Amino acid dipepetide frequency for Birch leaf roll-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.414AlaAla: 2.414 ± 1.008
1.207AlaCys: 1.207 ± 0.606
2.012AlaAsp: 2.012 ± 1.011
2.817AlaGlu: 2.817 ± 1.415
3.622AlaPhe: 3.622 ± 0.744
2.817AlaGly: 2.817 ± 0.883
1.207AlaHis: 1.207 ± 0.951
4.829AlaIle: 4.829 ± 1.041
2.817AlaLys: 2.817 ± 1.882
5.231AlaLeu: 5.231 ± 1.202
3.219AlaMet: 3.219 ± 1.771
2.012AlaAsn: 2.012 ± 0.802
3.219AlaPro: 3.219 ± 1.074
3.622AlaGln: 3.622 ± 1.043
3.219AlaArg: 3.219 ± 2.044
2.414AlaSer: 2.414 ± 2.976
4.024AlaThr: 4.024 ± 1.805
4.829AlaVal: 4.829 ± 1.081
0.0AlaTrp: 0.0 ± 0.0
4.829AlaTyr: 4.829 ± 2.655
0.0AlaXaa: 0.0 ± 0.0
Cys
1.207CysAla: 1.207 ± 0.606
0.805CysCys: 0.805 ± 0.404
0.805CysAsp: 0.805 ± 0.404
0.402CysGlu: 0.402 ± 0.202
0.402CysPhe: 0.402 ± 0.202
1.207CysGly: 1.207 ± 0.606
0.0CysHis: 0.0 ± 0.0
0.402CysIle: 0.402 ± 0.202
2.817CysLys: 2.817 ± 1.415
0.402CysLeu: 0.402 ± 0.202
0.402CysMet: 0.402 ± 0.202
1.207CysAsn: 1.207 ± 0.951
1.207CysPro: 1.207 ± 0.606
0.805CysGln: 0.805 ± 0.404
0.805CysArg: 0.805 ± 0.404
0.805CysSer: 0.805 ± 0.404
0.402CysThr: 0.402 ± 0.202
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.805CysTyr: 0.805 ± 0.933
0.0CysXaa: 0.0 ± 0.0
Asp
1.61AspAla: 1.61 ± 1.472
2.012AspCys: 2.012 ± 1.011
4.024AspAsp: 4.024 ± 0.844
5.231AspGlu: 5.231 ± 1.839
2.012AspPhe: 2.012 ± 1.011
3.219AspGly: 3.219 ± 1.617
1.207AspHis: 1.207 ± 1.488
3.219AspIle: 3.219 ± 1.242
4.024AspLys: 4.024 ± 1.379
4.024AspLeu: 4.024 ± 2.31
1.207AspMet: 1.207 ± 0.606
2.414AspAsn: 2.414 ± 1.008
2.817AspPro: 2.817 ± 1.959
3.219AspGln: 3.219 ± 0.938
1.61AspArg: 1.61 ± 2.571
4.427AspSer: 4.427 ± 1.566
2.012AspThr: 2.012 ± 0.802
2.414AspVal: 2.414 ± 1.186
0.402AspTrp: 0.402 ± 1.177
3.219AspTyr: 3.219 ± 1.597
0.0AspXaa: 0.0 ± 0.0
Glu
6.841GluAla: 6.841 ± 2.626
1.207GluCys: 1.207 ± 0.606
2.817GluAsp: 2.817 ± 1.872
13.28GluGlu: 13.28 ± 0.882
1.207GluPhe: 1.207 ± 0.606
8.853GluGly: 8.853 ± 1.611
2.414GluHis: 2.414 ± 0.889
6.439GluIle: 6.439 ± 0.849
7.646GluLys: 7.646 ± 4.08
5.634GluLeu: 5.634 ± 3.251
1.61GluMet: 1.61 ± 0.808
2.817GluAsn: 2.817 ± 1.022
2.012GluPro: 2.012 ± 0.864
3.219GluGln: 3.219 ± 1.841
5.231GluArg: 5.231 ± 3.802
4.024GluSer: 4.024 ± 1.379
4.829GluThr: 4.829 ± 2.425
2.012GluVal: 2.012 ± 1.233
1.207GluTrp: 1.207 ± 0.606
1.207GluTyr: 1.207 ± 1.535
0.0GluXaa: 0.0 ± 0.0
Phe
1.207PheAla: 1.207 ± 0.606
1.207PheCys: 1.207 ± 0.606
1.61PheAsp: 1.61 ± 0.798
1.61PheGlu: 1.61 ± 0.886
0.402PhePhe: 0.402 ± 0.202
1.61PheGly: 1.61 ± 0.798
0.805PheHis: 0.805 ± 0.404
2.012PheIle: 2.012 ± 1.011
2.012PheLys: 2.012 ± 0.912
2.414PheLeu: 2.414 ± 1.213
0.0PheMet: 0.0 ± 0.0
1.207PheAsn: 1.207 ± 0.844
0.402PhePro: 0.402 ± 1.178
2.817PheGln: 2.817 ± 0.95
1.61PheArg: 1.61 ± 0.808
2.414PheSer: 2.414 ± 1.107
0.805PheThr: 0.805 ± 0.404
0.805PheVal: 0.805 ± 0.404
0.0PheTrp: 0.0 ± 0.0
2.012PheTyr: 2.012 ± 1.011
0.0PheXaa: 0.0 ± 0.0
Gly
3.622GlyAla: 3.622 ± 1.819
1.207GlyCys: 1.207 ± 0.606
3.622GlyAsp: 3.622 ± 1.819
6.036GlyGlu: 6.036 ± 1.291
2.817GlyPhe: 2.817 ± 0.883
4.427GlyGly: 4.427 ± 1.566
2.012GlyHis: 2.012 ± 0.802
4.427GlyIle: 4.427 ± 0.966
4.829GlyLys: 4.829 ± 1.735
4.829GlyLeu: 4.829 ± 1.746
0.805GlyMet: 0.805 ± 0.404
2.414GlyAsn: 2.414 ± 1.902
2.414GlyPro: 2.414 ± 1.213
2.012GlyGln: 2.012 ± 1.233
4.829GlyArg: 4.829 ± 2.655
4.427GlySer: 4.427 ± 1.566
4.427GlyThr: 4.427 ± 1.495
3.622GlyVal: 3.622 ± 0.911
2.012GlyTrp: 2.012 ± 1.011
2.414GlyTyr: 2.414 ± 1.213
0.0GlyXaa: 0.0 ± 0.0
His
0.805HisAla: 0.805 ± 2.357
0.805HisCys: 0.805 ± 0.404
0.805HisAsp: 0.805 ± 1.051
0.402HisGlu: 0.402 ± 0.202
0.402HisPhe: 0.402 ± 0.202
1.207HisGly: 1.207 ± 0.951
0.402HisHis: 0.402 ± 0.202
2.012HisIle: 2.012 ± 0.864
2.012HisLys: 2.012 ± 1.011
2.414HisLeu: 2.414 ± 0.947
0.0HisMet: 0.0 ± 0.0
0.805HisAsn: 0.805 ± 0.404
1.207HisPro: 1.207 ± 0.606
0.805HisGln: 0.805 ± 0.404
2.012HisArg: 2.012 ± 0.802
1.207HisSer: 1.207 ± 1.979
2.012HisThr: 2.012 ± 1.011
2.414HisVal: 2.414 ± 0.947
0.805HisTrp: 0.805 ± 1.051
1.207HisTyr: 1.207 ± 0.951
0.0HisXaa: 0.0 ± 0.0
Ile
6.036IleAla: 6.036 ± 1.627
0.402IleCys: 0.402 ± 0.202
4.024IleAsp: 4.024 ± 0.928
4.024IleGlu: 4.024 ± 1.728
1.61IlePhe: 1.61 ± 0.808
4.427IleGly: 4.427 ± 2.223
1.207IleHis: 1.207 ± 0.972
4.829IleIle: 4.829 ± 2.425
4.024IleLys: 4.024 ± 1.849
4.024IleLeu: 4.024 ± 1.844
2.012IleMet: 2.012 ± 0.832
2.414IleAsn: 2.414 ± 1.213
5.231IlePro: 5.231 ± 1.885
5.634IleGln: 5.634 ± 2.243
2.414IleArg: 2.414 ± 0.889
1.61IleSer: 1.61 ± 0.808
3.622IleThr: 3.622 ± 2.038
2.817IleVal: 2.817 ± 0.95
1.207IleTrp: 1.207 ± 0.951
0.402IleTyr: 0.402 ± 0.202
0.0IleXaa: 0.0 ± 0.0
Lys
1.61LysAla: 1.61 ± 0.808
1.61LysCys: 1.61 ± 0.808
3.219LysAsp: 3.219 ± 1.129
8.451LysGlu: 8.451 ± 4.9
2.012LysPhe: 2.012 ± 1.011
4.024LysGly: 4.024 ± 2.466
1.61LysHis: 1.61 ± 0.808
4.829LysIle: 4.829 ± 1.735
4.829LysLys: 4.829 ± 4.059
3.622LysLeu: 3.622 ± 1.259
2.817LysMet: 2.817 ± 1.088
2.012LysAsn: 2.012 ± 1.322
3.219LysPro: 3.219 ± 1.617
2.012LysGln: 2.012 ± 1.768
3.622LysArg: 3.622 ± 1.219
2.817LysSer: 2.817 ± 1.006
4.024LysThr: 4.024 ± 0.928
3.622LysVal: 3.622 ± 3.143
0.805LysTrp: 0.805 ± 0.404
1.207LysTyr: 1.207 ± 0.606
0.0LysXaa: 0.0 ± 0.0
Leu
4.024LeuAla: 4.024 ± 1.844
0.402LeuCys: 0.402 ± 0.202
5.634LeuAsp: 5.634 ± 3.918
6.841LeuGlu: 6.841 ± 3.627
1.207LeuPhe: 1.207 ± 0.844
4.024LeuGly: 4.024 ± 1.379
0.805LeuHis: 0.805 ± 0.404
4.829LeuIle: 4.829 ± 1.746
4.024LeuLys: 4.024 ± 1.406
4.829LeuLeu: 4.829 ± 1.725
2.012LeuMet: 2.012 ± 0.864
4.829LeuAsn: 4.829 ± 1.711
4.829LeuPro: 4.829 ± 1.041
3.622LeuGln: 3.622 ± 1.588
7.243LeuArg: 7.243 ± 2.478
6.841LeuSer: 6.841 ± 1.895
4.427LeuThr: 4.427 ± 0.966
4.829LeuVal: 4.829 ± 2.462
0.402LeuTrp: 0.402 ± 0.202
2.414LeuTyr: 2.414 ± 1.213
0.0LeuXaa: 0.0 ± 0.0
Met
2.414MetAla: 2.414 ± 1.186
0.0MetCys: 0.0 ± 0.0
2.012MetAsp: 2.012 ± 0.864
4.024MetGlu: 4.024 ± 1.335
0.402MetPhe: 0.402 ± 0.202
0.805MetGly: 0.805 ± 0.404
0.402MetHis: 0.402 ± 1.178
2.817MetIle: 2.817 ± 1.827
2.414MetLys: 2.414 ± 1.213
2.414MetLeu: 2.414 ± 1.213
0.402MetMet: 0.402 ± 0.202
1.207MetAsn: 1.207 ± 0.606
1.61MetPro: 1.61 ± 0.808
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.207MetSer: 1.207 ± 1.488
2.012MetThr: 2.012 ± 1.011
2.817MetVal: 2.817 ± 1.415
0.402MetTrp: 0.402 ± 0.202
0.402MetTyr: 0.402 ± 0.202
0.0MetXaa: 0.0 ± 0.0
Asn
2.817AsnAla: 2.817 ± 0.95
0.402AsnCys: 0.402 ± 0.202
1.61AsnAsp: 1.61 ± 2.046
1.207AsnGlu: 1.207 ± 0.606
2.414AsnPhe: 2.414 ± 1.107
3.219AsnGly: 3.219 ± 1.771
1.61AsnHis: 1.61 ± 0.886
1.207AsnIle: 1.207 ± 0.844
1.207AsnLys: 1.207 ± 0.606
2.012AsnLeu: 2.012 ± 1.768
0.805AsnMet: 0.805 ± 0.404
2.012AsnAsn: 2.012 ± 1.322
2.012AsnPro: 2.012 ± 1.011
2.012AsnGln: 2.012 ± 1.011
3.622AsnArg: 3.622 ± 1.819
4.829AsnSer: 4.829 ± 1.633
3.622AsnThr: 3.622 ± 0.744
1.61AsnVal: 1.61 ± 0.92
0.0AsnTrp: 0.0 ± 0.0
1.61AsnTyr: 1.61 ± 0.886
0.0AsnXaa: 0.0 ± 0.0
Pro
4.427ProAla: 4.427 ± 1.548
0.805ProCys: 0.805 ± 1.666
4.024ProAsp: 4.024 ± 0.93
6.439ProGlu: 6.439 ± 0.428
1.207ProPhe: 1.207 ± 0.606
4.427ProGly: 4.427 ± 1.741
2.012ProHis: 2.012 ± 1.011
1.61ProIle: 1.61 ± 1.317
2.817ProLys: 2.817 ± 1.631
3.219ProLeu: 3.219 ± 1.617
0.805ProMet: 0.805 ± 0.374
0.0ProAsn: 0.0 ± 0.0
4.427ProPro: 4.427 ± 2.709
4.024ProGln: 4.024 ± 1.728
2.817ProArg: 2.817 ± 2.041
2.817ProSer: 2.817 ± 0.883
3.219ProThr: 3.219 ± 1.617
1.207ProVal: 1.207 ± 0.606
0.805ProTrp: 0.805 ± 0.404
1.207ProTyr: 1.207 ± 0.972
0.0ProXaa: 0.0 ± 0.0
Gln
4.024GlnAla: 4.024 ± 0.93
1.61GlnCys: 1.61 ± 0.808
2.414GlnAsp: 2.414 ± 1.186
2.817GlnGlu: 2.817 ± 0.883
1.207GlnPhe: 1.207 ± 0.606
4.024GlnGly: 4.024 ± 1.379
2.817GlnHis: 2.817 ± 1.415
3.219GlnIle: 3.219 ± 1.074
3.219GlnLys: 3.219 ± 1.841
3.219GlnLeu: 3.219 ± 2.865
0.805GlnMet: 0.805 ± 0.404
2.414GlnAsn: 2.414 ± 0.947
3.219GlnPro: 3.219 ± 1.729
1.61GlnGln: 1.61 ± 0.798
6.036GlnArg: 6.036 ± 3.605
3.622GlnSer: 3.622 ± 2.915
1.207GlnThr: 1.207 ± 1.634
2.012GlnVal: 2.012 ± 1.768
1.207GlnTrp: 1.207 ± 0.606
3.219GlnTyr: 3.219 ± 1.059
0.0GlnXaa: 0.0 ± 0.0
Arg
5.231ArgAla: 5.231 ± 3.784
0.0ArgCys: 0.0 ± 0.0
2.817ArgAsp: 2.817 ± 1.443
4.829ArgGlu: 4.829 ± 2.969
2.012ArgPhe: 2.012 ± 1.233
3.622ArgGly: 3.622 ± 0.744
1.61ArgHis: 1.61 ± 0.886
3.219ArgIle: 3.219 ± 1.771
3.622ArgLys: 3.622 ± 1.219
5.634ArgLeu: 5.634 ± 2.292
3.622ArgMet: 3.622 ± 1.738
2.012ArgAsn: 2.012 ± 0.864
3.219ArgPro: 3.219 ± 1.617
6.841ArgGln: 6.841 ± 3.53
4.829ArgArg: 4.829 ± 4.044
5.231ArgSer: 5.231 ± 1.839
2.817ArgThr: 2.817 ± 1.443
2.817ArgVal: 2.817 ± 1.072
2.414ArgTrp: 2.414 ± 1.213
1.207ArgTyr: 1.207 ± 0.844
0.0ArgXaa: 0.0 ± 0.0
Ser
2.817SerAla: 2.817 ± 2.803
0.805SerCys: 0.805 ± 0.404
2.012SerAsp: 2.012 ± 1.011
4.427SerGlu: 4.427 ± 1.566
1.207SerPhe: 1.207 ± 0.606
4.024SerGly: 4.024 ± 1.844
0.805SerHis: 0.805 ± 0.404
2.817SerIle: 2.817 ± 1.006
4.024SerLys: 4.024 ± 2.471
8.048SerLeu: 8.048 ± 2.614
2.012SerMet: 2.012 ± 1.011
1.207SerAsn: 1.207 ± 0.606
3.622SerPro: 3.622 ± 1.738
4.829SerGln: 4.829 ± 1.479
6.439SerArg: 6.439 ± 0.849
6.036SerSer: 6.036 ± 2.273
4.829SerThr: 4.829 ± 0.458
2.012SerVal: 2.012 ± 1.011
0.805SerTrp: 0.805 ± 0.404
1.61SerTyr: 1.61 ± 0.92
0.0SerXaa: 0.0 ± 0.0
Thr
4.829ThrAla: 4.829 ± 0.909
0.0ThrCys: 0.0 ± 0.0
6.036ThrAsp: 6.036 ± 1.354
4.427ThrGlu: 4.427 ± 0.987
0.805ThrPhe: 0.805 ± 0.404
4.829ThrGly: 4.829 ± 2.425
0.805ThrHis: 0.805 ± 0.404
4.829ThrIle: 4.829 ± 0.909
1.61ThrLys: 1.61 ± 0.92
6.841ThrLeu: 6.841 ± 5.483
1.61ThrMet: 1.61 ± 0.886
3.219ThrAsn: 3.219 ± 1.597
4.024ThrPro: 4.024 ± 1.805
1.207ThrGln: 1.207 ± 0.844
3.622ThrArg: 3.622 ± 1.738
2.817ThrSer: 2.817 ± 1.022
6.841ThrThr: 6.841 ± 1.141
2.817ThrVal: 2.817 ± 0.95
0.805ThrTrp: 0.805 ± 0.404
1.61ThrTyr: 1.61 ± 0.808
0.0ThrXaa: 0.0 ± 0.0
Val
2.414ValAla: 2.414 ± 2.1
0.402ValCys: 0.402 ± 0.202
3.219ValAsp: 3.219 ± 1.829
3.622ValGlu: 3.622 ± 1.043
2.012ValPhe: 2.012 ± 1.011
3.219ValGly: 3.219 ± 2.068
0.0ValHis: 0.0 ± 0.0
2.012ValIle: 2.012 ± 0.912
1.207ValLys: 1.207 ± 1.535
3.219ValLeu: 3.219 ± 1.074
1.207ValMet: 1.207 ± 0.606
1.61ValAsn: 1.61 ± 0.92
1.207ValPro: 1.207 ± 0.606
3.219ValGln: 3.219 ± 1.129
4.024ValArg: 4.024 ± 1.379
4.427ValSer: 4.427 ± 0.808
4.427ValThr: 4.427 ± 0.987
3.219ValVal: 3.219 ± 3.27
0.402ValTrp: 0.402 ± 0.202
2.012ValTyr: 2.012 ± 1.233
0.0ValXaa: 0.0 ± 0.0
Trp
0.805TrpAla: 0.805 ± 0.404
0.0TrpCys: 0.0 ± 0.0
1.61TrpAsp: 1.61 ± 0.808
0.805TrpGlu: 0.805 ± 0.404
0.0TrpPhe: 0.0 ± 0.0
1.207TrpGly: 1.207 ± 0.606
0.0TrpHis: 0.0 ± 0.0
0.805TrpIle: 0.805 ± 1.06
1.207TrpLys: 1.207 ± 0.606
1.61TrpLeu: 1.61 ± 0.808
1.207TrpMet: 1.207 ± 0.606
0.402TrpAsn: 0.402 ± 1.178
0.402TrpPro: 0.402 ± 1.178
0.0TrpGln: 0.0 ± 0.0
1.207TrpArg: 1.207 ± 0.606
0.402TrpSer: 0.402 ± 0.202
1.207TrpThr: 1.207 ± 0.606
0.0TrpVal: 0.0 ± 0.0
0.402TrpTrp: 0.402 ± 0.202
0.805TrpTyr: 0.805 ± 0.404
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.207TyrAla: 1.207 ± 0.606
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
2.817TyrGlu: 2.817 ± 1.006
0.0TyrPhe: 0.0 ± 0.0
2.012TyrGly: 2.012 ± 1.011
2.012TyrHis: 2.012 ± 1.844
2.012TyrIle: 2.012 ± 1.155
1.61TyrLys: 1.61 ± 0.808
4.427TyrLeu: 4.427 ± 1.548
0.805TyrMet: 0.805 ± 0.404
3.622TyrAsn: 3.622 ± 1.188
2.012TyrPro: 2.012 ± 0.802
2.414TyrGln: 2.414 ± 0.947
2.414TyrArg: 2.414 ± 0.889
2.012TyrSer: 2.012 ± 0.802
2.817TyrThr: 2.817 ± 1.443
1.207TyrVal: 1.207 ± 0.951
0.0TyrTrp: 0.0 ± 0.0
2.012TyrTyr: 2.012 ± 0.864
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski