Amino acid dipepetide frequency for Paenibacillus sp. 1_12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.784AlaAla: 7.784 ± 0.092	0.671AlaCys: 0.671 ± 0.019	3.912AlaAsp: 3.912 ± 0.049	4.692AlaGlu: 4.692 ± 0.054	3.19AlaPhe: 3.19 ± 0.044	5.579AlaGly: 5.579 ± 0.072	1.358AlaHis: 1.358 ± 0.03	5.485AlaIle: 5.485 ± 0.061	4.128AlaLys: 4.128 ± 0.047	7.526AlaLeu: 7.526 ± 0.074	2.111AlaMet: 2.111 ± 0.035	2.852AlaAsn: 2.852 ± 0.038	2.569AlaPro: 2.569 ± 0.056	2.834AlaGln: 2.834 ± 0.04	2.962AlaArg: 2.962 ± 0.045	5.022AlaSer: 5.022 ± 0.066	3.786AlaThr: 3.786 ± 0.084	5.787AlaVal: 5.787 ± 0.06	0.821AlaTrp: 0.821 ± 0.02	2.619AlaTyr: 2.619 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.511CysAla: 0.511 ± 0.016	0.118CysCys: 0.118 ± 0.007	0.375CysAsp: 0.375 ± 0.013	0.458CysGlu: 0.458 ± 0.016	0.358CysPhe: 0.358 ± 0.012	0.679CysGly: 0.679 ± 0.02	0.206CysHis: 0.206 ± 0.011	0.584CysIle: 0.584 ± 0.018	0.381CysLys: 0.381 ± 0.015	0.787CysLeu: 0.787 ± 0.019	0.233CysMet: 0.233 ± 0.01	0.29CysAsn: 0.29 ± 0.013	0.313CysPro: 0.313 ± 0.012	0.23CysGln: 0.23 ± 0.011	0.403CysArg: 0.403 ± 0.014	0.651CysSer: 0.651 ± 0.017	0.432CysThr: 0.432 ± 0.014	0.459CysVal: 0.459 ± 0.014	0.097CysTrp: 0.097 ± 0.007	0.29CysTyr: 0.29 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.571AspAla: 3.571 ± 0.042	0.425AspCys: 0.425 ± 0.014	2.318AspAsp: 2.318 ± 0.037	3.476AspGlu: 3.476 ± 0.051	2.164AspPhe: 2.164 ± 0.033	3.762AspGly: 3.762 ± 0.044	1.207AspHis: 1.207 ± 0.027	3.632AspIle: 3.632 ± 0.046	3.08AspLys: 3.08 ± 0.043	4.947AspLeu: 4.947 ± 0.047	1.336AspMet: 1.336 ± 0.023	1.995AspAsn: 1.995 ± 0.034	2.271AspPro: 2.271 ± 0.035	2.155AspGln: 2.155 ± 0.031	2.415AspArg: 2.415 ± 0.033	3.017AspSer: 3.017 ± 0.041	2.692AspThr: 2.692 ± 0.037	3.366AspVal: 3.366 ± 0.04	0.862AspTrp: 0.862 ± 0.021	2.153AspTyr: 2.153 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.353GluAla: 5.353 ± 0.063	0.38GluCys: 0.38 ± 0.013	2.851GluAsp: 2.851 ± 0.041	4.473GluGlu: 4.473 ± 0.069	2.193GluPhe: 2.193 ± 0.036	3.86GluGly: 3.86 ± 0.053	1.558GluHis: 1.558 ± 0.032	4.418GluIle: 4.418 ± 0.05	3.819GluLys: 3.819 ± 0.052	6.959GluLeu: 6.959 ± 0.084	1.94GluMet: 1.94 ± 0.034	2.391GluAsn: 2.391 ± 0.033	2.093GluPro: 2.093 ± 0.034	3.84GluGln: 3.84 ± 0.056	3.392GluArg: 3.392 ± 0.051	3.615GluSer: 3.615 ± 0.045	3.23GluThr: 3.23 ± 0.042	4.201GluVal: 4.201 ± 0.054	0.909GluTrp: 0.909 ± 0.021	1.909GluTyr: 1.909 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.009PheAla: 3.009 ± 0.043	0.358PheCys: 0.358 ± 0.013	2.338PheAsp: 2.338 ± 0.031	2.469PheGlu: 2.469 ± 0.031	1.937PhePhe: 1.937 ± 0.038	2.995PheGly: 2.995 ± 0.041	0.97PheHis: 0.97 ± 0.024	3.249PheIle: 3.249 ± 0.047	2.281PheLys: 2.281 ± 0.038	3.885PheLeu: 3.885 ± 0.055	1.172PheMet: 1.172 ± 0.025	1.816PheAsn: 1.816 ± 0.032	1.651PhePro: 1.651 ± 0.028	1.574PheGln: 1.574 ± 0.029	1.849PheArg: 1.849 ± 0.03	2.959PheSer: 2.959 ± 0.031	2.66PheThr: 2.66 ± 0.038	2.968PheVal: 2.968 ± 0.039	0.539PheTrp: 0.539 ± 0.018	1.543PheTyr: 1.543 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.043GlyAla: 5.043 ± 0.08	0.73GlyCys: 0.73 ± 0.019	3.21GlyAsp: 3.21 ± 0.044	3.879GlyGlu: 3.879 ± 0.057	3.141GlyPhe: 3.141 ± 0.041	4.873GlyGly: 4.873 ± 0.075	1.455GlyHis: 1.455 ± 0.028	5.721GlyIle: 5.721 ± 0.056	4.546GlyLys: 4.546 ± 0.056	6.889GlyLeu: 6.889 ± 0.066	2.231GlyMet: 2.231 ± 0.035	2.824GlyAsn: 2.824 ± 0.049	1.798GlyPro: 1.798 ± 0.034	2.541GlyGln: 2.541 ± 0.038	2.924GlyArg: 2.924 ± 0.039	4.857GlySer: 4.857 ± 0.059	4.39GlyThr: 4.39 ± 0.071	4.947GlyVal: 4.947 ± 0.055	1.01GlyTrp: 1.01 ± 0.024	2.772GlyTyr: 2.772 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.475HisAla: 1.475 ± 0.026	0.211HisCys: 0.211 ± 0.01	1.069HisAsp: 1.069 ± 0.024	1.258HisGlu: 1.258 ± 0.025	1.084HisPhe: 1.084 ± 0.022	1.457HisGly: 1.457 ± 0.03	0.662HisHis: 0.662 ± 0.022	1.658HisIle: 1.658 ± 0.026	1.001HisLys: 1.001 ± 0.022	2.113HisLeu: 2.113 ± 0.038	0.604HisMet: 0.604 ± 0.017	0.82HisAsn: 0.82 ± 0.017	1.134HisPro: 1.134 ± 0.026	0.856HisGln: 0.856 ± 0.02	1.048HisArg: 1.048 ± 0.025	1.309HisSer: 1.309 ± 0.026	1.172HisThr: 1.172 ± 0.027	1.388HisVal: 1.388 ± 0.026	0.35HisTrp: 0.35 ± 0.013	0.909HisTyr: 0.909 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.651IleAla: 5.651 ± 0.055	0.664IleCys: 0.664 ± 0.017	3.996IleAsp: 3.996 ± 0.042	4.609IleGlu: 4.609 ± 0.054	2.677IlePhe: 2.677 ± 0.042	5.476IleGly: 5.476 ± 0.054	1.675IleHis: 1.675 ± 0.027	4.975IleIle: 4.975 ± 0.061	3.572IleLys: 3.572 ± 0.047	6.344IleLeu: 6.344 ± 0.066	1.805IleMet: 1.805 ± 0.032	2.982IleAsn: 2.982 ± 0.042	3.369IlePro: 3.369 ± 0.044	3.016IleGln: 3.016 ± 0.04	3.663IleArg: 3.663 ± 0.049	5.153IleSer: 5.153 ± 0.048	4.306IleThr: 4.306 ± 0.049	5.403IleVal: 5.403 ± 0.056	0.84IleTrp: 0.84 ± 0.022	2.317IleTyr: 2.317 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.335LysAla: 4.335 ± 0.061	0.268LysCys: 0.268 ± 0.011	3.171LysAsp: 3.171 ± 0.04	4.39LysGlu: 4.39 ± 0.051	1.743LysPhe: 1.743 ± 0.031	3.749LysGly: 3.749 ± 0.046	1.227LysHis: 1.227 ± 0.026	3.572LysIle: 3.572 ± 0.038	3.729LysLys: 3.729 ± 0.057	6.013LysLeu: 6.013 ± 0.063	1.779LysMet: 1.779 ± 0.029	2.367LysAsn: 2.367 ± 0.041	2.411LysPro: 2.411 ± 0.037	2.943LysGln: 2.943 ± 0.043	2.752LysArg: 2.752 ± 0.038	3.402LysSer: 3.402 ± 0.038	2.996LysThr: 2.996 ± 0.042	3.866LysVal: 3.866 ± 0.047	0.751LysTrp: 0.751 ± 0.018	1.94LysTyr: 1.94 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	7.478LeuAla: 7.478 ± 0.063	0.864LeuCys: 0.864 ± 0.02	5.072LeuAsp: 5.072 ± 0.055	6.0LeuGlu: 6.0 ± 0.071	4.598LeuPhe: 4.598 ± 0.057	6.48LeuGly: 6.48 ± 0.061	2.145LeuHis: 2.145 ± 0.035	7.053LeuIle: 7.053 ± 0.068	5.752LeuLys: 5.752 ± 0.051	11.101LeuLeu: 11.101 ± 0.108	2.721LeuMet: 2.721 ± 0.036	4.334LeuAsn: 4.334 ± 0.047	4.352LeuPro: 4.352 ± 0.048	4.504LeuGln: 4.504 ± 0.056	4.503LeuArg: 4.503 ± 0.062	7.382LeuSer: 7.382 ± 0.065	5.753LeuThr: 5.753 ± 0.055	6.271LeuVal: 6.271 ± 0.057	1.094LeuTrp: 1.094 ± 0.023	3.358LeuTyr: 3.358 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.064MetAla: 2.064 ± 0.029	0.173MetCys: 0.173 ± 0.009	1.65MetAsp: 1.65 ± 0.027	1.934MetGlu: 1.934 ± 0.029	1.053MetPhe: 1.053 ± 0.021	1.781MetGly: 1.781 ± 0.034	0.489MetHis: 0.489 ± 0.015	2.126MetIle: 2.126 ± 0.037	2.134MetLys: 2.134 ± 0.031	3.03MetLeu: 3.03 ± 0.038	0.919MetMet: 0.919 ± 0.025	1.62MetAsn: 1.62 ± 0.027	1.089MetPro: 1.089 ± 0.022	1.047MetGln: 1.047 ± 0.021	1.193MetArg: 1.193 ± 0.027	1.867MetSer: 1.867 ± 0.033	1.624MetThr: 1.624 ± 0.025	1.83MetVal: 1.83 ± 0.032	0.253MetTrp: 0.253 ± 0.012	0.834MetTyr: 0.834 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.882AsnAla: 2.882 ± 0.044	0.289AsnCys: 0.289 ± 0.011	2.12AsnAsp: 2.12 ± 0.033	2.8AsnGlu: 2.8 ± 0.038	1.518AsnPhe: 1.518 ± 0.032	3.445AsnGly: 3.445 ± 0.061	1.001AsnHis: 1.001 ± 0.022	2.686AsnIle: 2.686 ± 0.043	2.593AsnLys: 2.593 ± 0.042	3.624AsnLeu: 3.624 ± 0.05	1.135AsnMet: 1.135 ± 0.022	1.948AsnAsn: 1.948 ± 0.043	2.175AsnPro: 2.175 ± 0.035	1.907AsnGln: 1.907 ± 0.028	2.138AsnArg: 2.138 ± 0.034	2.567AsnSer: 2.567 ± 0.043	2.325AsnThr: 2.325 ± 0.042	2.837AsnVal: 2.837 ± 0.04	0.577AsnTrp: 0.577 ± 0.016	1.551AsnTyr: 1.551 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	2.966ProAla: 2.966 ± 0.05	0.247ProCys: 0.247 ± 0.01	2.406ProAsp: 2.406 ± 0.037	2.947ProGlu: 2.947 ± 0.043	1.877ProPhe: 1.877 ± 0.029	2.499ProGly: 2.499 ± 0.045	0.889ProHis: 0.889 ± 0.019	2.854ProIle: 2.854 ± 0.041	1.89ProLys: 1.89 ± 0.038	3.95ProLeu: 3.95 ± 0.043	1.053ProMet: 1.053 ± 0.023	1.758ProAsn: 1.758 ± 0.028	1.169ProPro: 1.169 ± 0.026	1.519ProGln: 1.519 ± 0.029	1.295ProArg: 1.295 ± 0.023	2.694ProSer: 2.694 ± 0.039	2.179ProThr: 2.179 ± 0.039	2.979ProVal: 2.979 ± 0.046	0.492ProTrp: 0.492 ± 0.016	1.574ProTyr: 1.574 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.471GlnAla: 3.471 ± 0.042	0.219GlnCys: 0.219 ± 0.011	1.793GlnAsp: 1.793 ± 0.033	2.731GlnGlu: 2.731 ± 0.043	1.766GlnPhe: 1.766 ± 0.029	2.712GlnGly: 2.712 ± 0.041	0.892GlnHis: 0.892 ± 0.021	2.981GlnIle: 2.981 ± 0.039	2.164GlnLys: 2.164 ± 0.032	4.846GlnLeu: 4.846 ± 0.06	1.298GlnMet: 1.298 ± 0.026	1.528GlnAsn: 1.528 ± 0.03	1.617GlnPro: 1.617 ± 0.029	2.371GlnGln: 2.371 ± 0.041	1.898GlnArg: 1.898 ± 0.032	2.592GlnSer: 2.592 ± 0.039	2.295GlnThr: 2.295 ± 0.034	2.76GlnVal: 2.76 ± 0.042	0.572GlnTrp: 0.572 ± 0.018	1.474GlnTyr: 1.474 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	2.8ArgAla: 2.8 ± 0.033	0.335ArgCys: 0.335 ± 0.013	2.204ArgAsp: 2.204 ± 0.032	3.037ArgGlu: 3.037 ± 0.054	2.168ArgPhe: 2.168 ± 0.035	2.563ArgGly: 2.563 ± 0.034	0.928ArgHis: 0.928 ± 0.021	3.658ArgIle: 3.658 ± 0.042	2.95ArgLys: 2.95 ± 0.037	4.791ArgLeu: 4.791 ± 0.059	1.548ArgMet: 1.548 ± 0.03	2.036ArgAsn: 2.036 ± 0.034	1.497ArgPro: 1.497 ± 0.029	1.863ArgGln: 1.863 ± 0.033	2.103ArgArg: 2.103 ± 0.039	2.916ArgSer: 2.916 ± 0.041	2.429ArgThr: 2.429 ± 0.032	2.853ArgVal: 2.853 ± 0.04	0.643ArgTrp: 0.643 ± 0.019	1.733ArgTyr: 1.733 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	4.611SerAla: 4.611 ± 0.065	0.491SerCys: 0.491 ± 0.017	3.207SerAsp: 3.207 ± 0.039	3.869SerGlu: 3.869 ± 0.043	3.151SerPhe: 3.151 ± 0.038	5.285SerGly: 5.285 ± 0.055	1.269SerHis: 1.269 ± 0.027	4.988SerIle: 4.988 ± 0.052	3.847SerLys: 3.847 ± 0.047	6.717SerLeu: 6.717 ± 0.062	1.98SerMet: 1.98 ± 0.029	2.826SerAsn: 2.826 ± 0.042	2.44SerPro: 2.44 ± 0.039	2.334SerGln: 2.334 ± 0.034	2.957SerArg: 2.957 ± 0.042	4.927SerSer: 4.927 ± 0.069	3.729SerThr: 3.729 ± 0.055	4.577SerVal: 4.577 ± 0.057	0.896SerTrp: 0.896 ± 0.022	2.535SerTyr: 2.535 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.574ThrAla: 4.574 ± 0.069	0.376ThrCys: 0.376 ± 0.013	2.969ThrAsp: 2.969 ± 0.043	3.236ThrGlu: 3.236 ± 0.04	2.425ThrPhe: 2.425 ± 0.035	4.57ThrGly: 4.57 ± 0.124	1.126ThrHis: 1.126 ± 0.023	4.383ThrIle: 4.383 ± 0.05	2.842ThrLys: 2.842 ± 0.038	5.583ThrLeu: 5.583 ± 0.058	1.453ThrMet: 1.453 ± 0.028	2.392ThrAsn: 2.392 ± 0.045	2.557ThrPro: 2.557 ± 0.045	1.845ThrGln: 1.845 ± 0.026	2.137ThrArg: 2.137 ± 0.03	3.653ThrSer: 3.653 ± 0.058	3.218ThrThr: 3.218 ± 0.055	4.379ThrVal: 4.379 ± 0.059	0.693ThrTrp: 0.693 ± 0.021	2.048ThrTyr: 2.048 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	4.838ValAla: 4.838 ± 0.053	0.625ValCys: 0.625 ± 0.018	3.533ValAsp: 3.533 ± 0.041	4.145ValGlu: 4.145 ± 0.048	2.941ValPhe: 2.941 ± 0.041	4.548ValGly: 4.548 ± 0.052	1.44ValHis: 1.44 ± 0.026	5.192ValIle: 5.192 ± 0.057	3.984ValLys: 3.984 ± 0.045	6.818ValLeu: 6.818 ± 0.064	1.974ValMet: 1.974 ± 0.029	3.034ValAsn: 3.034 ± 0.04	2.829ValPro: 2.829 ± 0.043	2.723ValGln: 2.723 ± 0.034	3.013ValArg: 3.013 ± 0.042	4.9ValSer: 4.9 ± 0.056	4.487ValThr: 4.487 ± 0.078	4.948ValVal: 4.948 ± 0.056	0.855ValTrp: 0.855 ± 0.023	2.324ValTyr: 2.324 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.784TrpAla: 0.784 ± 0.021	0.098TrpCys: 0.098 ± 0.007	0.702TrpAsp: 0.702 ± 0.02	0.742TrpGlu: 0.742 ± 0.023	0.594TrpPhe: 0.594 ± 0.017	0.9TrpGly: 0.9 ± 0.022	0.294TrpHis: 0.294 ± 0.012	0.949TrpIle: 0.949 ± 0.025	0.81TrpLys: 0.81 ± 0.02	1.449TrpLeu: 1.449 ± 0.029	0.429TrpMet: 0.429 ± 0.014	0.723TrpAsn: 0.723 ± 0.02	0.338TrpPro: 0.338 ± 0.013	0.497TrpGln: 0.497 ± 0.016	0.56TrpArg: 0.56 ± 0.017	0.854TrpSer: 0.854 ± 0.023	0.711TrpThr: 0.711 ± 0.019	0.879TrpVal: 0.879 ± 0.023	0.168TrpTrp: 0.168 ± 0.009	0.414TrpTyr: 0.414 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.488TyrAla: 2.488 ± 0.037	0.316TyrCys: 0.316 ± 0.012	1.949TyrAsp: 1.949 ± 0.038	2.239TyrGlu: 2.239 ± 0.029	1.642TyrPhe: 1.642 ± 0.029	2.567TyrGly: 2.567 ± 0.041	0.784TyrHis: 0.784 ± 0.017	2.333TyrIle: 2.333 ± 0.034	1.899TyrLys: 1.899 ± 0.031	3.447TyrLeu: 3.447 ± 0.042	0.989TyrMet: 0.989 ± 0.022	1.581TyrAsn: 1.581 ± 0.03	1.565TyrPro: 1.565 ± 0.028	1.382TyrGln: 1.382 ± 0.024	1.851TyrArg: 1.851 ± 0.033	2.299TyrSer: 2.299 ± 0.035	2.045TyrThr: 2.045 ± 0.034	2.45TyrVal: 2.45 ± 0.039	0.472TyrTrp: 0.472 ± 0.017	1.403TyrTyr: 1.403 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6757 proteins (2176029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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