Amino acid dipepetide frequency for Plasmodium falciparum MaliPS096_E11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	0.901AlaAla: 0.901 ± 0.034	0.521AlaCys: 0.521 ± 0.018	1.071AlaAsp: 1.071 ± 0.02	1.183AlaGlu: 1.183 ± 0.029	0.947AlaPhe: 0.947 ± 0.017	0.742AlaGly: 0.742 ± 0.022	0.585AlaHis: 0.585 ± 0.013	1.622AlaIle: 1.622 ± 0.027	1.774AlaLys: 1.774 ± 0.031	1.915AlaLeu: 1.915 ± 0.031	0.375AlaMet: 0.375 ± 0.012	1.585AlaAsn: 1.585 ± 0.027	0.584AlaPro: 0.584 ± 0.018	0.697AlaGln: 0.697 ± 0.017	0.592AlaArg: 0.592 ± 0.016	1.488AlaSer: 1.488 ± 0.027	0.987AlaThr: 0.987 ± 0.026	0.858AlaVal: 0.858 ± 0.019	0.132AlaTrp: 0.132 ± 0.006	1.103AlaTyr: 1.103 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.555CysAla: 0.555 ± 0.014	0.332CysCys: 0.332 ± 0.01	1.281CysAsp: 1.281 ± 0.026	1.123CysGlu: 1.123 ± 0.019	0.866CysPhe: 0.866 ± 0.014	0.726CysGly: 0.726 ± 0.018	0.334CysHis: 0.334 ± 0.009	1.804CysIle: 1.804 ± 0.024	1.72CysLys: 1.72 ± 0.036	1.572CysLeu: 1.572 ± 0.025	0.379CysMet: 0.379 ± 0.012	1.937CysAsn: 1.937 ± 0.029	0.482CysPro: 0.482 ± 0.014	0.362CysGln: 0.362 ± 0.01	0.53CysArg: 0.53 ± 0.017	1.453CysSer: 1.453 ± 0.023	0.993CysThr: 0.993 ± 0.021	0.909CysVal: 0.909 ± 0.018	0.07CysTrp: 0.07 ± 0.004	0.855CysTyr: 0.855 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	1.226AspAla: 1.226 ± 0.027	0.704AspCys: 0.704 ± 0.015	6.505AspAsp: 6.505 ± 0.096	5.692AspGlu: 5.692 ± 0.06	2.15AspPhe: 2.15 ± 0.025	1.731AspGly: 1.731 ± 0.035	1.452AspHis: 1.452 ± 0.02	7.343AspIle: 7.343 ± 0.057	6.712AspLys: 6.712 ± 0.055	3.804AspLeu: 3.804 ± 0.039	1.71AspMet: 1.71 ± 0.026	8.707AspAsn: 8.707 ± 0.08	0.991AspPro: 0.991 ± 0.021	1.432AspGln: 1.432 ± 0.021	1.194AspArg: 1.194 ± 0.025	3.13AspSer: 3.13 ± 0.035	2.673AspThr: 2.673 ± 0.024	2.814AspVal: 2.814 ± 0.032	0.229AspTrp: 0.229 ± 0.01	2.84AspTyr: 2.84 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	1.448GluAla: 1.448 ± 0.032	1.124GluCys: 1.124 ± 0.022	4.659GluAsp: 4.659 ± 0.053	7.834GluGlu: 7.834 ± 0.156	2.05GluPhe: 2.05 ± 0.026	2.003GluGly: 2.003 ± 0.033	1.833GluHis: 1.833 ± 0.026	5.294GluIle: 5.294 ± 0.057	10.61GluLys: 10.61 ± 0.077	4.519GluLeu: 4.519 ± 0.056	1.372GluMet: 1.372 ± 0.021	8.949GluAsn: 8.949 ± 0.071	0.979GluPro: 0.979 ± 0.023	2.646GluGln: 2.646 ± 0.036	2.078GluArg: 2.078 ± 0.033	3.264GluSer: 3.264 ± 0.039	2.433GluThr: 2.433 ± 0.034	2.029GluVal: 2.029 ± 0.043	0.516GluTrp: 0.516 ± 0.021	3.72GluTyr: 3.72 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	0.814PheAla: 0.814 ± 0.019	1.023PheCys: 1.023 ± 0.018	2.481PheAsp: 2.481 ± 0.026	2.361PheGlu: 2.361 ± 0.032	3.632PhePhe: 3.632 ± 0.054	1.17PheGly: 1.17 ± 0.025	1.157PheHis: 1.157 ± 0.019	4.428PheIle: 4.428 ± 0.05	3.78PheLys: 3.78 ± 0.031	5.246PheLeu: 5.246 ± 0.054	0.924PheMet: 0.924 ± 0.017	4.413PheAsn: 4.413 ± 0.04	1.023PhePro: 1.023 ± 0.015	1.133PheGln: 1.133 ± 0.017	1.013PheArg: 1.013 ± 0.018	3.314PheSer: 3.314 ± 0.04	1.596PheThr: 1.596 ± 0.023	2.002PheVal: 2.002 ± 0.026	0.213PheTrp: 0.213 ± 0.007	2.995PheTyr: 2.995 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	0.837GlyAla: 0.837 ± 0.023	0.546GlyCys: 0.546 ± 0.015	2.076GlyAsp: 2.076 ± 0.04	1.874GlyGlu: 1.874 ± 0.032	1.088GlyPhe: 1.088 ± 0.024	1.509GlyGly: 1.509 ± 0.044	0.626GlyHis: 0.626 ± 0.015	2.403GlyIle: 2.403 ± 0.031	3.097GlyLys: 3.097 ± 0.039	1.945GlyLeu: 1.945 ± 0.027	0.599GlyMet: 0.599 ± 0.016	3.05GlyAsn: 3.05 ± 0.034	0.551GlyPro: 0.551 ± 0.016	0.693GlyGln: 0.693 ± 0.018	0.891GlyArg: 0.891 ± 0.02	1.983GlySer: 1.983 ± 0.038	1.492GlyThr: 1.492 ± 0.031	1.316GlyVal: 1.316 ± 0.024	0.173GlyTrp: 0.173 ± 0.007	1.475GlyTyr: 1.475 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	0.477HisAla: 0.477 ± 0.013	0.317HisCys: 0.317 ± 0.009	1.351HisAsp: 1.351 ± 0.022	1.314HisGlu: 1.314 ± 0.019	1.346HisPhe: 1.346 ± 0.02	0.604HisGly: 0.604 ± 0.015	0.748HisHis: 0.748 ± 0.022	2.962HisIle: 2.962 ± 0.034	2.316HisLys: 2.316 ± 0.032	1.927HisLeu: 1.927 ± 0.026	0.862HisMet: 0.862 ± 0.015	3.356HisAsn: 3.356 ± 0.041	0.553HisPro: 0.553 ± 0.011	0.526HisGln: 0.526 ± 0.014	0.534HisArg: 0.534 ± 0.013	1.4HisSer: 1.4 ± 0.022	1.159HisThr: 1.159 ± 0.02	1.134HisVal: 1.134 ± 0.021	0.091HisTrp: 0.091 ± 0.005	1.094HisTyr: 1.094 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	1.474IleAla: 1.474 ± 0.025	2.119IleCys: 2.119 ± 0.03	4.829IleAsp: 4.829 ± 0.041	5.147IleGlu: 5.147 ± 0.047	4.945IlePhe: 4.945 ± 0.057	2.203IleGly: 2.203 ± 0.029	2.633IleHis: 2.633 ± 0.03	8.64IleIle: 8.64 ± 0.079	10.822IleLys: 10.822 ± 0.086	8.506IleLeu: 8.506 ± 0.071	1.689IleMet: 1.689 ± 0.025	12.893IleAsn: 12.893 ± 0.122	2.359IlePro: 2.359 ± 0.03	2.981IleGln: 2.981 ± 0.033	2.314IleArg: 2.314 ± 0.028	6.223IleSer: 6.223 ± 0.051	3.53IleThr: 3.53 ± 0.036	2.88IleVal: 2.88 ± 0.037	0.525IleTrp: 0.525 ± 0.014	6.646IleTyr: 6.646 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	1.841LysAla: 1.841 ± 0.034	2.14LysCys: 2.14 ± 0.034	6.954LysAsp: 6.954 ± 0.06	10.118LysGlu: 10.118 ± 0.09	3.256LysPhe: 3.256 ± 0.029	3.458LysGly: 3.458 ± 0.041	2.383LysHis: 2.383 ± 0.027	9.665LysIle: 9.665 ± 0.066	20.047LysLys: 20.047 ± 0.156	7.54LysLeu: 7.54 ± 0.06	2.59LysMet: 2.59 ± 0.033	17.12LysAsn: 17.12 ± 0.129	1.488LysPro: 1.488 ± 0.027	3.178LysGln: 3.178 ± 0.037	4.295LysArg: 4.295 ± 0.04	6.205LysSer: 6.205 ± 0.055	4.237LysThr: 4.237 ± 0.037	3.37LysVal: 3.37 ± 0.033	0.651LysTrp: 0.651 ± 0.016	7.139LysTyr: 7.139 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	1.544LeuAla: 1.544 ± 0.029	1.856LeuCys: 1.856 ± 0.026	3.617LeuAsp: 3.617 ± 0.033	4.396LeuGlu: 4.396 ± 0.053	4.622LeuPhe: 4.622 ± 0.052	2.011LeuGly: 2.011 ± 0.03	1.885LeuHis: 1.885 ± 0.024	6.375LeuIle: 6.375 ± 0.053	9.233LeuLys: 9.233 ± 0.064	7.666LeuLeu: 7.666 ± 0.066	1.335LeuMet: 1.335 ± 0.021	8.928LeuAsn: 8.928 ± 0.061	1.832LeuPro: 1.832 ± 0.027	2.404LeuGln: 2.404 ± 0.028	2.387LeuArg: 2.387 ± 0.029	5.698LeuSer: 5.698 ± 0.048	2.924LeuThr: 2.924 ± 0.03	2.362LeuVal: 2.362 ± 0.031	0.49LeuTrp: 0.49 ± 0.013	5.151LeuTyr: 5.151 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	0.388MetAla: 0.388 ± 0.011	0.473MetCys: 0.473 ± 0.011	1.548MetAsp: 1.548 ± 0.024	1.5MetGlu: 1.5 ± 0.021	0.915MetPhe: 0.915 ± 0.017	0.589MetGly: 0.589 ± 0.016	0.445MetHis: 0.445 ± 0.011	1.583MetIle: 1.583 ± 0.022	2.902MetLys: 2.902 ± 0.033	1.715MetLeu: 1.715 ± 0.025	0.515MetMet: 0.515 ± 0.015	3.968MetAsn: 3.968 ± 0.063	0.4MetPro: 0.4 ± 0.012	0.528MetGln: 0.528 ± 0.012	0.553MetArg: 0.553 ± 0.012	1.407MetSer: 1.407 ± 0.021	0.688MetThr: 0.688 ± 0.016	0.69MetVal: 0.69 ± 0.015	0.126MetTrp: 0.126 ± 0.005	1.204MetTyr: 1.204 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	1.924AsnAla: 1.924 ± 0.027	1.637AsnCys: 1.637 ± 0.024	9.762AsnAsp: 9.762 ± 0.08	9.448AsnGlu: 9.448 ± 0.076	4.863AsnPhe: 4.863 ± 0.042	3.055AsnGly: 3.055 ± 0.051	2.783AsnHis: 2.783 ± 0.039	16.326AsnIle: 16.326 ± 0.153	15.486AsnLys: 15.486 ± 0.124	7.675AsnLeu: 7.675 ± 0.057	4.052AsnMet: 4.052 ± 0.068	32.265AsnAsn: 32.265 ± 0.465	1.713AsnPro: 1.713 ± 0.024	2.83AsnGln: 2.83 ± 0.038	2.491AsnArg: 2.491 ± 0.029	7.697AsnSer: 7.697 ± 0.084	5.47AsnThr: 5.47 ± 0.052	6.202AsnVal: 6.202 ± 0.06	0.341AsnTrp: 0.341 ± 0.011	7.17AsnTyr: 7.17 ± 0.079	0.0AsnXaa: 0.0 ± 0.0
Pro	0.446ProAla: 0.446 ± 0.016	0.463ProCys: 0.463 ± 0.016	0.826ProAsp: 0.826 ± 0.02	1.063ProGlu: 1.063 ± 0.023	1.239ProPhe: 1.239 ± 0.019	0.551ProGly: 0.551 ± 0.017	0.547ProHis: 0.547 ± 0.013	1.682ProIle: 1.682 ± 0.027	1.674ProLys: 1.674 ± 0.028	1.871ProLeu: 1.871 ± 0.022	0.372ProMet: 0.372 ± 0.01	1.994ProAsn: 1.994 ± 0.03	0.875ProPro: 0.875 ± 0.041	0.703ProGln: 0.703 ± 0.019	0.569ProArg: 0.569 ± 0.016	1.599ProSer: 1.599 ± 0.019	1.011ProThr: 1.011 ± 0.024	0.784ProVal: 0.784 ± 0.018	0.139ProTrp: 0.139 ± 0.006	1.322ProTyr: 1.322 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	0.596GlnAla: 0.596 ± 0.014	0.432GlnCys: 0.432 ± 0.011	1.391GlnAsp: 1.391 ± 0.02	1.969GlnGlu: 1.969 ± 0.03	0.996GlnPhe: 0.996 ± 0.017	0.77GlnGly: 0.77 ± 0.017	0.728GlnHis: 0.728 ± 0.015	2.471GlnIle: 2.471 ± 0.032	3.628GlnLys: 3.628 ± 0.038	1.934GlnLeu: 1.934 ± 0.027	0.694GlnMet: 0.694 ± 0.014	4.246GlnAsn: 4.246 ± 0.045	0.541GlnPro: 0.541 ± 0.015	1.101GlnGln: 1.101 ± 0.029	0.838GlnArg: 0.838 ± 0.016	1.439GlnSer: 1.439 ± 0.021	1.265GlnThr: 1.265 ± 0.019	0.942GlnVal: 0.942 ± 0.018	0.173GlnTrp: 0.173 ± 0.008	1.393GlnTyr: 1.393 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	0.652ArgAla: 0.652 ± 0.016	0.46ArgCys: 0.46 ± 0.01	1.508ArgAsp: 1.508 ± 0.03	1.775ArgGlu: 1.775 ± 0.028	0.985ArgPhe: 0.985 ± 0.019	0.985ArgGly: 0.985 ± 0.021	0.566ArgHis: 0.566 ± 0.013	2.193ArgIle: 2.193 ± 0.028	3.982ArgLys: 3.982 ± 0.035	1.763ArgLeu: 1.763 ± 0.025	0.533ArgMet: 0.533 ± 0.012	3.453ArgAsn: 3.453 ± 0.036	0.477ArgPro: 0.477 ± 0.015	0.713ArgGln: 0.713 ± 0.015	1.457ArgArg: 1.457 ± 0.028	1.638ArgSer: 1.638 ± 0.031	1.138ArgThr: 1.138 ± 0.02	0.889ArgVal: 0.889 ± 0.014	0.229ArgTrp: 0.229 ± 0.012	1.352ArgTyr: 1.352 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	1.398SerAla: 1.398 ± 0.029	1.263SerCys: 1.263 ± 0.02	3.897SerAsp: 3.897 ± 0.041	3.446SerGlu: 3.446 ± 0.041	3.613SerPhe: 3.613 ± 0.029	2.013SerGly: 2.013 ± 0.042	1.504SerHis: 1.504 ± 0.026	5.531SerIle: 5.531 ± 0.049	5.725SerLys: 5.725 ± 0.049	5.392SerLeu: 5.392 ± 0.04	1.209SerMet: 1.209 ± 0.021	8.125SerAsn: 8.125 ± 0.085	1.356SerPro: 1.356 ± 0.02	1.602SerGln: 1.602 ± 0.023	1.573SerArg: 1.573 ± 0.026	6.375SerSer: 6.375 ± 0.066	3.097SerThr: 3.097 ± 0.033	2.611SerVal: 2.611 ± 0.046	0.282SerTrp: 0.282 ± 0.009	3.872SerTyr: 3.872 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	0.917ThrAla: 0.917 ± 0.025	1.04ThrCys: 1.04 ± 0.019	2.031ThrAsp: 2.031 ± 0.027	2.082ThrGlu: 2.082 ± 0.052	2.249ThrPhe: 2.249 ± 0.025	1.111ThrGly: 1.111 ± 0.022	1.2ThrHis: 1.2 ± 0.019	3.164ThrIle: 3.164 ± 0.03	4.108ThrLys: 4.108 ± 0.035	3.443ThrLeu: 3.443 ± 0.036	0.687ThrMet: 0.687 ± 0.014	5.72ThrAsn: 5.72 ± 0.056	1.169ThrPro: 1.169 ± 0.026	1.36ThrGln: 1.36 ± 0.022	0.948ThrArg: 0.948 ± 0.016	3.199ThrSer: 3.199 ± 0.028	2.268ThrThr: 2.268 ± 0.035	1.337ThrVal: 1.337 ± 0.024	0.229ThrTrp: 0.229 ± 0.008	2.822ThrTyr: 2.822 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	0.939ValAla: 0.939 ± 0.023	0.86ValCys: 0.86 ± 0.017	2.614ValAsp: 2.614 ± 0.03	2.737ValGlu: 2.737 ± 0.051	1.624ValPhe: 1.624 ± 0.024	1.273ValGly: 1.273 ± 0.024	1.232ValHis: 1.232 ± 0.017	3.038ValIle: 3.038 ± 0.031	3.589ValLys: 3.589 ± 0.034	3.365ValLeu: 3.365 ± 0.032	0.687ValMet: 0.687 ± 0.012	3.994ValAsn: 3.994 ± 0.043	1.118ValPro: 1.118 ± 0.022	1.351ValGln: 1.351 ± 0.022	1.009ValArg: 1.009 ± 0.018	2.569ValSer: 2.569 ± 0.038	1.612ValThr: 1.612 ± 0.031	1.67ValVal: 1.67 ± 0.028	0.239ValTrp: 0.239 ± 0.009	1.988ValTyr: 1.988 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	0.164TrpAla: 0.164 ± 0.009	0.1TrpCys: 0.1 ± 0.005	0.294TrpAsp: 0.294 ± 0.009	0.327TrpGlu: 0.327 ± 0.013	0.263TrpPhe: 0.263 ± 0.009	0.22TrpGly: 0.22 ± 0.009	0.087TrpHis: 0.087 ± 0.005	0.488TrpIle: 0.488 ± 0.012	0.68TrpLys: 0.68 ± 0.019	0.43TrpLeu: 0.43 ± 0.013	0.115TrpMet: 0.115 ± 0.006	0.542TrpAsn: 0.542 ± 0.014	0.1TrpPro: 0.1 ± 0.005	0.092TrpGln: 0.092 ± 0.005	0.182TrpArg: 0.182 ± 0.007	0.318TrpSer: 0.318 ± 0.01	0.206TrpThr: 0.206 ± 0.008	0.238TrpVal: 0.238 ± 0.009	0.109TrpTrp: 0.109 ± 0.008	0.223TrpTyr: 0.223 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.12TyrAla: 1.12 ± 0.019	0.873TyrCys: 0.873 ± 0.019	4.345TyrAsp: 4.345 ± 0.049	3.968TyrGlu: 3.968 ± 0.038	3.069TyrPhe: 3.069 ± 0.036	1.499TyrGly: 1.499 ± 0.023	1.342TyrHis: 1.342 ± 0.026	6.344TyrIle: 6.344 ± 0.065	5.787TyrLys: 5.787 ± 0.051	4.489TyrLeu: 4.489 ± 0.048	1.436TyrMet: 1.436 ± 0.021	7.945TyrAsn: 7.945 ± 0.084	1.14TyrPro: 1.14 ± 0.019	1.216TyrGln: 1.216 ± 0.02	1.303TyrArg: 1.303 ± 0.018	3.486TyrSer: 3.486 ± 0.034	2.307TyrThr: 2.307 ± 0.026	2.473TyrVal: 2.473 ± 0.028	0.224TyrTrp: 0.224 ± 0.008	3.527TyrTyr: 3.527 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6301 proteins (3932225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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