Amino acid dipepetide frequency for Pandoraea thiooxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.477AlaAla: 17.477 ± 0.185
1.366AlaCys: 1.366 ± 0.035
6.21AlaAsp: 6.21 ± 0.063
6.22AlaGlu: 6.22 ± 0.078
4.113AlaPhe: 4.113 ± 0.066
10.912AlaGly: 10.912 ± 0.111
2.971AlaHis: 2.971 ± 0.05
5.914AlaIle: 5.914 ± 0.08
3.332AlaLys: 3.332 ± 0.054
15.149AlaLeu: 15.149 ± 0.137
3.433AlaMet: 3.433 ± 0.058
2.971AlaAsn: 2.971 ± 0.052
6.233AlaPro: 6.233 ± 0.091
5.894AlaGln: 5.894 ± 0.082
9.328AlaArg: 9.328 ± 0.094
6.749AlaSer: 6.749 ± 0.087
5.878AlaThr: 5.878 ± 0.085
8.808AlaVal: 8.808 ± 0.081
1.758AlaTrp: 1.758 ± 0.036
2.869AlaTyr: 2.869 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.332CysAla: 1.332 ± 0.03
0.13CysCys: 0.13 ± 0.01
0.598CysAsp: 0.598 ± 0.025
0.559CysGlu: 0.559 ± 0.021
0.343CysPhe: 0.343 ± 0.016
1.117CysGly: 1.117 ± 0.034
0.281CysHis: 0.281 ± 0.013
0.398CysIle: 0.398 ± 0.019
0.194CysLys: 0.194 ± 0.012
0.927CysLeu: 0.927 ± 0.026
0.21CysMet: 0.21 ± 0.012
0.233CysAsn: 0.233 ± 0.013
0.468CysPro: 0.468 ± 0.022
0.297CysGln: 0.297 ± 0.015
0.663CysArg: 0.663 ± 0.026
0.458CysSer: 0.458 ± 0.02
0.458CysThr: 0.458 ± 0.02
0.833CysVal: 0.833 ± 0.029
0.118CysTrp: 0.118 ± 0.009
0.252CysTyr: 0.252 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.976AspAla: 6.976 ± 0.08
0.47AspCys: 0.47 ± 0.02
2.859AspAsp: 2.859 ± 0.054
3.122AspGlu: 3.122 ± 0.052
1.994AspPhe: 1.994 ± 0.038
4.472AspGly: 4.472 ± 0.064
1.087AspHis: 1.087 ± 0.027
2.587AspIle: 2.587 ± 0.05
1.599AspLys: 1.599 ± 0.034
5.093AspLeu: 5.093 ± 0.065
1.22AspMet: 1.22 ± 0.03
1.282AspAsn: 1.282 ± 0.031
2.877AspPro: 2.877 ± 0.053
1.662AspGln: 1.662 ± 0.034
3.146AspArg: 3.146 ± 0.054
2.153AspSer: 2.153 ± 0.045
2.62AspThr: 2.62 ± 0.05
3.902AspVal: 3.902 ± 0.065
0.905AspTrp: 0.905 ± 0.03
1.475AspTyr: 1.475 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.456GluAla: 6.456 ± 0.091
0.442GluCys: 0.442 ± 0.019
1.883GluAsp: 1.883 ± 0.044
2.166GluGlu: 2.166 ± 0.06
1.854GluPhe: 1.854 ± 0.039
3.078GluGly: 3.078 ± 0.052
1.488GluHis: 1.488 ± 0.035
3.065GluIle: 3.065 ± 0.048
1.739GluLys: 1.739 ± 0.038
5.511GluLeu: 5.511 ± 0.075
1.289GluMet: 1.289 ± 0.034
1.377GluAsn: 1.377 ± 0.035
2.354GluPro: 2.354 ± 0.042
2.699GluGln: 2.699 ± 0.05
4.768GluArg: 4.768 ± 0.069
2.302GluSer: 2.302 ± 0.048
2.476GluThr: 2.476 ± 0.039
3.552GluVal: 3.552 ± 0.069
0.61GluTrp: 0.61 ± 0.025
1.153GluTyr: 1.153 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.501PheAla: 4.501 ± 0.066
0.435PheCys: 0.435 ± 0.017
2.477PheAsp: 2.477 ± 0.044
2.049PheGlu: 2.049 ± 0.042
1.474PhePhe: 1.474 ± 0.046
3.65PheGly: 3.65 ± 0.061
0.82PheHis: 0.82 ± 0.028
1.674PheIle: 1.674 ± 0.037
1.035PheLys: 1.035 ± 0.028
3.307PheLeu: 3.307 ± 0.053
0.816PheMet: 0.816 ± 0.029
1.148PheAsn: 1.148 ± 0.03
1.57PhePro: 1.57 ± 0.037
0.986PheGln: 0.986 ± 0.027
1.96PheArg: 1.96 ± 0.043
2.319PheSer: 2.319 ± 0.044
1.86PheThr: 1.86 ± 0.04
2.965PheVal: 2.965 ± 0.048
0.517PheTrp: 0.517 ± 0.022
0.968PheTyr: 0.968 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
9.62GlyAla: 9.62 ± 0.109
0.923GlyCys: 0.923 ± 0.029
3.816GlyAsp: 3.816 ± 0.058
4.196GlyGlu: 4.196 ± 0.054
3.285GlyPhe: 3.285 ± 0.056
6.721GlyGly: 6.721 ± 0.116
1.999GlyHis: 1.999 ± 0.041
4.418GlyIle: 4.418 ± 0.062
3.249GlyLys: 3.249 ± 0.057
8.788GlyLeu: 8.788 ± 0.094
2.372GlyMet: 2.372 ± 0.044
2.306GlyAsn: 2.306 ± 0.054
2.998GlyPro: 2.998 ± 0.056
3.37GlyGln: 3.37 ± 0.06
5.248GlyArg: 5.248 ± 0.061
4.275GlySer: 4.275 ± 0.063
4.493GlyThr: 4.493 ± 0.073
6.725GlyVal: 6.725 ± 0.074
1.394GlyTrp: 1.394 ± 0.034
2.441GlyTyr: 2.441 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
3.082HisAla: 3.082 ± 0.058
0.293HisCys: 0.293 ± 0.016
1.388HisAsp: 1.388 ± 0.033
1.23HisGlu: 1.23 ± 0.036
1.016HisPhe: 1.016 ± 0.026
2.369HisGly: 2.369 ± 0.051
0.681HisHis: 0.681 ± 0.023
1.075HisIle: 1.075 ± 0.028
0.517HisLys: 0.517 ± 0.019
2.431HisLeu: 2.431 ± 0.041
0.541HisMet: 0.541 ± 0.022
0.585HisAsn: 0.585 ± 0.02
1.584HisPro: 1.584 ± 0.036
0.808HisGln: 0.808 ± 0.029
1.641HisArg: 1.641 ± 0.042
1.079HisSer: 1.079 ± 0.026
1.157HisThr: 1.157 ± 0.03
1.716HisVal: 1.716 ± 0.037
0.468HisTrp: 0.468 ± 0.02
0.738HisTyr: 0.738 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.812IleAla: 6.812 ± 0.072
0.499IleCys: 0.499 ± 0.02
3.464IleAsp: 3.464 ± 0.055
3.227IleGlu: 3.227 ± 0.055
1.651IlePhe: 1.651 ± 0.04
4.835IleGly: 4.835 ± 0.061
1.008IleHis: 1.008 ± 0.028
1.806IleIle: 1.806 ± 0.039
1.536IleLys: 1.536 ± 0.042
4.017IleLeu: 4.017 ± 0.061
0.891IleMet: 0.891 ± 0.027
1.464IleAsn: 1.464 ± 0.036
2.184IlePro: 2.184 ± 0.046
1.358IleGln: 1.358 ± 0.035
2.885IleArg: 2.885 ± 0.051
2.635IleSer: 2.635 ± 0.053
2.423IleThr: 2.423 ± 0.045
4.146IleVal: 4.146 ± 0.064
0.527IleTrp: 0.527 ± 0.018
1.206IleTyr: 1.206 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.3LysAla: 3.3 ± 0.059
0.166LysCys: 0.166 ± 0.012
1.335LysAsp: 1.335 ± 0.035
1.305LysGlu: 1.305 ± 0.034
0.976LysPhe: 0.976 ± 0.028
1.859LysGly: 1.859 ± 0.045
0.724LysHis: 0.724 ± 0.022
1.672LysIle: 1.672 ± 0.038
1.119LysLys: 1.119 ± 0.037
3.283LysLeu: 3.283 ± 0.05
0.778LysMet: 0.778 ± 0.025
0.846LysAsn: 0.846 ± 0.027
1.786LysPro: 1.786 ± 0.04
1.296LysGln: 1.296 ± 0.031
2.226LysArg: 2.226 ± 0.044
1.613LysSer: 1.613 ± 0.038
1.831LysThr: 1.831 ± 0.042
2.187LysVal: 2.187 ± 0.045
0.339LysTrp: 0.339 ± 0.016
0.718LysTyr: 0.718 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.408LeuAla: 15.408 ± 0.138
1.135LeuCys: 1.135 ± 0.028
5.973LeuAsp: 5.973 ± 0.067
5.159LeuGlu: 5.159 ± 0.076
3.718LeuPhe: 3.718 ± 0.066
9.118LeuGly: 9.118 ± 0.098
2.476LeuHis: 2.476 ± 0.04
4.965LeuIle: 4.965 ± 0.071
3.287LeuLys: 3.287 ± 0.049
11.544LeuLeu: 11.544 ± 0.128
2.421LeuMet: 2.421 ± 0.046
2.772LeuAsn: 2.772 ± 0.05
6.175LeuPro: 6.175 ± 0.081
3.794LeuGln: 3.794 ± 0.065
7.649LeuArg: 7.649 ± 0.091
6.579LeuSer: 6.579 ± 0.073
5.715LeuThr: 5.715 ± 0.068
7.48LeuVal: 7.48 ± 0.087
1.289LeuTrp: 1.289 ± 0.031
2.289LeuTyr: 2.289 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.806MetAla: 2.806 ± 0.051
0.214MetCys: 0.214 ± 0.013
0.916MetAsp: 0.916 ± 0.027
0.958MetGlu: 0.958 ± 0.031
0.756MetPhe: 0.756 ± 0.025
1.628MetGly: 1.628 ± 0.041
0.605MetHis: 0.605 ± 0.019
1.177MetIle: 1.177 ± 0.031
0.919MetLys: 0.919 ± 0.03
2.876MetLeu: 2.876 ± 0.046
0.626MetMet: 0.626 ± 0.023
0.848MetAsn: 0.848 ± 0.024
1.554MetPro: 1.554 ± 0.032
1.068MetGln: 1.068 ± 0.025
1.921MetArg: 1.921 ± 0.04
1.647MetSer: 1.647 ± 0.035
1.646MetThr: 1.646 ± 0.036
1.624MetVal: 1.624 ± 0.036
0.224MetTrp: 0.224 ± 0.013
0.41MetTyr: 0.41 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.186AsnAla: 3.186 ± 0.052
0.239AsnCys: 0.239 ± 0.013
1.324AsnAsp: 1.324 ± 0.039
1.196AsnGlu: 1.196 ± 0.034
1.04AsnPhe: 1.04 ± 0.033
2.302AsnGly: 2.302 ± 0.042
0.547AsnHis: 0.547 ± 0.02
1.268AsnIle: 1.268 ± 0.03
0.701AsnLys: 0.701 ± 0.027
2.811AsnLeu: 2.811 ± 0.051
0.587AsnMet: 0.587 ± 0.022
0.753AsnAsn: 0.753 ± 0.027
1.845AsnPro: 1.845 ± 0.041
1.013AsnGln: 1.013 ± 0.029
1.793AsnArg: 1.793 ± 0.035
1.218AsnSer: 1.218 ± 0.036
1.374AsnThr: 1.374 ± 0.039
2.078AsnVal: 2.078 ± 0.048
0.408AsnTrp: 0.408 ± 0.019
0.743AsnTyr: 0.743 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
7.076ProAla: 7.076 ± 0.078
0.408ProCys: 0.408 ± 0.019
3.065ProAsp: 3.065 ± 0.05
2.903ProGlu: 2.903 ± 0.052
1.884ProPhe: 1.884 ± 0.04
4.574ProGly: 4.574 ± 0.07
1.356ProHis: 1.356 ± 0.035
2.191ProIle: 2.191 ± 0.041
1.355ProLys: 1.355 ± 0.036
5.476ProLeu: 5.476 ± 0.067
1.172ProMet: 1.172 ± 0.03
1.402ProAsn: 1.402 ± 0.037
2.476ProPro: 2.476 ± 0.051
2.01ProGln: 2.01 ± 0.041
2.987ProArg: 2.987 ± 0.058
2.715ProSer: 2.715 ± 0.052
2.536ProThr: 2.536 ± 0.048
4.165ProVal: 4.165 ± 0.057
0.723ProTrp: 0.723 ± 0.023
1.28ProTyr: 1.28 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
5.695GlnAla: 5.695 ± 0.094
0.329GlnCys: 0.329 ± 0.016
1.558GlnAsp: 1.558 ± 0.035
1.575GlnGlu: 1.575 ± 0.035
1.321GlnPhe: 1.321 ± 0.034
2.808GlnGly: 2.808 ± 0.051
1.046GlnHis: 1.046 ± 0.028
2.163GlnIle: 2.163 ± 0.044
1.007GlnLys: 1.007 ± 0.028
4.132GlnLeu: 4.132 ± 0.064
1.0GlnMet: 1.0 ± 0.029
0.906GlnAsn: 0.906 ± 0.029
2.038GlnPro: 2.038 ± 0.039
1.926GlnGln: 1.926 ± 0.051
3.315GlnArg: 3.315 ± 0.063
2.104GlnSer: 2.104 ± 0.045
2.163GlnThr: 2.163 ± 0.045
2.83GlnVal: 2.83 ± 0.057
0.671GlnTrp: 0.671 ± 0.022
0.941GlnTyr: 0.941 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.298ArgAla: 8.298 ± 0.094
0.612ArgCys: 0.612 ± 0.021
3.692ArgAsp: 3.692 ± 0.061
4.216ArgGlu: 4.216 ± 0.07
2.816ArgPhe: 2.816 ± 0.058
4.724ArgGly: 4.724 ± 0.065
2.141ArgHis: 2.141 ± 0.042
3.674ArgIle: 3.674 ± 0.058
1.938ArgLys: 1.938 ± 0.04
8.016ArgLeu: 8.016 ± 0.075
1.854ArgMet: 1.854 ± 0.04
1.807ArgAsn: 1.807 ± 0.037
3.195ArgPro: 3.195 ± 0.062
3.202ArgGln: 3.202 ± 0.059
5.647ArgArg: 5.647 ± 0.085
3.081ArgSer: 3.081 ± 0.057
3.274ArgThr: 3.274 ± 0.053
5.085ArgVal: 5.085 ± 0.067
1.087ArgTrp: 1.087 ± 0.032
2.003ArgTyr: 2.003 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.571SerAla: 6.571 ± 0.081
0.464SerCys: 0.464 ± 0.021
2.65SerAsp: 2.65 ± 0.049
2.465SerGlu: 2.465 ± 0.046
1.965SerPhe: 1.965 ± 0.038
5.134SerGly: 5.134 ± 0.084
1.227SerHis: 1.227 ± 0.03
2.632SerIle: 2.632 ± 0.048
1.408SerLys: 1.408 ± 0.033
5.822SerLeu: 5.822 ± 0.077
1.352SerMet: 1.352 ± 0.035
1.453SerAsn: 1.453 ± 0.035
2.896SerPro: 2.896 ± 0.056
1.881SerGln: 1.881 ± 0.044
3.393SerArg: 3.393 ± 0.056
2.946SerSer: 2.946 ± 0.065
2.681SerThr: 2.681 ± 0.05
3.91SerVal: 3.91 ± 0.054
0.687SerTrp: 0.687 ± 0.025
1.318SerTyr: 1.318 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.667ThrAla: 5.667 ± 0.079
0.467ThrCys: 0.467 ± 0.017
2.503ThrAsp: 2.503 ± 0.049
2.253ThrGlu: 2.253 ± 0.038
1.915ThrPhe: 1.915 ± 0.041
4.647ThrGly: 4.647 ± 0.073
1.338ThrHis: 1.338 ± 0.034
2.465ThrIle: 2.465 ± 0.05
1.105ThrLys: 1.105 ± 0.031
6.525ThrLeu: 6.525 ± 0.077
1.092ThrMet: 1.092 ± 0.034
1.212ThrAsn: 1.212 ± 0.036
3.523ThrPro: 3.523 ± 0.05
1.976ThrGln: 1.976 ± 0.047
3.373ThrArg: 3.373 ± 0.052
2.628ThrSer: 2.628 ± 0.059
2.586ThrThr: 2.586 ± 0.06
4.167ThrVal: 4.167 ± 0.064
0.652ThrTrp: 0.652 ± 0.024
1.242ThrTyr: 1.242 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
9.331ValAla: 9.331 ± 0.081
0.827ValCys: 0.827 ± 0.026
3.892ValAsp: 3.892 ± 0.059
3.755ValGlu: 3.755 ± 0.065
2.806ValPhe: 2.806 ± 0.049
5.482ValGly: 5.482 ± 0.07
1.538ValHis: 1.538 ± 0.036
3.847ValIle: 3.847 ± 0.056
2.35ValLys: 2.35 ± 0.044
8.376ValLeu: 8.376 ± 0.09
1.937ValMet: 1.937 ± 0.044
2.085ValAsn: 2.085 ± 0.04
3.975ValPro: 3.975 ± 0.054
2.464ValGln: 2.464 ± 0.044
5.02ValArg: 5.02 ± 0.071
4.422ValSer: 4.422 ± 0.067
4.301ValThr: 4.301 ± 0.068
6.011ValVal: 6.011 ± 0.078
0.931ValTrp: 0.931 ± 0.027
1.645ValTyr: 1.645 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.157TrpAla: 1.157 ± 0.031
0.162TrpCys: 0.162 ± 0.011
0.572TrpAsp: 0.572 ± 0.021
0.533TrpGlu: 0.533 ± 0.022
0.547TrpPhe: 0.547 ± 0.024
0.923TrpGly: 0.923 ± 0.031
0.463TrpHis: 0.463 ± 0.02
0.674TrpIle: 0.674 ± 0.024
0.339TrpLys: 0.339 ± 0.016
2.126TrpLeu: 2.126 ± 0.045
0.371TrpMet: 0.371 ± 0.02
0.36TrpAsn: 0.36 ± 0.016
0.709TrpPro: 0.709 ± 0.025
0.829TrpGln: 0.829 ± 0.028
1.342TrpArg: 1.342 ± 0.035
0.713TrpSer: 0.713 ± 0.023
0.613TrpThr: 0.613 ± 0.021
0.955TrpVal: 0.955 ± 0.027
0.224TrpTrp: 0.224 ± 0.014
0.312TrpTyr: 0.312 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.833TyrAla: 2.833 ± 0.052
0.289TyrCys: 0.289 ± 0.016
1.325TyrAsp: 1.325 ± 0.03
1.176TyrGlu: 1.176 ± 0.025
1.056TyrPhe: 1.056 ± 0.024
2.284TyrGly: 2.284 ± 0.046
0.601TyrHis: 0.601 ± 0.019
0.91TyrIle: 0.91 ± 0.024
0.627TyrLys: 0.627 ± 0.024
2.733TyrLeu: 2.733 ± 0.048
0.462TyrMet: 0.462 ± 0.019
0.618TyrAsn: 0.618 ± 0.024
1.317TyrPro: 1.317 ± 0.033
0.996TyrGln: 0.996 ± 0.032
2.057TyrArg: 2.057 ± 0.041
1.22TyrSer: 1.22 ± 0.03
1.25TyrThr: 1.25 ± 0.031
1.856TyrVal: 1.856 ± 0.036
0.394TyrTrp: 0.394 ± 0.017
0.724TyrTyr: 0.724 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3963 proteins (1287374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski