Amino acid dipepetide frequency for Ictalurid herpesvirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.212AlaAla: 6.212 ± 0.424
1.003AlaCys: 1.003 ± 0.175
2.758AlaAsp: 2.758 ± 0.242
4.039AlaGlu: 4.039 ± 0.435
2.312AlaPhe: 2.312 ± 0.283
4.039AlaGly: 4.039 ± 0.304
1.755AlaHis: 1.755 ± 0.211
4.819AlaIle: 4.819 ± 0.414
2.758AlaLys: 2.758 ± 0.356
6.88AlaLeu: 6.88 ± 0.447
1.894AlaMet: 1.894 ± 0.215
1.95AlaAsn: 1.95 ± 0.215
6.797AlaPro: 6.797 ± 0.891
2.479AlaGln: 2.479 ± 0.456
4.903AlaArg: 4.903 ± 0.388
3.705AlaSer: 3.705 ± 0.303
6.24AlaThr: 6.24 ± 0.579
4.206AlaVal: 4.206 ± 0.356
0.864AlaTrp: 0.864 ± 0.175
1.588AlaTyr: 1.588 ± 0.163
0.0AlaXaa: 0.0 ± 0.0
Cys
1.616CysAla: 1.616 ± 0.189
0.529CysCys: 0.529 ± 0.155
1.059CysAsp: 1.059 ± 0.158
1.142CysGlu: 1.142 ± 0.209
0.529CysPhe: 0.529 ± 0.116
1.476CysGly: 1.476 ± 0.199
0.474CysHis: 0.474 ± 0.118
0.78CysIle: 0.78 ± 0.153
0.724CysLys: 0.724 ± 0.2
1.309CysLeu: 1.309 ± 0.251
0.446CysMet: 0.446 ± 0.125
0.529CysAsn: 0.529 ± 0.135
1.114CysPro: 1.114 ± 0.224
0.362CysGln: 0.362 ± 0.1
0.529CysArg: 0.529 ± 0.148
1.142CysSer: 1.142 ± 0.179
1.504CysThr: 1.504 ± 0.19
1.114CysVal: 1.114 ± 0.161
0.223CysTrp: 0.223 ± 0.083
0.501CysTyr: 0.501 ± 0.176
0.0CysXaa: 0.0 ± 0.0
Asp
2.841AspAla: 2.841 ± 0.276
0.585AspCys: 0.585 ± 0.127
4.401AspAsp: 4.401 ± 0.348
3.761AspGlu: 3.761 ± 0.361
2.145AspPhe: 2.145 ± 0.223
3.761AspGly: 3.761 ± 0.243
1.337AspHis: 1.337 ± 0.201
2.758AspIle: 2.758 ± 0.305
1.894AspLys: 1.894 ± 0.22
5.85AspLeu: 5.85 ± 0.457
1.421AspMet: 1.421 ± 0.179
1.365AspAsn: 1.365 ± 0.19
3.816AspPro: 3.816 ± 0.305
1.811AspGln: 1.811 ± 0.23
4.262AspArg: 4.262 ± 0.358
2.73AspSer: 2.73 ± 0.322
3.538AspThr: 3.538 ± 0.349
3.566AspVal: 3.566 ± 0.302
0.724AspTrp: 0.724 ± 0.141
2.006AspTyr: 2.006 ± 0.231
0.0AspXaa: 0.0 ± 0.0
Glu
4.373GluAla: 4.373 ± 0.454
1.254GluCys: 1.254 ± 0.232
2.953GluAsp: 2.953 ± 0.211
5.293GluGlu: 5.293 ± 0.777
2.563GluPhe: 2.563 ± 0.221
3.008GluGly: 3.008 ± 0.312
1.114GluHis: 1.114 ± 0.18
3.454GluIle: 3.454 ± 0.352
2.618GluLys: 2.618 ± 0.258
7.02GluLeu: 7.02 ± 0.576
2.117GluMet: 2.117 ± 0.278
1.978GluAsn: 1.978 ± 0.285
3.371GluPro: 3.371 ± 0.343
1.504GluGln: 1.504 ± 0.166
4.095GluArg: 4.095 ± 0.53
3.983GluSer: 3.983 ± 0.466
4.958GluThr: 4.958 ± 0.359
3.761GluVal: 3.761 ± 0.338
0.891GluTrp: 0.891 ± 0.143
1.783GluTyr: 1.783 ± 0.285
0.0GluXaa: 0.0 ± 0.0
Phe
2.145PheAla: 2.145 ± 0.226
1.086PheCys: 1.086 ± 0.176
2.368PheAsp: 2.368 ± 0.3
1.588PheGlu: 1.588 ± 0.213
1.727PhePhe: 1.727 ± 0.224
2.73PheGly: 2.73 ± 0.263
1.031PheHis: 1.031 ± 0.184
2.451PheIle: 2.451 ± 0.281
2.033PheLys: 2.033 ± 0.286
3.788PheLeu: 3.788 ± 0.341
1.254PheMet: 1.254 ± 0.177
1.922PheAsn: 1.922 ± 0.237
1.365PhePro: 1.365 ± 0.222
1.476PheGln: 1.476 ± 0.197
2.284PheArg: 2.284 ± 0.283
2.702PheSer: 2.702 ± 0.271
2.618PheThr: 2.618 ± 0.313
2.201PheVal: 2.201 ± 0.264
0.557PheTrp: 0.557 ± 0.138
1.031PheTyr: 1.031 ± 0.166
0.0PheXaa: 0.0 ± 0.0
Gly
5.599GlyAla: 5.599 ± 0.339
1.198GlyCys: 1.198 ± 0.231
4.847GlyAsp: 4.847 ± 0.323
4.763GlyGlu: 4.763 ± 0.384
3.036GlyPhe: 3.036 ± 0.261
6.017GlyGly: 6.017 ± 0.457
1.476GlyHis: 1.476 ± 0.224
3.064GlyIle: 3.064 ± 0.265
2.284GlyLys: 2.284 ± 0.265
6.24GlyLeu: 6.24 ± 0.394
1.588GlyMet: 1.588 ± 0.184
2.256GlyAsn: 2.256 ± 0.221
3.092GlyPro: 3.092 ± 0.349
1.504GlyGln: 1.504 ± 0.236
4.123GlyArg: 4.123 ± 0.412
4.513GlySer: 4.513 ± 0.325
4.819GlyThr: 4.819 ± 0.388
6.407GlyVal: 6.407 ± 0.505
1.114GlyTrp: 1.114 ± 0.171
2.646GlyTyr: 2.646 ± 0.34
0.0GlyXaa: 0.0 ± 0.0
His
1.588HisAla: 1.588 ± 0.26
0.362HisCys: 0.362 ± 0.111
0.585HisAsp: 0.585 ± 0.109
1.476HisGlu: 1.476 ± 0.232
0.975HisPhe: 0.975 ± 0.153
1.894HisGly: 1.894 ± 0.225
0.724HisHis: 0.724 ± 0.137
1.17HisIle: 1.17 ± 0.177
1.086HisLys: 1.086 ± 0.176
2.256HisLeu: 2.256 ± 0.238
0.947HisMet: 0.947 ± 0.165
0.696HisAsn: 0.696 ± 0.138
1.393HisPro: 1.393 ± 0.224
0.696HisGln: 0.696 ± 0.138
1.616HisArg: 1.616 ± 0.211
1.254HisSer: 1.254 ± 0.14
1.476HisThr: 1.476 ± 0.189
2.006HisVal: 2.006 ± 0.274
0.251HisTrp: 0.251 ± 0.076
0.752HisTyr: 0.752 ± 0.143
0.0HisXaa: 0.0 ± 0.0
Ile
3.621IleAla: 3.621 ± 0.365
0.864IleCys: 0.864 ± 0.162
3.259IleAsp: 3.259 ± 0.306
3.092IleGlu: 3.092 ± 0.322
2.73IlePhe: 2.73 ± 0.343
3.538IleGly: 3.538 ± 0.324
1.393IleHis: 1.393 ± 0.202
4.067IleIle: 4.067 ± 0.324
3.092IleLys: 3.092 ± 0.319
5.042IleLeu: 5.042 ± 0.371
1.532IleMet: 1.532 ± 0.203
2.786IleAsn: 2.786 ± 0.279
4.011IlePro: 4.011 ± 0.266
2.089IleGln: 2.089 ± 0.22
2.953IleArg: 2.953 ± 0.306
3.788IleSer: 3.788 ± 0.369
4.513IleThr: 4.513 ± 0.399
3.677IleVal: 3.677 ± 0.34
0.474IleTrp: 0.474 ± 0.122
2.033IleTyr: 2.033 ± 0.213
0.0IleXaa: 0.0 ± 0.0
Lys
2.423LysAla: 2.423 ± 0.31
0.891LysCys: 0.891 ± 0.151
2.061LysAsp: 2.061 ± 0.242
2.228LysGlu: 2.228 ± 0.279
1.755LysPhe: 1.755 ± 0.175
2.423LysGly: 2.423 ± 0.261
1.17LysHis: 1.17 ± 0.183
2.813LysIle: 2.813 ± 0.339
3.426LysLys: 3.426 ± 0.44
4.875LysLeu: 4.875 ± 0.429
1.56LysMet: 1.56 ± 0.232
2.256LysAsn: 2.256 ± 0.25
2.451LysPro: 2.451 ± 0.304
1.476LysGln: 1.476 ± 0.245
3.788LysArg: 3.788 ± 0.31
2.173LysSer: 2.173 ± 0.325
3.203LysThr: 3.203 ± 0.377
3.092LysVal: 3.092 ± 0.354
0.446LysTrp: 0.446 ± 0.1
1.393LysTyr: 1.393 ± 0.213
0.0LysXaa: 0.0 ± 0.0
Leu
5.989LeuAla: 5.989 ± 0.424
1.476LeuCys: 1.476 ± 0.193
5.599LeuAsp: 5.599 ± 0.45
5.432LeuGlu: 5.432 ± 0.496
3.844LeuPhe: 3.844 ± 0.344
6.574LeuGly: 6.574 ± 0.394
2.312LeuHis: 2.312 ± 0.295
5.515LeuIle: 5.515 ± 0.414
5.348LeuLys: 5.348 ± 0.504
8.412LeuLeu: 8.412 ± 0.609
3.12LeuMet: 3.12 ± 0.328
3.51LeuAsn: 3.51 ± 0.33
5.209LeuPro: 5.209 ± 0.469
2.702LeuGln: 2.702 ± 0.356
5.794LeuArg: 5.794 ± 0.449
6.184LeuSer: 6.184 ± 0.349
6.24LeuThr: 6.24 ± 0.504
6.602LeuVal: 6.602 ± 0.345
0.919LeuTrp: 0.919 ± 0.131
2.869LeuTyr: 2.869 ± 0.261
0.0LeuXaa: 0.0 ± 0.0
Met
2.786MetAla: 2.786 ± 0.211
0.836MetCys: 0.836 ± 0.141
2.228MetAsp: 2.228 ± 0.252
2.061MetGlu: 2.061 ± 0.219
0.975MetPhe: 0.975 ± 0.165
2.953MetGly: 2.953 ± 0.275
0.474MetHis: 0.474 ± 0.113
1.838MetIle: 1.838 ± 0.185
0.891MetLys: 0.891 ± 0.163
2.228MetLeu: 2.228 ± 0.291
1.281MetMet: 1.281 ± 0.163
0.752MetAsn: 0.752 ± 0.157
0.836MetPro: 0.836 ± 0.158
0.306MetGln: 0.306 ± 0.084
1.365MetArg: 1.365 ± 0.225
1.588MetSer: 1.588 ± 0.219
1.978MetThr: 1.978 ± 0.219
2.228MetVal: 2.228 ± 0.249
0.418MetTrp: 0.418 ± 0.095
1.198MetTyr: 1.198 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
2.145AsnAla: 2.145 ± 0.246
0.501AsnCys: 0.501 ± 0.13
1.365AsnAsp: 1.365 ± 0.212
1.811AsnGlu: 1.811 ± 0.238
1.421AsnPhe: 1.421 ± 0.203
2.368AsnGly: 2.368 ± 0.236
0.919AsnHis: 0.919 ± 0.146
2.479AsnIle: 2.479 ± 0.27
1.699AsnLys: 1.699 ± 0.208
3.593AsnLeu: 3.593 ± 0.335
1.17AsnMet: 1.17 ± 0.153
1.56AsnAsn: 1.56 ± 0.192
2.284AsnPro: 2.284 ± 0.256
1.031AsnGln: 1.031 ± 0.17
2.117AsnArg: 2.117 ± 0.24
1.671AsnSer: 1.671 ± 0.287
2.591AsnThr: 2.591 ± 0.234
2.033AsnVal: 2.033 ± 0.226
0.585AsnTrp: 0.585 ± 0.16
1.198AsnTyr: 1.198 ± 0.204
0.0AsnXaa: 0.0 ± 0.0
Pro
4.986ProAla: 4.986 ± 0.71
0.529ProCys: 0.529 ± 0.095
2.674ProAsp: 2.674 ± 0.292
4.346ProGlu: 4.346 ± 0.362
1.421ProPhe: 1.421 ± 0.184
4.457ProGly: 4.457 ± 0.467
1.337ProHis: 1.337 ± 0.24
3.482ProIle: 3.482 ± 0.336
2.618ProLys: 2.618 ± 0.306
4.429ProLeu: 4.429 ± 0.372
1.643ProMet: 1.643 ± 0.223
1.504ProAsn: 1.504 ± 0.173
5.989ProPro: 5.989 ± 0.775
2.089ProGln: 2.089 ± 0.283
4.318ProArg: 4.318 ± 0.402
4.206ProSer: 4.206 ± 0.397
4.68ProThr: 4.68 ± 0.434
5.098ProVal: 5.098 ± 0.422
0.78ProTrp: 0.78 ± 0.163
1.114ProTyr: 1.114 ± 0.2
0.0ProXaa: 0.0 ± 0.0
Gln
1.95GlnAla: 1.95 ± 0.237
0.501GlnCys: 0.501 ± 0.122
1.059GlnAsp: 1.059 ± 0.194
1.783GlnGlu: 1.783 ± 0.301
1.17GlnPhe: 1.17 ± 0.221
1.532GlnGly: 1.532 ± 0.185
0.891GlnHis: 0.891 ± 0.177
1.56GlnIle: 1.56 ± 0.222
1.476GlnLys: 1.476 ± 0.3
3.371GlnLeu: 3.371 ± 0.454
0.947GlnMet: 0.947 ± 0.158
1.198GlnAsn: 1.198 ± 0.19
2.089GlnPro: 2.089 ± 0.332
1.476GlnGln: 1.476 ± 0.354
2.033GlnArg: 2.033 ± 0.273
1.337GlnSer: 1.337 ± 0.223
1.866GlnThr: 1.866 ± 0.223
2.256GlnVal: 2.256 ± 0.253
0.446GlnTrp: 0.446 ± 0.11
0.919GlnTyr: 0.919 ± 0.176
0.0GlnXaa: 0.0 ± 0.0
Arg
5.098ArgAla: 5.098 ± 0.338
1.254ArgCys: 1.254 ± 0.221
3.538ArgAsp: 3.538 ± 0.303
4.067ArgGlu: 4.067 ± 0.372
2.312ArgPhe: 2.312 ± 0.216
5.571ArgGly: 5.571 ± 0.515
1.059ArgHis: 1.059 ± 0.192
3.064ArgIle: 3.064 ± 0.343
3.454ArgLys: 3.454 ± 0.247
6.658ArgLeu: 6.658 ± 0.38
1.616ArgMet: 1.616 ± 0.21
1.671ArgAsn: 1.671 ± 0.245
2.925ArgPro: 2.925 ± 0.298
1.17ArgGln: 1.17 ± 0.181
4.401ArgArg: 4.401 ± 0.427
3.398ArgSer: 3.398 ± 0.345
4.151ArgThr: 4.151 ± 0.364
5.209ArgVal: 5.209 ± 0.421
0.696ArgTrp: 0.696 ± 0.153
2.145ArgTyr: 2.145 ± 0.233
0.0ArgXaa: 0.0 ± 0.0
Ser
4.095SerAla: 4.095 ± 0.301
0.752SerCys: 0.752 ± 0.182
3.593SerAsp: 3.593 ± 0.374
3.9SerGlu: 3.9 ± 0.417
2.618SerPhe: 2.618 ± 0.227
5.293SerGly: 5.293 ± 0.473
1.003SerHis: 1.003 ± 0.158
3.566SerIle: 3.566 ± 0.377
2.34SerLys: 2.34 ± 0.248
5.293SerLeu: 5.293 ± 0.446
1.421SerMet: 1.421 ± 0.186
1.838SerAsn: 1.838 ± 0.232
3.816SerPro: 3.816 ± 0.433
1.783SerGln: 1.783 ± 0.244
3.593SerArg: 3.593 ± 0.349
4.819SerSer: 4.819 ± 0.711
4.958SerThr: 4.958 ± 0.445
3.426SerVal: 3.426 ± 0.26
0.641SerTrp: 0.641 ± 0.141
1.281SerTyr: 1.281 ± 0.168
0.0SerXaa: 0.0 ± 0.0
Thr
4.596ThrAla: 4.596 ± 0.412
1.532ThrCys: 1.532 ± 0.257
3.677ThrAsp: 3.677 ± 0.319
4.039ThrGlu: 4.039 ± 0.369
2.201ThrPhe: 2.201 ± 0.239
5.571ThrGly: 5.571 ± 0.429
1.727ThrHis: 1.727 ± 0.193
4.791ThrIle: 4.791 ± 0.462
3.287ThrLys: 3.287 ± 0.299
6.658ThrLeu: 6.658 ± 0.464
2.061ThrMet: 2.061 ± 0.239
2.591ThrAsn: 2.591 ± 0.246
6.407ThrPro: 6.407 ± 0.534
2.563ThrGln: 2.563 ± 0.252
4.596ThrArg: 4.596 ± 0.405
4.318ThrSer: 4.318 ± 0.499
5.878ThrThr: 5.878 ± 0.477
5.042ThrVal: 5.042 ± 0.383
1.114ThrTrp: 1.114 ± 0.171
1.727ThrTyr: 1.727 ± 0.231
0.0ThrXaa: 0.0 ± 0.0
Val
6.212ValAla: 6.212 ± 0.46
1.226ValCys: 1.226 ± 0.218
4.262ValAsp: 4.262 ± 0.41
4.847ValGlu: 4.847 ± 0.393
2.925ValPhe: 2.925 ± 0.303
4.151ValGly: 4.151 ± 0.37
1.755ValHis: 1.755 ± 0.229
4.485ValIle: 4.485 ± 0.347
2.897ValLys: 2.897 ± 0.263
6.073ValLeu: 6.073 ± 0.432
1.838ValMet: 1.838 ± 0.228
2.312ValAsn: 2.312 ± 0.296
3.092ValPro: 3.092 ± 0.298
2.145ValGln: 2.145 ± 0.255
3.9ValArg: 3.9 ± 0.354
4.123ValSer: 4.123 ± 0.434
5.599ValThr: 5.599 ± 0.452
5.209ValVal: 5.209 ± 0.421
0.947ValTrp: 0.947 ± 0.186
1.811ValTyr: 1.811 ± 0.192
0.0ValXaa: 0.0 ± 0.0
Trp
1.114TrpAla: 1.114 ± 0.178
0.167TrpCys: 0.167 ± 0.065
0.836TrpAsp: 0.836 ± 0.135
0.864TrpGlu: 0.864 ± 0.156
0.696TrpPhe: 0.696 ± 0.107
1.476TrpGly: 1.476 ± 0.216
0.279TrpHis: 0.279 ± 0.091
0.613TrpIle: 0.613 ± 0.123
0.669TrpLys: 0.669 ± 0.157
1.198TrpLeu: 1.198 ± 0.23
0.334TrpMet: 0.334 ± 0.114
0.446TrpAsn: 0.446 ± 0.111
0.334TrpPro: 0.334 ± 0.09
0.139TrpGln: 0.139 ± 0.064
0.836TrpArg: 0.836 ± 0.16
0.557TrpSer: 0.557 ± 0.113
1.003TrpThr: 1.003 ± 0.166
0.641TrpVal: 0.641 ± 0.13
0.223TrpTrp: 0.223 ± 0.069
0.334TrpTyr: 0.334 ± 0.107
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.811TyrAla: 1.811 ± 0.221
0.557TyrCys: 0.557 ± 0.15
1.449TyrAsp: 1.449 ± 0.185
1.56TyrGlu: 1.56 ± 0.209
1.003TyrPhe: 1.003 ± 0.159
1.783TyrGly: 1.783 ± 0.239
0.975TyrHis: 0.975 ± 0.172
1.783TyrIle: 1.783 ± 0.23
1.309TyrLys: 1.309 ± 0.195
2.479TyrLeu: 2.479 ± 0.262
1.003TyrMet: 1.003 ± 0.125
1.421TyrAsn: 1.421 ± 0.227
1.309TyrPro: 1.309 ± 0.194
1.059TyrGln: 1.059 ± 0.195
1.95TyrArg: 1.95 ± 0.189
1.838TyrSer: 1.838 ± 0.249
2.563TyrThr: 2.563 ± 0.29
2.033TyrVal: 2.033 ± 0.244
0.446TyrTrp: 0.446 ± 0.131
0.696TyrTyr: 0.696 ± 0.127
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (35900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski