Amino acid dipepetide frequency for Candidatus Moduliflexus flocculans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.354AlaAla: 9.354 ± 0.109	1.109AlaCys: 1.109 ± 0.024	4.653AlaAsp: 4.653 ± 0.056	6.333AlaGlu: 6.333 ± 0.071	4.219AlaPhe: 4.219 ± 0.058	5.779AlaGly: 5.779 ± 0.06	1.961AlaHis: 1.961 ± 0.033	6.363AlaIle: 6.363 ± 0.065	4.171AlaLys: 4.171 ± 0.05	10.155AlaLeu: 10.155 ± 0.088	2.669AlaMet: 2.669 ± 0.033	3.087AlaAsn: 3.087 ± 0.049	3.317AlaPro: 3.317 ± 0.052	4.395AlaGln: 4.395 ± 0.052	4.541AlaArg: 4.541 ± 0.054	4.851AlaSer: 4.851 ± 0.049	4.452AlaThr: 4.452 ± 0.051	5.848AlaVal: 5.848 ± 0.06	1.033AlaTrp: 1.033 ± 0.029	2.923AlaTyr: 2.923 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	1.036CysAla: 1.036 ± 0.023	0.202CysCys: 0.202 ± 0.011	0.588CysAsp: 0.588 ± 0.017	0.641CysGlu: 0.641 ± 0.018	0.476CysPhe: 0.476 ± 0.014	1.026CysGly: 1.026 ± 0.029	0.326CysHis: 0.326 ± 0.014	0.553CysIle: 0.553 ± 0.019	0.371CysLys: 0.371 ± 0.014	1.099CysLeu: 1.099 ± 0.025	0.207CysMet: 0.207 ± 0.01	0.301CysAsn: 0.301 ± 0.014	0.554CysPro: 0.554 ± 0.017	0.542CysGln: 0.542 ± 0.018	0.735CysArg: 0.735 ± 0.023	0.617CysSer: 0.617 ± 0.018	0.366CysThr: 0.366 ± 0.015	0.823CysVal: 0.823 ± 0.021	0.178CysTrp: 0.178 ± 0.009	0.362CysTyr: 0.362 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.481AspAla: 5.481 ± 0.065	0.464AspCys: 0.464 ± 0.015	2.965AspAsp: 2.965 ± 0.048	3.775AspGlu: 3.775 ± 0.048	2.382AspPhe: 2.382 ± 0.036	3.596AspGly: 3.596 ± 0.049	1.022AspHis: 1.022 ± 0.021	3.808AspIle: 3.808 ± 0.05	1.839AspLys: 1.839 ± 0.03	4.772AspLeu: 4.772 ± 0.057	1.407AspMet: 1.407 ± 0.026	1.513AspAsn: 1.513 ± 0.03	2.138AspPro: 2.138 ± 0.033	1.711AspGln: 1.711 ± 0.032	2.609AspArg: 2.609 ± 0.038	2.255AspSer: 2.255 ± 0.037	2.455AspThr: 2.455 ± 0.035	4.201AspVal: 4.201 ± 0.043	0.693AspTrp: 0.693 ± 0.019	1.758AspTyr: 1.758 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.403GluAla: 5.403 ± 0.06	0.619GluCys: 0.619 ± 0.02	2.691GluAsp: 2.691 ± 0.043	4.719GluGlu: 4.719 ± 0.077	2.877GluPhe: 2.877 ± 0.039	3.303GluGly: 3.303 ± 0.043	1.806GluHis: 1.806 ± 0.036	4.997GluIle: 4.997 ± 0.057	3.738GluLys: 3.738 ± 0.052	6.897GluLeu: 6.897 ± 0.072	2.077GluMet: 2.077 ± 0.034	2.511GluAsn: 2.511 ± 0.037	2.267GluPro: 2.267 ± 0.034	4.219GluGln: 4.219 ± 0.055	4.947GluArg: 4.947 ± 0.059	3.013GluSer: 3.013 ± 0.038	4.035GluThr: 4.035 ± 0.052	3.522GluVal: 3.522 ± 0.043	0.835GluTrp: 0.835 ± 0.022	2.178GluTyr: 2.178 ± 0.037	0.001GluXaa: 0.001 ± 0.001
Phe	4.201PheAla: 4.201 ± 0.05	0.639PheCys: 0.639 ± 0.016	2.841PheAsp: 2.841 ± 0.04	2.911PheGlu: 2.911 ± 0.039	2.244PhePhe: 2.244 ± 0.047	3.281PheGly: 3.281 ± 0.046	1.084PheHis: 1.084 ± 0.023	2.492PheIle: 2.492 ± 0.04	1.565PheLys: 1.565 ± 0.029	4.709PheLeu: 4.709 ± 0.062	0.972PheMet: 0.972 ± 0.025	1.403PheAsn: 1.403 ± 0.025	2.108PhePro: 2.108 ± 0.035	1.949PheGln: 1.949 ± 0.031	2.458PheArg: 2.458 ± 0.039	3.15PheSer: 3.15 ± 0.044	2.398PheThr: 2.398 ± 0.04	2.956PheVal: 2.956 ± 0.044	0.693PheTrp: 0.693 ± 0.021	1.51PheTyr: 1.51 ± 0.034	0.001PheXaa: 0.001 ± 0.001
Gly	5.219GlyAla: 5.219 ± 0.074	0.88GlyCys: 0.88 ± 0.023	3.249GlyAsp: 3.249 ± 0.047	4.299GlyGlu: 4.299 ± 0.051	3.134GlyPhe: 3.134 ± 0.043	4.459GlyGly: 4.459 ± 0.064	1.364GlyHis: 1.364 ± 0.03	5.056GlyIle: 5.056 ± 0.053	4.105GlyLys: 4.105 ± 0.045	6.201GlyLeu: 6.201 ± 0.064	2.077GlyMet: 2.077 ± 0.04	2.398GlyAsn: 2.398 ± 0.043	1.172GlyPro: 1.172 ± 0.027	2.625GlyGln: 2.625 ± 0.04	3.289GlyArg: 3.289 ± 0.042	3.322GlySer: 3.322 ± 0.043	3.623GlyThr: 3.623 ± 0.053	5.081GlyVal: 5.081 ± 0.055	0.969GlyTrp: 0.969 ± 0.023	2.436GlyTyr: 2.436 ± 0.039	0.001GlyXaa: 0.001 ± 0.001
His	2.178HisAla: 2.178 ± 0.035	0.259HisCys: 0.259 ± 0.013	1.429HisAsp: 1.429 ± 0.027	1.427HisGlu: 1.427 ± 0.029	1.086HisPhe: 1.086 ± 0.023	1.601HisGly: 1.601 ± 0.032	0.738HisHis: 0.738 ± 0.019	1.572HisIle: 1.572 ± 0.029	0.755HisLys: 0.755 ± 0.02	2.646HisLeu: 2.646 ± 0.04	0.22HisMet: 0.22 ± 0.01	0.674HisAsn: 0.674 ± 0.02	1.389HisPro: 1.389 ± 0.027	1.087HisGln: 1.087 ± 0.022	1.317HisArg: 1.317 ± 0.024	1.139HisSer: 1.139 ± 0.024	0.983HisThr: 0.983 ± 0.024	1.592HisVal: 1.592 ± 0.032	0.279HisTrp: 0.279 ± 0.012	0.782HisTyr: 0.782 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.934IleAla: 6.934 ± 0.061	0.779IleCys: 0.779 ± 0.02	3.381IleAsp: 3.381 ± 0.046	4.735IleGlu: 4.735 ± 0.054	3.098IlePhe: 3.098 ± 0.051	5.048IleGly: 5.048 ± 0.059	1.519IleHis: 1.519 ± 0.029	4.094IleIle: 4.094 ± 0.049	2.66IleLys: 2.66 ± 0.04	6.668IleLeu: 6.668 ± 0.06	1.43IleMet: 1.43 ± 0.028	2.159IleAsn: 2.159 ± 0.034	3.385IlePro: 3.385 ± 0.045	2.691IleGln: 2.691 ± 0.044	3.933IleArg: 3.933 ± 0.046	4.243IleSer: 4.243 ± 0.051	3.581IleThr: 3.581 ± 0.043	4.76IleVal: 4.76 ± 0.051	0.712IleTrp: 0.712 ± 0.022	1.91IleTyr: 1.91 ± 0.036	0.0IleXaa: 0.0 ± 0.001
Lys	3.841LysAla: 3.841 ± 0.049	0.358LysCys: 0.358 ± 0.015	2.362LysAsp: 2.362 ± 0.036	3.466LysGlu: 3.466 ± 0.048	1.77LysPhe: 1.77 ± 0.027	2.726LysGly: 2.726 ± 0.042	1.148LysHis: 1.148 ± 0.025	3.572LysIle: 3.572 ± 0.043	2.87LysLys: 2.87 ± 0.045	4.107LysLeu: 4.107 ± 0.051	1.4LysMet: 1.4 ± 0.024	1.947LysAsn: 1.947 ± 0.03	2.05LysPro: 2.05 ± 0.034	2.504LysGln: 2.504 ± 0.046	2.909LysArg: 2.909 ± 0.036	2.306LysSer: 2.306 ± 0.035	3.19LysThr: 3.19 ± 0.045	2.426LysVal: 2.426 ± 0.036	0.485LysTrp: 0.485 ± 0.016	1.495LysTyr: 1.495 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	9.463LeuAla: 9.463 ± 0.08	1.209LeuCys: 1.209 ± 0.026	5.153LeuAsp: 5.153 ± 0.054	6.192LeuGlu: 6.192 ± 0.065	4.819LeuPhe: 4.819 ± 0.061	6.084LeuGly: 6.084 ± 0.065	2.313LeuHis: 2.313 ± 0.038	6.271LeuIle: 6.271 ± 0.069	5.089LeuLys: 5.089 ± 0.045	11.526LeuLeu: 11.526 ± 0.126	2.509LeuMet: 2.509 ± 0.037	3.943LeuAsn: 3.943 ± 0.041	5.265LeuPro: 5.265 ± 0.056	4.621LeuGln: 4.621 ± 0.057	6.478LeuArg: 6.478 ± 0.079	6.763LeuSer: 6.763 ± 0.072	6.108LeuThr: 6.108 ± 0.055	5.628LeuVal: 5.628 ± 0.054	1.159LeuTrp: 1.159 ± 0.029	2.922LeuTyr: 2.922 ± 0.044	0.004LeuXaa: 0.004 ± 0.001
Met	2.33MetAla: 2.33 ± 0.037	0.206MetCys: 0.206 ± 0.009	0.968MetAsp: 0.968 ± 0.025	1.325MetGlu: 1.325 ± 0.025	1.108MetPhe: 1.108 ± 0.025	1.402MetGly: 1.402 ± 0.027	0.404MetHis: 0.404 ± 0.016	1.868MetIle: 1.868 ± 0.032	1.686MetLys: 1.686 ± 0.032	2.994MetLeu: 2.994 ± 0.05	0.879MetMet: 0.879 ± 0.024	1.238MetAsn: 1.238 ± 0.026	1.345MetPro: 1.345 ± 0.026	1.148MetGln: 1.148 ± 0.024	1.554MetArg: 1.554 ± 0.027	1.54MetSer: 1.54 ± 0.03	1.827MetThr: 1.827 ± 0.031	1.507MetVal: 1.507 ± 0.028	0.18MetTrp: 0.18 ± 0.009	0.687MetTyr: 0.687 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.758AsnAla: 3.758 ± 0.046	0.357AsnCys: 0.357 ± 0.014	1.835AsnAsp: 1.835 ± 0.031	1.991AsnGlu: 1.991 ± 0.032	1.459AsnPhe: 1.459 ± 0.03	2.455AsnGly: 2.455 ± 0.039	0.725AsnHis: 0.725 ± 0.018	2.708AsnIle: 2.708 ± 0.042	1.239AsnLys: 1.239 ± 0.023	3.681AsnLeu: 3.681 ± 0.052	0.962AsnMet: 0.962 ± 0.023	1.178AsnAsn: 1.178 ± 0.025	1.984AsnPro: 1.984 ± 0.032	1.406AsnGln: 1.406 ± 0.025	1.928AsnArg: 1.928 ± 0.031	1.821AsnSer: 1.821 ± 0.032	1.814AsnThr: 1.814 ± 0.033	2.56AsnVal: 2.56 ± 0.039	0.469AsnTrp: 0.469 ± 0.015	1.139AsnTyr: 1.139 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	3.636ProAla: 3.636 ± 0.05	0.409ProCys: 0.409 ± 0.015	2.912ProAsp: 2.912 ± 0.044	3.736ProGlu: 3.736 ± 0.046	2.041ProPhe: 2.041 ± 0.032	2.702ProGly: 2.702 ± 0.045	1.028ProHis: 1.028 ± 0.025	2.729ProIle: 2.729 ± 0.039	1.934ProLys: 1.934 ± 0.035	4.292ProLeu: 4.292 ± 0.048	0.993ProMet: 0.993 ± 0.023	1.586ProAsn: 1.586 ± 0.03	2.004ProPro: 2.004 ± 0.036	1.981ProGln: 1.981 ± 0.034	1.809ProArg: 1.809 ± 0.039	2.351ProSer: 2.351 ± 0.039	2.566ProThr: 2.566 ± 0.047	3.106ProVal: 3.106 ± 0.04	0.44ProTrp: 0.44 ± 0.016	1.466ProTyr: 1.466 ± 0.029	0.001ProXaa: 0.001 ± 0.001
Gln	4.531GlnAla: 4.531 ± 0.058	0.383GlnCys: 0.383 ± 0.013	1.919GlnAsp: 1.919 ± 0.034	3.515GlnGlu: 3.515 ± 0.052	1.844GlnPhe: 1.844 ± 0.03	2.64GlnGly: 2.64 ± 0.036	1.32GlnHis: 1.32 ± 0.029	3.163GlnIle: 3.163 ± 0.042	2.544GlnLys: 2.544 ± 0.042	4.052GlnLeu: 4.052 ± 0.047	1.277GlnMet: 1.277 ± 0.03	1.659GlnAsn: 1.659 ± 0.031	1.934GlnPro: 1.934 ± 0.039	3.25GlnGln: 3.25 ± 0.069	3.18GlnArg: 3.18 ± 0.047	2.106GlnSer: 2.106 ± 0.038	2.806GlnThr: 2.806 ± 0.04	2.568GlnVal: 2.568 ± 0.041	0.518GlnTrp: 0.518 ± 0.017	1.534GlnTyr: 1.534 ± 0.03	0.0GlnXaa: 0.0 ± 0.001
Arg	4.307ArgAla: 4.307 ± 0.057	0.629ArgCys: 0.629 ± 0.017	3.07ArgAsp: 3.07 ± 0.041	4.127ArgGlu: 4.127 ± 0.053	2.735ArgPhe: 2.735 ± 0.041	3.201ArgGly: 3.201 ± 0.041	1.501ArgHis: 1.501 ± 0.03	3.988ArgIle: 3.988 ± 0.042	2.911ArgLys: 2.911 ± 0.047	6.272ArgLeu: 6.272 ± 0.064	1.573ArgMet: 1.573 ± 0.028	2.003ArgAsn: 2.003 ± 0.034	2.05ArgPro: 2.05 ± 0.033	3.339ArgGln: 3.339 ± 0.047	3.527ArgArg: 3.527 ± 0.053	2.754ArgSer: 2.754 ± 0.033	2.544ArgThr: 2.544 ± 0.035	3.637ArgVal: 3.637 ± 0.042	0.781ArgTrp: 0.781 ± 0.02	2.06ArgTyr: 2.06 ± 0.037	0.001ArgXaa: 0.001 ± 0.001
Ser	5.061SerAla: 5.061 ± 0.05	0.578SerCys: 0.578 ± 0.017	2.801SerAsp: 2.801 ± 0.042	3.358SerGlu: 3.358 ± 0.051	2.479SerPhe: 2.479 ± 0.032	4.585SerGly: 4.585 ± 0.049	1.201SerHis: 1.201 ± 0.025	3.361SerIle: 3.361 ± 0.044	2.274SerLys: 2.274 ± 0.03	5.846SerLeu: 5.846 ± 0.062	1.366SerMet: 1.366 ± 0.025	1.787SerAsn: 1.787 ± 0.035	2.777SerPro: 2.777 ± 0.042	2.294SerGln: 2.294 ± 0.037	2.936SerArg: 2.936 ± 0.038	3.49SerSer: 3.49 ± 0.06	2.593SerThr: 2.593 ± 0.034	3.925SerVal: 3.925 ± 0.043	0.706SerTrp: 0.706 ± 0.02	1.66SerTyr: 1.66 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	4.665ThrAla: 4.665 ± 0.054	0.537ThrCys: 0.537 ± 0.017	2.551ThrAsp: 2.551 ± 0.034	2.998ThrGlu: 2.998 ± 0.046	2.544ThrPhe: 2.544 ± 0.035	3.846ThrGly: 3.846 ± 0.057	1.294ThrHis: 1.294 ± 0.029	3.942ThrIle: 3.942 ± 0.041	2.011ThrLys: 2.011 ± 0.036	6.338ThrLeu: 6.338 ± 0.061	1.338ThrMet: 1.338 ± 0.028	1.795ThrAsn: 1.795 ± 0.033	3.514ThrPro: 3.514 ± 0.055	2.276ThrGln: 2.276 ± 0.037	2.685ThrArg: 2.685 ± 0.044	2.906ThrSer: 2.906 ± 0.042	3.096ThrThr: 3.096 ± 0.046	3.768ThrVal: 3.768 ± 0.047	0.608ThrTrp: 0.608 ± 0.016	1.75ThrTyr: 1.75 ± 0.035	0.001ThrXaa: 0.001 ± 0.001
Val	6.018ValAla: 6.018 ± 0.056	0.84ValCys: 0.84 ± 0.025	3.069ValAsp: 3.069 ± 0.039	4.437ValGlu: 4.437 ± 0.053	3.043ValPhe: 3.043 ± 0.039	4.203ValGly: 4.203 ± 0.06	1.145ValHis: 1.145 ± 0.021	4.719ValIle: 4.719 ± 0.056	3.34ValLys: 3.34 ± 0.045	6.35ValLeu: 6.35 ± 0.063	1.848ValMet: 1.848 ± 0.032	2.581ValAsn: 2.581 ± 0.034	2.591ValPro: 2.591 ± 0.039	2.166ValGln: 2.166 ± 0.029	3.315ValArg: 3.315 ± 0.044	4.213ValSer: 4.213 ± 0.048	3.853ValThr: 3.853 ± 0.052	4.789ValVal: 4.789 ± 0.061	0.747ValTrp: 0.747 ± 0.021	2.02ValTyr: 2.02 ± 0.038	0.001ValXaa: 0.001 ± 0.001
Trp	0.805TrpAla: 0.805 ± 0.021	0.144TrpCys: 0.144 ± 0.009	0.587TrpAsp: 0.587 ± 0.022	0.776TrpGlu: 0.776 ± 0.02	0.594TrpPhe: 0.594 ± 0.017	0.822TrpGly: 0.822 ± 0.024	0.316TrpHis: 0.316 ± 0.015	0.715TrpIle: 0.715 ± 0.021	0.676TrpLys: 0.676 ± 0.021	1.398TrpLeu: 1.398 ± 0.033	0.364TrpMet: 0.364 ± 0.017	0.619TrpAsn: 0.619 ± 0.02	0.395TrpPro: 0.395 ± 0.015	0.729TrpGln: 0.729 ± 0.021	0.751TrpArg: 0.751 ± 0.019	0.591TrpSer: 0.591 ± 0.016	0.637TrpThr: 0.637 ± 0.02	0.649TrpVal: 0.649 ± 0.02	0.21TrpTrp: 0.21 ± 0.012	0.403TrpTyr: 0.403 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.99TyrAla: 2.99 ± 0.044	0.402TyrCys: 0.402 ± 0.014	1.82TyrAsp: 1.82 ± 0.032	1.894TyrGlu: 1.894 ± 0.032	1.612TyrPhe: 1.612 ± 0.029	2.198TyrGly: 2.198 ± 0.033	0.939TyrHis: 0.939 ± 0.02	1.748TyrIle: 1.748 ± 0.032	1.151TyrLys: 1.151 ± 0.026	3.515TyrLeu: 3.515 ± 0.045	0.627TyrMet: 0.627 ± 0.016	1.09TyrAsn: 1.09 ± 0.026	1.483TyrPro: 1.483 ± 0.032	1.81TyrGln: 1.81 ± 0.036	2.104TyrArg: 2.104 ± 0.033	1.645TyrSer: 1.645 ± 0.032	1.535TyrThr: 1.535 ± 0.027	1.945TyrVal: 1.945 ± 0.035	0.486TyrTrp: 0.486 ± 0.015	1.264TyrTyr: 1.264 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5960 proteins (2000297 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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