeu: 1.587 ± 0.039	0.272TrpMet: 0.272 ± 0.015	0.403TrpAsn: 0.403 ± 0.019	0.753TrpPro: 0.753 ± 0.026	0.522TrpGln: 0.522 ± 0.02	1.221TrpArg: 1.221 ± 0.039	1.069TrpSer: 1.069 ± 0.031	1.063TrpThr: 1.063 ± 0.031	1.302TrpVal: 1.302 ± 0.034	0.423TrpTrp: 0.423 ± 0.023	0.315TrpTyr: 0.315 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.051	0.123TyrCys: 0.123 ± 0.01	1.301TyrAsp: 1.301 ± 0.034	1.072TyrGlu: 1.072 ± 0.027	0.631TyrPhe: 0.631 ± 0.026	1.876TyrGly: 1.876 ± 0.043	0.287TyrHis: 0.287 ± 0.015	0.452TyrIle: 0.452 ± 0.022	0.32TyrLys: 0.32 ± 0.017	2.095TyrLeu: 2.095 ± 0.046	0.232TyrMet: 0.232 ± 0.014	0.349TyrAsn: 0.349 ± 0.019	1.024TyrPro: 1.024 ± 0.032	0.591TyrGln: 0.591 ± 0.024	1.526TyrArg: 1.526 ± 0.036	1.013TyrSer: 1.013 ± 0.029	1.105TyrThr: 1.105 ± 0.03	1.776TyrVal: 1.776 ± 0.04	0.302TyrTrp: 0.302 ± 0.018	0.436TyrTyr: 0.436 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3618 proteins (1211724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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