Amino acid dipepetide frequency for Serratia sp. (strain ATCC 39006)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.188AlaAla: 9.188 ± 0.119	1.092AlaCys: 1.092 ± 0.032	4.791AlaAsp: 4.791 ± 0.085	5.317AlaGlu: 5.317 ± 0.069	3.422AlaPhe: 3.422 ± 0.054	7.157AlaGly: 7.157 ± 0.103	1.807AlaHis: 1.807 ± 0.039	5.983AlaIle: 5.983 ± 0.072	3.417AlaLys: 3.417 ± 0.053	11.376AlaLeu: 11.376 ± 0.118	2.798AlaMet: 2.798 ± 0.057	2.924AlaAsn: 2.924 ± 0.052	3.218AlaPro: 3.218 ± 0.057	4.156AlaGln: 4.156 ± 0.066	5.062AlaArg: 5.062 ± 0.07	5.447AlaSer: 5.447 ± 0.078	4.848AlaThr: 4.848 ± 0.095	6.535AlaVal: 6.535 ± 0.073	1.21AlaTrp: 1.21 ± 0.038	2.291AlaTyr: 2.291 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.951CysAla: 0.951 ± 0.025	0.212CysCys: 0.212 ± 0.014	0.636CysAsp: 0.636 ± 0.024	0.584CysGlu: 0.584 ± 0.02	0.511CysPhe: 0.511 ± 0.021	1.141CysGly: 1.141 ± 0.029	0.39CysHis: 0.39 ± 0.017	0.645CysIle: 0.645 ± 0.021	0.307CysLys: 0.307 ± 0.015	1.126CysLeu: 1.126 ± 0.032	0.263CysMet: 0.263 ± 0.012	0.38CysAsn: 0.38 ± 0.017	0.533CysPro: 0.533 ± 0.021	0.543CysGln: 0.543 ± 0.022	0.702CysArg: 0.702 ± 0.026	0.704CysSer: 0.704 ± 0.022	0.522CysThr: 0.522 ± 0.022	0.796CysVal: 0.796 ± 0.023	0.213CysTrp: 0.213 ± 0.012	0.394CysTyr: 0.394 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.891AspAla: 4.891 ± 0.068	0.57AspCys: 0.57 ± 0.019	2.939AspAsp: 2.939 ± 0.05	3.328AspGlu: 3.328 ± 0.053	2.084AspPhe: 2.084 ± 0.037	3.752AspGly: 3.752 ± 0.052	1.119AspHis: 1.119 ± 0.034	3.87AspIle: 3.87 ± 0.058	2.238AspLys: 2.238 ± 0.042	4.71AspLeu: 4.71 ± 0.072	1.46AspMet: 1.46 ± 0.037	2.23AspAsn: 2.23 ± 0.052	2.237AspPro: 2.237 ± 0.041	1.736AspGln: 1.736 ± 0.039	2.63AspArg: 2.63 ± 0.048	2.958AspSer: 2.958 ± 0.051	2.694AspThr: 2.694 ± 0.072	3.968AspVal: 3.968 ± 0.062	0.847AspTrp: 0.847 ± 0.025	1.862AspTyr: 1.862 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	4.568GluAla: 4.568 ± 0.065	0.473GluCys: 0.473 ± 0.022	2.286GluAsp: 2.286 ± 0.038	2.899GluGlu: 2.899 ± 0.057	1.746GluPhe: 1.746 ± 0.039	3.162GluGly: 3.162 ± 0.052	1.53GluHis: 1.53 ± 0.037	3.376GluIle: 3.376 ± 0.056	2.942GluLys: 2.942 ± 0.062	5.724GluLeu: 5.724 ± 0.068	1.641GluMet: 1.641 ± 0.036	2.354GluAsn: 2.354 ± 0.042	2.064GluPro: 2.064 ± 0.04	3.488GluGln: 3.488 ± 0.062	3.599GluArg: 3.599 ± 0.058	2.872GluSer: 2.872 ± 0.044	2.872GluThr: 2.872 ± 0.059	3.384GluVal: 3.384 ± 0.057	0.704GluTrp: 0.704 ± 0.02	1.421GluTyr: 1.421 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.365PheAla: 3.365 ± 0.056	0.568PheCys: 0.568 ± 0.017	2.389PheAsp: 2.389 ± 0.045	1.623PheGlu: 1.623 ± 0.031	1.689PhePhe: 1.689 ± 0.048	3.058PheGly: 3.058 ± 0.057	0.921PheHis: 0.921 ± 0.027	2.756PheIle: 2.756 ± 0.053	1.205PheLys: 1.205 ± 0.033	3.375PheLeu: 3.375 ± 0.062	0.986PheMet: 0.986 ± 0.027	1.748PheAsn: 1.748 ± 0.04	1.565PhePro: 1.565 ± 0.031	1.243PheGln: 1.243 ± 0.028	1.841PheArg: 1.841 ± 0.038	3.268PheSer: 3.268 ± 0.05	2.271PheThr: 2.271 ± 0.046	2.386PheVal: 2.386 ± 0.047	0.558PheTrp: 0.558 ± 0.02	1.22PheTyr: 1.22 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.689GlyAla: 5.689 ± 0.078	1.104GlyCys: 1.104 ± 0.028	3.614GlyAsp: 3.614 ± 0.073	4.147GlyGlu: 4.147 ± 0.055	3.161GlyPhe: 3.161 ± 0.049	5.145GlyGly: 5.145 ± 0.093	1.69GlyHis: 1.69 ± 0.035	5.357GlyIle: 5.357 ± 0.075	3.848GlyLys: 3.848 ± 0.055	7.518GlyLeu: 7.518 ± 0.083	2.311GlyMet: 2.311 ± 0.048	2.89GlyAsn: 2.89 ± 0.078	2.037GlyPro: 2.037 ± 0.044	3.022GlyGln: 3.022 ± 0.054	3.781GlyArg: 3.781 ± 0.057	4.334GlySer: 4.334 ± 0.088	3.633GlyThr: 3.633 ± 0.07	5.46GlyVal: 5.46 ± 0.063	1.215GlyTrp: 1.215 ± 0.027	2.614GlyTyr: 2.614 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.955HisAla: 1.955 ± 0.044	0.404HisCys: 0.404 ± 0.017	1.314HisAsp: 1.314 ± 0.031	1.143HisGlu: 1.143 ± 0.031	1.097HisPhe: 1.097 ± 0.031	1.745HisGly: 1.745 ± 0.037	0.911HisHis: 0.911 ± 0.027	1.578HisIle: 1.578 ± 0.039	0.756HisLys: 0.756 ± 0.026	2.495HisLeu: 2.495 ± 0.046	0.555HisMet: 0.555 ± 0.02	0.882HisAsn: 0.882 ± 0.023	1.463HisPro: 1.463 ± 0.037	1.465HisGln: 1.465 ± 0.038	1.384HisArg: 1.384 ± 0.035	1.395HisSer: 1.395 ± 0.034	1.197HisThr: 1.197 ± 0.029	1.378HisVal: 1.378 ± 0.03	0.471HisTrp: 0.471 ± 0.017	1.0HisTyr: 1.0 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.553IleAla: 6.553 ± 0.082	0.776IleCys: 0.776 ± 0.028	3.747IleAsp: 3.747 ± 0.058	3.481IleGlu: 3.481 ± 0.056	2.168IlePhe: 2.168 ± 0.045	4.936IleGly: 4.936 ± 0.07	1.356IleHis: 1.356 ± 0.033	3.809IleIle: 3.809 ± 0.071	2.47IleLys: 2.47 ± 0.053	5.474IleLeu: 5.474 ± 0.069	1.408IleMet: 1.408 ± 0.035	2.848IleAsn: 2.848 ± 0.05	3.043IlePro: 3.043 ± 0.049	2.208IleGln: 2.208 ± 0.037	3.298IleArg: 3.298 ± 0.052	4.43IleSer: 4.43 ± 0.052	4.001IleThr: 4.001 ± 0.064	4.114IleVal: 4.114 ± 0.067	0.654IleTrp: 0.654 ± 0.021	1.721IleTyr: 1.721 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.614LysAla: 3.614 ± 0.056	0.294LysCys: 0.294 ± 0.015	1.981LysAsp: 1.981 ± 0.042	2.138LysGlu: 2.138 ± 0.047	1.062LysPhe: 1.062 ± 0.028	2.655LysGly: 2.655 ± 0.047	0.89LysHis: 0.89 ± 0.026	2.448LysIle: 2.448 ± 0.054	2.186LysLys: 2.186 ± 0.055	4.055LysLeu: 4.055 ± 0.072	1.147LysMet: 1.147 ± 0.032	1.797LysAsn: 1.797 ± 0.042	2.019LysPro: 2.019 ± 0.036	2.027LysGln: 2.027 ± 0.04	2.353LysArg: 2.353 ± 0.046	2.403LysSer: 2.403 ± 0.051	2.482LysThr: 2.482 ± 0.045	2.759LysVal: 2.759 ± 0.05	0.399LysTrp: 0.399 ± 0.019	1.075LysTyr: 1.075 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.957LeuAla: 10.957 ± 0.111	1.344LeuCys: 1.344 ± 0.032	5.601LeuAsp: 5.601 ± 0.066	5.316LeuGlu: 5.316 ± 0.077	4.227LeuPhe: 4.227 ± 0.067	7.451LeuGly: 7.451 ± 0.087	2.494LeuHis: 2.494 ± 0.045	6.331LeuIle: 6.331 ± 0.085	4.416LeuLys: 4.416 ± 0.067	12.519LeuLeu: 12.519 ± 0.151	3.05LeuMet: 3.05 ± 0.064	4.299LeuAsn: 4.299 ± 0.062	5.835LeuPro: 5.835 ± 0.073	4.45LeuGln: 4.45 ± 0.064	6.098LeuArg: 6.098 ± 0.07	8.041LeuSer: 8.041 ± 0.086	6.474LeuThr: 6.474 ± 0.085	7.25LeuVal: 7.25 ± 0.092	1.319LeuTrp: 1.319 ± 0.039	2.702LeuTyr: 2.702 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.791MetAla: 2.791 ± 0.049	0.22MetCys: 0.22 ± 0.013	1.225MetAsp: 1.225 ± 0.03	1.187MetGlu: 1.187 ± 0.028	0.862MetPhe: 0.862 ± 0.031	1.859MetGly: 1.859 ± 0.042	0.552MetHis: 0.552 ± 0.017	1.577MetIle: 1.577 ± 0.034	1.326MetLys: 1.326 ± 0.034	3.251MetLeu: 3.251 ± 0.056	0.856MetMet: 0.856 ± 0.03	1.104MetAsn: 1.104 ± 0.025	1.378MetPro: 1.378 ± 0.037	1.194MetGln: 1.194 ± 0.028	1.401MetArg: 1.401 ± 0.034	1.951MetSer: 1.951 ± 0.039	1.787MetThr: 1.787 ± 0.037	1.972MetVal: 1.972 ± 0.041	0.222MetTrp: 0.222 ± 0.013	0.495MetTyr: 0.495 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.562AsnAla: 3.562 ± 0.065	0.375AsnCys: 0.375 ± 0.015	2.072AsnAsp: 2.072 ± 0.048	1.848AsnGlu: 1.848 ± 0.04	1.302AsnPhe: 1.302 ± 0.031	2.955AsnGly: 2.955 ± 0.051	0.967AsnHis: 0.967 ± 0.028	2.586AsnIle: 2.586 ± 0.049	1.533AsnLys: 1.533 ± 0.036	3.565AsnLeu: 3.565 ± 0.052	0.941AsnMet: 0.941 ± 0.028	1.692AsnAsn: 1.692 ± 0.041	2.108AsnPro: 2.108 ± 0.046	1.739AsnGln: 1.739 ± 0.043	2.076AsnArg: 2.076 ± 0.044	2.123AsnSer: 2.123 ± 0.048	2.15AsnThr: 2.15 ± 0.045	2.596AsnVal: 2.596 ± 0.049	0.556AsnTrp: 0.556 ± 0.023	1.185AsnTyr: 1.185 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.234ProAla: 4.234 ± 0.06	0.404ProCys: 0.404 ± 0.016	2.849ProAsp: 2.849 ± 0.053	3.093ProGlu: 3.093 ± 0.047	1.829ProPhe: 1.829 ± 0.042	3.323ProGly: 3.323 ± 0.053	1.145ProHis: 1.145 ± 0.03	2.212ProIle: 2.212 ± 0.044	1.483ProLys: 1.483 ± 0.037	5.204ProLeu: 5.204 ± 0.065	1.086ProMet: 1.086 ± 0.024	1.307ProAsn: 1.307 ± 0.03	1.667ProPro: 1.667 ± 0.042	2.2ProGln: 2.2 ± 0.042	1.992ProArg: 1.992 ± 0.043	2.474ProSer: 2.474 ± 0.045	2.354ProThr: 2.354 ± 0.042	3.74ProVal: 3.74 ± 0.054	0.684ProTrp: 0.684 ± 0.025	1.342ProTyr: 1.342 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.698GlnAla: 4.698 ± 0.072	0.439GlnCys: 0.439 ± 0.019	2.026GlnAsp: 2.026 ± 0.036	2.22GlnGlu: 2.22 ± 0.038	1.458GlnPhe: 1.458 ± 0.033	3.169GlnGly: 3.169 ± 0.054	1.512GlnHis: 1.512 ± 0.036	2.534GlnIle: 2.534 ± 0.046	1.737GlnLys: 1.737 ± 0.042	5.451GlnLeu: 5.451 ± 0.075	1.167GlnMet: 1.167 ± 0.035	1.462GlnAsn: 1.462 ± 0.041	2.269GlnPro: 2.269 ± 0.044	3.775GlnGln: 3.775 ± 0.089	3.362GlnArg: 3.362 ± 0.052	2.539GlnSer: 2.539 ± 0.048	2.337GlnThr: 2.337 ± 0.069	3.312GlnVal: 3.312 ± 0.082	0.704GlnTrp: 0.704 ± 0.022	1.189GlnTyr: 1.189 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.317ArgAla: 4.317 ± 0.066	0.698ArgCys: 0.698 ± 0.025	2.873ArgAsp: 2.873 ± 0.046	3.375ArgGlu: 3.375 ± 0.052	2.471ArgPhe: 2.471 ± 0.045	3.236ArgGly: 3.236 ± 0.05	1.725ArgHis: 1.725 ± 0.041	3.592ArgIle: 3.592 ± 0.054	2.157ArgLys: 2.157 ± 0.047	6.612ArgLeu: 6.612 ± 0.083	1.505ArgMet: 1.505 ± 0.031	1.995ArgAsn: 1.995 ± 0.039	2.182ArgPro: 2.182 ± 0.04	3.514ArgGln: 3.514 ± 0.06	3.511ArgArg: 3.511 ± 0.059	2.823ArgSer: 2.823 ± 0.053	2.512ArgThr: 2.512 ± 0.038	3.765ArgVal: 3.765 ± 0.058	0.953ArgTrp: 0.953 ± 0.025	2.208ArgTyr: 2.208 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.85SerAla: 5.85 ± 0.078	0.652SerCys: 0.652 ± 0.025	3.235SerAsp: 3.235 ± 0.052	3.205SerGlu: 3.205 ± 0.053	2.343SerPhe: 2.343 ± 0.045	5.577SerGly: 5.577 ± 0.078	1.593SerHis: 1.593 ± 0.037	3.558SerIle: 3.558 ± 0.067	1.994SerLys: 1.994 ± 0.038	7.259SerLeu: 7.259 ± 0.078	1.622SerMet: 1.622 ± 0.037	2.023SerAsn: 2.023 ± 0.053	2.729SerPro: 2.729 ± 0.049	2.803SerGln: 2.803 ± 0.045	3.52SerArg: 3.52 ± 0.058	4.149SerSer: 4.149 ± 0.069	3.307SerThr: 3.307 ± 0.057	4.522SerVal: 4.522 ± 0.085	0.939SerTrp: 0.939 ± 0.028	1.713SerTyr: 1.713 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.088ThrAla: 5.088 ± 0.106	0.511ThrCys: 0.511 ± 0.021	2.727ThrAsp: 2.727 ± 0.048	2.782ThrGlu: 2.782 ± 0.054	2.044ThrPhe: 2.044 ± 0.043	4.414ThrGly: 4.414 ± 0.066	1.364ThrHis: 1.364 ± 0.034	3.154ThrIle: 3.154 ± 0.072	1.513ThrLys: 1.513 ± 0.041	7.487ThrLeu: 7.487 ± 0.087	1.198ThrMet: 1.198 ± 0.03	1.712ThrAsn: 1.712 ± 0.041	3.199ThrPro: 3.199 ± 0.048	2.359ThrGln: 2.359 ± 0.059	2.924ThrArg: 2.924 ± 0.048	3.169ThrSer: 3.169 ± 0.057	3.065ThrThr: 3.065 ± 0.08	4.134ThrVal: 4.134 ± 0.132	0.68ThrTrp: 0.68 ± 0.023	1.295ThrTyr: 1.295 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.523ValAla: 6.523 ± 0.08	0.822ValCys: 0.822 ± 0.02	3.74ValAsp: 3.74 ± 0.055	3.674ValGlu: 3.674 ± 0.059	2.703ValPhe: 2.703 ± 0.048	4.801ValGly: 4.801 ± 0.075	1.291ValHis: 1.291 ± 0.035	4.82ValIle: 4.82 ± 0.065	2.857ValLys: 2.857 ± 0.057	7.457ValLeu: 7.457 ± 0.088	2.194ValMet: 2.194 ± 0.05	2.823ValAsn: 2.823 ± 0.045	2.957ValPro: 2.957 ± 0.046	2.469ValGln: 2.469 ± 0.048	3.538ValArg: 3.538 ± 0.058	4.948ValSer: 4.948 ± 0.071	4.39ValThr: 4.39 ± 0.124	5.469ValVal: 5.469 ± 0.076	0.917ValTrp: 0.917 ± 0.032	1.781ValTyr: 1.781 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.872TrpAla: 0.872 ± 0.027	0.179TrpCys: 0.179 ± 0.012	0.574TrpAsp: 0.574 ± 0.021	0.559TrpGlu: 0.559 ± 0.02	0.619TrpPhe: 0.619 ± 0.021	0.867TrpGly: 0.867 ± 0.028	0.417TrpHis: 0.417 ± 0.018	0.711TrpIle: 0.711 ± 0.025	0.483TrpLys: 0.483 ± 0.019	2.204TrpLeu: 2.204 ± 0.046	0.399TrpMet: 0.399 ± 0.016	0.465TrpAsn: 0.465 ± 0.019	0.611TrpPro: 0.611 ± 0.022	1.151TrpGln: 1.151 ± 0.035	0.971TrpArg: 0.971 ± 0.026	0.849TrpSer: 0.849 ± 0.033	0.515TrpThr: 0.515 ± 0.022	0.896TrpVal: 0.896 ± 0.029	0.236TrpTrp: 0.236 ± 0.014	0.374TrpTyr: 0.374 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.375TyrAla: 2.375 ± 0.044	0.419TyrCys: 0.419 ± 0.017	1.504TyrAsp: 1.504 ± 0.033	1.188TyrGlu: 1.188 ± 0.027	1.238TyrPhe: 1.238 ± 0.033	2.168TyrGly: 2.168 ± 0.041	0.914TyrHis: 0.914 ± 0.026	1.599TyrIle: 1.599 ± 0.034	0.915TyrLys: 0.915 ± 0.028	3.311TyrLeu: 3.311 ± 0.051	0.621TyrMet: 0.621 ± 0.022	0.995TyrAsn: 0.995 ± 0.029	1.507TyrPro: 1.507 ± 0.035	1.817TyrGln: 1.817 ± 0.057	1.979TyrArg: 1.979 ± 0.041	1.716TyrSer: 1.716 ± 0.034	1.407TyrThr: 1.407 ± 0.028	1.737TyrVal: 1.737 ± 0.039	0.471TyrTrp: 0.471 ± 0.019	0.967TyrTyr: 0.967 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4305 proteins (1404364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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