Amino acid dipepetide frequency for Aneurinibacillus soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.904AlaAla: 7.904 ± 0.121	0.845AlaCys: 0.845 ± 0.028	4.392AlaAsp: 4.392 ± 0.077	5.69AlaGlu: 5.69 ± 0.09	3.244AlaPhe: 3.244 ± 0.062	6.515AlaGly: 6.515 ± 0.087	1.656AlaHis: 1.656 ± 0.041	5.707AlaIle: 5.707 ± 0.068	4.367AlaLys: 4.367 ± 0.071	8.018AlaLeu: 8.018 ± 0.088	2.247AlaMet: 2.247 ± 0.046	2.736AlaAsn: 2.736 ± 0.053	2.683AlaPro: 2.683 ± 0.061	3.104AlaGln: 3.104 ± 0.06	4.268AlaArg: 4.268 ± 0.072	4.982AlaSer: 4.982 ± 0.093	4.097AlaThr: 4.097 ± 0.07	6.557AlaVal: 6.557 ± 0.103	0.739AlaTrp: 0.739 ± 0.028	2.602AlaTyr: 2.602 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.619CysAla: 0.619 ± 0.027	0.13CysCys: 0.13 ± 0.011	0.49CysAsp: 0.49 ± 0.023	0.505CysGlu: 0.505 ± 0.021	0.355CysPhe: 0.355 ± 0.017	0.85CysGly: 0.85 ± 0.03	0.19CysHis: 0.19 ± 0.012	0.58CysIle: 0.58 ± 0.023	0.405CysLys: 0.405 ± 0.021	0.802CysLeu: 0.802 ± 0.026	0.25CysMet: 0.25 ± 0.015	0.294CysAsn: 0.294 ± 0.017	0.428CysPro: 0.428 ± 0.021	0.251CysGln: 0.251 ± 0.015	0.515CysArg: 0.515 ± 0.021	0.539CysSer: 0.539 ± 0.023	0.542CysThr: 0.542 ± 0.019	0.586CysVal: 0.586 ± 0.024	0.096CysTrp: 0.096 ± 0.01	0.24CysTyr: 0.24 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.871AspAla: 3.871 ± 0.063	0.429AspCys: 0.429 ± 0.022	2.285AspAsp: 2.285 ± 0.054	4.069AspGlu: 4.069 ± 0.069	1.988AspPhe: 1.988 ± 0.045	3.656AspGly: 3.656 ± 0.08	1.021AspHis: 1.021 ± 0.028	3.815AspIle: 3.815 ± 0.061	2.713AspLys: 2.713 ± 0.051	4.271AspLeu: 4.271 ± 0.057	1.669AspMet: 1.669 ± 0.038	1.565AspAsn: 1.565 ± 0.043	1.873AspPro: 1.873 ± 0.039	1.718AspGln: 1.718 ± 0.042	2.592AspArg: 2.592 ± 0.051	2.496AspSer: 2.496 ± 0.051	2.836AspThr: 2.836 ± 0.052	4.242AspVal: 4.242 ± 0.076	0.642AspTrp: 0.642 ± 0.026	1.682AspTyr: 1.682 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.227GluAla: 6.227 ± 0.088	0.42GluCys: 0.42 ± 0.019	3.111GluAsp: 3.111 ± 0.066	6.315GluGlu: 6.315 ± 0.115	2.184GluPhe: 2.184 ± 0.05	4.233GluGly: 4.233 ± 0.062	1.509GluHis: 1.509 ± 0.036	4.883GluIle: 4.883 ± 0.07	5.389GluLys: 5.389 ± 0.084	6.743GluLeu: 6.743 ± 0.086	2.336GluMet: 2.336 ± 0.057	2.8GluAsn: 2.8 ± 0.052	1.95GluPro: 1.95 ± 0.047	3.929GluGln: 3.929 ± 0.068	4.231GluArg: 4.231 ± 0.075	3.202GluSer: 3.202 ± 0.052	3.537GluThr: 3.537 ± 0.056	4.912GluVal: 4.912 ± 0.073	0.848GluTrp: 0.848 ± 0.024	2.037GluTyr: 2.037 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.309PheAla: 3.309 ± 0.054	0.389PheCys: 0.389 ± 0.018	2.058PheAsp: 2.058 ± 0.046	2.235PheGlu: 2.235 ± 0.042	1.901PhePhe: 1.901 ± 0.051	3.064PheGly: 3.064 ± 0.048	0.893PheHis: 0.893 ± 0.027	2.803PheIle: 2.803 ± 0.06	1.653PheLys: 1.653 ± 0.042	4.029PheLeu: 4.029 ± 0.081	1.045PheMet: 1.045 ± 0.03	1.372PheAsn: 1.372 ± 0.04	1.502PhePro: 1.502 ± 0.039	1.271PheGln: 1.271 ± 0.037	1.796PheArg: 1.796 ± 0.044	2.687PheSer: 2.687 ± 0.061	2.627PheThr: 2.627 ± 0.05	3.082PheVal: 3.082 ± 0.066	0.446PheTrp: 0.446 ± 0.021	1.436PheTyr: 1.436 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.402GlyAla: 5.402 ± 0.086	0.749GlyCys: 0.749 ± 0.025	3.367GlyAsp: 3.367 ± 0.061	4.571GlyGlu: 4.571 ± 0.076	3.01GlyPhe: 3.01 ± 0.059	5.227GlyGly: 5.227 ± 0.084	1.498GlyHis: 1.498 ± 0.038	5.628GlyIle: 5.628 ± 0.071	4.65GlyLys: 4.65 ± 0.069	6.572GlyLeu: 6.572 ± 0.089	2.385GlyMet: 2.385 ± 0.047	2.511GlyAsn: 2.511 ± 0.058	1.716GlyPro: 1.716 ± 0.039	2.7GlyGln: 2.7 ± 0.053	3.518GlyArg: 3.518 ± 0.063	4.045GlySer: 4.045 ± 0.071	4.679GlyThr: 4.679 ± 0.09	5.541GlyVal: 5.541 ± 0.073	0.901GlyTrp: 0.901 ± 0.034	2.761GlyTyr: 2.761 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.554HisAla: 1.554 ± 0.038	0.195HisCys: 0.195 ± 0.012	1.119HisAsp: 1.119 ± 0.032	1.428HisGlu: 1.428 ± 0.038	0.901HisPhe: 0.901 ± 0.026	1.533HisGly: 1.533 ± 0.042	0.68HisHis: 0.68 ± 0.026	1.537HisIle: 1.537 ± 0.04	1.034HisLys: 1.034 ± 0.027	2.082HisLeu: 2.082 ± 0.051	0.615HisMet: 0.615 ± 0.023	0.757HisAsn: 0.757 ± 0.025	1.255HisPro: 1.255 ± 0.032	0.838HisGln: 0.838 ± 0.027	1.017HisArg: 1.017 ± 0.032	1.214HisSer: 1.214 ± 0.036	1.37HisThr: 1.37 ± 0.033	1.74HisVal: 1.74 ± 0.044	0.225HisTrp: 0.225 ± 0.013	0.768HisTyr: 0.768 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.051IleAla: 6.051 ± 0.076	0.676IleCys: 0.676 ± 0.029	3.695IleAsp: 3.695 ± 0.059	5.26IleGlu: 5.26 ± 0.077	2.468IlePhe: 2.468 ± 0.059	5.538IleGly: 5.538 ± 0.081	1.604IleHis: 1.604 ± 0.036	4.637IleIle: 4.637 ± 0.069	3.347IleLys: 3.347 ± 0.06	5.897IleLeu: 5.897 ± 0.083	1.833IleMet: 1.833 ± 0.04	2.459IleAsn: 2.459 ± 0.048	3.185IlePro: 3.185 ± 0.054	2.81IleGln: 2.81 ± 0.046	3.713IleArg: 3.713 ± 0.06	4.343IleSer: 4.343 ± 0.07	4.426IleThr: 4.426 ± 0.062	5.35IleVal: 5.35 ± 0.077	0.624IleTrp: 0.624 ± 0.024	1.832IleTyr: 1.832 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.424LysAla: 4.424 ± 0.076	0.319LysCys: 0.319 ± 0.018	2.777LysAsp: 2.777 ± 0.05	4.965LysGlu: 4.965 ± 0.09	1.578LysPhe: 1.578 ± 0.038	3.646LysGly: 3.646 ± 0.064	1.095LysHis: 1.095 ± 0.033	3.633LysIle: 3.633 ± 0.056	4.479LysLys: 4.479 ± 0.083	5.116LysLeu: 5.116 ± 0.065	1.86LysMet: 1.86 ± 0.04	2.501LysAsn: 2.501 ± 0.05	2.254LysPro: 2.254 ± 0.043	3.171LysGln: 3.171 ± 0.059	3.075LysArg: 3.075 ± 0.061	2.858LysSer: 2.858 ± 0.055	3.125LysThr: 3.125 ± 0.056	3.99LysVal: 3.99 ± 0.069	0.696LysTrp: 0.696 ± 0.025	1.751LysTyr: 1.751 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	8.798LeuAla: 8.798 ± 0.106	0.895LeuCys: 0.895 ± 0.03	4.849LeuAsp: 4.849 ± 0.077	5.847LeuGlu: 5.847 ± 0.09	4.233LeuPhe: 4.233 ± 0.083	6.394LeuGly: 6.394 ± 0.077	2.342LeuHis: 2.342 ± 0.046	6.059LeuIle: 6.059 ± 0.085	4.704LeuLys: 4.704 ± 0.069	10.232LeuLeu: 10.232 ± 0.139	2.37LeuMet: 2.37 ± 0.047	3.406LeuAsn: 3.406 ± 0.051	4.17LeuPro: 4.17 ± 0.065	3.57LeuGln: 3.57 ± 0.058	4.696LeuArg: 4.696 ± 0.072	6.475LeuSer: 6.475 ± 0.094	5.867LeuThr: 5.867 ± 0.083	6.613LeuVal: 6.613 ± 0.096	0.795LeuTrp: 0.795 ± 0.028	3.224LeuTyr: 3.224 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.349MetAla: 2.349 ± 0.051	0.191MetCys: 0.191 ± 0.012	1.417MetAsp: 1.417 ± 0.038	2.104MetGlu: 2.104 ± 0.045	0.98MetPhe: 0.98 ± 0.032	1.886MetGly: 1.886 ± 0.041	0.509MetHis: 0.509 ± 0.024	2.007MetIle: 2.007 ± 0.044	2.185MetLys: 2.185 ± 0.044	2.873MetLeu: 2.873 ± 0.049	1.037MetMet: 1.037 ± 0.038	1.533MetAsn: 1.533 ± 0.039	1.179MetPro: 1.179 ± 0.034	1.255MetGln: 1.255 ± 0.035	1.539MetArg: 1.539 ± 0.039	1.782MetSer: 1.782 ± 0.041	1.638MetThr: 1.638 ± 0.04	1.873MetVal: 1.873 ± 0.035	0.218MetTrp: 0.218 ± 0.015	0.905MetTyr: 0.905 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.757AsnAla: 2.757 ± 0.054	0.286AsnCys: 0.286 ± 0.014	1.68AsnAsp: 1.68 ± 0.045	2.502AsnGlu: 2.502 ± 0.051	1.248AsnPhe: 1.248 ± 0.034	3.101AsnGly: 3.101 ± 0.074	0.884AsnHis: 0.884 ± 0.028	2.576AsnIle: 2.576 ± 0.047	2.199AsnLys: 2.199 ± 0.048	3.186AsnLeu: 3.186 ± 0.058	1.138AsnMet: 1.138 ± 0.027	1.43AsnAsn: 1.43 ± 0.045	2.071AsnPro: 2.071 ± 0.045	1.647AsnGln: 1.647 ± 0.04	2.106AsnArg: 2.106 ± 0.049	1.883AsnSer: 1.883 ± 0.047	2.041AsnThr: 2.041 ± 0.046	2.93AsnVal: 2.93 ± 0.059	0.417AsnTrp: 0.417 ± 0.021	1.124AsnTyr: 1.124 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.028ProAla: 3.028 ± 0.062	0.272ProCys: 0.272 ± 0.016	2.464ProAsp: 2.464 ± 0.051	2.975ProGlu: 2.975 ± 0.057	1.786ProPhe: 1.786 ± 0.046	2.765ProGly: 2.765 ± 0.053	0.937ProHis: 0.937 ± 0.029	2.453ProIle: 2.453 ± 0.055	1.92ProLys: 1.92 ± 0.046	3.822ProLeu: 3.822 ± 0.07	0.875ProMet: 0.875 ± 0.026	1.457ProAsn: 1.457 ± 0.034	1.276ProPro: 1.276 ± 0.043	1.398ProGln: 1.398 ± 0.035	1.433ProArg: 1.433 ± 0.032	2.282ProSer: 2.282 ± 0.05	2.159ProThr: 2.159 ± 0.053	3.328ProVal: 3.328 ± 0.057	0.376ProTrp: 0.376 ± 0.019	1.493ProTyr: 1.493 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.814GlnAla: 3.814 ± 0.072	0.226GlnCys: 0.226 ± 0.015	1.706GlnAsp: 1.706 ± 0.034	3.213GlnGlu: 3.213 ± 0.061	1.433GlnPhe: 1.433 ± 0.037	2.489GlnGly: 2.489 ± 0.045	0.87GlnHis: 0.87 ± 0.023	2.684GlnIle: 2.684 ± 0.047	2.715GlnLys: 2.715 ± 0.057	3.929GlnLeu: 3.929 ± 0.061	1.341GlnMet: 1.341 ± 0.035	1.545GlnAsn: 1.545 ± 0.04	1.464GlnPro: 1.464 ± 0.037	2.201GlnGln: 2.201 ± 0.058	1.957GlnArg: 1.957 ± 0.042	2.19GlnSer: 2.19 ± 0.048	2.426GlnThr: 2.426 ± 0.048	2.952GlnVal: 2.952 ± 0.05	0.429GlnTrp: 0.429 ± 0.02	1.322GlnTyr: 1.322 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.705ArgAla: 3.705 ± 0.067	0.399ArgCys: 0.399 ± 0.019	2.584ArgAsp: 2.584 ± 0.054	3.875ArgGlu: 3.875 ± 0.067	2.13ArgPhe: 2.13 ± 0.049	2.967ArgGly: 2.967 ± 0.055	1.117ArgHis: 1.117 ± 0.032	3.905ArgIle: 3.905 ± 0.061	3.207ArgLys: 3.207 ± 0.056	5.177ArgLeu: 5.177 ± 0.079	1.768ArgMet: 1.768 ± 0.036	1.9ArgAsn: 1.9 ± 0.041	1.7ArgPro: 1.7 ± 0.039	2.216ArgGln: 2.216 ± 0.053	2.994ArgArg: 2.994 ± 0.062	2.754ArgSer: 2.754 ± 0.052	2.909ArgThr: 2.909 ± 0.05	3.615ArgVal: 3.615 ± 0.054	0.56ArgTrp: 0.56 ± 0.023	1.88ArgTyr: 1.88 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.306SerAla: 4.306 ± 0.08	0.541SerCys: 0.541 ± 0.021	2.627SerAsp: 2.627 ± 0.058	3.45SerGlu: 3.45 ± 0.057	2.77SerPhe: 2.77 ± 0.056	4.751SerGly: 4.751 ± 0.078	1.299SerHis: 1.299 ± 0.036	4.401SerIle: 4.401 ± 0.071	2.892SerLys: 2.892 ± 0.059	5.826SerLeu: 5.826 ± 0.078	1.78SerMet: 1.78 ± 0.038	2.112SerAsn: 2.112 ± 0.056	2.217SerPro: 2.217 ± 0.048	2.115SerGln: 2.115 ± 0.045	2.917SerArg: 2.917 ± 0.041	3.876SerSer: 3.876 ± 0.083	3.268SerThr: 3.268 ± 0.064	4.354SerVal: 4.354 ± 0.073	0.613SerTrp: 0.613 ± 0.023	2.19SerTyr: 2.19 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.909ThrAla: 4.909 ± 0.086	0.477ThrCys: 0.477 ± 0.02	2.838ThrAsp: 2.838 ± 0.055	3.686ThrGlu: 3.686 ± 0.056	2.565ThrPhe: 2.565 ± 0.054	4.833ThrGly: 4.833 ± 0.064	1.171ThrHis: 1.171 ± 0.035	4.252ThrIle: 4.252 ± 0.062	2.969ThrLys: 2.969 ± 0.059	5.424ThrLeu: 5.424 ± 0.079	1.475ThrMet: 1.475 ± 0.034	2.216ThrAsn: 2.216 ± 0.056	2.684ThrPro: 2.684 ± 0.058	1.848ThrGln: 1.848 ± 0.043	2.591ThrArg: 2.591 ± 0.052	3.445ThrSer: 3.445 ± 0.068	3.245ThrThr: 3.245 ± 0.07	4.922ThrVal: 4.922 ± 0.088	0.631ThrTrp: 0.631 ± 0.027	2.03ThrTyr: 2.03 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	6.102ValAla: 6.102 ± 0.087	0.791ValCys: 0.791 ± 0.026	3.704ValAsp: 3.704 ± 0.065	5.109ValGlu: 5.109 ± 0.085	2.886ValPhe: 2.886 ± 0.053	4.822ValGly: 4.822 ± 0.079	1.578ValHis: 1.578 ± 0.035	5.228ValIle: 5.228 ± 0.071	4.138ValLys: 4.138 ± 0.067	7.457ValLeu: 7.457 ± 0.101	2.113ValMet: 2.113 ± 0.043	2.849ValAsn: 2.849 ± 0.056	3.186ValPro: 3.186 ± 0.056	3.101ValGln: 3.101 ± 0.054	3.962ValArg: 3.962 ± 0.064	4.744ValSer: 4.744 ± 0.073	4.793ValThr: 4.793 ± 0.09	5.642ValVal: 5.642 ± 0.088	0.75ValTrp: 0.75 ± 0.026	2.474ValTyr: 2.474 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.028	0.084TrpCys: 0.084 ± 0.008	0.544TrpAsp: 0.544 ± 0.025	0.656TrpGlu: 0.656 ± 0.024	0.495TrpPhe: 0.495 ± 0.021	0.667TrpGly: 0.667 ± 0.031	0.231TrpHis: 0.231 ± 0.015	0.736TrpIle: 0.736 ± 0.027	0.646TrpLys: 0.646 ± 0.026	1.201TrpLeu: 1.201 ± 0.041	0.41TrpMet: 0.41 ± 0.019	0.51TrpAsn: 0.51 ± 0.024	0.281TrpPro: 0.281 ± 0.015	0.433TrpGln: 0.433 ± 0.017	0.509TrpArg: 0.509 ± 0.024	0.597TrpSer: 0.597 ± 0.024	0.576TrpThr: 0.576 ± 0.031	0.661TrpVal: 0.661 ± 0.022	0.139TrpTrp: 0.139 ± 0.012	0.387TrpTyr: 0.387 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.509TyrAla: 2.509 ± 0.057	0.355TyrCys: 0.355 ± 0.02	1.727TyrAsp: 1.727 ± 0.037	2.339TyrGlu: 2.339 ± 0.053	1.445TyrPhe: 1.445 ± 0.04	2.494TyrGly: 2.494 ± 0.051	0.774TyrHis: 0.774 ± 0.029	2.225TyrIle: 2.225 ± 0.048	1.701TyrLys: 1.701 ± 0.042	2.881TyrLeu: 2.881 ± 0.052	0.914TyrMet: 0.914 ± 0.027	1.252TyrAsn: 1.252 ± 0.038	1.424TyrPro: 1.424 ± 0.038	1.331TyrGln: 1.331 ± 0.039	1.933TyrArg: 1.933 ± 0.042	1.912TyrSer: 1.912 ± 0.041	2.049TyrThr: 2.049 ± 0.045	2.538TyrVal: 2.538 ± 0.052	0.334TyrTrp: 0.334 ± 0.017	1.267TyrTyr: 1.267 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3962 proteins (1158177 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---