Amino acid dipepetide frequency for Candidatus Endolissoclinum faulkneri L5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.502AlaAla: 8.502 ± 0.262
1.318AlaCys: 1.318 ± 0.064
4.402AlaAsp: 4.402 ± 0.136
4.716AlaGlu: 4.716 ± 0.163
3.255AlaPhe: 3.255 ± 0.121
6.358AlaGly: 6.358 ± 0.21
1.535AlaHis: 1.535 ± 0.072
7.476AlaIle: 7.476 ± 0.172
4.858AlaLys: 4.858 ± 0.136
9.453AlaLeu: 9.453 ± 0.27
2.675AlaMet: 2.675 ± 0.104
4.068AlaAsn: 4.068 ± 0.125
2.721AlaPro: 2.721 ± 0.117
2.597AlaGln: 2.597 ± 0.112
5.286AlaArg: 5.286 ± 0.143
5.521AlaSer: 5.521 ± 0.168
4.274AlaThr: 4.274 ± 0.135
6.372AlaVal: 6.372 ± 0.185
1.008AlaTrp: 1.008 ± 0.06
2.354AlaTyr: 2.354 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
0.912CysAla: 0.912 ± 0.059
0.189CysCys: 0.189 ± 0.028
0.791CysAsp: 0.791 ± 0.057
0.641CysGlu: 0.641 ± 0.047
0.541CysPhe: 0.541 ± 0.048
1.044CysGly: 1.044 ± 0.067
0.367CysHis: 0.367 ± 0.035
0.908CysIle: 0.908 ± 0.057
0.623CysLys: 0.623 ± 0.054
1.15CysLeu: 1.15 ± 0.068
0.281CysMet: 0.281 ± 0.031
0.502CysAsn: 0.502 ± 0.049
0.513CysPro: 0.513 ± 0.047
0.424CysGln: 0.424 ± 0.04
0.719CysArg: 0.719 ± 0.055
0.962CysSer: 0.962 ± 0.065
0.62CysThr: 0.62 ± 0.054
0.812CysVal: 0.812 ± 0.056
0.15CysTrp: 0.15 ± 0.024
0.356CysTyr: 0.356 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.253AspAla: 4.253 ± 0.138
0.759AspCys: 0.759 ± 0.061
2.361AspAsp: 2.361 ± 0.116
2.693AspGlu: 2.693 ± 0.104
2.005AspPhe: 2.005 ± 0.092
3.815AspGly: 3.815 ± 0.14
1.079AspHis: 1.079 ± 0.063
4.41AspIle: 4.41 ± 0.126
2.86AspLys: 2.86 ± 0.103
5.738AspLeu: 5.738 ± 0.155
1.311AspMet: 1.311 ± 0.073
2.607AspAsn: 2.607 ± 0.092
2.618AspPro: 2.618 ± 0.109
1.667AspGln: 1.667 ± 0.093
2.971AspArg: 2.971 ± 0.101
3.138AspSer: 3.138 ± 0.105
2.536AspThr: 2.536 ± 0.1
3.555AspVal: 3.555 ± 0.108
0.766AspTrp: 0.766 ± 0.05
1.596AspTyr: 1.596 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
5.125GluAla: 5.125 ± 0.185
0.556GluCys: 0.556 ± 0.048
2.572GluAsp: 2.572 ± 0.103
3.373GluGlu: 3.373 ± 0.128
1.792GluPhe: 1.792 ± 0.082
3.049GluGly: 3.049 ± 0.109
1.14GluHis: 1.14 ± 0.07
5.147GluIle: 5.147 ± 0.135
2.789GluLys: 2.789 ± 0.104
5.001GluLeu: 5.001 ± 0.141
1.453GluMet: 1.453 ± 0.079
2.436GluAsn: 2.436 ± 0.096
1.685GluPro: 1.685 ± 0.092
2.052GluGln: 2.052 ± 0.089
3.583GluArg: 3.583 ± 0.108
3.117GluSer: 3.117 ± 0.107
2.636GluThr: 2.636 ± 0.095
4.171GluVal: 4.171 ± 0.141
0.563GluTrp: 0.563 ± 0.042
1.329GluTyr: 1.329 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
3.562PheAla: 3.562 ± 0.121
0.606PheCys: 0.606 ± 0.053
2.518PheAsp: 2.518 ± 0.098
2.073PheGlu: 2.073 ± 0.088
1.717PhePhe: 1.717 ± 0.11
3.142PheGly: 3.142 ± 0.123
0.716PheHis: 0.716 ± 0.054
2.625PheIle: 2.625 ± 0.125
1.524PheLys: 1.524 ± 0.084
3.74PheLeu: 3.74 ± 0.151
0.89PheMet: 0.89 ± 0.07
1.913PheAsn: 1.913 ± 0.101
1.567PhePro: 1.567 ± 0.075
0.937PheGln: 0.937 ± 0.057
1.884PheArg: 1.884 ± 0.088
2.735PheSer: 2.735 ± 0.104
2.141PheThr: 2.141 ± 0.088
2.447PheVal: 2.447 ± 0.103
0.484PheTrp: 0.484 ± 0.055
0.994PheTyr: 0.994 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
5.425GlyAla: 5.425 ± 0.153
1.026GlyCys: 1.026 ± 0.065
3.312GlyAsp: 3.312 ± 0.117
3.419GlyGlu: 3.419 ± 0.118
2.999GlyPhe: 2.999 ± 0.102
5.239GlyGly: 5.239 ± 0.197
1.546GlyHis: 1.546 ± 0.077
5.97GlyIle: 5.97 ± 0.162
3.929GlyLys: 3.929 ± 0.115
7.113GlyLeu: 7.113 ± 0.187
1.98GlyMet: 1.98 ± 0.096
2.654GlyAsn: 2.654 ± 0.101
2.219GlyPro: 2.219 ± 0.086
2.055GlyGln: 2.055 ± 0.087
4.256GlyArg: 4.256 ± 0.152
4.595GlySer: 4.595 ± 0.125
3.626GlyThr: 3.626 ± 0.137
5.068GlyVal: 5.068 ± 0.161
0.93GlyTrp: 0.93 ± 0.054
2.319GlyTyr: 2.319 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
1.777HisAla: 1.777 ± 0.08
0.335HisCys: 0.335 ± 0.033
0.972HisAsp: 0.972 ± 0.055
0.94HisGlu: 0.94 ± 0.061
0.748HisPhe: 0.748 ± 0.048
1.642HisGly: 1.642 ± 0.08
0.484HisHis: 0.484 ± 0.044
1.524HisIle: 1.524 ± 0.087
0.862HisLys: 0.862 ± 0.061
2.105HisLeu: 2.105 ± 0.09
0.502HisMet: 0.502 ± 0.039
0.947HisAsn: 0.947 ± 0.068
1.175HisPro: 1.175 ± 0.063
0.606HisGln: 0.606 ± 0.04
1.325HisArg: 1.325 ± 0.079
1.3HisSer: 1.3 ± 0.074
1.058HisThr: 1.058 ± 0.066
1.25HisVal: 1.25 ± 0.064
0.253HisTrp: 0.253 ± 0.027
0.673HisTyr: 0.673 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
8.484IleAla: 8.484 ± 0.224
0.994IleCys: 0.994 ± 0.058
5.841IleAsp: 5.841 ± 0.156
4.862IleGlu: 4.862 ± 0.121
2.946IlePhe: 2.946 ± 0.123
6.308IleGly: 6.308 ± 0.16
1.503IleHis: 1.503 ± 0.066
6.169IleIle: 6.169 ± 0.203
4.424IleLys: 4.424 ± 0.167
7.141IleLeu: 7.141 ± 0.17
1.688IleMet: 1.688 ± 0.071
4.516IleAsn: 4.516 ± 0.136
3.248IlePro: 3.248 ± 0.086
1.841IleGln: 1.841 ± 0.1
4.093IleArg: 4.093 ± 0.126
6.155IleSer: 6.155 ± 0.17
4.655IleThr: 4.655 ± 0.124
5.631IleVal: 5.631 ± 0.151
0.673IleTrp: 0.673 ± 0.056
2.002IleTyr: 2.002 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
4.317LysAla: 4.317 ± 0.119
0.488LysCys: 0.488 ± 0.042
2.49LysAsp: 2.49 ± 0.096
2.643LysGlu: 2.643 ± 0.107
1.745LysPhe: 1.745 ± 0.073
2.803LysGly: 2.803 ± 0.101
1.036LysHis: 1.036 ± 0.067
4.841LysIle: 4.841 ± 0.165
3.088LysLys: 3.088 ± 0.132
5.211LysLeu: 5.211 ± 0.127
1.41LysMet: 1.41 ± 0.073
2.882LysAsn: 2.882 ± 0.119
1.995LysPro: 1.995 ± 0.086
1.77LysGln: 1.77 ± 0.084
3.327LysArg: 3.327 ± 0.129
3.398LysSer: 3.398 ± 0.108
2.924LysThr: 2.924 ± 0.096
3.597LysVal: 3.597 ± 0.139
0.417LysTrp: 0.417 ± 0.034
1.282LysTyr: 1.282 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
10.311LeuAla: 10.311 ± 0.294
0.933LeuCys: 0.933 ± 0.063
5.482LeuAsp: 5.482 ± 0.132
5.596LeuGlu: 5.596 ± 0.155
3.583LeuPhe: 3.583 ± 0.154
6.817LeuGly: 6.817 ± 0.171
2.173LeuHis: 2.173 ± 0.082
8.021LeuIle: 8.021 ± 0.201
4.841LeuLys: 4.841 ± 0.11
9.841LeuLeu: 9.841 ± 0.253
2.443LeuMet: 2.443 ± 0.114
4.107LeuAsn: 4.107 ± 0.119
4.954LeuPro: 4.954 ± 0.133
2.743LeuGln: 2.743 ± 0.095
5.991LeuArg: 5.991 ± 0.164
7.971LeuSer: 7.971 ± 0.177
5.421LeuThr: 5.421 ± 0.138
6.953LeuVal: 6.953 ± 0.168
0.883LeuTrp: 0.883 ± 0.063
2.134LeuTyr: 2.134 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
2.187MetAla: 2.187 ± 0.084
0.242MetCys: 0.242 ± 0.038
1.115MetAsp: 1.115 ± 0.074
1.243MetGlu: 1.243 ± 0.069
0.784MetPhe: 0.784 ± 0.054
1.535MetGly: 1.535 ± 0.079
0.552MetHis: 0.552 ± 0.05
2.208MetIle: 2.208 ± 0.115
1.318MetLys: 1.318 ± 0.068
2.874MetLeu: 2.874 ± 0.122
0.616MetMet: 0.616 ± 0.048
1.361MetAsn: 1.361 ± 0.065
1.361MetPro: 1.361 ± 0.077
0.816MetGln: 0.816 ± 0.063
1.674MetArg: 1.674 ± 0.089
1.727MetSer: 1.727 ± 0.092
1.418MetThr: 1.418 ± 0.076
1.688MetVal: 1.688 ± 0.087
0.157MetTrp: 0.157 ± 0.027
0.481MetTyr: 0.481 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
4.06AsnAla: 4.06 ± 0.141
0.623AsnCys: 0.623 ± 0.053
2.404AsnAsp: 2.404 ± 0.113
2.329AsnGlu: 2.329 ± 0.083
1.884AsnPhe: 1.884 ± 0.099
3.17AsnGly: 3.17 ± 0.094
1.044AsnHis: 1.044 ± 0.061
3.765AsnIle: 3.765 ± 0.12
2.707AsnLys: 2.707 ± 0.113
4.627AsnLeu: 4.627 ± 0.142
1.022AsnMet: 1.022 ± 0.062
2.565AsnAsn: 2.565 ± 0.107
2.24AsnPro: 2.24 ± 0.101
1.567AsnGln: 1.567 ± 0.07
2.693AsnArg: 2.693 ± 0.104
2.775AsnSer: 2.775 ± 0.097
2.322AsnThr: 2.322 ± 0.099
2.924AsnVal: 2.924 ± 0.096
0.584AsnTrp: 0.584 ± 0.047
1.282AsnTyr: 1.282 ± 0.076
0.0AsnXaa: 0.0 ± 0.0
Pro
2.832ProAla: 2.832 ± 0.107
0.438ProCys: 0.438 ± 0.049
2.18ProAsp: 2.18 ± 0.095
2.625ProGlu: 2.625 ± 0.1
1.742ProPhe: 1.742 ± 0.084
3.003ProGly: 3.003 ± 0.096
0.776ProHis: 0.776 ± 0.051
3.697ProIle: 3.697 ± 0.131
2.055ProLys: 2.055 ± 0.083
3.914ProLeu: 3.914 ± 0.137
0.933ProMet: 0.933 ± 0.068
2.005ProAsn: 2.005 ± 0.078
1.375ProPro: 1.375 ± 0.063
1.232ProGln: 1.232 ± 0.072
1.927ProArg: 1.927 ± 0.086
2.849ProSer: 2.849 ± 0.101
2.276ProThr: 2.276 ± 0.085
2.871ProVal: 2.871 ± 0.098
0.502ProTrp: 0.502 ± 0.042
1.136ProTyr: 1.136 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
3.06GlnAla: 3.06 ± 0.099
0.324GlnCys: 0.324 ± 0.035
1.24GlnAsp: 1.24 ± 0.066
1.528GlnGlu: 1.528 ± 0.078
1.04GlnPhe: 1.04 ± 0.072
1.678GlnGly: 1.678 ± 0.081
0.623GlnHis: 0.623 ± 0.05
2.835GlnIle: 2.835 ± 0.117
1.617GlnLys: 1.617 ± 0.083
3.152GlnLeu: 3.152 ± 0.133
0.816GlnMet: 0.816 ± 0.052
1.19GlnAsn: 1.19 ± 0.075
1.24GlnPro: 1.24 ± 0.063
1.133GlnGln: 1.133 ± 0.067
2.012GlnArg: 2.012 ± 0.088
2.062GlnSer: 2.062 ± 0.092
1.471GlnThr: 1.471 ± 0.075
2.208GlnVal: 2.208 ± 0.087
0.253GlnTrp: 0.253 ± 0.032
0.719GlnTyr: 0.719 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
4.737ArgAla: 4.737 ± 0.174
0.719ArgCys: 0.719 ± 0.057
2.814ArgAsp: 2.814 ± 0.092
3.188ArgGlu: 3.188 ± 0.106
2.497ArgPhe: 2.497 ± 0.097
3.516ArgGly: 3.516 ± 0.111
1.215ArgHis: 1.215 ± 0.067
5.026ArgIle: 5.026 ± 0.132
3.07ArgLys: 3.07 ± 0.119
6.639ArgLeu: 6.639 ± 0.183
1.51ArgMet: 1.51 ± 0.071
2.383ArgAsn: 2.383 ± 0.107
2.219ArgPro: 2.219 ± 0.083
2.062ArgGln: 2.062 ± 0.118
4.053ArgArg: 4.053 ± 0.156
3.783ArgSer: 3.783 ± 0.124
2.696ArgThr: 2.696 ± 0.094
3.9ArgVal: 3.9 ± 0.139
0.727ArgTrp: 0.727 ± 0.053
1.831ArgTyr: 1.831 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
5.578SerAla: 5.578 ± 0.18
0.955SerCys: 0.955 ± 0.068
3.402SerAsp: 3.402 ± 0.106
3.434SerGlu: 3.434 ± 0.12
2.832SerPhe: 2.832 ± 0.11
5.211SerGly: 5.211 ± 0.172
1.396SerHis: 1.396 ± 0.07
5.784SerIle: 5.784 ± 0.124
3.658SerLys: 3.658 ± 0.112
6.76SerLeu: 6.76 ± 0.18
1.792SerMet: 1.792 ± 0.079
3.305SerAsn: 3.305 ± 0.108
2.301SerPro: 2.301 ± 0.099
2.02SerGln: 2.02 ± 0.093
3.754SerArg: 3.754 ± 0.103
4.905SerSer: 4.905 ± 0.194
3.423SerThr: 3.423 ± 0.101
4.481SerVal: 4.481 ± 0.124
0.78SerTrp: 0.78 ± 0.047
1.991SerTyr: 1.991 ± 0.089
0.0SerXaa: 0.0 ± 0.0
Thr
4.57ThrAla: 4.57 ± 0.135
0.595ThrCys: 0.595 ± 0.046
2.515ThrAsp: 2.515 ± 0.104
2.536ThrGlu: 2.536 ± 0.101
1.948ThrPhe: 1.948 ± 0.08
3.907ThrGly: 3.907 ± 0.114
0.962ThrHis: 0.962 ± 0.063
4.36ThrIle: 4.36 ± 0.123
2.565ThrLys: 2.565 ± 0.089
5.353ThrLeu: 5.353 ± 0.126
1.318ThrMet: 1.318 ± 0.078
2.379ThrAsn: 2.379 ± 0.081
2.465ThrPro: 2.465 ± 0.098
1.386ThrGln: 1.386 ± 0.065
2.536ThrArg: 2.536 ± 0.092
3.64ThrSer: 3.64 ± 0.114
3.085ThrThr: 3.085 ± 0.13
3.979ThrVal: 3.979 ± 0.107
0.509ThrTrp: 0.509 ± 0.048
1.453ThrTyr: 1.453 ± 0.083
0.0ThrXaa: 0.0 ± 0.0
Val
6.279ValAla: 6.279 ± 0.208
0.88ValCys: 0.88 ± 0.059
4.157ValAsp: 4.157 ± 0.132
4.057ValGlu: 4.057 ± 0.144
2.575ValPhe: 2.575 ± 0.106
4.556ValGly: 4.556 ± 0.131
1.418ValHis: 1.418 ± 0.071
5.873ValIle: 5.873 ± 0.162
3.017ValLys: 3.017 ± 0.112
7.188ValLeu: 7.188 ± 0.169
1.82ValMet: 1.82 ± 0.08
3.124ValAsn: 3.124 ± 0.107
2.775ValPro: 2.775 ± 0.101
1.891ValGln: 1.891 ± 0.078
3.904ValArg: 3.904 ± 0.144
4.655ValSer: 4.655 ± 0.138
3.622ValThr: 3.622 ± 0.111
5.332ValVal: 5.332 ± 0.181
0.709ValTrp: 0.709 ± 0.059
1.631ValTyr: 1.631 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.716TrpAla: 0.716 ± 0.045
0.135TrpCys: 0.135 ± 0.021
0.431TrpAsp: 0.431 ± 0.042
0.427TrpGlu: 0.427 ± 0.04
0.435TrpPhe: 0.435 ± 0.038
0.741TrpGly: 0.741 ± 0.048
0.292TrpHis: 0.292 ± 0.029
0.876TrpIle: 0.876 ± 0.052
0.538TrpLys: 0.538 ± 0.039
1.443TrpLeu: 1.443 ± 0.081
0.274TrpMet: 0.274 ± 0.037
0.495TrpAsn: 0.495 ± 0.046
0.563TrpPro: 0.563 ± 0.043
0.509TrpGln: 0.509 ± 0.05
0.858TrpArg: 0.858 ± 0.06
0.641TrpSer: 0.641 ± 0.043
0.499TrpThr: 0.499 ± 0.043
0.63TrpVal: 0.63 ± 0.049
0.167TrpTrp: 0.167 ± 0.022
0.224TrpTyr: 0.224 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.062TyrAla: 2.062 ± 0.08
0.392TyrCys: 0.392 ± 0.041
1.738TyrAsp: 1.738 ± 0.08
1.243TyrGlu: 1.243 ± 0.071
1.147TyrPhe: 1.147 ± 0.066
2.148TyrGly: 2.148 ± 0.099
0.623TyrHis: 0.623 ± 0.052
1.66TyrIle: 1.66 ± 0.089
1.321TyrLys: 1.321 ± 0.089
2.753TyrLeu: 2.753 ± 0.121
0.616TyrMet: 0.616 ± 0.051
1.15TyrAsn: 1.15 ± 0.082
1.136TyrPro: 1.136 ± 0.065
0.894TyrGln: 0.894 ± 0.059
1.738TyrArg: 1.738 ± 0.088
1.831TyrSer: 1.831 ± 0.091
1.357TyrThr: 1.357 ± 0.068
1.592TyrVal: 1.592 ± 0.073
0.381TyrTrp: 0.381 ± 0.041
0.969TyrTyr: 0.969 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 770 proteins (280757 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski