Amino acid dipepetide frequency for Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.051AlaAla: 18.051 ± 0.148	1.408AlaCys: 1.408 ± 0.024	6.746AlaAsp: 6.746 ± 0.059	6.6AlaGlu: 6.6 ± 0.072	4.107AlaPhe: 4.107 ± 0.042	11.636AlaGly: 11.636 ± 0.085	2.556AlaHis: 2.556 ± 0.039	5.655AlaIle: 5.655 ± 0.058	3.459AlaLys: 3.459 ± 0.054	13.886AlaLeu: 13.886 ± 0.12	3.897AlaMet: 3.897 ± 0.049	3.171AlaAsn: 3.171 ± 0.049	6.083AlaPro: 6.083 ± 0.057	5.348AlaGln: 5.348 ± 0.069	9.39AlaArg: 9.39 ± 0.079	7.016AlaSer: 7.016 ± 0.069	6.448AlaThr: 6.448 ± 0.062	9.227AlaVal: 9.227 ± 0.08	1.792AlaTrp: 1.792 ± 0.035	2.598AlaTyr: 2.598 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.29CysAla: 1.29 ± 0.028	0.144CysCys: 0.144 ± 0.009	0.544CysAsp: 0.544 ± 0.019	0.538CysGlu: 0.538 ± 0.015	0.355CysPhe: 0.355 ± 0.013	1.039CysGly: 1.039 ± 0.023	0.294CysHis: 0.294 ± 0.013	0.41CysIle: 0.41 ± 0.014	0.233CysLys: 0.233 ± 0.011	0.897CysLeu: 0.897 ± 0.019	0.238CysMet: 0.238 ± 0.011	0.27CysAsn: 0.27 ± 0.01	0.508CysPro: 0.508 ± 0.019	0.286CysGln: 0.286 ± 0.012	0.681CysArg: 0.681 ± 0.019	0.536CysSer: 0.536 ± 0.016	0.515CysThr: 0.515 ± 0.017	0.731CysVal: 0.731 ± 0.018	0.128CysTrp: 0.128 ± 0.008	0.24CysTyr: 0.24 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.244AspAla: 7.244 ± 0.069	0.5AspCys: 0.5 ± 0.015	2.803AspAsp: 2.803 ± 0.039	2.964AspGlu: 2.964 ± 0.037	1.937AspPhe: 1.937 ± 0.035	4.56AspGly: 4.56 ± 0.057	1.123AspHis: 1.123 ± 0.023	2.596AspIle: 2.596 ± 0.033	1.63AspLys: 1.63 ± 0.027	5.082AspLeu: 5.082 ± 0.053	1.398AspMet: 1.398 ± 0.028	1.378AspAsn: 1.378 ± 0.029	2.986AspPro: 2.986 ± 0.046	1.553AspGln: 1.553 ± 0.029	3.449AspArg: 3.449 ± 0.046	2.353AspSer: 2.353 ± 0.036	2.748AspThr: 2.748 ± 0.037	4.208AspVal: 4.208 ± 0.041	0.891AspTrp: 0.891 ± 0.023	1.441AspTyr: 1.441 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.937GluAla: 6.937 ± 0.075	0.434GluCys: 0.434 ± 0.016	2.344GluAsp: 2.344 ± 0.039	2.515GluGlu: 2.515 ± 0.043	1.625GluPhe: 1.625 ± 0.03	3.629GluGly: 3.629 ± 0.047	1.383GluHis: 1.383 ± 0.028	2.843GluIle: 2.843 ± 0.042	1.677GluLys: 1.677 ± 0.033	5.385GluLeu: 5.385 ± 0.059	1.313GluMet: 1.313 ± 0.024	1.295GluAsn: 1.295 ± 0.023	2.397GluPro: 2.397 ± 0.034	2.537GluGln: 2.537 ± 0.039	4.586GluArg: 4.586 ± 0.059	2.672GluSer: 2.672 ± 0.037	2.691GluThr: 2.691 ± 0.038	3.716GluVal: 3.716 ± 0.045	0.693GluTrp: 0.693 ± 0.017	1.145GluTyr: 1.145 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.348PheAla: 4.348 ± 0.048	0.444PheCys: 0.444 ± 0.014	2.35PheAsp: 2.35 ± 0.033	1.83PheGlu: 1.83 ± 0.03	1.289PhePhe: 1.289 ± 0.029	3.633PheGly: 3.633 ± 0.047	0.75PheHis: 0.75 ± 0.018	1.473PheIle: 1.473 ± 0.029	0.905PheLys: 0.905 ± 0.023	3.043PheLeu: 3.043 ± 0.043	0.776PheMet: 0.776 ± 0.019	1.047PheAsn: 1.047 ± 0.022	1.583PhePro: 1.583 ± 0.03	0.992PheGln: 0.992 ± 0.023	2.147PheArg: 2.147 ± 0.031	2.15PheSer: 2.15 ± 0.033	1.86PheThr: 1.86 ± 0.031	2.732PheVal: 2.732 ± 0.034	0.49PheTrp: 0.49 ± 0.016	0.903PheTyr: 0.903 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.546GlyAla: 9.546 ± 0.084	0.92GlyCys: 0.92 ± 0.019	3.919GlyAsp: 3.919 ± 0.048	4.372GlyGlu: 4.372 ± 0.046	3.28GlyPhe: 3.28 ± 0.042	7.297GlyGly: 7.297 ± 0.083	1.898GlyHis: 1.898 ± 0.033	4.315GlyIle: 4.315 ± 0.049	3.558GlyLys: 3.558 ± 0.054	8.455GlyLeu: 8.455 ± 0.07	2.662GlyMet: 2.662 ± 0.036	2.521GlyAsn: 2.521 ± 0.043	3.154GlyPro: 3.154 ± 0.043	3.247GlyGln: 3.247 ± 0.042	5.52GlyArg: 5.52 ± 0.053	4.703GlySer: 4.703 ± 0.05	4.981GlyThr: 4.981 ± 0.059	6.702GlyVal: 6.702 ± 0.058	1.404GlyTrp: 1.404 ± 0.029	2.513GlyTyr: 2.513 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	3.092HisAla: 3.092 ± 0.038	0.273HisCys: 0.273 ± 0.012	1.291HisAsp: 1.291 ± 0.028	1.101HisGlu: 1.101 ± 0.026	0.886HisPhe: 0.886 ± 0.021	2.228HisGly: 2.228 ± 0.034	0.662HisHis: 0.662 ± 0.019	0.98HisIle: 0.98 ± 0.022	0.526HisLys: 0.526 ± 0.017	2.065HisLeu: 2.065 ± 0.029	0.561HisMet: 0.561 ± 0.018	0.503HisAsn: 0.503 ± 0.016	1.522HisPro: 1.522 ± 0.029	0.664HisGln: 0.664 ± 0.018	1.498HisArg: 1.498 ± 0.03	1.024HisSer: 1.024 ± 0.023	1.059HisThr: 1.059 ± 0.023	1.713HisVal: 1.713 ± 0.032	0.42HisTrp: 0.42 ± 0.016	0.677HisTyr: 0.677 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.455IleAla: 6.455 ± 0.063	0.478IleCys: 0.478 ± 0.016	3.072IleAsp: 3.072 ± 0.045	2.911IleGlu: 2.911 ± 0.042	1.325IlePhe: 1.325 ± 0.026	4.637IleGly: 4.637 ± 0.057	0.952IleHis: 0.952 ± 0.02	1.673IleIle: 1.673 ± 0.033	1.272IleLys: 1.272 ± 0.027	3.513IleLeu: 3.513 ± 0.046	0.803IleMet: 0.803 ± 0.021	1.359IleAsn: 1.359 ± 0.026	2.173IlePro: 2.173 ± 0.034	1.305IleGln: 1.305 ± 0.024	3.002IleArg: 3.002 ± 0.04	2.48IleSer: 2.48 ± 0.038	2.375IleThr: 2.375 ± 0.038	3.855IleVal: 3.855 ± 0.037	0.473IleTrp: 0.473 ± 0.016	0.982IleTyr: 0.982 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.76LysAla: 3.76 ± 0.048	0.157LysCys: 0.157 ± 0.009	1.453LysAsp: 1.453 ± 0.029	1.417LysGlu: 1.417 ± 0.031	0.839LysPhe: 0.839 ± 0.022	2.238LysGly: 2.238 ± 0.037	0.626LysHis: 0.626 ± 0.018	1.389LysIle: 1.389 ± 0.029	1.089LysLys: 1.089 ± 0.034	3.236LysLeu: 3.236 ± 0.044	0.75LysMet: 0.75 ± 0.02	0.741LysAsn: 0.741 ± 0.019	1.917LysPro: 1.917 ± 0.034	1.188LysGln: 1.188 ± 0.024	2.127LysArg: 2.127 ± 0.034	1.591LysSer: 1.591 ± 0.031	1.768LysThr: 1.768 ± 0.03	2.404LysVal: 2.404 ± 0.039	0.357LysTrp: 0.357 ± 0.014	0.702LysTyr: 0.702 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.414LeuAla: 14.414 ± 0.12	1.091LeuCys: 1.091 ± 0.027	5.609LeuAsp: 5.609 ± 0.054	4.982LeuGlu: 4.982 ± 0.056	3.415LeuPhe: 3.415 ± 0.045	8.393LeuGly: 8.393 ± 0.078	2.282LeuHis: 2.282 ± 0.036	4.208LeuIle: 4.208 ± 0.048	3.041LeuLys: 3.041 ± 0.04	10.319LeuLeu: 10.319 ± 0.103	2.421LeuMet: 2.421 ± 0.035	2.612LeuAsn: 2.612 ± 0.044	6.059LeuPro: 6.059 ± 0.055	3.661LeuGln: 3.661 ± 0.051	7.547LeuArg: 7.547 ± 0.066	6.154LeuSer: 6.154 ± 0.059	5.343LeuThr: 5.343 ± 0.061	7.672LeuVal: 7.672 ± 0.077	1.166LeuTrp: 1.166 ± 0.028	2.149LeuTyr: 2.149 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	3.173MetAla: 3.173 ± 0.041	0.206MetCys: 0.206 ± 0.01	1.128MetAsp: 1.128 ± 0.024	1.225MetGlu: 1.225 ± 0.026	0.785MetPhe: 0.785 ± 0.021	1.827MetGly: 1.827 ± 0.032	0.611MetHis: 0.611 ± 0.017	1.096MetIle: 1.096 ± 0.023	0.962MetLys: 0.962 ± 0.021	2.904MetLeu: 2.904 ± 0.037	0.695MetMet: 0.695 ± 0.02	0.819MetAsn: 0.819 ± 0.021	1.745MetPro: 1.745 ± 0.029	1.15MetGln: 1.15 ± 0.027	1.95MetArg: 1.95 ± 0.032	1.674MetSer: 1.674 ± 0.027	1.78MetThr: 1.78 ± 0.029	1.838MetVal: 1.838 ± 0.03	0.222MetTrp: 0.222 ± 0.01	0.369MetTyr: 0.369 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.438AsnAla: 3.438 ± 0.052	0.287AsnCys: 0.287 ± 0.012	1.323AsnAsp: 1.323 ± 0.027	1.202AsnGlu: 1.202 ± 0.023	0.914AsnPhe: 0.914 ± 0.019	2.457AsnGly: 2.457 ± 0.045	0.541AsnHis: 0.541 ± 0.016	1.264AsnIle: 1.264 ± 0.025	0.757AsnLys: 0.757 ± 0.021	2.629AsnLeu: 2.629 ± 0.04	0.615AsnMet: 0.615 ± 0.018	0.753AsnAsn: 0.753 ± 0.025	1.834AsnPro: 1.834 ± 0.026	0.882AsnGln: 0.882 ± 0.021	1.771AsnArg: 1.771 ± 0.03	1.229AsnSer: 1.229 ± 0.029	1.451AsnThr: 1.451 ± 0.03	2.103AsnVal: 2.103 ± 0.036	0.412AsnTrp: 0.412 ± 0.015	0.718AsnTyr: 0.718 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.363ProAla: 7.363 ± 0.069	0.401ProCys: 0.401 ± 0.014	3.434ProAsp: 3.434 ± 0.038	3.308ProGlu: 3.308 ± 0.045	1.837ProPhe: 1.837 ± 0.03	4.671ProGly: 4.671 ± 0.049	1.175ProHis: 1.175 ± 0.026	1.97ProIle: 1.97 ± 0.033	1.38ProLys: 1.38 ± 0.029	5.114ProLeu: 5.114 ± 0.056	1.297ProMet: 1.297 ± 0.027	1.334ProAsn: 1.334 ± 0.027	2.579ProPro: 2.579 ± 0.039	1.931ProGln: 1.931 ± 0.029	3.054ProArg: 3.054 ± 0.044	2.871ProSer: 2.871 ± 0.034	2.551ProThr: 2.551 ± 0.037	4.593ProVal: 4.593 ± 0.046	0.684ProTrp: 0.684 ± 0.019	1.326ProTyr: 1.326 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.311GlnAla: 5.311 ± 0.071	0.309GlnCys: 0.309 ± 0.012	1.616GlnAsp: 1.616 ± 0.028	1.649GlnGlu: 1.649 ± 0.029	1.284GlnPhe: 1.284 ± 0.023	2.789GlnGly: 2.789 ± 0.039	0.948GlnHis: 0.948 ± 0.024	1.754GlnIle: 1.754 ± 0.028	1.033GlnLys: 1.033 ± 0.024	3.725GlnLeu: 3.725 ± 0.044	1.041GlnMet: 1.041 ± 0.02	0.884GlnAsn: 0.884 ± 0.023	2.206GlnPro: 2.206 ± 0.037	1.939GlnGln: 1.939 ± 0.05	3.086GlnArg: 3.086 ± 0.043	2.017GlnSer: 2.017 ± 0.031	1.937GlnThr: 1.937 ± 0.035	2.773GlnVal: 2.773 ± 0.048	0.591GlnTrp: 0.591 ± 0.017	0.899GlnTyr: 0.899 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.136ArgAla: 8.136 ± 0.072	0.641ArgCys: 0.641 ± 0.016	3.911ArgAsp: 3.911 ± 0.043	4.343ArgGlu: 4.343 ± 0.051	2.79ArgPhe: 2.79 ± 0.04	4.718ArgGly: 4.718 ± 0.047	1.973ArgHis: 1.973 ± 0.03	3.576ArgIle: 3.576 ± 0.045	2.24ArgLys: 2.24 ± 0.033	7.752ArgLeu: 7.752 ± 0.075	2.039ArgMet: 2.039 ± 0.03	1.955ArgAsn: 1.955 ± 0.033	3.36ArgPro: 3.36 ± 0.042	3.094ArgGln: 3.094 ± 0.042	5.381ArgArg: 5.381 ± 0.069	3.485ArgSer: 3.485 ± 0.045	3.525ArgThr: 3.525 ± 0.037	5.146ArgVal: 5.146 ± 0.055	1.081ArgTrp: 1.081 ± 0.023	1.972ArgTyr: 1.972 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.649SerAla: 6.649 ± 0.066	0.492SerCys: 0.492 ± 0.017	2.669SerAsp: 2.669 ± 0.035	2.527SerGlu: 2.527 ± 0.034	1.976SerPhe: 1.976 ± 0.032	5.437SerGly: 5.437 ± 0.054	1.288SerHis: 1.288 ± 0.028	2.368SerIle: 2.368 ± 0.036	1.436SerLys: 1.436 ± 0.028	5.653SerLeu: 5.653 ± 0.052	1.51SerMet: 1.51 ± 0.028	1.446SerAsn: 1.446 ± 0.028	2.899SerPro: 2.899 ± 0.04	1.929SerGln: 1.929 ± 0.038	3.822SerArg: 3.822 ± 0.047	3.008SerSer: 3.008 ± 0.041	2.887SerThr: 2.887 ± 0.043	4.122SerVal: 4.122 ± 0.044	0.737SerTrp: 0.737 ± 0.018	1.282SerTyr: 1.282 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	6.2ThrAla: 6.2 ± 0.061	0.458ThrCys: 0.458 ± 0.014	2.676ThrAsp: 2.676 ± 0.037	2.516ThrGlu: 2.516 ± 0.037	1.888ThrPhe: 1.888 ± 0.03	4.965ThrGly: 4.965 ± 0.047	1.216ThrHis: 1.216 ± 0.022	2.417ThrIle: 2.417 ± 0.037	1.158ThrLys: 1.158 ± 0.026	6.244ThrLeu: 6.244 ± 0.067	1.253ThrMet: 1.253 ± 0.026	1.244ThrAsn: 1.244 ± 0.026	3.455ThrPro: 3.455 ± 0.044	1.848ThrGln: 1.848 ± 0.035	3.534ThrArg: 3.534 ± 0.044	2.77ThrSer: 2.77 ± 0.04	2.856ThrThr: 2.856 ± 0.048	4.555ThrVal: 4.555 ± 0.051	0.683ThrTrp: 0.683 ± 0.019	1.185ThrTyr: 1.185 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.684ValAla: 9.684 ± 0.068	0.79ValCys: 0.79 ± 0.022	4.064ValAsp: 4.064 ± 0.046	4.078ValGlu: 4.078 ± 0.049	2.695ValPhe: 2.695 ± 0.038	5.675ValGly: 5.675 ± 0.059	1.548ValHis: 1.548 ± 0.024	3.569ValIle: 3.569 ± 0.042	2.252ValLys: 2.252 ± 0.043	8.173ValLeu: 8.173 ± 0.078	2.006ValMet: 2.006 ± 0.034	2.218ValAsn: 2.218 ± 0.042	4.503ValPro: 4.503 ± 0.039	2.607ValGln: 2.607 ± 0.036	5.534ValArg: 5.534 ± 0.047	4.456ValSer: 4.456 ± 0.049	4.402ValThr: 4.402 ± 0.048	6.533ValVal: 6.533 ± 0.066	0.923ValTrp: 0.923 ± 0.022	1.605ValTyr: 1.605 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.162TrpAla: 1.162 ± 0.027	0.159TrpCys: 0.159 ± 0.01	0.609TrpAsp: 0.609 ± 0.019	0.584TrpGlu: 0.584 ± 0.017	0.547TrpPhe: 0.547 ± 0.019	0.935TrpGly: 0.935 ± 0.024	0.422TrpHis: 0.422 ± 0.016	0.687TrpIle: 0.687 ± 0.016	0.436TrpLys: 0.436 ± 0.015	1.974TrpLeu: 1.974 ± 0.036	0.424TrpMet: 0.424 ± 0.015	0.425TrpAsn: 0.425 ± 0.015	0.644TrpPro: 0.644 ± 0.018	0.755TrpGln: 0.755 ± 0.022	1.141TrpArg: 1.141 ± 0.026	0.722TrpSer: 0.722 ± 0.018	0.683TrpThr: 0.683 ± 0.019	0.889TrpVal: 0.889 ± 0.024	0.247TrpTrp: 0.247 ± 0.012	0.319TrpTyr: 0.319 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.819TyrAla: 2.819 ± 0.035	0.285TyrCys: 0.285 ± 0.011	1.284TyrAsp: 1.284 ± 0.024	1.157TyrGlu: 1.157 ± 0.022	0.972TyrPhe: 0.972 ± 0.023	2.206TyrGly: 2.206 ± 0.036	0.496TyrHis: 0.496 ± 0.015	0.852TyrIle: 0.852 ± 0.023	0.706TyrLys: 0.706 ± 0.022	2.489TyrLeu: 2.489 ± 0.037	0.457TyrMet: 0.457 ± 0.015	0.605TyrAsn: 0.605 ± 0.017	1.265TyrPro: 1.265 ± 0.025	0.876TyrGln: 0.876 ± 0.02	1.896TyrArg: 1.896 ± 0.03	1.225TyrSer: 1.225 ± 0.026	1.263TyrThr: 1.263 ± 0.031	1.801TyrVal: 1.801 ± 0.033	0.372TyrTrp: 0.372 ± 0.015	0.661TyrTyr: 0.661 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6433 proteins (2109372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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