Amino acid dipepetide frequency for Desulfuromonas acetoxidans (strain DSM 684 / 11070)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.811AlaAla: 8.811 ± 0.136	1.218AlaCys: 1.218 ± 0.035	5.127AlaAsp: 5.127 ± 0.086	6.005AlaGlu: 6.005 ± 0.081	3.253AlaPhe: 3.253 ± 0.058	6.543AlaGly: 6.543 ± 0.14	1.747AlaHis: 1.747 ± 0.042	5.103AlaIle: 5.103 ± 0.093	3.396AlaLys: 3.396 ± 0.066	10.386AlaLeu: 10.386 ± 0.123	2.61AlaMet: 2.61 ± 0.057	2.621AlaAsn: 2.621 ± 0.073	3.123AlaPro: 3.123 ± 0.07	3.955AlaGln: 3.955 ± 0.064	4.602AlaArg: 4.602 ± 0.083	4.773AlaSer: 4.773 ± 0.101	4.911AlaThr: 4.911 ± 0.088	6.773AlaVal: 6.773 ± 0.11	0.86AlaTrp: 0.86 ± 0.035	2.159AlaTyr: 2.159 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.062CysAla: 1.062 ± 0.03	0.309CysCys: 0.309 ± 0.016	0.819CysAsp: 0.819 ± 0.027	0.731CysGlu: 0.731 ± 0.024	0.538CysPhe: 0.538 ± 0.024	1.276CysGly: 1.276 ± 0.045	0.737CysHis: 0.737 ± 0.06	0.58CysIle: 0.58 ± 0.024	0.367CysLys: 0.367 ± 0.019	1.395CysLeu: 1.395 ± 0.044	0.251CysMet: 0.251 ± 0.013	0.393CysAsn: 0.393 ± 0.022	0.723CysPro: 0.723 ± 0.029	0.649CysGln: 0.649 ± 0.026	0.978CysArg: 0.978 ± 0.03	0.943CysSer: 0.943 ± 0.03	0.572CysThr: 0.572 ± 0.027	0.89CysVal: 0.89 ± 0.03	0.166CysTrp: 0.166 ± 0.013	0.402CysTyr: 0.402 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.886AspAla: 4.886 ± 0.11	0.878AspCys: 0.878 ± 0.031	3.818AspAsp: 3.818 ± 0.097	4.155AspGlu: 4.155 ± 0.069	2.359AspPhe: 2.359 ± 0.047	4.51AspGly: 4.51 ± 0.136	1.507AspHis: 1.507 ± 0.042	3.448AspIle: 3.448 ± 0.066	2.377AspLys: 2.377 ± 0.052	6.196AspLeu: 6.196 ± 0.093	1.34AspMet: 1.34 ± 0.034	2.162AspAsn: 2.162 ± 0.047	2.512AspPro: 2.512 ± 0.05	2.781AspGln: 2.781 ± 0.06	3.077AspArg: 3.077 ± 0.066	3.436AspSer: 3.436 ± 0.1	2.794AspThr: 2.794 ± 0.09	4.302AspVal: 4.302 ± 0.084	0.738AspTrp: 0.738 ± 0.029	2.213AspTyr: 2.213 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.305GluAla: 5.305 ± 0.08	0.629GluCys: 0.629 ± 0.026	3.218GluAsp: 3.218 ± 0.064	4.644GluGlu: 4.644 ± 0.09	2.18GluPhe: 2.18 ± 0.052	3.696GluGly: 3.696 ± 0.071	1.52GluHis: 1.52 ± 0.036	4.097GluIle: 4.097 ± 0.085	3.612GluLys: 3.612 ± 0.077	6.821GluLeu: 6.821 ± 0.09	1.765GluMet: 1.765 ± 0.04	2.305GluAsn: 2.305 ± 0.05	2.142GluPro: 2.142 ± 0.062	4.329GluGln: 4.329 ± 0.083	3.887GluArg: 3.887 ± 0.076	3.17GluSer: 3.17 ± 0.064	3.487GluThr: 3.487 ± 0.063	4.455GluVal: 4.455 ± 0.073	0.571GluTrp: 0.571 ± 0.026	1.498GluTyr: 1.498 ± 0.04	0.001GluXaa: 0.001 ± 0.001
Phe	3.201PheAla: 3.201 ± 0.062	0.672PheCys: 0.672 ± 0.027	2.666PheAsp: 2.666 ± 0.048	2.261PheGlu: 2.261 ± 0.046	1.827PhePhe: 1.827 ± 0.047	2.944PheGly: 2.944 ± 0.052	0.887PheHis: 0.887 ± 0.032	2.321PheIle: 2.321 ± 0.061	1.5PheLys: 1.5 ± 0.041	3.658PheLeu: 3.658 ± 0.076	0.962PheMet: 0.962 ± 0.031	1.53PheAsn: 1.53 ± 0.038	1.513PhePro: 1.513 ± 0.041	1.186PheGln: 1.186 ± 0.037	1.857PheArg: 1.857 ± 0.044	3.262PheSer: 3.262 ± 0.063	2.189PheThr: 2.189 ± 0.047	2.788PheVal: 2.788 ± 0.056	0.47PheTrp: 0.47 ± 0.025	1.373PheTyr: 1.373 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.699GlyAla: 5.699 ± 0.101	1.189GlyCys: 1.189 ± 0.035	4.284GlyAsp: 4.284 ± 0.128	4.385GlyGlu: 4.385 ± 0.056	3.065GlyPhe: 3.065 ± 0.058	5.426GlyGly: 5.426 ± 0.146	1.83GlyHis: 1.83 ± 0.039	4.475GlyIle: 4.475 ± 0.073	3.453GlyLys: 3.453 ± 0.067	7.337GlyLeu: 7.337 ± 0.077	2.062GlyMet: 2.062 ± 0.048	2.396GlyAsn: 2.396 ± 0.072	1.965GlyPro: 1.965 ± 0.049	3.047GlyGln: 3.047 ± 0.056	3.989GlyArg: 3.989 ± 0.08	4.247GlySer: 4.247 ± 0.134	3.956GlyThr: 3.956 ± 0.105	5.507GlyVal: 5.507 ± 0.089	0.929GlyTrp: 0.929 ± 0.031	2.56GlyTyr: 2.56 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.746HisAla: 1.746 ± 0.041	0.422HisCys: 0.422 ± 0.022	1.444HisAsp: 1.444 ± 0.037	1.298HisGlu: 1.298 ± 0.039	1.008HisPhe: 1.008 ± 0.031	1.854HisGly: 1.854 ± 0.045	0.893HisHis: 0.893 ± 0.034	1.192HisIle: 1.192 ± 0.039	0.841HisLys: 0.841 ± 0.027	2.653HisLeu: 2.653 ± 0.058	0.503HisMet: 0.503 ± 0.025	0.879HisAsn: 0.879 ± 0.03	1.366HisPro: 1.366 ± 0.034	1.281HisGln: 1.281 ± 0.038	1.375HisArg: 1.375 ± 0.039	1.42HisSer: 1.42 ± 0.039	1.034HisThr: 1.034 ± 0.032	1.465HisVal: 1.465 ± 0.04	0.337HisTrp: 0.337 ± 0.018	0.897HisTyr: 0.897 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.547IleAla: 5.547 ± 0.079	0.732IleCys: 0.732 ± 0.028	4.388IleAsp: 4.388 ± 0.076	3.952IleGlu: 3.952 ± 0.066	2.036IlePhe: 2.036 ± 0.052	4.458IleGly: 4.458 ± 0.073	1.34IleHis: 1.34 ± 0.036	3.181IleIle: 3.181 ± 0.06	2.473IleLys: 2.473 ± 0.057	5.478IleLeu: 5.478 ± 0.078	1.128IleMet: 1.128 ± 0.036	2.387IleAsn: 2.387 ± 0.041	2.526IlePro: 2.526 ± 0.056	1.871IleGln: 1.871 ± 0.046	3.19IleArg: 3.19 ± 0.056	3.936IleSer: 3.936 ± 0.073	3.456IleThr: 3.456 ± 0.076	4.145IleVal: 4.145 ± 0.064	0.428IleTrp: 0.428 ± 0.02	1.538IleTyr: 1.538 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.691LysAla: 3.691 ± 0.068	0.326LysCys: 0.326 ± 0.02	2.254LysAsp: 2.254 ± 0.054	3.086LysGlu: 3.086 ± 0.063	1.159LysPhe: 1.159 ± 0.035	2.675LysGly: 2.675 ± 0.062	0.893LysHis: 0.893 ± 0.029	2.772LysIle: 2.772 ± 0.061	3.04LysLys: 3.04 ± 0.075	3.888LysLeu: 3.888 ± 0.066	1.144LysMet: 1.144 ± 0.035	1.789LysAsn: 1.789 ± 0.045	1.701LysPro: 1.701 ± 0.048	2.209LysGln: 2.209 ± 0.045	2.619LysArg: 2.619 ± 0.063	2.262LysSer: 2.262 ± 0.054	2.583LysThr: 2.583 ± 0.055	3.001LysVal: 3.001 ± 0.066	0.337LysTrp: 0.337 ± 0.018	0.991LysTyr: 0.991 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.957LeuAla: 9.957 ± 0.116	1.594LeuCys: 1.594 ± 0.043	6.296LeuAsp: 6.296 ± 0.094	6.395LeuGlu: 6.395 ± 0.1	4.483LeuPhe: 4.483 ± 0.092	7.24LeuGly: 7.24 ± 0.096	2.338LeuHis: 2.338 ± 0.053	6.063LeuIle: 6.063 ± 0.085	5.02LeuLys: 5.02 ± 0.09	11.527LeuLeu: 11.527 ± 0.14	2.479LeuMet: 2.479 ± 0.046	3.875LeuAsn: 3.875 ± 0.057	5.025LeuPro: 5.025 ± 0.093	4.486LeuGln: 4.486 ± 0.083	5.669LeuArg: 5.669 ± 0.087	7.413LeuSer: 7.413 ± 0.098	6.392LeuThr: 6.392 ± 0.098	7.563LeuVal: 7.563 ± 0.107	1.112LeuTrp: 1.112 ± 0.036	2.731LeuTyr: 2.731 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.773MetAla: 2.773 ± 0.058	0.242MetCys: 0.242 ± 0.016	1.448MetAsp: 1.448 ± 0.033	1.539MetGlu: 1.539 ± 0.038	0.79MetPhe: 0.79 ± 0.029	1.648MetGly: 1.648 ± 0.043	0.418MetHis: 0.418 ± 0.019	1.567MetIle: 1.567 ± 0.039	1.315MetLys: 1.315 ± 0.036	2.396MetLeu: 2.396 ± 0.051	0.751MetMet: 0.751 ± 0.027	0.91MetAsn: 0.91 ± 0.028	1.111MetPro: 1.111 ± 0.038	0.872MetGln: 0.872 ± 0.03	1.227MetArg: 1.227 ± 0.037	1.519MetSer: 1.519 ± 0.039	1.739MetThr: 1.739 ± 0.037	1.976MetVal: 1.976 ± 0.049	0.18MetTrp: 0.18 ± 0.013	0.456MetTyr: 0.456 ± 0.022	0.001MetXaa: 0.001 ± 0.001
Asn	2.782AsnAla: 2.782 ± 0.057	0.463AsnCys: 0.463 ± 0.021	2.188AsnAsp: 2.188 ± 0.055	1.955AsnGlu: 1.955 ± 0.047	1.245AsnPhe: 1.245 ± 0.036	2.58AsnGly: 2.58 ± 0.062	0.876AsnHis: 0.876 ± 0.031	2.05AsnIle: 2.05 ± 0.051	1.416AsnLys: 1.416 ± 0.043	3.728AsnLeu: 3.728 ± 0.058	0.79AsnMet: 0.79 ± 0.03	1.387AsnAsn: 1.387 ± 0.041	1.8AsnPro: 1.8 ± 0.044	1.459AsnGln: 1.459 ± 0.036	2.166AsnArg: 2.166 ± 0.05	2.007AsnSer: 2.007 ± 0.06	1.762AsnThr: 1.762 ± 0.056	2.343AsnVal: 2.343 ± 0.075	0.395AsnTrp: 0.395 ± 0.019	1.091AsnTyr: 1.091 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.526ProAla: 3.526 ± 0.068	0.516ProCys: 0.516 ± 0.022	2.64ProAsp: 2.64 ± 0.06	3.176ProGlu: 3.176 ± 0.074	1.853ProPhe: 1.853 ± 0.048	2.998ProGly: 2.998 ± 0.062	1.011ProHis: 1.011 ± 0.034	2.017ProIle: 2.017 ± 0.04	1.446ProLys: 1.446 ± 0.043	4.68ProLeu: 4.68 ± 0.08	0.992ProMet: 0.992 ± 0.033	1.136ProAsn: 1.136 ± 0.034	1.585ProPro: 1.585 ± 0.044	2.304ProGln: 2.304 ± 0.058	1.824ProArg: 1.824 ± 0.049	2.236ProSer: 2.236 ± 0.052	2.087ProThr: 2.087 ± 0.051	3.528ProVal: 3.528 ± 0.073	0.541ProTrp: 0.541 ± 0.023	1.193ProTyr: 1.193 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.449GlnAla: 4.449 ± 0.075	0.605GlnCys: 0.605 ± 0.029	2.066GlnAsp: 2.066 ± 0.048	2.622GlnGlu: 2.622 ± 0.053	1.423GlnPhe: 1.423 ± 0.037	3.246GlnGly: 3.246 ± 0.059	1.166GlnHis: 1.166 ± 0.035	2.633GlnIle: 2.633 ± 0.061	1.936GlnLys: 1.936 ± 0.046	5.3GlnLeu: 5.3 ± 0.093	1.201GlnMet: 1.201 ± 0.034	1.329GlnAsn: 1.329 ± 0.036	2.196GlnPro: 2.196 ± 0.058	3.563GlnGln: 3.563 ± 0.083	3.542GlnArg: 3.542 ± 0.07	2.311GlnSer: 2.311 ± 0.05	2.299GlnThr: 2.299 ± 0.043	3.46GlnVal: 3.46 ± 0.059	0.654GlnTrp: 0.654 ± 0.028	0.932GlnTyr: 0.932 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.789ArgAla: 3.789 ± 0.07	0.85ArgCys: 0.85 ± 0.031	3.229ArgAsp: 3.229 ± 0.067	3.529ArgGlu: 3.529 ± 0.063	2.616ArgPhe: 2.616 ± 0.052	3.188ArgGly: 3.188 ± 0.06	1.742ArgHis: 1.742 ± 0.046	3.58ArgIle: 3.58 ± 0.066	2.381ArgLys: 2.381 ± 0.06	6.532ArgLeu: 6.532 ± 0.099	1.44ArgMet: 1.44 ± 0.035	2.015ArgAsn: 2.015 ± 0.049	2.005ArgPro: 2.005 ± 0.052	3.449ArgGln: 3.449 ± 0.072	3.738ArgArg: 3.738 ± 0.073	3.23ArgSer: 3.23 ± 0.057	2.455ArgThr: 2.455 ± 0.049	3.709ArgVal: 3.709 ± 0.07	0.796ArgTrp: 0.796 ± 0.033	2.099ArgTyr: 2.099 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.251SerAla: 5.251 ± 0.088	0.922SerCys: 0.922 ± 0.034	3.529SerAsp: 3.529 ± 0.091	3.498SerGlu: 3.498 ± 0.062	2.507SerPhe: 2.507 ± 0.046	5.405SerGly: 5.405 ± 0.168	1.44SerHis: 1.44 ± 0.041	3.219SerIle: 3.219 ± 0.064	2.012SerLys: 2.012 ± 0.047	6.688SerLeu: 6.688 ± 0.089	1.597SerMet: 1.597 ± 0.038	1.807SerAsn: 1.807 ± 0.042	2.41SerPro: 2.41 ± 0.051	2.703SerGln: 2.703 ± 0.06	3.484SerArg: 3.484 ± 0.062	3.971SerSer: 3.971 ± 0.092	3.077SerThr: 3.077 ± 0.094	4.287SerVal: 4.287 ± 0.09	0.812SerTrp: 0.812 ± 0.025	1.869SerTyr: 1.869 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.068ThrAla: 5.068 ± 0.104	0.716ThrCys: 0.716 ± 0.031	2.999ThrAsp: 2.999 ± 0.084	2.968ThrGlu: 2.968 ± 0.058	2.122ThrPhe: 2.122 ± 0.05	4.186ThrGly: 4.186 ± 0.091	1.055ThrHis: 1.055 ± 0.027	3.551ThrIle: 3.551 ± 0.074	1.635ThrLys: 1.635 ± 0.047	6.756ThrLeu: 6.756 ± 0.114	1.362ThrMet: 1.362 ± 0.034	1.651ThrAsn: 1.651 ± 0.059	2.859ThrPro: 2.859 ± 0.061	1.898ThrGln: 1.898 ± 0.045	2.701ThrArg: 2.701 ± 0.05	3.228ThrSer: 3.228 ± 0.082	3.541ThrThr: 3.541 ± 0.095	4.445ThrVal: 4.445 ± 0.112	0.525ThrTrp: 0.525 ± 0.024	1.454ThrTyr: 1.454 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	7.326ValAla: 7.326 ± 0.119	0.959ValCys: 0.959 ± 0.031	4.675ValAsp: 4.675 ± 0.088	5.039ValGlu: 5.039 ± 0.082	2.855ValPhe: 2.855 ± 0.057	4.99ValGly: 4.99 ± 0.08	1.449ValHis: 1.449 ± 0.037	4.453ValIle: 4.453 ± 0.081	2.88ValLys: 2.88 ± 0.057	7.552ValLeu: 7.552 ± 0.11	1.755ValMet: 1.755 ± 0.04	2.519ValAsn: 2.519 ± 0.056	2.904ValPro: 2.904 ± 0.059	2.49ValGln: 2.49 ± 0.045	3.667ValArg: 3.667 ± 0.066	4.594ValSer: 4.594 ± 0.087	4.475ValThr: 4.475 ± 0.097	6.426ValVal: 6.426 ± 0.093	0.71ValTrp: 0.71 ± 0.027	1.807ValTyr: 1.807 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.776TrpAla: 0.776 ± 0.032	0.129TrpCys: 0.129 ± 0.01	0.538TrpAsp: 0.538 ± 0.023	0.526TrpGlu: 0.526 ± 0.021	0.461TrpPhe: 0.461 ± 0.022	0.769TrpGly: 0.769 ± 0.03	0.292TrpHis: 0.292 ± 0.016	0.577TrpIle: 0.577 ± 0.025	0.431TrpLys: 0.431 ± 0.02	1.438TrpLeu: 1.438 ± 0.042	0.277TrpMet: 0.277 ± 0.015	0.429TrpAsn: 0.429 ± 0.023	0.478TrpPro: 0.478 ± 0.021	0.856TrpGln: 0.856 ± 0.035	0.71TrpArg: 0.71 ± 0.031	0.703TrpSer: 0.703 ± 0.028	0.499TrpThr: 0.499 ± 0.021	0.666TrpVal: 0.666 ± 0.025	0.194TrpTrp: 0.194 ± 0.014	0.336TrpTyr: 0.336 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.33TyrAla: 2.33 ± 0.046	0.41TyrCys: 0.41 ± 0.02	1.864TyrAsp: 1.864 ± 0.057	1.571TyrGlu: 1.571 ± 0.048	1.289TyrPhe: 1.289 ± 0.038	2.168TyrGly: 2.168 ± 0.05	0.771TyrHis: 0.771 ± 0.025	1.312TyrIle: 1.312 ± 0.038	0.886TyrLys: 0.886 ± 0.032	3.248TyrLeu: 3.248 ± 0.062	0.47TyrMet: 0.47 ± 0.022	0.962TyrAsn: 0.962 ± 0.03	1.344TyrPro: 1.344 ± 0.042	1.544TyrGln: 1.544 ± 0.041	2.07TyrArg: 2.07 ± 0.052	1.827TyrSer: 1.827 ± 0.047	1.414TyrThr: 1.414 ± 0.042	1.795TyrVal: 1.795 ± 0.044	0.326TyrTrp: 0.326 ± 0.018	0.994TyrTyr: 0.994 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.005

Statistics based on 3204 proteins (1103131 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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