Amino acid dipepetide frequency for Woeseia oceani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.387AlaAla: 14.387 ± 0.158	1.099AlaCys: 1.099 ± 0.032	7.218AlaAsp: 7.218 ± 0.07	7.148AlaGlu: 7.148 ± 0.088	3.557AlaPhe: 3.557 ± 0.064	9.546AlaGly: 9.546 ± 0.096	1.94AlaHis: 1.94 ± 0.049	5.826AlaIle: 5.826 ± 0.076	3.072AlaLys: 3.072 ± 0.053	11.587AlaLeu: 11.587 ± 0.119	2.941AlaMet: 2.941 ± 0.058	3.455AlaAsn: 3.455 ± 0.055	4.072AlaPro: 4.072 ± 0.06	3.546AlaGln: 3.546 ± 0.057	7.055AlaArg: 7.055 ± 0.095	6.437AlaSer: 6.437 ± 0.082	5.9AlaThr: 5.9 ± 0.069	8.207AlaVal: 8.207 ± 0.092	1.376AlaTrp: 1.376 ± 0.038	2.591AlaTyr: 2.591 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.95CysAla: 0.95 ± 0.03	0.118CysCys: 0.118 ± 0.01	0.561CysAsp: 0.561 ± 0.021	0.497CysGlu: 0.497 ± 0.021	0.316CysPhe: 0.316 ± 0.016	1.014CysGly: 1.014 ± 0.033	0.283CysHis: 0.283 ± 0.02	0.442CysIle: 0.442 ± 0.02	0.222CysLys: 0.222 ± 0.012	0.844CysLeu: 0.844 ± 0.027	0.176CysMet: 0.176 ± 0.011	0.313CysAsn: 0.313 ± 0.017	0.403CysPro: 0.403 ± 0.023	0.311CysGln: 0.311 ± 0.016	0.656CysArg: 0.656 ± 0.024	0.577CysSer: 0.577 ± 0.023	0.449CysThr: 0.449 ± 0.021	0.663CysVal: 0.663 ± 0.026	0.124CysTrp: 0.124 ± 0.011	0.242CysTyr: 0.242 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.587AspAla: 6.587 ± 0.088	0.533AspCys: 0.533 ± 0.021	4.137AspAsp: 4.137 ± 0.076	4.21AspGlu: 4.21 ± 0.064	2.381AspPhe: 2.381 ± 0.048	5.439AspGly: 5.439 ± 0.09	1.141AspHis: 1.141 ± 0.031	3.462AspIle: 3.462 ± 0.062	1.928AspLys: 1.928 ± 0.048	5.691AspLeu: 5.691 ± 0.073	1.459AspMet: 1.459 ± 0.035	2.075AspAsn: 2.075 ± 0.042	3.024AspPro: 3.024 ± 0.056	1.944AspGln: 1.944 ± 0.04	4.107AspArg: 4.107 ± 0.067	3.528AspSer: 3.528 ± 0.056	2.981AspThr: 2.981 ± 0.056	4.356AspVal: 4.356 ± 0.066	1.01AspTrp: 1.01 ± 0.029	1.918AspTyr: 1.918 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.941GluAla: 5.941 ± 0.084	0.441GluCys: 0.441 ± 0.022	2.783GluAsp: 2.783 ± 0.055	3.12GluGlu: 3.12 ± 0.063	2.498GluPhe: 2.498 ± 0.051	3.446GluGly: 3.446 ± 0.056	1.444GluHis: 1.444 ± 0.039	3.427GluIle: 3.427 ± 0.056	2.048GluLys: 2.048 ± 0.051	6.927GluLeu: 6.927 ± 0.1	1.4GluMet: 1.4 ± 0.04	1.891GluAsn: 1.891 ± 0.042	2.724GluPro: 2.724 ± 0.05	3.173GluGln: 3.173 ± 0.062	4.917GluArg: 4.917 ± 0.077	3.519GluSer: 3.519 ± 0.055	3.149GluThr: 3.149 ± 0.051	4.091GluVal: 4.091 ± 0.058	0.823GluTrp: 0.823 ± 0.028	1.564GluTyr: 1.564 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.334PheAla: 4.334 ± 0.064	0.374PheCys: 0.374 ± 0.018	2.823PheAsp: 2.823 ± 0.055	2.312PheGlu: 2.312 ± 0.047	1.467PhePhe: 1.467 ± 0.043	3.395PheGly: 3.395 ± 0.062	0.673PheHis: 0.673 ± 0.024	1.744PheIle: 1.744 ± 0.037	0.919PheLys: 0.919 ± 0.03	3.214PheLeu: 3.214 ± 0.059	0.825PheMet: 0.825 ± 0.027	1.291PheAsn: 1.291 ± 0.033	1.465PhePro: 1.465 ± 0.036	1.043PheGln: 1.043 ± 0.03	2.316PheArg: 2.316 ± 0.047	2.56PheSer: 2.56 ± 0.049	1.899PheThr: 1.899 ± 0.045	2.87PheVal: 2.87 ± 0.054	0.482PheTrp: 0.482 ± 0.022	1.038PheTyr: 1.038 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.341GlyAla: 7.341 ± 0.081	0.847GlyCys: 0.847 ± 0.033	4.772GlyAsp: 4.772 ± 0.069	4.539GlyGlu: 4.539 ± 0.062	3.276GlyPhe: 3.276 ± 0.057	6.312GlyGly: 6.312 ± 0.114	1.706GlyHis: 1.706 ± 0.036	4.824GlyIle: 4.824 ± 0.069	3.088GlyLys: 3.088 ± 0.059	7.828GlyLeu: 7.828 ± 0.09	2.206GlyMet: 2.206 ± 0.052	2.787GlyAsn: 2.787 ± 0.052	2.732GlyPro: 2.732 ± 0.056	2.885GlyGln: 2.885 ± 0.051	5.132GlyArg: 5.132 ± 0.065	5.069GlySer: 5.069 ± 0.072	4.433GlyThr: 4.433 ± 0.072	5.914GlyVal: 5.914 ± 0.081	1.207GlyTrp: 1.207 ± 0.035	2.519GlyTyr: 2.519 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.034HisAla: 2.034 ± 0.046	0.326HisCys: 0.326 ± 0.015	1.24HisAsp: 1.24 ± 0.037	1.187HisGlu: 1.187 ± 0.038	0.845HisPhe: 0.845 ± 0.025	1.833HisGly: 1.833 ± 0.045	0.468HisHis: 0.468 ± 0.022	0.935HisIle: 0.935 ± 0.027	0.565HisLys: 0.565 ± 0.024	1.936HisLeu: 1.936 ± 0.041	0.454HisMet: 0.454 ± 0.019	0.623HisAsn: 0.623 ± 0.029	1.129HisPro: 1.129 ± 0.031	0.643HisGln: 0.643 ± 0.024	1.443HisArg: 1.443 ± 0.042	1.202HisSer: 1.202 ± 0.03	1.006HisThr: 1.006 ± 0.027	1.385HisVal: 1.385 ± 0.033	0.353HisTrp: 0.353 ± 0.017	0.715HisTyr: 0.715 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.598IleAla: 6.598 ± 0.084	0.464IleCys: 0.464 ± 0.019	4.062IleAsp: 4.062 ± 0.067	3.802IleGlu: 3.802 ± 0.068	1.464IlePhe: 1.464 ± 0.045	4.557IleGly: 4.557 ± 0.07	0.889IleHis: 0.889 ± 0.03	2.244IleIle: 2.244 ± 0.048	1.564IleLys: 1.564 ± 0.04	4.201IleLeu: 4.201 ± 0.067	0.997IleMet: 0.997 ± 0.036	1.952IleAsn: 1.952 ± 0.039	2.342IlePro: 2.342 ± 0.047	1.368IleGln: 1.368 ± 0.034	3.373IleArg: 3.373 ± 0.061	3.343IleSer: 3.343 ± 0.052	2.668IleThr: 2.668 ± 0.052	4.298IleVal: 4.298 ± 0.067	0.539IleTrp: 0.539 ± 0.02	1.258IleTyr: 1.258 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.145LysAla: 3.145 ± 0.056	0.172LysCys: 0.172 ± 0.014	1.65LysAsp: 1.65 ± 0.042	1.661LysGlu: 1.661 ± 0.044	0.892LysPhe: 0.892 ± 0.026	2.028LysGly: 2.028 ± 0.05	0.679LysHis: 0.679 ± 0.026	1.604LysIle: 1.604 ± 0.038	1.336LysLys: 1.336 ± 0.062	3.22LysLeu: 3.22 ± 0.058	0.695LysMet: 0.695 ± 0.022	0.983LysAsn: 0.983 ± 0.03	1.678LysPro: 1.678 ± 0.044	1.232LysGln: 1.232 ± 0.036	2.249LysArg: 2.249 ± 0.048	1.922LysSer: 1.922 ± 0.047	1.752LysThr: 1.752 ± 0.044	2.265LysVal: 2.265 ± 0.053	0.292LysTrp: 0.292 ± 0.014	0.786LysTyr: 0.786 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.344LeuAla: 12.344 ± 0.13	0.954LeuCys: 0.954 ± 0.029	6.177LeuAsp: 6.177 ± 0.093	5.686LeuGlu: 5.686 ± 0.071	3.733LeuPhe: 3.733 ± 0.063	7.588LeuGly: 7.588 ± 0.091	2.129LeuHis: 2.129 ± 0.05	5.067LeuIle: 5.067 ± 0.075	3.125LeuLys: 3.125 ± 0.06	11.385LeuLeu: 11.385 ± 0.149	2.248LeuMet: 2.248 ± 0.041	3.321LeuAsn: 3.321 ± 0.055	5.428LeuPro: 5.428 ± 0.077	4.299LeuGln: 4.299 ± 0.065	7.181LeuArg: 7.181 ± 0.091	6.657LeuSer: 6.657 ± 0.079	5.514LeuThr: 5.514 ± 0.069	6.862LeuVal: 6.862 ± 0.095	1.101LeuTrp: 1.101 ± 0.034	2.39LeuTyr: 2.39 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.452MetAla: 2.452 ± 0.052	0.156MetCys: 0.156 ± 0.013	1.207MetAsp: 1.207 ± 0.035	1.065MetGlu: 1.065 ± 0.03	0.741MetPhe: 0.741 ± 0.028	1.446MetGly: 1.446 ± 0.037	0.544MetHis: 0.544 ± 0.024	1.113MetIle: 1.113 ± 0.034	0.839MetLys: 0.839 ± 0.025	2.639MetLeu: 2.639 ± 0.045	0.519MetMet: 0.519 ± 0.023	0.982MetAsn: 0.982 ± 0.029	1.389MetPro: 1.389 ± 0.033	1.143MetGln: 1.143 ± 0.03	1.669MetArg: 1.669 ± 0.038	1.847MetSer: 1.847 ± 0.041	1.549MetThr: 1.549 ± 0.036	1.437MetVal: 1.437 ± 0.041	0.211MetTrp: 0.211 ± 0.014	0.474MetTyr: 0.474 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.639AsnAla: 3.639 ± 0.06	0.314AsnCys: 0.314 ± 0.016	2.048AsnAsp: 2.048 ± 0.04	1.963AsnGlu: 1.963 ± 0.036	1.213AsnPhe: 1.213 ± 0.036	2.878AsnGly: 2.878 ± 0.051	0.582AsnHis: 0.582 ± 0.025	1.782AsnIle: 1.782 ± 0.042	0.941AsnLys: 0.941 ± 0.025	3.1AsnLeu: 3.1 ± 0.05	0.719AsnMet: 0.719 ± 0.021	1.264AsnAsn: 1.264 ± 0.033	1.923AsnPro: 1.923 ± 0.042	1.01AsnGln: 1.01 ± 0.03	2.209AsnArg: 2.209 ± 0.047	1.909AsnSer: 1.909 ± 0.041	1.737AsnThr: 1.737 ± 0.041	2.494AsnVal: 2.494 ± 0.049	0.543AsnTrp: 0.543 ± 0.02	1.053AsnTyr: 1.053 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.501ProAla: 5.501 ± 0.075	0.315ProCys: 0.315 ± 0.014	3.385ProAsp: 3.385 ± 0.057	3.274ProGlu: 3.274 ± 0.048	1.709ProPhe: 1.709 ± 0.042	4.159ProGly: 4.159 ± 0.057	0.871ProHis: 0.871 ± 0.023	1.925ProIle: 1.925 ± 0.045	1.218ProLys: 1.218 ± 0.033	4.706ProLeu: 4.706 ± 0.067	1.06ProMet: 1.06 ± 0.033	1.391ProAsn: 1.391 ± 0.04	1.916ProPro: 1.916 ± 0.049	1.528ProGln: 1.528 ± 0.036	2.446ProArg: 2.446 ± 0.053	2.325ProSer: 2.325 ± 0.041	2.101ProThr: 2.101 ± 0.042	3.958ProVal: 3.958 ± 0.053	0.626ProTrp: 0.626 ± 0.025	1.212ProTyr: 1.212 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.948GlnAla: 3.948 ± 0.057	0.277GlnCys: 0.277 ± 0.018	1.816GlnAsp: 1.816 ± 0.039	1.898GlnGlu: 1.898 ± 0.045	1.403GlnPhe: 1.403 ± 0.038	2.328GlnGly: 2.328 ± 0.042	0.918GlnHis: 0.918 ± 0.028	1.851GlnIle: 1.851 ± 0.042	1.171GlnLys: 1.171 ± 0.037	4.062GlnLeu: 4.062 ± 0.067	0.852GlnMet: 0.852 ± 0.03	1.14GlnAsn: 1.14 ± 0.033	1.816GlnPro: 1.816 ± 0.042	1.955GlnGln: 1.955 ± 0.049	3.184GlnArg: 3.184 ± 0.049	2.344GlnSer: 2.344 ± 0.042	1.829GlnThr: 1.829 ± 0.036	2.52GlnVal: 2.52 ± 0.043	0.53GlnTrp: 0.53 ± 0.023	0.902GlnTyr: 0.902 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.58ArgAla: 6.58 ± 0.074	0.596ArgCys: 0.596 ± 0.025	4.161ArgAsp: 4.161 ± 0.064	4.389ArgGlu: 4.389 ± 0.06	2.867ArgPhe: 2.867 ± 0.046	4.388ArgGly: 4.388 ± 0.067	1.588ArgHis: 1.588 ± 0.036	4.05ArgIle: 4.05 ± 0.061	2.316ArgLys: 2.316 ± 0.042	7.438ArgLeu: 7.438 ± 0.098	1.693ArgMet: 1.693 ± 0.032	2.415ArgAsn: 2.415 ± 0.041	2.81ArgPro: 2.81 ± 0.046	2.889ArgGln: 2.889 ± 0.056	5.159ArgArg: 5.159 ± 0.08	3.965ArgSer: 3.965 ± 0.066	3.245ArgThr: 3.245 ± 0.057	4.712ArgVal: 4.712 ± 0.075	1.051ArgTrp: 1.051 ± 0.033	2.384ArgTyr: 2.384 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.865SerAla: 6.865 ± 0.082	0.541SerCys: 0.541 ± 0.024	3.767SerAsp: 3.767 ± 0.06	3.375SerGlu: 3.375 ± 0.057	2.354SerPhe: 2.354 ± 0.05	6.002SerGly: 6.002 ± 0.087	1.128SerHis: 1.128 ± 0.029	3.175SerIle: 3.175 ± 0.046	1.79SerLys: 1.79 ± 0.046	6.267SerLeu: 6.267 ± 0.085	1.512SerMet: 1.512 ± 0.031	2.168SerAsn: 2.168 ± 0.041	2.629SerPro: 2.629 ± 0.048	1.989SerGln: 1.989 ± 0.037	4.07SerArg: 4.07 ± 0.066	3.793SerSer: 3.793 ± 0.068	3.104SerThr: 3.104 ± 0.052	4.602SerVal: 4.602 ± 0.062	0.89SerTrp: 0.89 ± 0.031	1.669SerTyr: 1.669 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.045ThrAla: 6.045 ± 0.08	0.396ThrCys: 0.396 ± 0.016	3.274ThrAsp: 3.274 ± 0.068	2.876ThrGlu: 2.876 ± 0.047	1.765ThrPhe: 1.765 ± 0.039	4.81ThrGly: 4.81 ± 0.068	0.989ThrHis: 0.989 ± 0.032	2.718ThrIle: 2.718 ± 0.051	1.106ThrLys: 1.106 ± 0.033	5.846ThrLeu: 5.846 ± 0.07	1.137ThrMet: 1.137 ± 0.03	1.478ThrAsn: 1.478 ± 0.044	2.806ThrPro: 2.806 ± 0.053	1.571ThrGln: 1.571 ± 0.035	3.207ThrArg: 3.207 ± 0.058	3.008ThrSer: 3.008 ± 0.051	2.875ThrThr: 2.875 ± 0.055	4.671ThrVal: 4.671 ± 0.065	0.63ThrTrp: 0.63 ± 0.025	1.309ThrTyr: 1.309 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.523ValAla: 8.523 ± 0.103	0.795ValCys: 0.795 ± 0.026	4.6ValAsp: 4.6 ± 0.075	4.168ValGlu: 4.168 ± 0.064	2.834ValPhe: 2.834 ± 0.048	5.142ValGly: 5.142 ± 0.075	1.478ValHis: 1.478 ± 0.039	4.058ValIle: 4.058 ± 0.068	1.919ValLys: 1.919 ± 0.038	7.596ValLeu: 7.596 ± 0.087	1.662ValMet: 1.662 ± 0.036	2.471ValAsn: 2.471 ± 0.049	3.441ValPro: 3.441 ± 0.052	2.346ValGln: 2.346 ± 0.048	4.909ValArg: 4.909 ± 0.062	4.989ValSer: 4.989 ± 0.067	4.228ValThr: 4.228 ± 0.064	5.878ValVal: 5.878 ± 0.085	0.907ValTrp: 0.907 ± 0.032	1.929ValTyr: 1.929 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.023TrpAla: 1.023 ± 0.032	0.14TrpCys: 0.14 ± 0.01	0.655TrpAsp: 0.655 ± 0.024	0.548TrpGlu: 0.548 ± 0.022	0.549TrpPhe: 0.549 ± 0.026	0.846TrpGly: 0.846 ± 0.029	0.359TrpHis: 0.359 ± 0.017	0.644TrpIle: 0.644 ± 0.022	0.363TrpLys: 0.363 ± 0.02	1.816TrpLeu: 1.816 ± 0.042	0.328TrpMet: 0.328 ± 0.014	0.481TrpAsn: 0.481 ± 0.024	0.616TrpPro: 0.616 ± 0.026	0.788TrpGln: 0.788 ± 0.023	1.093TrpArg: 1.093 ± 0.032	0.93TrpSer: 0.93 ± 0.029	0.655TrpThr: 0.655 ± 0.025	0.872TrpVal: 0.872 ± 0.024	0.215TrpTrp: 0.215 ± 0.014	0.391TrpTyr: 0.391 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.723TyrAla: 2.723 ± 0.05	0.301TyrCys: 0.301 ± 0.014	1.578TyrAsp: 1.578 ± 0.045	1.608TyrGlu: 1.608 ± 0.036	1.177TyrPhe: 1.177 ± 0.031	2.26TyrGly: 2.26 ± 0.05	0.516TyrHis: 0.516 ± 0.02	1.093TyrIle: 1.093 ± 0.029	0.711TyrLys: 0.711 ± 0.024	2.883TyrLeu: 2.883 ± 0.055	0.538TyrMet: 0.538 ± 0.022	0.843TyrAsn: 0.843 ± 0.029	1.283TyrPro: 1.283 ± 0.034	1.083TyrGln: 1.083 ± 0.029	2.321TyrArg: 2.321 ± 0.042	1.762TyrSer: 1.762 ± 0.039	1.443TyrThr: 1.443 ± 0.035	1.818TyrVal: 1.818 ± 0.041	0.402TyrTrp: 0.402 ± 0.018	0.903TyrTyr: 0.903 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3565 proteins (1201765 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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