Amino acid dipepetide frequency for Lihuaxuella thermophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.133AlaAla: 7.133 ± 0.094	0.794AlaCys: 0.794 ± 0.028	4.056AlaAsp: 4.056 ± 0.07	5.737AlaGlu: 5.737 ± 0.09	3.25AlaPhe: 3.25 ± 0.057	6.771AlaGly: 6.771 ± 0.104	1.556AlaHis: 1.556 ± 0.038	5.112AlaIle: 5.112 ± 0.08	4.605AlaLys: 4.605 ± 0.076	7.777AlaLeu: 7.777 ± 0.099	2.127AlaMet: 2.127 ± 0.047	2.27AlaAsn: 2.27 ± 0.052	2.482AlaPro: 2.482 ± 0.055	2.481AlaGln: 2.481 ± 0.05	4.169AlaArg: 4.169 ± 0.061	3.952AlaSer: 3.952 ± 0.065	3.317AlaThr: 3.317 ± 0.055	6.608AlaVal: 6.608 ± 0.083	0.936AlaTrp: 0.936 ± 0.031	2.443AlaTyr: 2.443 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.533CysAla: 0.533 ± 0.024	0.129CysCys: 0.129 ± 0.012	0.45CysAsp: 0.45 ± 0.024	0.525CysGlu: 0.525 ± 0.025	0.381CysPhe: 0.381 ± 0.018	0.81CysGly: 0.81 ± 0.029	0.24CysHis: 0.24 ± 0.014	0.531CysIle: 0.531 ± 0.02	0.395CysLys: 0.395 ± 0.02	0.948CysLeu: 0.948 ± 0.031	0.211CysMet: 0.211 ± 0.014	0.271CysAsn: 0.271 ± 0.015	0.464CysPro: 0.464 ± 0.023	0.273CysGln: 0.273 ± 0.014	0.615CysArg: 0.615 ± 0.027	0.613CysSer: 0.613 ± 0.026	0.475CysThr: 0.475 ± 0.021	0.485CysVal: 0.485 ± 0.021	0.112CysTrp: 0.112 ± 0.01	0.319CysTyr: 0.319 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.351AspAla: 3.351 ± 0.058	0.431AspCys: 0.431 ± 0.019	2.091AspAsp: 2.091 ± 0.046	3.952AspGlu: 3.952 ± 0.074	2.048AspPhe: 2.048 ± 0.044	3.505AspGly: 3.505 ± 0.064	1.314AspHis: 1.314 ± 0.037	2.858AspIle: 2.858 ± 0.055	2.214AspLys: 2.214 ± 0.052	5.357AspLeu: 5.357 ± 0.071	1.079AspMet: 1.079 ± 0.031	1.2AspAsn: 1.2 ± 0.037	2.896AspPro: 2.896 ± 0.051	2.355AspGln: 2.355 ± 0.049	3.187AspArg: 3.187 ± 0.059	2.254AspSer: 2.254 ± 0.051	1.985AspThr: 1.985 ± 0.046	3.455AspVal: 3.455 ± 0.058	0.866AspTrp: 0.866 ± 0.033	1.703AspTyr: 1.703 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.984GluAla: 5.984 ± 0.082	0.501GluCys: 0.501 ± 0.021	3.046GluAsp: 3.046 ± 0.052	6.536GluGlu: 6.536 ± 0.105	2.154GluPhe: 2.154 ± 0.047	4.29GluGly: 4.29 ± 0.072	1.574GluHis: 1.574 ± 0.041	5.049GluIle: 5.049 ± 0.08	5.685GluLys: 5.685 ± 0.085	6.858GluLeu: 6.858 ± 0.091	2.221GluMet: 2.221 ± 0.047	2.611GluAsn: 2.611 ± 0.046	2.427GluPro: 2.427 ± 0.053	3.699GluGln: 3.699 ± 0.06	4.606GluArg: 4.606 ± 0.09	3.264GluSer: 3.264 ± 0.054	3.698GluThr: 3.698 ± 0.056	4.93GluVal: 4.93 ± 0.083	1.118GluTrp: 1.118 ± 0.035	2.048GluTyr: 2.048 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.293PheAla: 3.293 ± 0.06	0.433PheCys: 0.433 ± 0.021	2.063PheAsp: 2.063 ± 0.045	2.344PheGlu: 2.344 ± 0.047	2.152PhePhe: 2.152 ± 0.06	3.099PheGly: 3.099 ± 0.059	1.101PheHis: 1.101 ± 0.034	2.733PheIle: 2.733 ± 0.058	1.686PheLys: 1.686 ± 0.042	4.269PheLeu: 4.269 ± 0.073	0.995PheMet: 0.995 ± 0.034	1.297PheAsn: 1.297 ± 0.039	2.008PhePro: 2.008 ± 0.054	1.566PheGln: 1.566 ± 0.04	2.223PheArg: 2.223 ± 0.043	2.841PheSer: 2.841 ± 0.057	2.225PheThr: 2.225 ± 0.052	2.84PheVal: 2.84 ± 0.053	0.564PheTrp: 0.564 ± 0.025	1.496PheTyr: 1.496 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.222GlyAla: 5.222 ± 0.087	0.838GlyCys: 0.838 ± 0.031	3.252GlyAsp: 3.252 ± 0.061	4.927GlyGlu: 4.927 ± 0.071	3.187GlyPhe: 3.187 ± 0.059	5.332GlyGly: 5.332 ± 0.088	1.507GlyHis: 1.507 ± 0.035	5.699GlyIle: 5.699 ± 0.074	5.171GlyLys: 5.171 ± 0.081	7.108GlyLeu: 7.108 ± 0.089	2.348GlyMet: 2.348 ± 0.046	2.541GlyAsn: 2.541 ± 0.048	2.297GlyPro: 2.297 ± 0.045	2.632GlyGln: 2.632 ± 0.053	3.896GlyArg: 3.896 ± 0.065	3.927GlySer: 3.927 ± 0.057	4.261GlyThr: 4.261 ± 0.07	5.478GlyVal: 5.478 ± 0.073	1.223GlyTrp: 1.223 ± 0.036	2.786GlyTyr: 2.786 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.666HisAla: 1.666 ± 0.039	0.209HisCys: 0.209 ± 0.014	0.937HisAsp: 0.937 ± 0.024	1.394HisGlu: 1.394 ± 0.039	1.099HisPhe: 1.099 ± 0.032	1.657HisGly: 1.657 ± 0.036	0.804HisHis: 0.804 ± 0.031	1.383HisIle: 1.383 ± 0.035	0.928HisLys: 0.928 ± 0.031	2.697HisLeu: 2.697 ± 0.06	0.512HisMet: 0.512 ± 0.022	0.619HisAsn: 0.619 ± 0.023	1.714HisPro: 1.714 ± 0.044	1.036HisGln: 1.036 ± 0.034	1.433HisArg: 1.433 ± 0.043	1.264HisSer: 1.264 ± 0.039	1.094HisThr: 1.094 ± 0.03	1.636HisVal: 1.636 ± 0.039	0.333HisTrp: 0.333 ± 0.019	0.802HisTyr: 0.802 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.627IleAla: 5.627 ± 0.08	0.73IleCys: 0.73 ± 0.027	3.505IleAsp: 3.505 ± 0.061	4.447IleGlu: 4.447 ± 0.067	2.599IlePhe: 2.599 ± 0.056	5.259IleGly: 5.259 ± 0.085	1.834IleHis: 1.834 ± 0.046	3.899IleIle: 3.899 ± 0.072	3.031IleLys: 3.031 ± 0.061	6.675IleLeu: 6.675 ± 0.113	1.356IleMet: 1.356 ± 0.038	2.07IleAsn: 2.07 ± 0.047	3.582IlePro: 3.582 ± 0.056	2.835IleGln: 2.835 ± 0.054	4.528IleArg: 4.528 ± 0.078	4.048IleSer: 4.048 ± 0.064	3.46IleThr: 3.46 ± 0.057	4.622IleVal: 4.622 ± 0.064	0.742IleTrp: 0.742 ± 0.025	2.199IleTyr: 2.199 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.328LysAla: 4.328 ± 0.079	0.364LysCys: 0.364 ± 0.02	2.629LysAsp: 2.629 ± 0.053	5.439LysGlu: 5.439 ± 0.073	1.536LysPhe: 1.536 ± 0.042	3.979LysGly: 3.979 ± 0.064	1.288LysHis: 1.288 ± 0.038	3.765LysIle: 3.765 ± 0.067	4.924LysLys: 4.924 ± 0.092	5.006LysLeu: 5.006 ± 0.078	1.856LysMet: 1.856 ± 0.044	2.439LysAsn: 2.439 ± 0.049	2.463LysPro: 2.463 ± 0.055	2.892LysGln: 2.892 ± 0.058	3.531LysArg: 3.531 ± 0.062	2.795LysSer: 2.795 ± 0.051	2.974LysThr: 2.974 ± 0.053	4.082LysVal: 4.082 ± 0.07	0.937LysTrp: 0.937 ± 0.027	1.795LysTyr: 1.795 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	8.592LeuAla: 8.592 ± 0.112	0.845LeuCys: 0.845 ± 0.028	4.991LeuAsp: 4.991 ± 0.062	6.596LeuGlu: 6.596 ± 0.113	4.696LeuPhe: 4.696 ± 0.088	6.938LeuGly: 6.938 ± 0.087	2.175LeuHis: 2.175 ± 0.04	6.938LeuIle: 6.938 ± 0.111	6.058LeuLys: 6.058 ± 0.076	10.443LeuLeu: 10.443 ± 0.159	2.51LeuMet: 2.51 ± 0.045	3.56LeuAsn: 3.56 ± 0.06	4.871LeuPro: 4.871 ± 0.074	3.692LeuGln: 3.692 ± 0.059	5.121LeuArg: 5.121 ± 0.08	6.856LeuSer: 6.856 ± 0.093	5.602LeuThr: 5.602 ± 0.071	6.71LeuVal: 6.71 ± 0.091	1.038LeuTrp: 1.038 ± 0.032	3.035LeuTyr: 3.035 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.208MetAla: 2.208 ± 0.051	0.164MetCys: 0.164 ± 0.011	1.378MetAsp: 1.378 ± 0.032	2.084MetGlu: 2.084 ± 0.041	0.93MetPhe: 0.93 ± 0.031	1.941MetGly: 1.941 ± 0.042	0.42MetHis: 0.42 ± 0.021	2.103MetIle: 2.103 ± 0.044	2.116MetLys: 2.116 ± 0.045	2.353MetLeu: 2.353 ± 0.047	0.844MetMet: 0.844 ± 0.031	1.309MetAsn: 1.309 ± 0.033	0.991MetPro: 0.991 ± 0.028	0.849MetGln: 0.849 ± 0.027	1.381MetArg: 1.381 ± 0.04	1.529MetSer: 1.529 ± 0.04	1.446MetThr: 1.446 ± 0.035	1.908MetVal: 1.908 ± 0.042	0.224MetTrp: 0.224 ± 0.014	0.663MetTyr: 0.663 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.25AsnAla: 2.25 ± 0.05	0.281AsnCys: 0.281 ± 0.018	1.515AsnAsp: 1.515 ± 0.035	2.268AsnGlu: 2.268 ± 0.048	1.109AsnPhe: 1.109 ± 0.033	2.748AsnGly: 2.748 ± 0.054	0.918AsnHis: 0.918 ± 0.028	2.304AsnIle: 2.304 ± 0.051	1.896AsnLys: 1.896 ± 0.048	3.269AsnLeu: 3.269 ± 0.057	0.822AsnMet: 0.822 ± 0.028	1.091AsnAsn: 1.091 ± 0.04	2.286AsnPro: 2.286 ± 0.05	1.774AsnGln: 1.774 ± 0.042	2.4AsnArg: 2.4 ± 0.051	1.551AsnSer: 1.551 ± 0.033	1.509AsnThr: 1.509 ± 0.036	2.127AsnVal: 2.127 ± 0.044	0.49AsnTrp: 0.49 ± 0.024	1.06AsnTyr: 1.06 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.446ProAla: 3.446 ± 0.062	0.301ProCys: 0.301 ± 0.017	2.958ProAsp: 2.958 ± 0.049	4.0ProGlu: 4.0 ± 0.064	2.174ProPhe: 2.174 ± 0.048	3.65ProGly: 3.65 ± 0.065	1.152ProHis: 1.152 ± 0.034	2.409ProIle: 2.409 ± 0.047	2.15ProLys: 2.15 ± 0.051	4.147ProLeu: 4.147 ± 0.064	0.967ProMet: 0.967 ± 0.032	1.43ProAsn: 1.43 ± 0.038	1.729ProPro: 1.729 ± 0.048	1.478ProGln: 1.478 ± 0.039	1.927ProArg: 1.927 ± 0.046	2.654ProSer: 2.654 ± 0.055	1.936ProThr: 1.936 ± 0.047	4.252ProVal: 4.252 ± 0.056	0.541ProTrp: 0.541 ± 0.025	1.615ProTyr: 1.615 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.532GlnAla: 3.532 ± 0.064	0.234GlnCys: 0.234 ± 0.015	1.575GlnAsp: 1.575 ± 0.042	2.928GlnGlu: 2.928 ± 0.056	1.396GlnPhe: 1.396 ± 0.036	2.478GlnGly: 2.478 ± 0.054	0.834GlnHis: 0.834 ± 0.031	2.84GlnIle: 2.84 ± 0.051	2.67GlnLys: 2.67 ± 0.048	4.385GlnLeu: 4.385 ± 0.062	1.259GlnMet: 1.259 ± 0.035	1.333GlnAsn: 1.333 ± 0.032	1.788GlnPro: 1.788 ± 0.046	1.781GlnGln: 1.781 ± 0.044	2.057GlnArg: 2.057 ± 0.043	1.934GlnSer: 1.934 ± 0.04	2.217GlnThr: 2.217 ± 0.048	3.067GlnVal: 3.067 ± 0.058	0.453GlnTrp: 0.453 ± 0.022	1.138GlnTyr: 1.138 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.685ArgAla: 3.685 ± 0.064	0.448ArgCys: 0.448 ± 0.023	2.63ArgAsp: 2.63 ± 0.05	4.868ArgGlu: 4.868 ± 0.069	2.547ArgPhe: 2.547 ± 0.048	3.364ArgGly: 3.364 ± 0.055	1.277ArgHis: 1.277 ± 0.034	3.999ArgIle: 3.999 ± 0.068	3.647ArgLys: 3.647 ± 0.076	6.28ArgLeu: 6.28 ± 0.09	1.819ArgMet: 1.819 ± 0.039	1.957ArgAsn: 1.957 ± 0.047	2.166ArgPro: 2.166 ± 0.043	2.488ArgGln: 2.488 ± 0.05	3.433ArgArg: 3.433 ± 0.069	3.042ArgSer: 3.042 ± 0.06	2.652ArgThr: 2.652 ± 0.052	4.143ArgVal: 4.143 ± 0.065	0.829ArgTrp: 0.829 ± 0.034	2.025ArgTyr: 2.025 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.015SerAla: 4.015 ± 0.059	0.501SerCys: 0.501 ± 0.022	2.479SerAsp: 2.479 ± 0.046	3.389SerGlu: 3.389 ± 0.06	2.779SerPhe: 2.779 ± 0.058	4.74SerGly: 4.74 ± 0.068	1.261SerHis: 1.261 ± 0.037	3.593SerIle: 3.593 ± 0.064	2.849SerLys: 2.849 ± 0.051	6.075SerLeu: 6.075 ± 0.079	1.589SerMet: 1.589 ± 0.04	1.695SerAsn: 1.695 ± 0.038	2.726SerPro: 2.726 ± 0.055	1.851SerGln: 1.851 ± 0.044	3.31SerArg: 3.31 ± 0.058	3.34SerSer: 3.34 ± 0.067	2.5SerThr: 2.5 ± 0.052	4.247SerVal: 4.247 ± 0.067	0.747SerTrp: 0.747 ± 0.025	1.907SerTyr: 1.907 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.165ThrAla: 4.165 ± 0.065	0.435ThrCys: 0.435 ± 0.02	2.581ThrAsp: 2.581 ± 0.051	3.12ThrGlu: 3.12 ± 0.059	2.199ThrPhe: 2.199 ± 0.045	4.754ThrGly: 4.754 ± 0.07	1.146ThrHis: 1.146 ± 0.031	3.432ThrIle: 3.432 ± 0.059	2.284ThrLys: 2.284 ± 0.045	5.124ThrLeu: 5.124 ± 0.076	1.153ThrMet: 1.153 ± 0.034	1.564ThrAsn: 1.564 ± 0.035	2.606ThrPro: 2.606 ± 0.05	1.486ThrGln: 1.486 ± 0.041	2.628ThrArg: 2.628 ± 0.052	2.761ThrSer: 2.761 ± 0.052	2.472ThrThr: 2.472 ± 0.053	4.052ThrVal: 4.052 ± 0.063	0.59ThrTrp: 0.59 ± 0.023	1.712ThrTyr: 1.712 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.482ValAla: 5.482 ± 0.074	0.73ValCys: 0.73 ± 0.03	3.62ValAsp: 3.62 ± 0.058	4.804ValGlu: 4.804 ± 0.087	2.965ValPhe: 2.965 ± 0.059	4.897ValGly: 4.897 ± 0.075	1.684ValHis: 1.684 ± 0.043	5.383ValIle: 5.383 ± 0.082	4.342ValLys: 4.342 ± 0.065	7.195ValLeu: 7.195 ± 0.103	1.902ValMet: 1.902 ± 0.043	2.697ValAsn: 2.697 ± 0.062	3.339ValPro: 3.339 ± 0.054	2.657ValGln: 2.657 ± 0.048	4.0ValArg: 4.0 ± 0.065	4.539ValSer: 4.539 ± 0.07	4.117ValThr: 4.117 ± 0.065	5.375ValVal: 5.375 ± 0.087	0.907ValTrp: 0.907 ± 0.031	2.498ValTyr: 2.498 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.794TrpAla: 0.794 ± 0.032	0.116TrpCys: 0.116 ± 0.012	0.607TrpAsp: 0.607 ± 0.026	0.883TrpGlu: 0.883 ± 0.029	0.568TrpPhe: 0.568 ± 0.025	0.908TrpGly: 0.908 ± 0.029	0.225TrpHis: 0.225 ± 0.015	1.045TrpIle: 1.045 ± 0.035	0.89TrpLys: 0.89 ± 0.031	1.615TrpLeu: 1.615 ± 0.042	0.536TrpMet: 0.536 ± 0.022	0.64TrpAsn: 0.64 ± 0.023	0.459TrpPro: 0.459 ± 0.023	0.472TrpGln: 0.472 ± 0.022	0.609TrpArg: 0.609 ± 0.024	0.72TrpSer: 0.72 ± 0.028	0.671TrpThr: 0.671 ± 0.026	0.937TrpVal: 0.937 ± 0.036	0.226TrpTrp: 0.226 ± 0.015	0.381TrpTyr: 0.381 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.268TyrAla: 2.268 ± 0.046	0.298TyrCys: 0.298 ± 0.017	1.739TyrAsp: 1.739 ± 0.043	2.062TyrGlu: 2.062 ± 0.043	1.459TyrPhe: 1.459 ± 0.039	2.514TyrGly: 2.514 ± 0.05	0.908TyrHis: 0.908 ± 0.028	1.973TyrIle: 1.973 ± 0.044	1.479TyrLys: 1.479 ± 0.042	3.689TyrLeu: 3.689 ± 0.072	0.733TyrMet: 0.733 ± 0.028	1.074TyrAsn: 1.074 ± 0.037	1.62TyrPro: 1.62 ± 0.043	1.598TyrGln: 1.598 ± 0.038	2.245TyrArg: 2.245 ± 0.049	1.707TyrSer: 1.707 ± 0.038	1.654TyrThr: 1.654 ± 0.042	2.18TyrVal: 2.18 ± 0.038	0.428TyrTrp: 0.428 ± 0.019	1.292TyrTyr: 1.292 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3710 proteins (1064601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---