Amino acid dipepetide frequency for Hyphomicrobium sp. xq

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.629AlaAla: 18.629 ± 0.183
1.087AlaCys: 1.087 ± 0.034
7.039AlaAsp: 7.039 ± 0.086
7.618AlaGlu: 7.618 ± 0.108
4.253AlaPhe: 4.253 ± 0.064
10.728AlaGly: 10.728 ± 0.14
2.381AlaHis: 2.381 ± 0.049
6.148AlaIle: 6.148 ± 0.091
4.987AlaLys: 4.987 ± 0.075
13.143AlaLeu: 13.143 ± 0.133
3.105AlaMet: 3.105 ± 0.06
3.176AlaAsn: 3.176 ± 0.057
6.451AlaPro: 6.451 ± 0.104
4.186AlaGln: 4.186 ± 0.075
8.857AlaArg: 8.857 ± 0.111
6.81AlaSer: 6.81 ± 0.088
6.365AlaThr: 6.365 ± 0.081
8.964AlaVal: 8.964 ± 0.095
1.542AlaTrp: 1.542 ± 0.04
2.638AlaTyr: 2.638 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
1.045CysAla: 1.045 ± 0.032
0.15CysCys: 0.15 ± 0.011
0.493CysAsp: 0.493 ± 0.024
0.467CysGlu: 0.467 ± 0.021
0.29CysPhe: 0.29 ± 0.019
0.892CysGly: 0.892 ± 0.035
0.227CysHis: 0.227 ± 0.019
0.393CysIle: 0.393 ± 0.018
0.296CysLys: 0.296 ± 0.017
0.786CysLeu: 0.786 ± 0.03
0.179CysMet: 0.179 ± 0.013
0.226CysAsn: 0.226 ± 0.016
0.466CysPro: 0.466 ± 0.023
0.214CysGln: 0.214 ± 0.015
0.68CysArg: 0.68 ± 0.026
0.479CysSer: 0.479 ± 0.023
0.443CysThr: 0.443 ± 0.023
0.67CysVal: 0.67 ± 0.028
0.096CysTrp: 0.096 ± 0.009
0.216CysTyr: 0.216 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.129AspAla: 7.129 ± 0.096
0.514AspCys: 0.514 ± 0.022
3.248AspAsp: 3.248 ± 0.077
3.424AspGlu: 3.424 ± 0.061
1.979AspPhe: 1.979 ± 0.044
5.194AspGly: 5.194 ± 0.087
1.03AspHis: 1.03 ± 0.031
2.958AspIle: 2.958 ± 0.06
2.224AspLys: 2.224 ± 0.05
5.57AspLeu: 5.57 ± 0.079
1.201AspMet: 1.201 ± 0.033
1.388AspAsn: 1.388 ± 0.042
3.195AspPro: 3.195 ± 0.058
1.692AspGln: 1.692 ± 0.046
3.875AspArg: 3.875 ± 0.068
2.11AspSer: 2.11 ± 0.042
2.754AspThr: 2.754 ± 0.086
4.478AspVal: 4.478 ± 0.071
0.904AspTrp: 0.904 ± 0.03
1.469AspTyr: 1.469 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.456GluAla: 7.456 ± 0.107
0.381GluCys: 0.381 ± 0.019
2.537GluAsp: 2.537 ± 0.047
3.103GluGlu: 3.103 ± 0.064
1.828GluPhe: 1.828 ± 0.045
4.184GluGly: 4.184 ± 0.06
1.235GluHis: 1.235 ± 0.037
3.167GluIle: 3.167 ± 0.066
2.501GluLys: 2.501 ± 0.051
5.803GluLeu: 5.803 ± 0.079
1.393GluMet: 1.393 ± 0.033
1.41GluAsn: 1.41 ± 0.039
2.896GluPro: 2.896 ± 0.06
2.147GluGln: 2.147 ± 0.05
5.223GluArg: 5.223 ± 0.086
2.323GluSer: 2.323 ± 0.045
3.221GluThr: 3.221 ± 0.057
4.154GluVal: 4.154 ± 0.062
0.658GluTrp: 0.658 ± 0.03
1.094GluTyr: 1.094 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.69PheAla: 4.69 ± 0.069
0.351PheCys: 0.351 ± 0.018
2.473PheAsp: 2.473 ± 0.047
2.13PheGlu: 2.13 ± 0.042
1.279PhePhe: 1.279 ± 0.039
3.383PheGly: 3.383 ± 0.058
0.679PheHis: 0.679 ± 0.023
1.583PheIle: 1.583 ± 0.036
1.211PheLys: 1.211 ± 0.036
3.082PheLeu: 3.082 ± 0.065
0.702PheMet: 0.702 ± 0.027
1.094PheAsn: 1.094 ± 0.033
1.493PhePro: 1.493 ± 0.034
0.875PheGln: 0.875 ± 0.026
2.088PheArg: 2.088 ± 0.05
2.088PheSer: 2.088 ± 0.043
1.929PheThr: 1.929 ± 0.042
2.804PheVal: 2.804 ± 0.054
0.519PheTrp: 0.519 ± 0.024
0.856PheTyr: 0.856 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
9.826GlyAla: 9.826 ± 0.12
0.875GlyCys: 0.875 ± 0.031
4.67GlyAsp: 4.67 ± 0.091
4.803GlyGlu: 4.803 ± 0.075
3.354GlyPhe: 3.354 ± 0.051
8.008GlyGly: 8.008 ± 0.271
1.762GlyHis: 1.762 ± 0.042
4.274GlyIle: 4.274 ± 0.068
3.703GlyLys: 3.703 ± 0.068
8.249GlyLeu: 8.249 ± 0.092
2.0GlyMet: 2.0 ± 0.05
2.381GlyAsn: 2.381 ± 0.104
3.497GlyPro: 3.497 ± 0.064
2.634GlyGln: 2.634 ± 0.052
6.007GlyArg: 6.007 ± 0.083
4.904GlySer: 4.904 ± 0.106
4.877GlyThr: 4.877 ± 0.107
6.179GlyVal: 6.179 ± 0.073
1.309GlyTrp: 1.309 ± 0.035
2.39GlyTyr: 2.39 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.424HisAla: 2.424 ± 0.048
0.225HisCys: 0.225 ± 0.015
1.155HisAsp: 1.155 ± 0.036
0.985HisGlu: 0.985 ± 0.028
0.817HisPhe: 0.817 ± 0.025
1.787HisGly: 1.787 ± 0.042
0.511HisHis: 0.511 ± 0.023
0.926HisIle: 0.926 ± 0.028
0.577HisLys: 0.577 ± 0.024
1.881HisLeu: 1.881 ± 0.038
0.505HisMet: 0.505 ± 0.02
0.448HisAsn: 0.448 ± 0.019
1.231HisPro: 1.231 ± 0.034
0.528HisGln: 0.528 ± 0.025
1.359HisArg: 1.359 ± 0.036
0.918HisSer: 0.918 ± 0.029
0.883HisThr: 0.883 ± 0.029
1.581HisVal: 1.581 ± 0.04
0.316HisTrp: 0.316 ± 0.019
0.575HisTyr: 0.575 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
7.271IleAla: 7.271 ± 0.082
0.447IleCys: 0.447 ± 0.021
3.673IleAsp: 3.673 ± 0.06
3.476IleGlu: 3.476 ± 0.056
1.561IlePhe: 1.561 ± 0.043
4.709IleGly: 4.709 ± 0.079
0.743IleHis: 0.743 ± 0.022
2.173IleIle: 2.173 ± 0.048
1.694IleLys: 1.694 ± 0.042
3.951IleLeu: 3.951 ± 0.068
0.814IleMet: 0.814 ± 0.026
1.469IleAsn: 1.469 ± 0.045
2.146IlePro: 2.146 ± 0.042
1.06IleGln: 1.06 ± 0.031
2.709IleArg: 2.709 ± 0.055
2.631IleSer: 2.631 ± 0.045
2.59IleThr: 2.59 ± 0.056
4.524IleVal: 4.524 ± 0.071
0.568IleTrp: 0.568 ± 0.025
1.146IleTyr: 1.146 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.582LysAla: 4.582 ± 0.071
0.246LysCys: 0.246 ± 0.017
2.076LysAsp: 2.076 ± 0.054
2.004LysGlu: 2.004 ± 0.051
1.067LysPhe: 1.067 ± 0.033
2.934LysGly: 2.934 ± 0.051
0.733LysHis: 0.733 ± 0.029
1.784LysIle: 1.784 ± 0.043
1.775LysLys: 1.775 ± 0.055
3.969LysLeu: 3.969 ± 0.064
0.788LysMet: 0.788 ± 0.025
0.978LysAsn: 0.978 ± 0.029
2.395LysPro: 2.395 ± 0.053
1.331LysGln: 1.331 ± 0.036
2.854LysArg: 2.854 ± 0.06
2.198LysSer: 2.198 ± 0.041
2.062LysThr: 2.062 ± 0.05
2.799LysVal: 2.799 ± 0.053
0.416LysTrp: 0.416 ± 0.02
0.75LysTyr: 0.75 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
13.7LeuAla: 13.7 ± 0.149
0.84LeuCys: 0.84 ± 0.028
5.728LeuAsp: 5.728 ± 0.088
5.29LeuGlu: 5.29 ± 0.075
3.341LeuPhe: 3.341 ± 0.069
7.968LeuGly: 7.968 ± 0.104
1.777LeuHis: 1.777 ± 0.037
4.907LeuIle: 4.907 ± 0.075
4.098LeuLys: 4.098 ± 0.067
9.262LeuLeu: 9.262 ± 0.136
2.11LeuMet: 2.11 ± 0.048
2.519LeuAsn: 2.519 ± 0.047
5.292LeuPro: 5.292 ± 0.066
2.925LeuGln: 2.925 ± 0.058
6.43LeuArg: 6.43 ± 0.086
6.075LeuSer: 6.075 ± 0.091
5.591LeuThr: 5.591 ± 0.084
7.247LeuVal: 7.247 ± 0.099
1.113LeuTrp: 1.113 ± 0.034
2.05LeuTyr: 2.05 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.686MetAla: 2.686 ± 0.059
0.158MetCys: 0.158 ± 0.012
0.881MetAsp: 0.881 ± 0.027
0.937MetGlu: 0.937 ± 0.028
0.658MetPhe: 0.658 ± 0.027
1.58MetGly: 1.58 ± 0.044
0.503MetHis: 0.503 ± 0.02
1.05MetIle: 1.05 ± 0.029
0.902MetLys: 0.902 ± 0.028
2.437MetLeu: 2.437 ± 0.055
0.455MetMet: 0.455 ± 0.02
0.656MetAsn: 0.656 ± 0.024
1.501MetPro: 1.501 ± 0.038
0.945MetGln: 0.945 ± 0.029
1.934MetArg: 1.934 ± 0.041
1.568MetSer: 1.568 ± 0.038
1.548MetThr: 1.548 ± 0.034
1.403MetVal: 1.403 ± 0.037
0.233MetTrp: 0.233 ± 0.014
0.33MetTyr: 0.33 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.298AsnAla: 3.298 ± 0.064
0.295AsnCys: 0.295 ± 0.017
1.468AsnAsp: 1.468 ± 0.046
1.365AsnGlu: 1.365 ± 0.037
0.966AsnPhe: 0.966 ± 0.031
2.471AsnGly: 2.471 ± 0.069
0.422AsnHis: 0.422 ± 0.018
1.374AsnIle: 1.374 ± 0.045
0.814AsnLys: 0.814 ± 0.03
2.499AsnLeu: 2.499 ± 0.049
0.566AsnMet: 0.566 ± 0.023
0.758AsnAsn: 0.758 ± 0.034
1.777AsnPro: 1.777 ± 0.047
0.726AsnGln: 0.726 ± 0.029
1.674AsnArg: 1.674 ± 0.039
1.368AsnSer: 1.368 ± 0.044
1.352AsnThr: 1.352 ± 0.046
2.229AsnVal: 2.229 ± 0.057
0.41AsnTrp: 0.41 ± 0.019
0.688AsnTyr: 0.688 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
6.613ProAla: 6.613 ± 0.104
0.327ProCys: 0.327 ± 0.022
3.464ProAsp: 3.464 ± 0.063
3.527ProGlu: 3.527 ± 0.058
1.806ProPhe: 1.806 ± 0.038
4.707ProGly: 4.707 ± 0.069
1.083ProHis: 1.083 ± 0.035
2.27ProIle: 2.27 ± 0.047
1.895ProLys: 1.895 ± 0.05
4.742ProLeu: 4.742 ± 0.076
1.158ProMet: 1.158 ± 0.035
1.433ProAsn: 1.433 ± 0.04
3.35ProPro: 3.35 ± 0.085
1.846ProGln: 1.846 ± 0.041
3.102ProArg: 3.102 ± 0.055
3.096ProSer: 3.096 ± 0.059
2.859ProThr: 2.859 ± 0.053
3.985ProVal: 3.985 ± 0.061
0.659ProTrp: 0.659 ± 0.026
1.21ProTyr: 1.21 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.884GlnAla: 3.884 ± 0.06
0.222GlnCys: 0.222 ± 0.016
1.346GlnAsp: 1.346 ± 0.035
1.487GlnGlu: 1.487 ± 0.037
1.061GlnPhe: 1.061 ± 0.032
2.351GlnGly: 2.351 ± 0.045
0.658GlnHis: 0.658 ± 0.026
1.637GlnIle: 1.637 ± 0.04
1.215GlnLys: 1.215 ± 0.031
3.154GlnLeu: 3.154 ± 0.056
0.804GlnMet: 0.804 ± 0.028
0.825GlnAsn: 0.825 ± 0.032
1.812GlnPro: 1.812 ± 0.055
1.277GlnGln: 1.277 ± 0.043
2.719GlnArg: 2.719 ± 0.055
1.912GlnSer: 1.912 ± 0.051
1.676GlnThr: 1.676 ± 0.046
2.295GlnVal: 2.295 ± 0.048
0.401GlnTrp: 0.401 ± 0.02
0.605GlnTyr: 0.605 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.262ArgAla: 8.262 ± 0.104
0.553ArgCys: 0.553 ± 0.024
3.858ArgAsp: 3.858 ± 0.063
4.162ArgGlu: 4.162 ± 0.079
2.753ArgPhe: 2.753 ± 0.052
4.948ArgGly: 4.948 ± 0.071
1.546ArgHis: 1.546 ± 0.039
3.795ArgIle: 3.795 ± 0.059
2.397ArgLys: 2.397 ± 0.051
7.563ArgLeu: 7.563 ± 0.093
1.752ArgMet: 1.752 ± 0.046
1.86ArgAsn: 1.86 ± 0.042
3.463ArgPro: 3.463 ± 0.064
2.411ArgGln: 2.411 ± 0.05
5.745ArgArg: 5.745 ± 0.102
3.836ArgSer: 3.836 ± 0.063
3.602ArgThr: 3.602 ± 0.063
4.976ArgVal: 4.976 ± 0.074
0.983ArgTrp: 0.983 ± 0.032
1.847ArgTyr: 1.847 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.477SerAla: 6.477 ± 0.079
0.462SerCys: 0.462 ± 0.024
3.0SerAsp: 3.0 ± 0.044
2.93SerGlu: 2.93 ± 0.053
2.118SerPhe: 2.118 ± 0.047
5.571SerGly: 5.571 ± 0.111
1.062SerHis: 1.062 ± 0.034
2.809SerIle: 2.809 ± 0.056
1.899SerLys: 1.899 ± 0.045
5.228SerLeu: 5.228 ± 0.082
1.279SerMet: 1.279 ± 0.035
1.436SerAsn: 1.436 ± 0.039
3.003SerPro: 3.003 ± 0.058
1.627SerGln: 1.627 ± 0.041
3.571SerArg: 3.571 ± 0.061
3.112SerSer: 3.112 ± 0.057
2.881SerThr: 2.881 ± 0.063
4.152SerVal: 4.152 ± 0.066
0.718SerTrp: 0.718 ± 0.028
1.335SerTyr: 1.335 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
6.608ThrAla: 6.608 ± 0.086
0.498ThrCys: 0.498 ± 0.025
2.797ThrAsp: 2.797 ± 0.068
2.602ThrGlu: 2.602 ± 0.047
2.019ThrPhe: 2.019 ± 0.038
5.207ThrGly: 5.207 ± 0.11
1.047ThrHis: 1.047 ± 0.026
2.729ThrIle: 2.729 ± 0.049
1.688ThrLys: 1.688 ± 0.039
5.688ThrLeu: 5.688 ± 0.089
1.144ThrMet: 1.144 ± 0.034
1.453ThrAsn: 1.453 ± 0.038
3.393ThrPro: 3.393 ± 0.064
1.548ThrGln: 1.548 ± 0.04
3.28ThrArg: 3.28 ± 0.055
2.975ThrSer: 2.975 ± 0.061
2.976ThrThr: 2.976 ± 0.055
4.306ThrVal: 4.306 ± 0.08
0.703ThrTrp: 0.703 ± 0.029
1.354ThrTyr: 1.354 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
9.707ValAla: 9.707 ± 0.109
0.671ValCys: 0.671 ± 0.025
4.348ValAsp: 4.348 ± 0.062
4.53ValGlu: 4.53 ± 0.071
2.665ValPhe: 2.665 ± 0.054
5.965ValGly: 5.965 ± 0.094
1.456ValHis: 1.456 ± 0.036
3.839ValIle: 3.839 ± 0.065
2.625ValLys: 2.625 ± 0.049
7.395ValLeu: 7.395 ± 0.103
1.666ValMet: 1.666 ± 0.038
2.03ValAsn: 2.03 ± 0.058
3.976ValPro: 3.976 ± 0.069
2.099ValGln: 2.099 ± 0.047
5.24ValArg: 5.24 ± 0.071
4.209ValSer: 4.209 ± 0.068
4.554ValThr: 4.554 ± 0.079
6.175ValVal: 6.175 ± 0.085
0.912ValTrp: 0.912 ± 0.03
1.57ValTyr: 1.57 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.234TrpAla: 1.234 ± 0.037
0.147TrpCys: 0.147 ± 0.011
0.582TrpAsp: 0.582 ± 0.028
0.587TrpGlu: 0.587 ± 0.025
0.495TrpPhe: 0.495 ± 0.019
0.972TrpGly: 0.972 ± 0.032
0.323TrpHis: 0.323 ± 0.017
0.607TrpIle: 0.607 ± 0.026
0.487TrpLys: 0.487 ± 0.023
1.627TrpLeu: 1.627 ± 0.041
0.336TrpMet: 0.336 ± 0.018
0.371TrpAsn: 0.371 ± 0.019
0.687TrpPro: 0.687 ± 0.024
0.548TrpGln: 0.548 ± 0.022
1.179TrpArg: 1.179 ± 0.036
0.854TrpSer: 0.854 ± 0.03
0.719TrpThr: 0.719 ± 0.026
0.809TrpVal: 0.809 ± 0.031
0.231TrpTrp: 0.231 ± 0.015
0.294TrpTyr: 0.294 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.585TyrAla: 2.585 ± 0.051
0.26TyrCys: 0.26 ± 0.017
1.499TyrAsp: 1.499 ± 0.04
1.284TyrGlu: 1.284 ± 0.034
1.001TyrPhe: 1.001 ± 0.031
2.143TyrGly: 2.143 ± 0.047
0.456TyrHis: 0.456 ± 0.02
0.93TyrIle: 0.93 ± 0.03
0.752TyrLys: 0.752 ± 0.028
2.234TyrLeu: 2.234 ± 0.05
0.409TyrMet: 0.409 ± 0.02
0.61TyrAsn: 0.61 ± 0.021
1.107TyrPro: 1.107 ± 0.035
0.721TyrGln: 0.721 ± 0.023
1.789TyrArg: 1.789 ± 0.043
1.203TyrSer: 1.203 ± 0.034
1.132TyrThr: 1.132 ± 0.039
1.904TyrVal: 1.904 ± 0.048
0.397TyrTrp: 0.397 ± 0.022
0.647TyrTyr: 0.647 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3664 proteins (1132951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski