Amino acid dipepetide frequency for Riesia pediculicola (strain USDA)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.725AlaAla: 1.725 ± 0.12
0.538AlaCys: 0.538 ± 0.058
1.148AlaAsp: 1.148 ± 0.096
1.765AlaGlu: 1.765 ± 0.133
1.646AlaPhe: 1.646 ± 0.117
1.883AlaGly: 1.883 ± 0.11
0.636AlaHis: 0.636 ± 0.068
4.369AlaIle: 4.369 ± 0.193
2.985AlaLys: 2.985 ± 0.129
2.847AlaLeu: 2.847 ± 0.12
0.879AlaMet: 0.879 ± 0.084
1.627AlaAsn: 1.627 ± 0.112
0.636AlaPro: 0.636 ± 0.058
0.781AlaGln: 0.781 ± 0.073
1.745AlaArg: 1.745 ± 0.123
2.67AlaSer: 2.67 ± 0.126
1.496AlaThr: 1.496 ± 0.106
2.02AlaVal: 2.02 ± 0.134
0.19AlaTrp: 0.19 ± 0.032
1.181AlaTyr: 1.181 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.492CysAla: 0.492 ± 0.057
0.151CysCys: 0.151 ± 0.031
0.63CysAsp: 0.63 ± 0.073
0.505CysGlu: 0.505 ± 0.056
0.912CysPhe: 0.912 ± 0.078
0.787CysGly: 0.787 ± 0.072
0.308CysHis: 0.308 ± 0.042
1.273CysIle: 1.273 ± 0.083
0.879CysLys: 0.879 ± 0.081
1.227CysLeu: 1.227 ± 0.109
0.275CysMet: 0.275 ± 0.043
0.695CysAsn: 0.695 ± 0.061
0.407CysPro: 0.407 ± 0.058
0.472CysGln: 0.472 ± 0.057
0.663CysArg: 0.663 ± 0.065
1.22CysSer: 1.22 ± 0.095
0.525CysThr: 0.525 ± 0.064
0.63CysVal: 0.63 ± 0.06
0.144CysTrp: 0.144 ± 0.026
0.407CysTyr: 0.407 ± 0.054
0.0CysXaa: 0.0 ± 0.0
Asp
1.345AspAla: 1.345 ± 0.091
0.512AspCys: 0.512 ± 0.06
1.41AspAsp: 1.41 ± 0.086
2.348AspGlu: 2.348 ± 0.143
2.801AspPhe: 2.801 ± 0.13
2.23AspGly: 2.23 ± 0.13
1.194AspHis: 1.194 ± 0.081
4.788AspIle: 4.788 ± 0.181
3.122AspLys: 3.122 ± 0.146
5.136AspLeu: 5.136 ± 0.189
1.023AspMet: 1.023 ± 0.08
1.574AspAsn: 1.574 ± 0.105
1.581AspPro: 1.581 ± 0.1
2.479AspGln: 2.479 ± 0.138
2.407AspArg: 2.407 ± 0.11
3.03AspSer: 3.03 ± 0.153
1.515AspThr: 1.515 ± 0.109
2.361AspVal: 2.361 ± 0.147
0.544AspTrp: 0.544 ± 0.056
1.633AspTyr: 1.633 ± 0.112
0.0AspXaa: 0.0 ± 0.0
Glu
1.981GluAla: 1.981 ± 0.127
0.518GluCys: 0.518 ± 0.054
2.676GluAsp: 2.676 ± 0.127
4.29GluGlu: 4.29 ± 0.197
2.355GluPhe: 2.355 ± 0.148
2.617GluGly: 2.617 ± 0.18
0.761GluHis: 0.761 ± 0.068
8.016GluIle: 8.016 ± 0.27
8.508GluLys: 8.508 ± 0.262
4.362GluLeu: 4.362 ± 0.165
1.581GluMet: 1.581 ± 0.11
4.579GluAsn: 4.579 ± 0.186
1.056GluPro: 1.056 ± 0.094
1.154GluGln: 1.154 ± 0.089
3.116GluArg: 3.116 ± 0.149
3.811GluSer: 3.811 ± 0.162
2.112GluThr: 2.112 ± 0.134
3.372GluVal: 3.372 ± 0.163
0.413GluTrp: 0.413 ± 0.059
1.778GluTyr: 1.778 ± 0.109
0.0GluXaa: 0.0 ± 0.0
Phe
1.338PheAla: 1.338 ± 0.082
1.017PheCys: 1.017 ± 0.077
2.545PheAsp: 2.545 ± 0.138
2.807PheGlu: 2.807 ± 0.147
5.077PhePhe: 5.077 ± 0.289
3.588PheGly: 3.588 ± 0.174
1.391PheHis: 1.391 ± 0.093
4.854PheIle: 4.854 ± 0.232
4.185PheLys: 4.185 ± 0.169
7.517PheLeu: 7.517 ± 0.326
1.004PheMet: 1.004 ± 0.077
2.683PheAsn: 2.683 ± 0.135
2.171PhePro: 2.171 ± 0.117
2.689PheGln: 2.689 ± 0.125
2.44PheArg: 2.44 ± 0.118
6.133PheSer: 6.133 ± 0.262
1.528PheThr: 1.528 ± 0.119
2.414PheVal: 2.414 ± 0.129
0.551PheTrp: 0.551 ± 0.067
2.256PheTyr: 2.256 ± 0.129
0.0PheXaa: 0.0 ± 0.0
Gly
2.145GlyAla: 2.145 ± 0.134
0.945GlyCys: 0.945 ± 0.085
2.165GlyAsp: 2.165 ± 0.134
2.794GlyGlu: 2.794 ± 0.14
2.676GlyPhe: 2.676 ± 0.156
3.693GlyGly: 3.693 ± 0.197
1.102GlyHis: 1.102 ± 0.09
6.54GlyIle: 6.54 ± 0.26
5.556GlyLys: 5.556 ± 0.204
4.513GlyLeu: 4.513 ± 0.177
1.555GlyMet: 1.555 ± 0.103
2.722GlyAsn: 2.722 ± 0.14
1.161GlyPro: 1.161 ± 0.091
1.312GlyGln: 1.312 ± 0.092
2.65GlyArg: 2.65 ± 0.151
4.329GlySer: 4.329 ± 0.176
2.729GlyThr: 2.729 ± 0.162
3.017GlyVal: 3.017 ± 0.166
0.453GlyTrp: 0.453 ± 0.06
2.138GlyTyr: 2.138 ± 0.128
0.0GlyXaa: 0.0 ± 0.0
His
0.781HisAla: 0.781 ± 0.073
0.249HisCys: 0.249 ± 0.043
0.643HisAsp: 0.643 ± 0.077
0.918HisGlu: 0.918 ± 0.068
1.279HisPhe: 1.279 ± 0.098
1.128HisGly: 1.128 ± 0.104
0.505HisHis: 0.505 ± 0.067
1.935HisIle: 1.935 ± 0.11
1.351HisLys: 1.351 ± 0.095
2.25HisLeu: 2.25 ± 0.123
0.361HisMet: 0.361 ± 0.051
0.754HisAsn: 0.754 ± 0.066
1.154HisPro: 1.154 ± 0.095
0.899HisGln: 0.899 ± 0.082
1.017HisArg: 1.017 ± 0.091
1.633HisSer: 1.633 ± 0.089
0.859HisThr: 0.859 ± 0.072
1.023HisVal: 1.023 ± 0.083
0.138HisTrp: 0.138 ± 0.03
0.794HisTyr: 0.794 ± 0.088
0.0HisXaa: 0.0 ± 0.0
Ile
4.415IleAla: 4.415 ± 0.162
1.437IleCys: 1.437 ± 0.1
6.074IleAsp: 6.074 ± 0.195
6.953IleGlu: 6.953 ± 0.239
7.065IlePhe: 7.065 ± 0.312
7.104IleGly: 7.104 ± 0.243
2.388IleHis: 2.388 ± 0.121
10.062IleIle: 10.062 ± 0.315
9.472IleLys: 9.472 ± 0.245
11.807IleLeu: 11.807 ± 0.327
2.112IleMet: 2.112 ± 0.13
6.133IleAsn: 6.133 ± 0.2
3.549IlePro: 3.549 ± 0.145
4.211IleGln: 4.211 ± 0.157
6.022IleArg: 6.022 ± 0.194
10.954IleSer: 10.954 ± 0.271
3.909IleThr: 3.909 ± 0.163
6.52IleVal: 6.52 ± 0.199
0.984IleTrp: 0.984 ± 0.079
3.726IleTyr: 3.726 ± 0.19
0.0IleXaa: 0.0 ± 0.0
Lys
2.099LysAla: 2.099 ± 0.116
0.741LysCys: 0.741 ± 0.069
4.5LysAsp: 4.5 ± 0.161
7.288LysGlu: 7.288 ± 0.205
4.821LysPhe: 4.821 ± 0.178
3.641LysGly: 3.641 ± 0.167
1.253LysHis: 1.253 ± 0.09
15.08LysIle: 15.08 ± 0.354
17.094LysLys: 17.094 ± 0.397
7.661LysLeu: 7.661 ± 0.221
2.919LysMet: 2.919 ± 0.141
9.505LysAsn: 9.505 ± 0.292
1.653LysPro: 1.653 ± 0.101
1.863LysGln: 1.863 ± 0.121
5.425LysArg: 5.425 ± 0.224
6.468LysSer: 6.468 ± 0.209
3.752LysThr: 3.752 ± 0.154
5.057LysVal: 5.057 ± 0.192
0.571LysTrp: 0.571 ± 0.059
3.752LysTyr: 3.752 ± 0.174
0.0LysXaa: 0.0 ± 0.0
Leu
3.135LeuAla: 3.135 ± 0.138
1.233LeuCys: 1.233 ± 0.085
3.949LeuAsp: 3.949 ± 0.134
5.838LeuGlu: 5.838 ± 0.199
5.169LeuPhe: 5.169 ± 0.272
4.585LeuGly: 4.585 ± 0.165
1.725LeuHis: 1.725 ± 0.102
10.495LeuIle: 10.495 ± 0.36
10.712LeuLys: 10.712 ± 0.278
7.95LeuLeu: 7.95 ± 0.294
2.217LeuMet: 2.217 ± 0.108
5.963LeuAsn: 5.963 ± 0.227
2.637LeuPro: 2.637 ± 0.127
2.473LeuGln: 2.473 ± 0.105
4.454LeuArg: 4.454 ± 0.194
8.56LeuSer: 8.56 ± 0.278
3.7LeuThr: 3.7 ± 0.16
4.579LeuVal: 4.579 ± 0.157
0.676LeuTrp: 0.676 ± 0.073
3.044LeuTyr: 3.044 ± 0.15
0.0LeuXaa: 0.0 ± 0.0
Met
0.754MetAla: 0.754 ± 0.085
0.171MetCys: 0.171 ± 0.035
1.017MetAsp: 1.017 ± 0.086
1.207MetGlu: 1.207 ± 0.096
1.115MetPhe: 1.115 ± 0.099
1.273MetGly: 1.273 ± 0.101
0.42MetHis: 0.42 ± 0.047
3.116MetIle: 3.116 ± 0.141
3.135MetLys: 3.135 ± 0.146
2.001MetLeu: 2.001 ± 0.128
0.676MetMet: 0.676 ± 0.062
1.824MetAsn: 1.824 ± 0.111
0.492MetPro: 0.492 ± 0.053
0.538MetGln: 0.538 ± 0.06
1.128MetArg: 1.128 ± 0.081
1.587MetSer: 1.587 ± 0.101
1.023MetThr: 1.023 ± 0.075
1.154MetVal: 1.154 ± 0.087
0.098MetTrp: 0.098 ± 0.024
0.689MetTyr: 0.689 ± 0.069
0.0MetXaa: 0.0 ± 0.0
Asn
1.574AsnAla: 1.574 ± 0.101
0.735AsnCys: 0.735 ± 0.077
2.44AsnAsp: 2.44 ± 0.127
2.88AsnGlu: 2.88 ± 0.153
4.71AsnPhe: 4.71 ± 0.189
2.755AsnGly: 2.755 ± 0.157
1.64AsnHis: 1.64 ± 0.097
6.271AsnIle: 6.271 ± 0.213
4.88AsnLys: 4.88 ± 0.162
6.612AsnLeu: 6.612 ± 0.262
1.332AsnMet: 1.332 ± 0.091
2.696AsnAsn: 2.696 ± 0.131
1.994AsnPro: 1.994 ± 0.13
3.017AsnGln: 3.017 ± 0.123
3.391AsnArg: 3.391 ± 0.14
4.592AsnSer: 4.592 ± 0.183
1.968AsnThr: 1.968 ± 0.125
2.781AsnVal: 2.781 ± 0.158
0.617AsnTrp: 0.617 ± 0.068
2.598AsnTyr: 2.598 ± 0.132
0.0AsnXaa: 0.0 ± 0.0
Pro
0.708ProAla: 0.708 ± 0.071
0.348ProCys: 0.348 ± 0.047
1.109ProAsp: 1.109 ± 0.089
1.765ProGlu: 1.765 ± 0.114
1.561ProPhe: 1.561 ± 0.102
1.581ProGly: 1.581 ± 0.118
0.466ProHis: 0.466 ± 0.062
3.929ProIle: 3.929 ± 0.154
3.076ProLys: 3.076 ± 0.17
1.955ProLeu: 1.955 ± 0.118
0.597ProMet: 0.597 ± 0.054
1.784ProAsn: 1.784 ± 0.122
0.551ProPro: 0.551 ± 0.061
0.459ProGln: 0.459 ± 0.058
0.8ProArg: 0.8 ± 0.076
2.283ProSer: 2.283 ± 0.129
1.279ProThr: 1.279 ± 0.091
1.43ProVal: 1.43 ± 0.083
0.275ProTrp: 0.275 ± 0.047
1.292ProTyr: 1.292 ± 0.092
0.0ProXaa: 0.0 ± 0.0
Gln
1.2GlnAla: 1.2 ± 0.099
0.321GlnCys: 0.321 ± 0.048
1.417GlnAsp: 1.417 ± 0.114
2.289GlnGlu: 2.289 ± 0.121
1.686GlnPhe: 1.686 ± 0.103
1.253GlnGly: 1.253 ± 0.094
0.505GlnHis: 0.505 ± 0.061
3.581GlnIle: 3.581 ± 0.153
4.428GlnLys: 4.428 ± 0.175
2.375GlnLeu: 2.375 ± 0.119
0.722GlnMet: 0.722 ± 0.062
2.237GlnAsn: 2.237 ± 0.132
0.689GlnPro: 0.689 ± 0.065
0.61GlnGln: 0.61 ± 0.065
1.227GlnArg: 1.227 ± 0.09
2.355GlnSer: 2.355 ± 0.124
1.194GlnThr: 1.194 ± 0.095
1.66GlnVal: 1.66 ± 0.102
0.197GlnTrp: 0.197 ± 0.035
1.397GlnTyr: 1.397 ± 0.089
0.0GlnXaa: 0.0 ± 0.0
Arg
1.594ArgAla: 1.594 ± 0.095
0.59ArgCys: 0.59 ± 0.063
1.988ArgAsp: 1.988 ± 0.132
2.768ArgGlu: 2.768 ± 0.145
2.571ArgPhe: 2.571 ± 0.115
2.283ArgGly: 2.283 ± 0.138
0.63ArgHis: 0.63 ± 0.065
5.569ArgIle: 5.569 ± 0.197
6.402ArgLys: 6.402 ± 0.222
3.824ArgLeu: 3.824 ± 0.181
1.371ArgMet: 1.371 ± 0.096
3.608ArgAsn: 3.608 ± 0.146
1.174ArgPro: 1.174 ± 0.101
1.122ArgGln: 1.122 ± 0.1
2.578ArgArg: 2.578 ± 0.118
4.683ArgSer: 4.683 ± 0.195
2.263ArgThr: 2.263 ± 0.126
2.197ArgVal: 2.197 ± 0.125
0.577ArgTrp: 0.577 ± 0.071
1.883ArgTyr: 1.883 ± 0.118
0.0ArgXaa: 0.0 ± 0.0
Ser
2.67SerAla: 2.67 ± 0.143
1.286SerCys: 1.286 ± 0.093
3.286SerAsp: 3.286 ± 0.141
5.011SerGlu: 5.011 ± 0.185
5.162SerPhe: 5.162 ± 0.22
4.762SerGly: 4.762 ± 0.195
1.581SerHis: 1.581 ± 0.098
9.977SerIle: 9.977 ± 0.295
8.186SerLys: 8.186 ± 0.243
7.78SerLeu: 7.78 ± 0.259
2.033SerMet: 2.033 ± 0.116
4.585SerAsn: 4.585 ± 0.179
1.876SerPro: 1.876 ± 0.118
2.407SerGln: 2.407 ± 0.121
3.857SerArg: 3.857 ± 0.144
7.452SerSer: 7.452 ± 0.253
3.168SerThr: 3.168 ± 0.154
4.27SerVal: 4.27 ± 0.169
0.702SerTrp: 0.702 ± 0.079
2.912SerTyr: 2.912 ± 0.137
0.0SerXaa: 0.0 ± 0.0
Thr
1.371ThrAla: 1.371 ± 0.096
0.433ThrCys: 0.433 ± 0.046
1.705ThrAsp: 1.705 ± 0.107
2.066ThrGlu: 2.066 ± 0.111
2.066ThrPhe: 2.066 ± 0.113
2.84ThrGly: 2.84 ± 0.137
0.879ThrHis: 0.879 ± 0.087
4.834ThrIle: 4.834 ± 0.178
3.208ThrLys: 3.208 ± 0.165
3.706ThrLeu: 3.706 ± 0.157
0.781ThrMet: 0.781 ± 0.076
1.974ThrAsn: 1.974 ± 0.103
1.227ThrPro: 1.227 ± 0.092
0.977ThrGln: 0.977 ± 0.084
1.509ThrArg: 1.509 ± 0.102
2.886ThrSer: 2.886 ± 0.136
1.863ThrThr: 1.863 ± 0.129
2.237ThrVal: 2.237 ± 0.126
0.341ThrTrp: 0.341 ± 0.036
1.2ThrTyr: 1.2 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
2.152ValAla: 2.152 ± 0.143
0.663ValCys: 0.663 ± 0.07
2.394ValAsp: 2.394 ± 0.136
2.978ValGlu: 2.978 ± 0.153
2.748ValPhe: 2.748 ± 0.135
3.496ValGly: 3.496 ± 0.169
1.273ValHis: 1.273 ± 0.095
5.562ValIle: 5.562 ± 0.188
4.106ValLys: 4.106 ± 0.176
5.116ValLeu: 5.116 ± 0.215
0.997ValMet: 0.997 ± 0.083
2.584ValAsn: 2.584 ± 0.152
1.81ValPro: 1.81 ± 0.104
1.935ValGln: 1.935 ± 0.104
2.683ValArg: 2.683 ± 0.132
4.657ValSer: 4.657 ± 0.16
1.824ValThr: 1.824 ± 0.1
2.643ValVal: 2.643 ± 0.132
0.42ValTrp: 0.42 ± 0.05
1.286ValTyr: 1.286 ± 0.099
0.0ValXaa: 0.0 ± 0.0
Trp
0.197TrpAla: 0.197 ± 0.036
0.092TrpCys: 0.092 ± 0.026
0.138TrpAsp: 0.138 ± 0.033
0.413TrpGlu: 0.413 ± 0.064
0.426TrpPhe: 0.426 ± 0.048
0.328TrpGly: 0.328 ± 0.043
0.092TrpHis: 0.092 ± 0.026
1.371TrpIle: 1.371 ± 0.116
1.259TrpLys: 1.259 ± 0.091
0.761TrpLeu: 0.761 ± 0.075
0.335TrpMet: 0.335 ± 0.044
0.597TrpAsn: 0.597 ± 0.063
0.203TrpPro: 0.203 ± 0.036
0.216TrpGln: 0.216 ± 0.041
0.361TrpArg: 0.361 ± 0.043
0.466TrpSer: 0.466 ± 0.059
0.335TrpThr: 0.335 ± 0.044
0.269TrpVal: 0.269 ± 0.04
0.072TrpTrp: 0.072 ± 0.023
0.354TrpTyr: 0.354 ± 0.054
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.089TyrAla: 1.089 ± 0.085
0.623TyrCys: 0.623 ± 0.059
1.804TyrAsp: 1.804 ± 0.107
2.171TyrGlu: 2.171 ± 0.124
2.342TyrPhe: 2.342 ± 0.127
2.368TyrGly: 2.368 ± 0.136
0.925TyrHis: 0.925 ± 0.081
3.273TyrIle: 3.273 ± 0.143
2.598TyrLys: 2.598 ± 0.125
3.693TyrLeu: 3.693 ± 0.143
0.643TyrMet: 0.643 ± 0.068
1.358TyrAsn: 1.358 ± 0.093
1.227TyrPro: 1.227 ± 0.091
1.725TyrGln: 1.725 ± 0.11
2.204TyrArg: 2.204 ± 0.14
3.194TyrSer: 3.194 ± 0.138
1.069TyrThr: 1.069 ± 0.078
1.692TyrVal: 1.692 ± 0.124
0.321TyrTrp: 0.321 ± 0.05
1.194TyrTyr: 1.194 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 540 proteins (152452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski