Amino acid dipepetide frequency for Aeromonas phage AsFcp_2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.401AlaAla: 5.401 ± 0.334
0.828AlaCys: 0.828 ± 0.119
3.84AlaAsp: 3.84 ± 0.231
4.27AlaGlu: 4.27 ± 0.293
2.804AlaPhe: 2.804 ± 0.204
4.907AlaGly: 4.907 ± 0.418
1.275AlaHis: 1.275 ± 0.142
4.939AlaIle: 4.939 ± 0.257
5.831AlaLys: 5.831 ± 0.325
4.477AlaLeu: 4.477 ± 0.254
2.406AlaMet: 2.406 ± 0.207
3.919AlaAsn: 3.919 ± 0.308
1.8AlaPro: 1.8 ± 0.181
2.629AlaGln: 2.629 ± 0.222
3.441AlaArg: 3.441 ± 0.265
3.441AlaSer: 3.441 ± 0.248
3.967AlaThr: 3.967 ± 0.322
4.684AlaVal: 4.684 ± 0.241
0.892AlaTrp: 0.892 ± 0.131
2.629AlaTyr: 2.629 ± 0.193
0.0AlaXaa: 0.0 ± 0.0
Cys
0.781CysAla: 0.781 ± 0.095
0.127CysCys: 0.127 ± 0.045
0.828CysAsp: 0.828 ± 0.115
0.797CysGlu: 0.797 ± 0.102
0.446CysPhe: 0.446 ± 0.093
0.876CysGly: 0.876 ± 0.141
0.366CysHis: 0.366 ± 0.067
0.717CysIle: 0.717 ± 0.126
1.036CysLys: 1.036 ± 0.13
0.717CysLeu: 0.717 ± 0.109
0.207CysMet: 0.207 ± 0.056
0.574CysAsn: 0.574 ± 0.096
0.526CysPro: 0.526 ± 0.104
0.287CysGln: 0.287 ± 0.067
0.749CysArg: 0.749 ± 0.097
0.828CysSer: 0.828 ± 0.133
0.621CysThr: 0.621 ± 0.106
1.036CysVal: 1.036 ± 0.118
0.175CysTrp: 0.175 ± 0.057
0.605CysTyr: 0.605 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
4.764AspAla: 4.764 ± 0.297
0.908AspCys: 0.908 ± 0.13
3.872AspAsp: 3.872 ± 0.249
4.349AspGlu: 4.349 ± 0.264
3.696AspPhe: 3.696 ± 0.221
4.732AspGly: 4.732 ± 0.302
1.179AspHis: 1.179 ± 0.158
4.302AspIle: 4.302 ± 0.278
4.222AspLys: 4.222 ± 0.286
4.78AspLeu: 4.78 ± 0.261
1.88AspMet: 1.88 ± 0.176
2.963AspAsn: 2.963 ± 0.193
1.992AspPro: 1.992 ± 0.201
1.848AspGln: 1.848 ± 0.16
2.708AspArg: 2.708 ± 0.208
3.696AspSer: 3.696 ± 0.237
2.963AspThr: 2.963 ± 0.21
5.035AspVal: 5.035 ± 0.289
1.052AspTrp: 1.052 ± 0.132
3.633AspTyr: 3.633 ± 0.256
0.0AspXaa: 0.0 ± 0.0
Glu
4.27GluAla: 4.27 ± 0.264
0.844GluCys: 0.844 ± 0.12
3.378GluAsp: 3.378 ± 0.252
3.76GluGlu: 3.76 ± 0.256
3.425GluPhe: 3.425 ± 0.284
2.756GluGly: 2.756 ± 0.237
1.514GluHis: 1.514 ± 0.135
5.353GluIle: 5.353 ± 0.281
4.461GluLys: 4.461 ± 0.305
6.612GluLeu: 6.612 ± 0.391
2.533GluMet: 2.533 ± 0.219
3.744GluAsn: 3.744 ± 0.269
1.259GluPro: 1.259 ± 0.167
3.202GluGln: 3.202 ± 0.22
3.887GluArg: 3.887 ± 0.289
3.983GluSer: 3.983 ± 0.249
4.095GluThr: 4.095 ± 0.25
4.668GluVal: 4.668 ± 0.28
0.844GluTrp: 0.844 ± 0.125
3.011GluTyr: 3.011 ± 0.201
0.0GluXaa: 0.0 ± 0.0
Phe
2.963PheAla: 2.963 ± 0.209
0.542PheCys: 0.542 ± 0.1
3.856PheAsp: 3.856 ± 0.223
3.362PheGlu: 3.362 ± 0.229
1.434PhePhe: 1.434 ± 0.142
3.266PheGly: 3.266 ± 0.236
0.828PheHis: 0.828 ± 0.138
2.517PheIle: 2.517 ± 0.175
3.441PheLys: 3.441 ± 0.265
2.485PheLeu: 2.485 ± 0.197
1.338PheMet: 1.338 ± 0.177
2.422PheAsn: 2.422 ± 0.233
1.052PhePro: 1.052 ± 0.135
1.131PheGln: 1.131 ± 0.137
1.816PheArg: 1.816 ± 0.185
2.469PheSer: 2.469 ± 0.176
2.517PheThr: 2.517 ± 0.172
3.633PheVal: 3.633 ± 0.215
0.494PheTrp: 0.494 ± 0.084
1.88PheTyr: 1.88 ± 0.169
0.0PheXaa: 0.0 ± 0.0
Gly
3.872GlyAla: 3.872 ± 0.332
0.765GlyCys: 0.765 ± 0.123
4.063GlyAsp: 4.063 ± 0.3
3.983GlyGlu: 3.983 ± 0.205
2.804GlyPhe: 2.804 ± 0.209
3.887GlyGly: 3.887 ± 0.402
1.004GlyHis: 1.004 ± 0.134
4.684GlyIle: 4.684 ± 0.268
5.385GlyLys: 5.385 ± 0.316
3.856GlyLeu: 3.856 ± 0.212
2.071GlyMet: 2.071 ± 0.169
3.776GlyAsn: 3.776 ± 0.375
1.067GlyPro: 1.067 ± 0.138
2.103GlyGln: 2.103 ± 0.19
2.9GlyArg: 2.9 ± 0.201
4.19GlySer: 4.19 ± 0.303
4.318GlyThr: 4.318 ± 0.302
4.971GlyVal: 4.971 ± 0.287
0.828GlyTrp: 0.828 ± 0.111
3.075GlyTyr: 3.075 ± 0.22
0.0GlyXaa: 0.0 ± 0.0
His
1.115HisAla: 1.115 ± 0.141
0.303HisCys: 0.303 ± 0.076
1.163HisAsp: 1.163 ± 0.124
1.418HisGlu: 1.418 ± 0.16
0.876HisPhe: 0.876 ± 0.125
1.418HisGly: 1.418 ± 0.143
0.43HisHis: 0.43 ± 0.098
1.179HisIle: 1.179 ± 0.142
1.195HisLys: 1.195 ± 0.135
1.386HisLeu: 1.386 ± 0.138
0.558HisMet: 0.558 ± 0.092
1.131HisAsn: 1.131 ± 0.136
0.637HisPro: 0.637 ± 0.097
0.701HisGln: 0.701 ± 0.103
0.876HisArg: 0.876 ± 0.121
1.211HisSer: 1.211 ± 0.136
0.813HisThr: 0.813 ± 0.11
1.482HisVal: 1.482 ± 0.151
0.366HisTrp: 0.366 ± 0.079
0.797HisTyr: 0.797 ± 0.102
0.0HisXaa: 0.0 ± 0.0
Ile
5.337IleAla: 5.337 ± 0.32
0.781IleCys: 0.781 ± 0.125
5.576IleAsp: 5.576 ± 0.268
5.911IleGlu: 5.911 ± 0.356
1.529IlePhe: 1.529 ± 0.152
4.509IleGly: 4.509 ± 0.272
0.988IleHis: 0.988 ± 0.13
3.808IleIle: 3.808 ± 0.234
5.64IleLys: 5.64 ± 0.3
3.903IleLeu: 3.903 ± 0.245
2.199IleMet: 2.199 ± 0.202
3.872IleAsn: 3.872 ± 0.258
2.533IlePro: 2.533 ± 0.154
2.055IleGln: 2.055 ± 0.198
3.76IleArg: 3.76 ± 0.238
3.792IleSer: 3.792 ± 0.255
3.601IleThr: 3.601 ± 0.279
4.397IleVal: 4.397 ± 0.219
0.542IleTrp: 0.542 ± 0.086
2.199IleTyr: 2.199 ± 0.184
0.0IleXaa: 0.0 ± 0.0
Lys
5.353LysAla: 5.353 ± 0.321
0.908LysCys: 0.908 ± 0.124
5.051LysAsp: 5.051 ± 0.263
5.465LysGlu: 5.465 ± 0.312
3.585LysPhe: 3.585 ± 0.26
3.362LysGly: 3.362 ± 0.245
1.689LysHis: 1.689 ± 0.201
5.098LysIle: 5.098 ± 0.245
5.481LysLys: 5.481 ± 0.356
5.847LysLeu: 5.847 ± 0.354
2.947LysMet: 2.947 ± 0.29
4.174LysAsn: 4.174 ± 0.23
2.374LysPro: 2.374 ± 0.221
3.298LysGln: 3.298 ± 0.233
3.664LysArg: 3.664 ± 0.24
5.146LysSer: 5.146 ± 0.32
4.365LysThr: 4.365 ± 0.302
4.955LysVal: 4.955 ± 0.257
1.259LysTrp: 1.259 ± 0.141
2.963LysTyr: 2.963 ± 0.254
0.0LysXaa: 0.0 ± 0.0
Leu
4.875LeuAla: 4.875 ± 0.315
0.972LeuCys: 0.972 ± 0.129
4.907LeuAsp: 4.907 ± 0.276
4.668LeuGlu: 4.668 ± 0.25
2.677LeuPhe: 2.677 ± 0.199
4.397LeuGly: 4.397 ± 0.294
1.402LeuHis: 1.402 ± 0.146
4.62LeuIle: 4.62 ± 0.281
5.975LeuLys: 5.975 ± 0.345
4.302LeuLeu: 4.302 ± 0.283
1.88LeuMet: 1.88 ± 0.164
4.445LeuAsn: 4.445 ± 0.295
2.661LeuPro: 2.661 ± 0.204
2.135LeuGln: 2.135 ± 0.175
3.489LeuArg: 3.489 ± 0.232
4.445LeuSer: 4.445 ± 0.269
4.19LeuThr: 4.19 ± 0.276
5.035LeuVal: 5.035 ± 0.285
0.685LeuTrp: 0.685 ± 0.114
2.772LeuTyr: 2.772 ± 0.213
0.0LeuXaa: 0.0 ± 0.0
Met
1.976MetAla: 1.976 ± 0.188
0.303MetCys: 0.303 ± 0.068
1.386MetAsp: 1.386 ± 0.174
1.721MetGlu: 1.721 ± 0.169
1.657MetPhe: 1.657 ± 0.148
1.45MetGly: 1.45 ± 0.172
0.589MetHis: 0.589 ± 0.097
2.597MetIle: 2.597 ± 0.205
3.346MetLys: 3.346 ± 0.3
2.613MetLeu: 2.613 ± 0.233
1.099MetMet: 1.099 ± 0.143
2.342MetAsn: 2.342 ± 0.203
0.94MetPro: 0.94 ± 0.124
1.067MetGln: 1.067 ± 0.143
1.275MetArg: 1.275 ± 0.145
2.613MetSer: 2.613 ± 0.207
2.294MetThr: 2.294 ± 0.191
1.466MetVal: 1.466 ± 0.18
0.335MetTrp: 0.335 ± 0.058
0.908MetTyr: 0.908 ± 0.11
0.0MetXaa: 0.0 ± 0.0
Asn
4.19AsnAla: 4.19 ± 0.273
0.717AsnCys: 0.717 ± 0.109
2.9AsnAsp: 2.9 ± 0.203
3.68AsnGlu: 3.68 ± 0.24
2.262AsnPhe: 2.262 ± 0.203
4.812AsnGly: 4.812 ± 0.274
1.195AsnHis: 1.195 ± 0.142
3.186AsnIle: 3.186 ± 0.223
4.063AsnLys: 4.063 ± 0.284
4.429AsnLeu: 4.429 ± 0.307
1.737AsnMet: 1.737 ± 0.151
2.469AsnAsn: 2.469 ± 0.226
2.246AsnPro: 2.246 ± 0.209
1.88AsnGln: 1.88 ± 0.163
2.469AsnArg: 2.469 ± 0.181
3.059AsnSer: 3.059 ± 0.258
3.202AsnThr: 3.202 ± 0.258
4.78AsnVal: 4.78 ± 0.325
0.669AsnTrp: 0.669 ± 0.102
1.705AsnTyr: 1.705 ± 0.163
0.0AsnXaa: 0.0 ± 0.0
Pro
1.912ProAla: 1.912 ± 0.183
0.366ProCys: 0.366 ± 0.076
2.262ProAsp: 2.262 ± 0.209
2.183ProGlu: 2.183 ± 0.215
1.418ProPhe: 1.418 ± 0.133
1.753ProGly: 1.753 ± 0.202
0.589ProHis: 0.589 ± 0.098
1.88ProIle: 1.88 ± 0.172
2.517ProLys: 2.517 ± 0.23
1.657ProLeu: 1.657 ± 0.16
0.94ProMet: 0.94 ± 0.135
1.768ProAsn: 1.768 ± 0.163
0.749ProPro: 0.749 ± 0.099
0.908ProGln: 0.908 ± 0.123
1.338ProArg: 1.338 ± 0.122
1.848ProSer: 1.848 ± 0.191
1.992ProThr: 1.992 ± 0.187
2.756ProVal: 2.756 ± 0.184
0.398ProTrp: 0.398 ± 0.077
1.099ProTyr: 1.099 ± 0.115
0.0ProXaa: 0.0 ± 0.0
Gln
2.693GlnAla: 2.693 ± 0.247
0.398GlnCys: 0.398 ± 0.07
1.848GlnAsp: 1.848 ± 0.162
2.358GlnGlu: 2.358 ± 0.198
1.577GlnPhe: 1.577 ± 0.164
1.944GlnGly: 1.944 ± 0.173
0.574GlnHis: 0.574 ± 0.086
2.804GlnIle: 2.804 ± 0.203
2.262GlnLys: 2.262 ± 0.205
2.645GlnLeu: 2.645 ± 0.196
1.291GlnMet: 1.291 ± 0.142
1.641GlnAsn: 1.641 ± 0.17
1.036GlnPro: 1.036 ± 0.115
1.195GlnGln: 1.195 ± 0.146
1.896GlnArg: 1.896 ± 0.18
1.944GlnSer: 1.944 ± 0.163
1.976GlnThr: 1.976 ± 0.143
2.645GlnVal: 2.645 ± 0.229
0.494GlnTrp: 0.494 ± 0.103
1.291GlnTyr: 1.291 ± 0.13
0.0GlnXaa: 0.0 ± 0.0
Arg
2.788ArgAla: 2.788 ± 0.245
0.589ArgCys: 0.589 ± 0.089
3.123ArgAsp: 3.123 ± 0.223
3.409ArgGlu: 3.409 ± 0.245
2.183ArgPhe: 2.183 ± 0.187
3.075ArgGly: 3.075 ± 0.215
1.02ArgHis: 1.02 ± 0.127
3.68ArgIle: 3.68 ± 0.264
3.569ArgLys: 3.569 ± 0.24
3.648ArgLeu: 3.648 ± 0.208
1.784ArgMet: 1.784 ± 0.16
2.485ArgAsn: 2.485 ± 0.202
1.322ArgPro: 1.322 ± 0.153
1.705ArgGln: 1.705 ± 0.19
2.167ArgArg: 2.167 ± 0.237
3.043ArgSer: 3.043 ± 0.207
2.278ArgThr: 2.278 ± 0.211
3.872ArgVal: 3.872 ± 0.247
0.733ArgTrp: 0.733 ± 0.095
2.756ArgTyr: 2.756 ± 0.221
0.0ArgXaa: 0.0 ± 0.0
Ser
3.633SerAla: 3.633 ± 0.27
0.733SerCys: 0.733 ± 0.128
3.983SerAsp: 3.983 ± 0.267
3.744SerGlu: 3.744 ± 0.277
2.852SerPhe: 2.852 ± 0.191
4.27SerGly: 4.27 ± 0.325
1.195SerHis: 1.195 ± 0.166
3.792SerIle: 3.792 ± 0.263
4.493SerLys: 4.493 ± 0.25
4.142SerLeu: 4.142 ± 0.223
1.992SerMet: 1.992 ± 0.192
3.218SerAsn: 3.218 ± 0.236
1.753SerPro: 1.753 ± 0.176
2.055SerGln: 2.055 ± 0.165
3.457SerArg: 3.457 ± 0.231
3.601SerSer: 3.601 ± 0.227
3.314SerThr: 3.314 ± 0.231
4.509SerVal: 4.509 ± 0.272
0.749SerTrp: 0.749 ± 0.107
2.294SerTyr: 2.294 ± 0.185
0.0SerXaa: 0.0 ± 0.0
Thr
3.967ThrAla: 3.967 ± 0.276
0.574ThrCys: 0.574 ± 0.104
3.537ThrAsp: 3.537 ± 0.243
3.856ThrGlu: 3.856 ± 0.256
2.533ThrPhe: 2.533 ± 0.187
4.349ThrGly: 4.349 ± 0.287
0.876ThrHis: 0.876 ± 0.106
3.887ThrIle: 3.887 ± 0.27
4.461ThrLys: 4.461 ± 0.221
4.047ThrLeu: 4.047 ± 0.248
1.545ThrMet: 1.545 ± 0.148
3.075ThrAsn: 3.075 ± 0.286
2.278ThrPro: 2.278 ± 0.226
1.848ThrGln: 1.848 ± 0.175
2.804ThrArg: 2.804 ± 0.202
2.979ThrSer: 2.979 ± 0.244
3.505ThrThr: 3.505 ± 0.316
4.238ThrVal: 4.238 ± 0.273
0.637ThrTrp: 0.637 ± 0.095
2.246ThrTyr: 2.246 ± 0.214
0.0ThrXaa: 0.0 ± 0.0
Val
5.21ValAla: 5.21 ± 0.269
0.924ValCys: 0.924 ± 0.134
5.082ValAsp: 5.082 ± 0.235
5.528ValGlu: 5.528 ± 0.297
3.33ValPhe: 3.33 ± 0.244
4.381ValGly: 4.381 ± 0.297
0.988ValHis: 0.988 ± 0.11
4.318ValIle: 4.318 ± 0.279
5.433ValLys: 5.433 ± 0.296
4.971ValLeu: 4.971 ± 0.286
2.055ValMet: 2.055 ± 0.194
4.318ValAsn: 4.318 ± 0.313
2.469ValPro: 2.469 ± 0.181
2.39ValGln: 2.39 ± 0.197
3.744ValArg: 3.744 ± 0.246
4.365ValSer: 4.365 ± 0.232
4.142ValThr: 4.142 ± 0.332
5.815ValVal: 5.815 ± 0.357
0.733ValTrp: 0.733 ± 0.112
3.425ValTyr: 3.425 ± 0.242
0.0ValXaa: 0.0 ± 0.0
Trp
0.637TrpAla: 0.637 ± 0.116
0.143TrpCys: 0.143 ± 0.049
1.052TrpAsp: 1.052 ± 0.112
0.94TrpGlu: 0.94 ± 0.129
0.685TrpPhe: 0.685 ± 0.108
0.526TrpGly: 0.526 ± 0.114
0.335TrpHis: 0.335 ± 0.089
0.813TrpIle: 0.813 ± 0.124
1.275TrpLys: 1.275 ± 0.138
0.94TrpLeu: 0.94 ± 0.148
0.446TrpMet: 0.446 ± 0.074
0.717TrpAsn: 0.717 ± 0.091
0.143TrpPro: 0.143 ± 0.045
0.542TrpGln: 0.542 ± 0.096
0.574TrpArg: 0.574 ± 0.098
0.669TrpSer: 0.669 ± 0.104
0.558TrpThr: 0.558 ± 0.097
0.988TrpVal: 0.988 ± 0.131
0.159TrpTrp: 0.159 ± 0.053
0.589TrpTyr: 0.589 ± 0.097
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.645TyrAla: 2.645 ± 0.193
0.574TyrCys: 0.574 ± 0.089
2.868TyrAsp: 2.868 ± 0.208
2.199TyrGlu: 2.199 ± 0.187
1.673TyrPhe: 1.673 ± 0.172
2.932TyrGly: 2.932 ± 0.232
1.02TyrHis: 1.02 ± 0.119
2.772TyrIle: 2.772 ± 0.211
2.9TyrLys: 2.9 ± 0.184
3.075TyrLeu: 3.075 ± 0.203
1.052TyrMet: 1.052 ± 0.125
2.597TyrAsn: 2.597 ± 0.199
1.498TyrPro: 1.498 ± 0.167
1.529TyrGln: 1.529 ± 0.175
2.215TyrArg: 2.215 ± 0.193
2.454TyrSer: 2.454 ± 0.193
2.533TyrThr: 2.533 ± 0.215
2.661TyrVal: 2.661 ± 0.193
0.685TyrTrp: 0.685 ± 0.105
1.641TyrTyr: 1.641 ± 0.184
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 303 proteins (62767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski