Amino acid dipepetide frequency for Phoenicopterus ruber ruber

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.618AlaAla: 5.618 ± 0.055	1.312AlaCys: 1.312 ± 0.022	2.99AlaAsp: 2.99 ± 0.033	4.606AlaGlu: 4.606 ± 0.047	2.608AlaPhe: 2.608 ± 0.032	3.787AlaGly: 3.787 ± 0.039	1.324AlaHis: 1.324 ± 0.02	3.105AlaIle: 3.105 ± 0.033	3.717AlaLys: 3.717 ± 0.039	6.423AlaLeu: 6.423 ± 0.049	1.513AlaMet: 1.513 ± 0.023	2.287AlaAsn: 2.287 ± 0.03	2.918AlaPro: 2.918 ± 0.042	2.732AlaGln: 2.732 ± 0.032	2.878AlaArg: 2.878 ± 0.031	5.196AlaSer: 5.196 ± 0.053	3.404AlaThr: 3.404 ± 0.037	4.833AlaVal: 4.833 ± 0.037	0.699AlaTrp: 0.699 ± 0.018	1.643AlaTyr: 1.643 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.167CysAla: 1.167 ± 0.024	0.656CysCys: 0.656 ± 0.019	1.04CysAsp: 1.04 ± 0.025	1.322CysGlu: 1.322 ± 0.027	0.929CysPhe: 0.929 ± 0.02	1.445CysGly: 1.445 ± 0.03	0.633CysHis: 0.633 ± 0.016	1.186CysIle: 1.186 ± 0.023	1.378CysLys: 1.378 ± 0.028	2.156CysLeu: 2.156 ± 0.032	0.443CysMet: 0.443 ± 0.011	0.967CysAsn: 0.967 ± 0.021	1.203CysPro: 1.203 ± 0.03	1.063CysGln: 1.063 ± 0.024	1.231CysArg: 1.231 ± 0.022	2.044CysSer: 2.044 ± 0.035	1.201CysThr: 1.201 ± 0.024	1.36CysVal: 1.36 ± 0.023	0.293CysTrp: 0.293 ± 0.01	0.7CysTyr: 0.7 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.922AspAla: 2.922 ± 0.031	1.12AspCys: 1.12 ± 0.024	2.887AspAsp: 2.887 ± 0.04	3.73AspGlu: 3.73 ± 0.048	2.247AspPhe: 2.247 ± 0.024	3.3AspGly: 3.3 ± 0.041	1.158AspHis: 1.158 ± 0.021	3.01AspIle: 3.01 ± 0.031	2.865AspLys: 2.865 ± 0.031	5.076AspLeu: 5.076 ± 0.043	1.165AspMet: 1.165 ± 0.021	1.967AspAsn: 1.967 ± 0.03	2.605AspPro: 2.605 ± 0.027	1.864AspGln: 1.864 ± 0.028	2.412AspArg: 2.412 ± 0.028	4.127AspSer: 4.127 ± 0.048	2.517AspThr: 2.517 ± 0.029	3.223AspVal: 3.223 ± 0.036	0.659AspTrp: 0.659 ± 0.017	1.655AspTyr: 1.655 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	4.699GluAla: 4.699 ± 0.055	1.337GluCys: 1.337 ± 0.032	4.55GluAsp: 4.55 ± 0.049	7.965GluGlu: 7.965 ± 0.1	2.248GluPhe: 2.248 ± 0.025	3.9GluGly: 3.9 ± 0.04	1.553GluHis: 1.553 ± 0.023	3.619GluIle: 3.619 ± 0.038	5.892GluLys: 5.892 ± 0.067	6.288GluLeu: 6.288 ± 0.061	1.798GluMet: 1.798 ± 0.023	3.549GluAsn: 3.549 ± 0.043	2.515GluPro: 2.515 ± 0.034	3.233GluGln: 3.233 ± 0.038	3.924GluArg: 3.924 ± 0.042	4.59GluSer: 4.59 ± 0.046	3.645GluThr: 3.645 ± 0.035	4.395GluVal: 4.395 ± 0.037	0.721GluTrp: 0.721 ± 0.017	1.842GluTyr: 1.842 ± 0.026	0.001GluXaa: 0.001 ± 0.0
Phe	2.168PheAla: 2.168 ± 0.027	0.998PheCys: 0.998 ± 0.02	1.844PheAsp: 1.844 ± 0.028	2.161PheGlu: 2.161 ± 0.024	1.887PhePhe: 1.887 ± 0.035	2.29PheGly: 2.29 ± 0.03	1.089PheHis: 1.089 ± 0.018	2.136PheIle: 2.136 ± 0.032	2.189PheLys: 2.189 ± 0.031	4.244PheLeu: 4.244 ± 0.044	0.818PheMet: 0.818 ± 0.018	1.545PheAsn: 1.545 ± 0.025	1.924PhePro: 1.924 ± 0.026	1.849PheGln: 1.849 ± 0.025	1.911PheArg: 1.911 ± 0.026	3.486PheSer: 3.486 ± 0.038	2.287PheThr: 2.287 ± 0.03	2.419PheVal: 2.419 ± 0.032	0.513PheTrp: 0.513 ± 0.013	1.336PheTyr: 1.336 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	3.44GlyAla: 3.44 ± 0.039	1.212GlyCys: 1.212 ± 0.023	2.893GlyAsp: 2.893 ± 0.035	3.711GlyGlu: 3.711 ± 0.046	2.494GlyPhe: 2.494 ± 0.034	3.755GlyGly: 3.755 ± 0.057	1.478GlyHis: 1.478 ± 0.025	3.102GlyIle: 3.102 ± 0.04	4.027GlyLys: 4.027 ± 0.04	5.024GlyLeu: 5.024 ± 0.051	1.334GlyMet: 1.334 ± 0.021	2.656GlyAsn: 2.656 ± 0.028	2.663GlyPro: 2.663 ± 0.062	2.493GlyGln: 2.493 ± 0.036	3.119GlyArg: 3.119 ± 0.035	4.966GlySer: 4.966 ± 0.055	3.335GlyThr: 3.335 ± 0.035	3.432GlyVal: 3.432 ± 0.038	0.749GlyTrp: 0.749 ± 0.02	1.852GlyTyr: 1.852 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.307HisAla: 1.307 ± 0.022	0.712HisCys: 0.712 ± 0.019	0.932HisAsp: 0.932 ± 0.019	1.363HisGlu: 1.363 ± 0.019	1.126HisPhe: 1.126 ± 0.019	1.428HisGly: 1.428 ± 0.022	0.855HisHis: 0.855 ± 0.02	1.35HisIle: 1.35 ± 0.018	1.434HisLys: 1.434 ± 0.022	2.805HisLeu: 2.805 ± 0.031	0.585HisMet: 0.585 ± 0.014	0.989HisAsn: 0.989 ± 0.018	1.444HisPro: 1.444 ± 0.025	1.171HisGln: 1.171 ± 0.02	1.442HisArg: 1.442 ± 0.022	2.162HisSer: 2.162 ± 0.028	1.304HisThr: 1.304 ± 0.023	1.511HisVal: 1.511 ± 0.022	0.417HisTrp: 0.417 ± 0.013	0.853HisTyr: 0.853 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.116IleAla: 3.116 ± 0.031	1.253IleCys: 1.253 ± 0.023	2.349IleAsp: 2.349 ± 0.032	2.991IleGlu: 2.991 ± 0.032	2.21IlePhe: 2.21 ± 0.033	2.527IleGly: 2.527 ± 0.034	1.404IleHis: 1.404 ± 0.019	2.791IleIle: 2.791 ± 0.036	3.146IleLys: 3.146 ± 0.032	5.052IleLeu: 5.052 ± 0.043	1.107IleMet: 1.107 ± 0.021	2.253IleAsn: 2.253 ± 0.031	2.895IlePro: 2.895 ± 0.032	2.487IleGln: 2.487 ± 0.028	2.591IleArg: 2.591 ± 0.031	4.158IleSer: 4.158 ± 0.036	2.849IleThr: 2.849 ± 0.033	3.001IleVal: 3.001 ± 0.035	0.589IleTrp: 0.589 ± 0.013	1.615IleTyr: 1.615 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.107LysAla: 4.107 ± 0.042	1.287LysCys: 1.287 ± 0.028	3.562LysAsp: 3.562 ± 0.045	5.876LysGlu: 5.876 ± 0.066	1.961LysPhe: 1.961 ± 0.026	3.427LysGly: 3.427 ± 0.045	1.62LysHis: 1.62 ± 0.023	3.29LysIle: 3.29 ± 0.036	5.517LysLys: 5.517 ± 0.053	5.904LysLeu: 5.904 ± 0.054	1.57LysMet: 1.57 ± 0.022	2.883LysAsn: 2.883 ± 0.03	3.133LysPro: 3.133 ± 0.039	3.062LysGln: 3.062 ± 0.033	3.607LysArg: 3.607 ± 0.039	4.361LysSer: 4.361 ± 0.049	3.528LysThr: 3.528 ± 0.033	3.826LysVal: 3.826 ± 0.035	0.686LysTrp: 0.686 ± 0.015	1.904LysTyr: 1.904 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	6.163LeuAla: 6.163 ± 0.049	2.204LeuCys: 2.204 ± 0.031	4.952LeuAsp: 4.952 ± 0.04	7.101LeuGlu: 7.101 ± 0.075	3.634LeuPhe: 3.634 ± 0.039	5.131LeuGly: 5.131 ± 0.051	2.636LeuHis: 2.636 ± 0.036	4.383LeuIle: 4.383 ± 0.046	6.554LeuLys: 6.554 ± 0.055	9.944LeuLeu: 9.944 ± 0.089	2.062LeuMet: 2.062 ± 0.029	3.942LeuAsn: 3.942 ± 0.041	5.373LeuPro: 5.373 ± 0.051	5.617LeuGln: 5.617 ± 0.057	5.102LeuArg: 5.102 ± 0.047	7.805LeuSer: 7.805 ± 0.057	5.024LeuThr: 5.024 ± 0.046	5.474LeuVal: 5.474 ± 0.051	1.086LeuTrp: 1.086 ± 0.019	2.79LeuTyr: 2.79 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.606MetAla: 1.606 ± 0.022	0.448MetCys: 0.448 ± 0.013	1.302MetAsp: 1.302 ± 0.021	1.863MetGlu: 1.863 ± 0.023	0.853MetPhe: 0.853 ± 0.018	1.217MetGly: 1.217 ± 0.02	0.537MetHis: 0.537 ± 0.011	1.001MetIle: 1.001 ± 0.017	1.642MetLys: 1.642 ± 0.023	2.087MetLeu: 2.087 ± 0.027	0.62MetMet: 0.62 ± 0.015	1.018MetAsn: 1.018 ± 0.02	1.045MetPro: 1.045 ± 0.02	1.029MetGln: 1.029 ± 0.018	1.113MetArg: 1.113 ± 0.02	1.569MetSer: 1.569 ± 0.024	1.154MetThr: 1.154 ± 0.019	1.426MetVal: 1.426 ± 0.022	0.253MetTrp: 0.253 ± 0.01	0.674MetTyr: 0.674 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.391AsnAla: 2.391 ± 0.032	0.986AsnCys: 0.986 ± 0.021	1.752AsnAsp: 1.752 ± 0.026	2.643AsnGlu: 2.643 ± 0.031	1.653AsnPhe: 1.653 ± 0.022	2.872AsnGly: 2.872 ± 0.044	1.003AsnHis: 1.003 ± 0.018	2.519AsnIle: 2.519 ± 0.033	2.67AsnLys: 2.67 ± 0.033	4.174AsnLeu: 4.174 ± 0.041	1.024AsnMet: 1.024 ± 0.017	1.92AsnAsn: 1.92 ± 0.031	2.293AsnPro: 2.293 ± 0.03	1.764AsnGln: 1.764 ± 0.025	2.079AsnArg: 2.079 ± 0.025	3.551AsnSer: 3.551 ± 0.041	2.292AsnThr: 2.292 ± 0.031	2.544AsnVal: 2.544 ± 0.031	0.52AsnTrp: 0.52 ± 0.015	1.343AsnTyr: 1.343 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	3.671ProAla: 3.671 ± 0.049	1.018ProCys: 1.018 ± 0.022	2.623ProAsp: 2.623 ± 0.026	3.788ProGlu: 3.788 ± 0.037	1.884ProPhe: 1.884 ± 0.028	3.479ProGly: 3.479 ± 0.086	1.235ProHis: 1.235 ± 0.02	2.041ProIle: 2.041 ± 0.028	2.775ProLys: 2.775 ± 0.031	4.595ProLeu: 4.595 ± 0.043	0.958ProMet: 0.958 ± 0.017	1.951ProAsn: 1.951 ± 0.029	4.122ProPro: 4.122 ± 0.073	2.298ProGln: 2.298 ± 0.038	2.47ProArg: 2.47 ± 0.029	4.956ProSer: 4.956 ± 0.061	2.651ProThr: 2.651 ± 0.035	3.775ProVal: 3.775 ± 0.043	0.542ProTrp: 0.542 ± 0.015	1.46ProTyr: 1.46 ± 0.024	0.001ProXaa: 0.001 ± 0.0
Gln	3.024GlnAla: 3.024 ± 0.039	0.961GlnCys: 0.961 ± 0.025	2.233GlnAsp: 2.233 ± 0.029	3.705GlnGlu: 3.705 ± 0.046	1.476GlnPhe: 1.476 ± 0.021	2.454GlnGly: 2.454 ± 0.035	1.269GlnHis: 1.269 ± 0.022	2.292GlnIle: 2.292 ± 0.028	3.257GlnLys: 3.257 ± 0.037	4.597GlnLeu: 4.597 ± 0.044	1.119GlnMet: 1.119 ± 0.019	2.104GlnAsn: 2.104 ± 0.029	2.353GlnPro: 2.353 ± 0.038	3.061GlnGln: 3.061 ± 0.059	2.623GlnArg: 2.623 ± 0.03	3.224GlnSer: 3.224 ± 0.038	2.412GlnThr: 2.412 ± 0.032	2.721GlnVal: 2.721 ± 0.033	0.51GlnTrp: 0.51 ± 0.012	1.331GlnTyr: 1.331 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	2.957ArgAla: 2.957 ± 0.033	1.092ArgCys: 1.092 ± 0.022	2.561ArgAsp: 2.561 ± 0.029	3.816ArgGlu: 3.816 ± 0.041	1.949ArgPhe: 1.949 ± 0.025	2.799ArgGly: 2.799 ± 0.043	1.427ArgHis: 1.427 ± 0.024	2.637ArgIle: 2.637 ± 0.03	3.95ArgLys: 3.95 ± 0.045	4.967ArgLeu: 4.967 ± 0.049	1.15ArgMet: 1.15 ± 0.019	2.266ArgAsn: 2.266 ± 0.028	2.349ArgPro: 2.349 ± 0.032	2.454ArgGln: 2.454 ± 0.028	3.65ArgArg: 3.65 ± 0.041	4.016ArgSer: 4.016 ± 0.049	2.67ArgThr: 2.67 ± 0.032	2.934ArgVal: 2.934 ± 0.032	0.621ArgTrp: 0.621 ± 0.015	1.64ArgTyr: 1.64 ± 0.024	0.001ArgXaa: 0.001 ± 0.0
Ser	5.122SerAla: 5.122 ± 0.049	1.866SerCys: 1.866 ± 0.032	4.03SerAsp: 4.03 ± 0.046	5.229SerGlu: 5.229 ± 0.057	3.179SerPhe: 3.179 ± 0.031	4.853SerGly: 4.853 ± 0.046	2.043SerHis: 2.043 ± 0.028	3.609SerIle: 3.609 ± 0.033	4.568SerLys: 4.568 ± 0.053	8.031SerLeu: 8.031 ± 0.058	1.628SerMet: 1.628 ± 0.022	3.17SerAsn: 3.17 ± 0.04	5.111SerPro: 5.111 ± 0.074	3.659SerGln: 3.659 ± 0.044	4.086SerArg: 4.086 ± 0.048	9.365SerSer: 9.365 ± 0.117	4.603SerThr: 4.603 ± 0.054	5.137SerVal: 5.137 ± 0.046	0.949SerTrp: 0.949 ± 0.018	2.338SerTyr: 2.338 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	3.8ThrAla: 3.8 ± 0.042	1.338ThrCys: 1.338 ± 0.032	2.766ThrAsp: 2.766 ± 0.03	3.79ThrGlu: 3.79 ± 0.04	2.24ThrPhe: 2.24 ± 0.032	3.354ThrGly: 3.354 ± 0.037	1.178ThrHis: 1.178 ± 0.02	2.646ThrIle: 2.646 ± 0.033	2.961ThrLys: 2.961 ± 0.034	5.158ThrLeu: 5.158 ± 0.037	1.165ThrMet: 1.165 ± 0.02	1.976ThrAsn: 1.976 ± 0.027	3.142ThrPro: 3.142 ± 0.044	2.147ThrGln: 2.147 ± 0.031	2.326ThrArg: 2.326 ± 0.03	4.728ThrSer: 4.728 ± 0.054	3.039ThrThr: 3.039 ± 0.044	4.148ThrVal: 4.148 ± 0.044	0.669ThrTrp: 0.669 ± 0.017	1.563ThrTyr: 1.563 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.073ValAla: 4.073 ± 0.042	1.559ValCys: 1.559 ± 0.023	3.124ValAsp: 3.124 ± 0.031	3.989ValGlu: 3.989 ± 0.039	2.666ValPhe: 2.666 ± 0.035	3.306ValGly: 3.306 ± 0.036	1.6ValHis: 1.6 ± 0.02	3.353ValIle: 3.353 ± 0.036	3.896ValLys: 3.896 ± 0.038	6.312ValLeu: 6.312 ± 0.057	1.411ValMet: 1.411 ± 0.02	2.599ValAsn: 2.599 ± 0.03	3.412ValPro: 3.412 ± 0.037	2.874ValGln: 2.874 ± 0.033	2.955ValArg: 2.955 ± 0.032	4.968ValSer: 4.968 ± 0.051	3.894ValThr: 3.894 ± 0.043	4.354ValVal: 4.354 ± 0.042	0.725ValTrp: 0.725 ± 0.018	1.878ValTyr: 1.878 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.654TrpAla: 0.654 ± 0.015	0.244TrpCys: 0.244 ± 0.01	0.659TrpAsp: 0.659 ± 0.016	0.749TrpGlu: 0.749 ± 0.016	0.467TrpPhe: 0.467 ± 0.013	0.634TrpGly: 0.634 ± 0.018	0.332TrpHis: 0.332 ± 0.012	0.636TrpIle: 0.636 ± 0.018	0.907TrpLys: 0.907 ± 0.016	1.169TrpLeu: 1.169 ± 0.024	0.309TrpMet: 0.309 ± 0.009	0.644TrpAsn: 0.644 ± 0.015	0.423TrpPro: 0.423 ± 0.012	0.559TrpGln: 0.559 ± 0.014	0.651TrpArg: 0.651 ± 0.014	0.868TrpSer: 0.868 ± 0.019	0.671TrpThr: 0.671 ± 0.016	0.657TrpVal: 0.657 ± 0.015	0.184TrpTrp: 0.184 ± 0.009	0.355TrpTyr: 0.355 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.591TyrAla: 1.591 ± 0.024	0.814TyrCys: 0.814 ± 0.018	1.459TyrAsp: 1.459 ± 0.022	1.861TyrGlu: 1.861 ± 0.026	1.387TyrPhe: 1.387 ± 0.027	1.781TyrGly: 1.781 ± 0.024	0.818TyrHis: 0.818 ± 0.017	1.68TyrIle: 1.68 ± 0.025	1.764TyrLys: 1.764 ± 0.027	2.97TyrLeu: 2.97 ± 0.036	0.678TyrMet: 0.678 ± 0.015	1.304TyrAsn: 1.304 ± 0.02	1.369TyrPro: 1.369 ± 0.02	1.31TyrGln: 1.31 ± 0.021	1.733TyrArg: 1.733 ± 0.023	2.435TyrSer: 2.435 ± 0.031	1.652TyrThr: 1.652 ± 0.027	1.777TyrVal: 1.777 ± 0.026	0.388TyrTrp: 0.388 ± 0.013	1.132TyrTyr: 1.132 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.018XaaXaa: 0.018 ± 0.005

Statistics based on 8220 proteins (3367651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---