Amino acid dipepetide frequency for Metschnikowia sp. JCM 33374

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.329AlaAla: 5.329 ± 0.067
0.778AlaCys: 0.778 ± 0.017
3.457AlaAsp: 3.457 ± 0.04
4.131AlaGlu: 4.131 ± 0.054
2.768AlaPhe: 2.768 ± 0.027
3.683AlaGly: 3.683 ± 0.043
1.503AlaHis: 1.503 ± 0.023
3.62AlaIle: 3.62 ± 0.043
4.468AlaLys: 4.468 ± 0.05
5.875AlaLeu: 5.875 ± 0.053
1.388AlaMet: 1.388 ± 0.024
3.122AlaAsn: 3.122 ± 0.035
3.372AlaPro: 3.372 ± 0.053
2.679AlaGln: 2.679 ± 0.038
3.019AlaArg: 3.019 ± 0.035
6.818AlaSer: 6.818 ± 0.083
4.251AlaThr: 4.251 ± 0.057
4.046AlaVal: 4.046 ± 0.05
0.614AlaTrp: 0.614 ± 0.015
1.944AlaTyr: 1.944 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
0.705CysAla: 0.705 ± 0.016
0.251CysCys: 0.251 ± 0.011
0.672CysAsp: 0.672 ± 0.017
0.66CysGlu: 0.66 ± 0.019
0.651CysPhe: 0.651 ± 0.015
0.856CysGly: 0.856 ± 0.022
0.345CysHis: 0.345 ± 0.014
0.701CysIle: 0.701 ± 0.019
0.625CysLys: 0.625 ± 0.014
1.185CysLeu: 1.185 ± 0.022
0.268CysMet: 0.268 ± 0.009
0.494CysAsn: 0.494 ± 0.014
0.559CysPro: 0.559 ± 0.015
0.412CysGln: 0.412 ± 0.011
0.489CysArg: 0.489 ± 0.013
1.046CysSer: 1.046 ± 0.023
0.599CysThr: 0.599 ± 0.016
0.775CysVal: 0.775 ± 0.016
0.162CysTrp: 0.162 ± 0.008
0.401CysTyr: 0.401 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.812AspAla: 3.812 ± 0.039
0.599AspCys: 0.599 ± 0.016
4.137AspAsp: 4.137 ± 0.07
4.47AspGlu: 4.47 ± 0.054
2.85AspPhe: 2.85 ± 0.038
3.452AspGly: 3.452 ± 0.06
1.322AspHis: 1.322 ± 0.024
3.503AspIle: 3.503 ± 0.033
2.937AspLys: 2.937 ± 0.037
5.44AspLeu: 5.44 ± 0.051
1.144AspMet: 1.144 ± 0.023
2.251AspAsn: 2.251 ± 0.027
2.678AspPro: 2.678 ± 0.028
1.824AspGln: 1.824 ± 0.024
2.062AspArg: 2.062 ± 0.03
5.224AspSer: 5.224 ± 0.072
3.095AspThr: 3.095 ± 0.031
3.722AspVal: 3.722 ± 0.043
0.633AspTrp: 0.633 ± 0.016
1.962AspTyr: 1.962 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
4.147GluAla: 4.147 ± 0.044
0.669GluCys: 0.669 ± 0.017
4.15GluAsp: 4.15 ± 0.049
5.299GluGlu: 5.299 ± 0.07
2.672GluPhe: 2.672 ± 0.031
2.84GluGly: 2.84 ± 0.038
1.341GluHis: 1.341 ± 0.023
3.947GluIle: 3.947 ± 0.035
4.955GluLys: 4.955 ± 0.052
5.599GluLeu: 5.599 ± 0.057
1.35GluMet: 1.35 ± 0.022
3.643GluAsn: 3.643 ± 0.045
2.358GluPro: 2.358 ± 0.03
2.292GluGln: 2.292 ± 0.033
2.754GluArg: 2.754 ± 0.032
5.442GluSer: 5.442 ± 0.068
4.22GluThr: 4.22 ± 0.059
3.783GluVal: 3.783 ± 0.047
0.64GluTrp: 0.64 ± 0.017
2.08GluTyr: 2.08 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
2.868PheAla: 2.868 ± 0.036
0.6PheCys: 0.6 ± 0.017
2.767PheAsp: 2.767 ± 0.034
2.67PheGlu: 2.67 ± 0.035
2.038PhePhe: 2.038 ± 0.036
2.839PheGly: 2.839 ± 0.039
1.125PheHis: 1.125 ± 0.02
2.317PheIle: 2.317 ± 0.035
2.52PheLys: 2.52 ± 0.032
3.957PheLeu: 3.957 ± 0.05
0.899PheMet: 0.899 ± 0.019
2.189PheAsn: 2.189 ± 0.029
1.948PhePro: 1.948 ± 0.028
1.782PheGln: 1.782 ± 0.025
1.844PheArg: 1.844 ± 0.026
4.216PheSer: 4.216 ± 0.045
2.486PheThr: 2.486 ± 0.035
2.821PheVal: 2.821 ± 0.033
0.547PheTrp: 0.547 ± 0.015
1.453PheTyr: 1.453 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
3.869GlyAla: 3.869 ± 0.061
0.731GlyCys: 0.731 ± 0.015
3.074GlyAsp: 3.074 ± 0.039
3.151GlyGlu: 3.151 ± 0.039
2.696GlyPhe: 2.696 ± 0.034
3.686GlyGly: 3.686 ± 0.058
1.41GlyHis: 1.41 ± 0.023
3.27GlyIle: 3.27 ± 0.043
3.523GlyLys: 3.523 ± 0.046
4.792GlyLeu: 4.792 ± 0.045
1.073GlyMet: 1.073 ± 0.022
2.635GlyAsn: 2.635 ± 0.041
2.386GlyPro: 2.386 ± 0.039
1.979GlyGln: 1.979 ± 0.042
2.297GlyArg: 2.297 ± 0.03
6.136GlySer: 6.136 ± 0.118
3.554GlyThr: 3.554 ± 0.071
3.688GlyVal: 3.688 ± 0.047
0.624GlyTrp: 0.624 ± 0.016
1.883GlyTyr: 1.883 ± 0.031
0.0GlyXaa: 0.0 ± 0.0
His
1.42HisAla: 1.42 ± 0.023
0.291HisCys: 0.291 ± 0.011
1.284HisAsp: 1.284 ± 0.023
1.472HisGlu: 1.472 ± 0.019
1.082HisPhe: 1.082 ± 0.02
1.382HisGly: 1.382 ± 0.026
0.774HisHis: 0.774 ± 0.021
1.333HisIle: 1.333 ± 0.021
1.327HisLys: 1.327 ± 0.022
2.25HisLeu: 2.25 ± 0.03
0.521HisMet: 0.521 ± 0.016
1.083HisAsn: 1.083 ± 0.021
1.323HisPro: 1.323 ± 0.024
1.12HisGln: 1.12 ± 0.024
1.05HisArg: 1.05 ± 0.018
2.135HisSer: 2.135 ± 0.034
1.324HisThr: 1.324 ± 0.022
1.449HisVal: 1.449 ± 0.024
0.244HisTrp: 0.244 ± 0.011
0.779HisTyr: 0.779 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
3.529IleAla: 3.529 ± 0.036
0.749IleCys: 0.749 ± 0.017
3.441IleAsp: 3.441 ± 0.037
3.418IleGlu: 3.418 ± 0.045
2.415IlePhe: 2.415 ± 0.035
2.875IleGly: 2.875 ± 0.037
1.371IleHis: 1.371 ± 0.024
2.986IleIle: 2.986 ± 0.038
3.292IleLys: 3.292 ± 0.04
5.1IleLeu: 5.1 ± 0.048
1.123IleMet: 1.123 ± 0.019
2.694IleAsn: 2.694 ± 0.036
3.087IlePro: 3.087 ± 0.033
2.022IleGln: 2.022 ± 0.034
2.43IleArg: 2.43 ± 0.033
5.411IleSer: 5.411 ± 0.055
3.188IleThr: 3.188 ± 0.036
3.527IleVal: 3.527 ± 0.045
0.576IleTrp: 0.576 ± 0.016
1.704IleTyr: 1.704 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
4.23LysAla: 4.23 ± 0.046
0.692LysCys: 0.692 ± 0.017
3.471LysAsp: 3.471 ± 0.045
4.271LysGlu: 4.271 ± 0.046
2.678LysPhe: 2.678 ± 0.033
2.773LysGly: 2.773 ± 0.039
1.526LysHis: 1.526 ± 0.023
3.653LysIle: 3.653 ± 0.041
5.17LysLys: 5.17 ± 0.059
6.062LysLeu: 6.062 ± 0.058
1.261LysMet: 1.261 ± 0.022
3.224LysAsn: 3.224 ± 0.038
3.083LysPro: 3.083 ± 0.045
2.421LysGln: 2.421 ± 0.03
3.271LysArg: 3.271 ± 0.037
5.652LysSer: 5.652 ± 0.048
4.106LysThr: 4.106 ± 0.057
3.758LysVal: 3.758 ± 0.039
0.653LysTrp: 0.653 ± 0.016
2.213LysTyr: 2.213 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
6.407LeuAla: 6.407 ± 0.054
1.161LeuCys: 1.161 ± 0.023
5.137LeuAsp: 5.137 ± 0.043
5.609LeuGlu: 5.609 ± 0.057
3.678LeuPhe: 3.678 ± 0.044
4.925LeuGly: 4.925 ± 0.044
2.07LeuHis: 2.07 ± 0.025
4.554LeuIle: 4.554 ± 0.053
5.926LeuLys: 5.926 ± 0.049
8.019LeuLeu: 8.019 ± 0.072
1.817LeuMet: 1.817 ± 0.027
4.274LeuAsn: 4.274 ± 0.047
4.402LeuPro: 4.402 ± 0.046
3.742LeuGln: 3.742 ± 0.045
4.529LeuArg: 4.529 ± 0.047
8.418LeuSer: 8.418 ± 0.074
4.846LeuThr: 4.846 ± 0.053
5.673LeuVal: 5.673 ± 0.06
0.857LeuTrp: 0.857 ± 0.018
2.643LeuTyr: 2.643 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
1.603MetAla: 1.603 ± 0.024
0.258MetCys: 0.258 ± 0.008
1.188MetAsp: 1.188 ± 0.022
1.227MetGlu: 1.227 ± 0.023
0.88MetPhe: 0.88 ± 0.016
1.179MetGly: 1.179 ± 0.021
0.389MetHis: 0.389 ± 0.011
1.063MetIle: 1.063 ± 0.017
1.366MetLys: 1.366 ± 0.021
1.677MetLeu: 1.677 ± 0.021
0.497MetMet: 0.497 ± 0.013
1.036MetAsn: 1.036 ± 0.023
0.936MetPro: 0.936 ± 0.022
0.638MetGln: 0.638 ± 0.016
0.943MetArg: 0.943 ± 0.019
2.104MetSer: 2.104 ± 0.026
1.125MetThr: 1.125 ± 0.024
1.279MetVal: 1.279 ± 0.019
0.183MetTrp: 0.183 ± 0.008
0.577MetTyr: 0.577 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.068AsnAla: 3.068 ± 0.033
0.532AsnCys: 0.532 ± 0.015
2.724AsnAsp: 2.724 ± 0.037
2.986AsnGlu: 2.986 ± 0.039
2.283AsnPhe: 2.283 ± 0.033
3.021AsnGly: 3.021 ± 0.041
1.176AsnHis: 1.176 ± 0.022
2.815AsnIle: 2.815 ± 0.035
2.742AsnLys: 2.742 ± 0.031
4.339AsnLeu: 4.339 ± 0.041
1.007AsnMet: 1.007 ± 0.02
2.404AsnAsn: 2.404 ± 0.036
2.509AsnPro: 2.509 ± 0.032
1.774AsnGln: 1.774 ± 0.032
1.848AsnArg: 1.848 ± 0.024
4.526AsnSer: 4.526 ± 0.045
3.051AsnThr: 3.051 ± 0.042
2.904AsnVal: 2.904 ± 0.034
0.554AsnTrp: 0.554 ± 0.014
1.624AsnTyr: 1.624 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
3.258ProAla: 3.258 ± 0.048
0.394ProCys: 0.394 ± 0.012
2.523ProAsp: 2.523 ± 0.036
3.704ProGlu: 3.704 ± 0.04
1.976ProPhe: 1.976 ± 0.027
2.777ProGly: 2.777 ± 0.051
1.227ProHis: 1.227 ± 0.025
2.501ProIle: 2.501 ± 0.039
3.189ProLys: 3.189 ± 0.039
3.851ProLeu: 3.851 ± 0.039
0.892ProMet: 0.892 ± 0.018
2.265ProAsn: 2.265 ± 0.036
3.008ProPro: 3.008 ± 0.076
2.489ProGln: 2.489 ± 0.046
2.258ProArg: 2.258 ± 0.031
5.076ProSer: 5.076 ± 0.058
3.238ProThr: 3.238 ± 0.082
3.539ProVal: 3.539 ± 0.055
0.433ProTrp: 0.433 ± 0.013
1.415ProTyr: 1.415 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
2.543GlnAla: 2.543 ± 0.042
0.409GlnCys: 0.409 ± 0.013
1.906GlnAsp: 1.906 ± 0.026
2.537GlnGlu: 2.537 ± 0.032
1.588GlnPhe: 1.588 ± 0.025
1.863GlnGly: 1.863 ± 0.028
1.0GlnHis: 1.0 ± 0.028
2.25GlnIle: 2.25 ± 0.025
2.775GlnLys: 2.775 ± 0.034
3.441GlnLeu: 3.441 ± 0.041
0.854GlnMet: 0.854 ± 0.018
2.183GlnAsn: 2.183 ± 0.032
1.916GlnPro: 1.916 ± 0.047
2.255GlnGln: 2.255 ± 0.073
1.762GlnArg: 1.762 ± 0.027
3.214GlnSer: 3.214 ± 0.041
2.354GlnThr: 2.354 ± 0.04
2.303GlnVal: 2.303 ± 0.026
0.373GlnTrp: 0.373 ± 0.012
1.28GlnTyr: 1.28 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
2.854ArgAla: 2.854 ± 0.035
0.522ArgCys: 0.522 ± 0.014
2.439ArgAsp: 2.439 ± 0.028
2.804ArgGlu: 2.804 ± 0.038
2.051ArgPhe: 2.051 ± 0.027
2.358ArgGly: 2.358 ± 0.034
1.07ArgHis: 1.07 ± 0.017
2.504ArgIle: 2.504 ± 0.029
3.406ArgLys: 3.406 ± 0.042
4.209ArgLeu: 4.209 ± 0.041
0.939ArgMet: 0.939 ± 0.018
2.267ArgAsn: 2.267 ± 0.031
2.021ArgPro: 2.021 ± 0.034
1.736ArgGln: 1.736 ± 0.026
2.743ArgArg: 2.743 ± 0.042
3.927ArgSer: 3.927 ± 0.04
2.374ArgThr: 2.374 ± 0.031
2.7ArgVal: 2.7 ± 0.034
0.475ArgTrp: 0.475 ± 0.013
1.408ArgTyr: 1.408 ± 0.024
0.0ArgXaa: 0.0 ± 0.0
Ser
6.44SerAla: 6.44 ± 0.081
1.02SerCys: 1.02 ± 0.019
5.336SerAsp: 5.336 ± 0.056
5.773SerGlu: 5.773 ± 0.055
4.174SerPhe: 4.174 ± 0.046
5.681SerGly: 5.681 ± 0.074
2.217SerHis: 2.217 ± 0.031
5.002SerIle: 5.002 ± 0.053
6.001SerLys: 6.001 ± 0.057
8.389SerLeu: 8.389 ± 0.079
1.916SerMet: 1.916 ± 0.029
4.309SerAsn: 4.309 ± 0.051
4.92SerPro: 4.92 ± 0.061
3.688SerGln: 3.688 ± 0.044
4.394SerArg: 4.394 ± 0.046
11.236SerSer: 11.236 ± 0.192
6.801SerThr: 6.801 ± 0.136
6.04SerVal: 6.04 ± 0.072
0.96SerTrp: 0.96 ± 0.022
2.865SerTyr: 2.865 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
3.768ThrAla: 3.768 ± 0.041
0.717ThrCys: 0.717 ± 0.015
3.265ThrAsp: 3.265 ± 0.064
3.583ThrGlu: 3.583 ± 0.052
2.539ThrPhe: 2.539 ± 0.034
4.421ThrGly: 4.421 ± 0.13
1.325ThrHis: 1.325 ± 0.024
3.263ThrIle: 3.263 ± 0.034
3.626ThrLys: 3.626 ± 0.045
5.041ThrLeu: 5.041 ± 0.057
1.075ThrMet: 1.075 ± 0.02
2.856ThrAsn: 2.856 ± 0.039
3.908ThrPro: 3.908 ± 0.076
2.263ThrGln: 2.263 ± 0.031
2.603ThrArg: 2.603 ± 0.03
6.718ThrSer: 6.718 ± 0.129
5.41ThrThr: 5.41 ± 0.221
4.169ThrVal: 4.169 ± 0.118
0.957ThrTrp: 0.957 ± 0.058
1.732ThrTyr: 1.732 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
4.437ValAla: 4.437 ± 0.047
0.819ValCys: 0.819 ± 0.018
3.705ValAsp: 3.705 ± 0.04
3.916ValGlu: 3.916 ± 0.059
2.872ValPhe: 2.872 ± 0.036
3.355ValGly: 3.355 ± 0.041
1.406ValHis: 1.406 ± 0.024
3.396ValIle: 3.396 ± 0.043
3.719ValLys: 3.719 ± 0.037
5.57ValLeu: 5.57 ± 0.055
1.206ValMet: 1.206 ± 0.019
2.779ValAsn: 2.779 ± 0.032
3.798ValPro: 3.798 ± 0.065
2.108ValGln: 2.108 ± 0.032
2.633ValArg: 2.633 ± 0.031
6.311ValSer: 6.311 ± 0.081
4.037ValThr: 4.037 ± 0.106
5.164ValVal: 5.164 ± 0.125
0.67ValTrp: 0.67 ± 0.019
1.958ValTyr: 1.958 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
0.658TrpAla: 0.658 ± 0.015
0.219TrpCys: 0.219 ± 0.009
0.603TrpAsp: 0.603 ± 0.015
0.575TrpGlu: 0.575 ± 0.014
0.497TrpPhe: 0.497 ± 0.013
0.595TrpGly: 0.595 ± 0.016
0.217TrpHis: 0.217 ± 0.008
0.572TrpIle: 0.572 ± 0.015
0.747TrpLys: 0.747 ± 0.015
0.925TrpLeu: 0.925 ± 0.017
0.225TrpMet: 0.225 ± 0.008
0.58TrpAsn: 0.58 ± 0.012
0.355TrpPro: 0.355 ± 0.012
0.357TrpGln: 0.357 ± 0.011
0.539TrpArg: 0.539 ± 0.014
0.862TrpSer: 0.862 ± 0.029
1.05TrpThr: 1.05 ± 0.068
0.639TrpVal: 0.639 ± 0.016
0.187TrpTrp: 0.187 ± 0.008
0.381TrpTyr: 0.381 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.923TyrAla: 1.923 ± 0.029
0.446TyrCys: 0.446 ± 0.013
1.838TyrAsp: 1.838 ± 0.029
1.924TyrGlu: 1.924 ± 0.028
1.499TyrPhe: 1.499 ± 0.022
1.895TyrGly: 1.895 ± 0.031
0.826TyrHis: 0.826 ± 0.016
1.69TyrIle: 1.69 ± 0.026
1.855TyrLys: 1.855 ± 0.029
2.966TyrLeu: 2.966 ± 0.033
0.691TyrMet: 0.691 ± 0.014
1.597TyrAsn: 1.597 ± 0.026
1.446TyrPro: 1.446 ± 0.028
1.224TyrGln: 1.224 ± 0.022
1.338TyrArg: 1.338 ± 0.022
2.69TyrSer: 2.69 ± 0.032
2.13TyrThr: 2.13 ± 0.066
1.879TyrVal: 1.879 ± 0.025
0.442TyrTrp: 0.442 ± 0.029
1.196TyrTyr: 1.196 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6652 proteins (3060062 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski