Amino acid dipepetide frequency for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.415AlaAla: 9.415 ± 0.076	1.042AlaCys: 1.042 ± 0.017	4.391AlaAsp: 4.391 ± 0.036	5.385AlaGlu: 5.385 ± 0.05	3.173AlaPhe: 3.173 ± 0.028	5.94AlaGly: 5.94 ± 0.041	1.845AlaHis: 1.845 ± 0.02	4.243AlaIle: 4.243 ± 0.037	3.895AlaLys: 3.895 ± 0.036	7.979AlaLeu: 7.979 ± 0.054	2.008AlaMet: 2.008 ± 0.021	2.867AlaAsn: 2.867 ± 0.026	4.922AlaPro: 4.922 ± 0.05	3.611AlaGln: 3.611 ± 0.034	5.171AlaArg: 5.171 ± 0.037	7.444AlaSer: 7.444 ± 0.05	5.289AlaThr: 5.289 ± 0.036	5.612AlaVal: 5.612 ± 0.039	1.135AlaTrp: 1.135 ± 0.015	2.165AlaTyr: 2.165 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.015	0.23CysCys: 0.23 ± 0.009	0.638CysAsp: 0.638 ± 0.012	0.567CysGlu: 0.567 ± 0.014	0.52CysPhe: 0.52 ± 0.013	0.906CysGly: 0.906 ± 0.016	0.328CysHis: 0.328 ± 0.009	0.667CysIle: 0.667 ± 0.012	0.468CysLys: 0.468 ± 0.01	1.274CysLeu: 1.274 ± 0.019	0.262CysMet: 0.262 ± 0.007	0.401CysAsn: 0.401 ± 0.01	0.636CysPro: 0.636 ± 0.015	0.445CysGln: 0.445 ± 0.01	0.759CysArg: 0.759 ± 0.014	0.884CysSer: 0.884 ± 0.015	0.642CysThr: 0.642 ± 0.013	0.792CysVal: 0.792 ± 0.015	0.188CysTrp: 0.188 ± 0.007	0.35CysTyr: 0.35 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.795AspAla: 4.795 ± 0.028	0.591AspCys: 0.591 ± 0.012	3.992AspAsp: 3.992 ± 0.041	4.427AspGlu: 4.427 ± 0.042	2.198AspPhe: 2.198 ± 0.022	3.934AspGly: 3.934 ± 0.03	1.306AspHis: 1.306 ± 0.016	2.979AspIle: 2.979 ± 0.027	2.202AspLys: 2.202 ± 0.026	5.204AspLeu: 5.204 ± 0.038	1.251AspMet: 1.251 ± 0.016	1.772AspAsn: 1.772 ± 0.02	3.382AspPro: 3.382 ± 0.027	1.981AspGln: 1.981 ± 0.021	3.195AspArg: 3.195 ± 0.031	4.2AspSer: 4.2 ± 0.03	2.882AspThr: 2.882 ± 0.023	3.643AspVal: 3.643 ± 0.029	0.853AspTrp: 0.853 ± 0.014	1.619AspTyr: 1.619 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.387GluAla: 5.387 ± 0.04	0.599GluCys: 0.599 ± 0.013	4.18GluAsp: 4.18 ± 0.037	5.661GluGlu: 5.661 ± 0.064	1.97GluPhe: 1.97 ± 0.019	3.689GluGly: 3.689 ± 0.031	1.422GluHis: 1.422 ± 0.019	3.132GluIle: 3.132 ± 0.029	3.658GluLys: 3.658 ± 0.039	5.312GluLeu: 5.312 ± 0.04	1.475GluMet: 1.475 ± 0.022	2.271GluAsn: 2.271 ± 0.025	2.879GluPro: 2.879 ± 0.053	2.602GluGln: 2.602 ± 0.031	4.028GluArg: 4.028 ± 0.039	4.42GluSer: 4.42 ± 0.039	3.55GluThr: 3.55 ± 0.033	3.597GluVal: 3.597 ± 0.03	0.862GluTrp: 0.862 ± 0.015	1.69GluTyr: 1.69 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.106PheAla: 3.106 ± 0.032	0.554PheCys: 0.554 ± 0.012	2.257PheAsp: 2.257 ± 0.021	2.097PheGlu: 2.097 ± 0.024	1.622PhePhe: 1.622 ± 0.022	2.777PheGly: 2.777 ± 0.035	0.924PheHis: 0.924 ± 0.017	1.775PheIle: 1.775 ± 0.024	1.402PheLys: 1.402 ± 0.019	3.556PheLeu: 3.556 ± 0.03	0.783PheMet: 0.783 ± 0.014	1.392PheAsn: 1.392 ± 0.019	1.998PhePro: 1.998 ± 0.021	1.444PheGln: 1.444 ± 0.018	2.03PheArg: 2.03 ± 0.023	2.986PheSer: 2.986 ± 0.028	2.109PheThr: 2.109 ± 0.023	2.375PheVal: 2.375 ± 0.025	0.637PheTrp: 0.637 ± 0.014	1.133PheTyr: 1.133 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.377GlyAla: 5.377 ± 0.045	0.841GlyCys: 0.841 ± 0.015	3.602GlyAsp: 3.602 ± 0.031	3.597GlyGlu: 3.597 ± 0.032	2.738GlyPhe: 2.738 ± 0.028	5.411GlyGly: 5.411 ± 0.06	1.669GlyHis: 1.669 ± 0.022	3.417GlyIle: 3.417 ± 0.03	3.291GlyLys: 3.291 ± 0.032	6.176GlyLeu: 6.176 ± 0.042	1.567GlyMet: 1.567 ± 0.022	2.373GlyAsn: 2.373 ± 0.027	3.381GlyPro: 3.381 ± 0.039	2.585GlyGln: 2.585 ± 0.027	4.119GlyArg: 4.119 ± 0.036	5.694GlySer: 5.694 ± 0.048	3.798GlyThr: 3.798 ± 0.032	4.361GlyVal: 4.361 ± 0.032	1.126GlyTrp: 1.126 ± 0.017	2.122GlyTyr: 2.122 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.939HisAla: 1.939 ± 0.023	0.325HisCys: 0.325 ± 0.009	1.323HisAsp: 1.323 ± 0.018	1.351HisGlu: 1.351 ± 0.017	0.931HisPhe: 0.931 ± 0.014	1.706HisGly: 1.706 ± 0.022	0.863HisHis: 0.863 ± 0.017	1.214HisIle: 1.214 ± 0.016	0.856HisLys: 0.856 ± 0.017	2.317HisLeu: 2.317 ± 0.026	0.49HisMet: 0.49 ± 0.011	0.821HisAsn: 0.821 ± 0.013	1.765HisPro: 1.765 ± 0.027	1.007HisGln: 1.007 ± 0.017	1.63HisArg: 1.63 ± 0.02	1.903HisSer: 1.903 ± 0.024	1.302HisThr: 1.302 ± 0.017	1.425HisVal: 1.425 ± 0.021	0.335HisTrp: 0.335 ± 0.009	0.685HisTyr: 0.685 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.232IleAla: 4.232 ± 0.034	0.737IleCys: 0.737 ± 0.014	2.828IleAsp: 2.828 ± 0.025	2.856IleGlu: 2.856 ± 0.025	2.001IlePhe: 2.001 ± 0.023	3.095IleGly: 3.095 ± 0.03	1.24IleHis: 1.24 ± 0.017	2.443IleIle: 2.443 ± 0.026	2.054IleLys: 2.054 ± 0.025	4.685IleLeu: 4.685 ± 0.041	0.95IleMet: 0.95 ± 0.016	1.722IleAsn: 1.722 ± 0.021	3.19IlePro: 3.19 ± 0.026	1.931IleGln: 1.931 ± 0.02	2.864IleArg: 2.864 ± 0.023	3.817IleSer: 3.817 ± 0.031	2.724IleThr: 2.724 ± 0.024	3.164IleVal: 3.164 ± 0.032	0.675IleTrp: 0.675 ± 0.015	1.398IleTyr: 1.398 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.045LysAla: 4.045 ± 0.039	0.457LysCys: 0.457 ± 0.011	2.669LysAsp: 2.669 ± 0.024	3.287LysGlu: 3.287 ± 0.034	1.362LysPhe: 1.362 ± 0.017	2.827LysGly: 2.827 ± 0.027	1.087LysHis: 1.087 ± 0.017	2.203LysIle: 2.203 ± 0.024	3.135LysLys: 3.135 ± 0.051	3.951LysLeu: 3.951 ± 0.036	0.963LysMet: 0.963 ± 0.015	1.677LysAsn: 1.677 ± 0.022	2.659LysPro: 2.659 ± 0.028	1.852LysGln: 1.852 ± 0.023	3.381LysArg: 3.381 ± 0.036	3.341LysSer: 3.341 ± 0.031	2.663LysThr: 2.663 ± 0.028	2.717LysVal: 2.717 ± 0.028	0.621LysTrp: 0.621 ± 0.014	1.343LysTyr: 1.343 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.092LeuAla: 8.092 ± 0.049	1.221LeuCys: 1.221 ± 0.016	5.288LeuAsp: 5.288 ± 0.039	5.66LeuGlu: 5.66 ± 0.044	3.409LeuPhe: 3.409 ± 0.04	6.0LeuGly: 6.0 ± 0.041	2.295LeuHis: 2.295 ± 0.024	4.005LeuIle: 4.005 ± 0.036	4.139LeuLys: 4.139 ± 0.037	8.763LeuLeu: 8.763 ± 0.063	1.805LeuMet: 1.805 ± 0.021	3.206LeuAsn: 3.206 ± 0.027	5.626LeuPro: 5.626 ± 0.037	3.961LeuGln: 3.961 ± 0.036	6.067LeuArg: 6.067 ± 0.036	7.644LeuSer: 7.644 ± 0.045	4.934LeuThr: 4.934 ± 0.036	5.614LeuVal: 5.614 ± 0.041	1.206LeuTrp: 1.206 ± 0.019	2.424LeuTyr: 2.424 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.185MetAla: 2.185 ± 0.022	0.237MetCys: 0.237 ± 0.008	1.269MetAsp: 1.269 ± 0.018	1.318MetGlu: 1.318 ± 0.018	0.728MetPhe: 0.728 ± 0.014	1.426MetGly: 1.426 ± 0.02	0.463MetHis: 0.463 ± 0.009	1.033MetIle: 1.033 ± 0.017	0.997MetLys: 0.997 ± 0.017	1.864MetLeu: 1.864 ± 0.019	0.56MetMet: 0.56 ± 0.013	0.782MetAsn: 0.782 ± 0.015	1.218MetPro: 1.218 ± 0.019	0.862MetGln: 0.862 ± 0.015	1.259MetArg: 1.259 ± 0.016	1.833MetSer: 1.833 ± 0.02	1.298MetThr: 1.298 ± 0.017	1.321MetVal: 1.321 ± 0.018	0.252MetTrp: 0.252 ± 0.008	0.518MetTyr: 0.518 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.076AsnAla: 3.076 ± 0.027	0.432AsnCys: 0.432 ± 0.01	1.864AsnAsp: 1.864 ± 0.023	2.001AsnGlu: 2.001 ± 0.023	1.282AsnPhe: 1.282 ± 0.016	2.8AsnGly: 2.8 ± 0.027	0.845AsnHis: 0.845 ± 0.015	1.936AsnIle: 1.936 ± 0.02	1.424AsnLys: 1.424 ± 0.021	3.208AsnLeu: 3.208 ± 0.028	0.788AsnMet: 0.788 ± 0.016	1.368AsnAsn: 1.368 ± 0.024	2.506AsnPro: 2.506 ± 0.026	1.336AsnGln: 1.336 ± 0.016	2.005AsnArg: 2.005 ± 0.02	2.588AsnSer: 2.588 ± 0.028	2.037AsnThr: 2.037 ± 0.023	2.236AsnVal: 2.236 ± 0.022	0.519AsnTrp: 0.519 ± 0.012	1.037AsnTyr: 1.037 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.539ProAla: 5.539 ± 0.054	0.532ProCys: 0.532 ± 0.012	3.209ProAsp: 3.209 ± 0.027	3.957ProGlu: 3.957 ± 0.051	2.11ProPhe: 2.11 ± 0.025	3.95ProGly: 3.95 ± 0.038	1.405ProHis: 1.405 ± 0.019	2.491ProIle: 2.491 ± 0.027	2.494ProLys: 2.494 ± 0.028	4.879ProLeu: 4.879 ± 0.034	1.081ProMet: 1.081 ± 0.02	2.096ProAsn: 2.096 ± 0.025	5.046ProPro: 5.046 ± 0.088	2.495ProGln: 2.495 ± 0.032	3.567ProArg: 3.567 ± 0.036	6.35ProSer: 6.35 ± 0.054	3.891ProThr: 3.891 ± 0.036	3.805ProVal: 3.805 ± 0.038	0.75ProTrp: 0.75 ± 0.013	1.488ProTyr: 1.488 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.56GlnAla: 3.56 ± 0.029	0.441GlnCys: 0.441 ± 0.011	2.05GlnAsp: 2.05 ± 0.023	2.505GlnGlu: 2.505 ± 0.025	1.312GlnPhe: 1.312 ± 0.016	2.421GlnGly: 2.421 ± 0.021	1.085GlnHis: 1.085 ± 0.02	1.96GlnIle: 1.96 ± 0.019	2.043GlnLys: 2.043 ± 0.024	3.625GlnLeu: 3.625 ± 0.031	0.903GlnMet: 0.903 ± 0.014	1.562GlnAsn: 1.562 ± 0.023	2.643GlnPro: 2.643 ± 0.035	2.466GlnGln: 2.466 ± 0.056	2.771GlnArg: 2.771 ± 0.026	3.319GlnSer: 3.319 ± 0.03	2.352GlnThr: 2.352 ± 0.024	2.216GlnVal: 2.216 ± 0.021	0.576GlnTrp: 0.576 ± 0.011	1.144GlnTyr: 1.144 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.98ArgAla: 4.98 ± 0.039	0.707ArgCys: 0.707 ± 0.013	3.432ArgAsp: 3.432 ± 0.032	4.0ArgGlu: 4.0 ± 0.039	2.264ArgPhe: 2.264 ± 0.024	3.788ArgGly: 3.788 ± 0.036	1.57ArgHis: 1.57 ± 0.023	2.957ArgIle: 2.957 ± 0.028	3.492ArgLys: 3.492 ± 0.033	5.794ArgLeu: 5.794 ± 0.036	1.341ArgMet: 1.341 ± 0.017	2.266ArgAsn: 2.266 ± 0.021	3.571ArgPro: 3.571 ± 0.034	2.694ArgGln: 2.694 ± 0.026	5.31ArgArg: 5.31 ± 0.056	5.002ArgSer: 5.002 ± 0.044	3.347ArgThr: 3.347 ± 0.03	3.575ArgVal: 3.575 ± 0.027	0.947ArgTrp: 0.947 ± 0.017	1.727ArgTyr: 1.727 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.867SerAla: 6.867 ± 0.041	0.837SerCys: 0.837 ± 0.015	4.285SerAsp: 4.285 ± 0.036	4.267SerGlu: 4.267 ± 0.035	3.046SerPhe: 3.046 ± 0.026	5.511SerGly: 5.511 ± 0.039	2.032SerHis: 2.032 ± 0.022	4.046SerIle: 4.046 ± 0.034	3.643SerLys: 3.643 ± 0.032	7.569SerLeu: 7.569 ± 0.042	1.716SerMet: 1.716 ± 0.02	2.919SerAsn: 2.919 ± 0.026	5.585SerPro: 5.585 ± 0.055	3.454SerGln: 3.454 ± 0.031	5.258SerArg: 5.258 ± 0.049	8.986SerSer: 8.986 ± 0.085	5.551SerThr: 5.551 ± 0.042	4.775SerVal: 4.775 ± 0.034	1.102SerTrp: 1.102 ± 0.015	2.023SerTyr: 2.023 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.314ThrAla: 5.314 ± 0.038	0.7ThrCys: 0.7 ± 0.013	2.877ThrAsp: 2.877 ± 0.026	3.173ThrGlu: 3.173 ± 0.029	2.151ThrPhe: 2.151 ± 0.021	4.143ThrGly: 4.143 ± 0.039	1.297ThrHis: 1.297 ± 0.016	3.001ThrIle: 3.001 ± 0.028	2.444ThrLys: 2.444 ± 0.028	5.299ThrLeu: 5.299 ± 0.034	1.172ThrMet: 1.172 ± 0.016	1.955ThrAsn: 1.955 ± 0.021	4.295ThrPro: 4.295 ± 0.041	2.052ThrGln: 2.052 ± 0.024	3.119ThrArg: 3.119 ± 0.029	5.164ThrSer: 5.164 ± 0.041	4.156ThrThr: 4.156 ± 0.045	3.876ThrVal: 3.876 ± 0.034	0.799ThrTrp: 0.799 ± 0.015	1.543ThrTyr: 1.543 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.369ValAla: 5.369 ± 0.038	0.825ValCys: 0.825 ± 0.014	3.779ValAsp: 3.779 ± 0.034	3.907ValGlu: 3.907 ± 0.033	2.455ValPhe: 2.455 ± 0.026	3.98ValGly: 3.98 ± 0.037	1.426ValHis: 1.426 ± 0.018	2.967ValIle: 2.967 ± 0.029	2.786ValLys: 2.786 ± 0.026	5.816ValLeu: 5.816 ± 0.04	1.332ValMet: 1.332 ± 0.017	2.163ValAsn: 2.163 ± 0.024	3.705ValPro: 3.705 ± 0.036	2.468ValGln: 2.468 ± 0.025	3.601ValArg: 3.601 ± 0.027	4.844ValSer: 4.844 ± 0.036	3.525ValThr: 3.525 ± 0.033	4.307ValVal: 4.307 ± 0.039	0.859ValTrp: 0.859 ± 0.017	1.796ValTyr: 1.796 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.11TrpAla: 1.11 ± 0.019	0.183TrpCys: 0.183 ± 0.005	0.865TrpAsp: 0.865 ± 0.015	0.825TrpGlu: 0.825 ± 0.016	0.51TrpPhe: 0.51 ± 0.011	0.902TrpGly: 0.902 ± 0.015	0.336TrpHis: 0.336 ± 0.008	0.728TrpIle: 0.728 ± 0.017	0.767TrpLys: 0.767 ± 0.014	1.354TrpLeu: 1.354 ± 0.02	0.381TrpMet: 0.381 ± 0.009	0.598TrpAsn: 0.598 ± 0.013	0.568TrpPro: 0.568 ± 0.012	0.566TrpGln: 0.566 ± 0.01	0.959TrpArg: 0.959 ± 0.016	1.04TrpSer: 1.04 ± 0.015	0.885TrpThr: 0.885 ± 0.014	0.857TrpVal: 0.857 ± 0.012	0.273TrpTrp: 0.273 ± 0.009	0.422TrpTyr: 0.422 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.2TyrAla: 2.2 ± 0.022	0.407TyrCys: 0.407 ± 0.01	1.61TyrAsp: 1.61 ± 0.021	1.539TyrGlu: 1.539 ± 0.019	1.176TyrPhe: 1.176 ± 0.019	2.037TyrGly: 2.037 ± 0.023	0.754TyrHis: 0.754 ± 0.011	1.408TyrIle: 1.408 ± 0.02	1.049TyrLys: 1.049 ± 0.016	2.734TyrLeu: 2.734 ± 0.027	0.598TyrMet: 0.598 ± 0.01	1.077TyrAsn: 1.077 ± 0.015	1.557TyrPro: 1.557 ± 0.02	1.144TyrGln: 1.144 ± 0.016	1.67TyrArg: 1.67 ± 0.019	2.015TyrSer: 2.015 ± 0.024	1.595TyrThr: 1.595 ± 0.019	1.641TyrVal: 1.641 ± 0.023	0.415TyrTrp: 0.415 ± 0.01	0.921TyrTyr: 0.921 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.036XaaXaa: 0.036 ± 0.016

Statistics based on 9140 proteins (4507684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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