Amino acid dipepetide frequency for Chlorobium phaeobacteroides (strain DSM 266)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.929AlaAla: 7.929 ± 0.132	1.035AlaCys: 1.035 ± 0.037	4.544AlaAsp: 4.544 ± 0.105	5.746AlaGlu: 5.746 ± 0.098	3.598AlaPhe: 3.598 ± 0.073	7.365AlaGly: 7.365 ± 0.147	1.518AlaHis: 1.518 ± 0.042	5.442AlaIle: 5.442 ± 0.102	3.794AlaLys: 3.794 ± 0.081	9.505AlaLeu: 9.505 ± 0.174	2.305AlaMet: 2.305 ± 0.064	2.438AlaAsn: 2.438 ± 0.066	2.553AlaPro: 2.553 ± 0.067	2.281AlaGln: 2.281 ± 0.078	4.391AlaArg: 4.391 ± 0.085	5.165AlaSer: 5.165 ± 0.077	3.817AlaThr: 3.817 ± 0.073	6.354AlaVal: 6.354 ± 0.092	0.9AlaTrp: 0.9 ± 0.036	2.301AlaTyr: 2.301 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.759CysAla: 0.759 ± 0.038	0.258CysCys: 0.258 ± 0.021	0.649CysAsp: 0.649 ± 0.031	0.57CysGlu: 0.57 ± 0.024	0.594CysPhe: 0.594 ± 0.028	1.075CysGly: 1.075 ± 0.038	0.311CysHis: 0.311 ± 0.021	0.697CysIle: 0.697 ± 0.031	0.48CysLys: 0.48 ± 0.025	0.95CysLeu: 0.95 ± 0.035	0.269CysMet: 0.269 ± 0.019	0.48CysAsn: 0.48 ± 0.023	0.582CysPro: 0.582 ± 0.033	0.336CysGln: 0.336 ± 0.018	0.83CysArg: 0.83 ± 0.032	0.939CysSer: 0.939 ± 0.038	0.518CysThr: 0.518 ± 0.026	0.636CysVal: 0.636 ± 0.028	0.126CysTrp: 0.126 ± 0.012	0.36CysTyr: 0.36 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.625AspAla: 4.625 ± 0.088	0.603AspCys: 0.603 ± 0.025	2.854AspAsp: 2.854 ± 0.087	3.858AspGlu: 3.858 ± 0.073	2.608AspPhe: 2.608 ± 0.074	3.809AspGly: 3.809 ± 0.157	1.136AspHis: 1.136 ± 0.041	3.922AspIle: 3.922 ± 0.08	2.633AspLys: 2.633 ± 0.061	5.289AspLeu: 5.289 ± 0.085	1.254AspMet: 1.254 ± 0.039	2.034AspAsn: 2.034 ± 0.093	2.453AspPro: 2.453 ± 0.064	1.537AspGln: 1.537 ± 0.047	3.29AspArg: 3.29 ± 0.074	3.135AspSer: 3.135 ± 0.084	2.689AspThr: 2.689 ± 0.102	3.443AspVal: 3.443 ± 0.085	0.646AspTrp: 0.646 ± 0.031	1.965AspTyr: 1.965 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.444GluAla: 5.444 ± 0.097	0.643GluCys: 0.643 ± 0.032	2.715GluAsp: 2.715 ± 0.068	4.708GluGlu: 4.708 ± 0.092	2.374GluPhe: 2.374 ± 0.055	4.055GluGly: 4.055 ± 0.078	1.612GluHis: 1.612 ± 0.043	4.563GluIle: 4.563 ± 0.081	5.257GluLys: 5.257 ± 0.107	7.219GluLeu: 7.219 ± 0.119	1.681GluMet: 1.681 ± 0.051	2.808GluAsn: 2.808 ± 0.06	2.271GluPro: 2.271 ± 0.056	2.734GluGln: 2.734 ± 0.067	4.106GluArg: 4.106 ± 0.088	4.044GluSer: 4.044 ± 0.083	3.531GluThr: 3.531 ± 0.077	3.804GluVal: 3.804 ± 0.073	0.763GluTrp: 0.763 ± 0.034	1.944GluTyr: 1.944 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.485PheAla: 3.485 ± 0.075	0.621PheCys: 0.621 ± 0.031	2.78PheAsp: 2.78 ± 0.065	2.631PheGlu: 2.631 ± 0.059	2.399PhePhe: 2.399 ± 0.068	3.235PheGly: 3.235 ± 0.07	0.913PheHis: 0.913 ± 0.036	2.843PheIle: 2.843 ± 0.072	1.679PheLys: 1.679 ± 0.049	4.406PheLeu: 4.406 ± 0.085	1.072PheMet: 1.072 ± 0.04	1.723PheAsn: 1.723 ± 0.048	1.758PhePro: 1.758 ± 0.047	1.216PheGln: 1.216 ± 0.045	2.639PheArg: 2.639 ± 0.066	3.928PheSer: 3.928 ± 0.075	2.484PheThr: 2.484 ± 0.072	2.781PheVal: 2.781 ± 0.06	0.511PheTrp: 0.511 ± 0.022	1.412PheTyr: 1.412 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.549GlyAla: 5.549 ± 0.14	0.956GlyCys: 0.956 ± 0.037	3.761GlyAsp: 3.761 ± 0.125	4.222GlyGlu: 4.222 ± 0.074	3.662GlyPhe: 3.662 ± 0.074	5.873GlyGly: 5.873 ± 0.479	1.446GlyHis: 1.446 ± 0.048	5.734GlyIle: 5.734 ± 0.113	4.789GlyLys: 4.789 ± 0.079	6.603GlyLeu: 6.603 ± 0.094	2.143GlyMet: 2.143 ± 0.052	3.057GlyAsn: 3.057 ± 0.144	1.672GlyPro: 1.672 ± 0.044	1.974GlyGln: 1.974 ± 0.051	3.86GlyArg: 3.86 ± 0.077	5.572GlySer: 5.572 ± 0.187	4.295GlyThr: 4.295 ± 0.172	5.015GlyVal: 5.015 ± 0.086	0.906GlyTrp: 0.906 ± 0.037	2.699GlyTyr: 2.699 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.825HisAla: 1.825 ± 0.051	0.333HisCys: 0.333 ± 0.022	1.228HisAsp: 1.228 ± 0.043	1.54HisGlu: 1.54 ± 0.046	0.909HisPhe: 0.909 ± 0.033	1.511HisGly: 1.511 ± 0.05	0.639HisHis: 0.639 ± 0.033	1.321HisIle: 1.321 ± 0.039	0.918HisLys: 0.918 ± 0.035	2.136HisLeu: 2.136 ± 0.055	0.403HisMet: 0.403 ± 0.023	0.756HisAsn: 0.756 ± 0.03	1.241HisPro: 1.241 ± 0.04	0.709HisGln: 0.709 ± 0.03	1.263HisArg: 1.263 ± 0.048	1.19HisSer: 1.19 ± 0.041	1.005HisThr: 1.005 ± 0.032	1.211HisVal: 1.211 ± 0.041	0.21HisTrp: 0.21 ± 0.017	0.836HisTyr: 0.836 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.332IleAla: 6.332 ± 0.107	0.761IleCys: 0.761 ± 0.033	4.227IleAsp: 4.227 ± 0.081	4.707IleGlu: 4.707 ± 0.087	2.547IlePhe: 2.547 ± 0.068	5.126IleGly: 5.126 ± 0.104	1.305IleHis: 1.305 ± 0.044	4.388IleIle: 4.388 ± 0.106	3.08IleLys: 3.08 ± 0.075	5.662IleLeu: 5.662 ± 0.093	1.416IleMet: 1.416 ± 0.047	2.494IleAsn: 2.494 ± 0.062	3.137IlePro: 3.137 ± 0.059	1.767IleGln: 1.767 ± 0.059	3.983IleArg: 3.983 ± 0.075	4.754IleSer: 4.754 ± 0.083	3.903IleThr: 3.903 ± 0.082	4.411IleVal: 4.411 ± 0.084	0.525IleTrp: 0.525 ± 0.028	1.818IleTyr: 1.818 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.67LysAla: 4.67 ± 0.083	0.338LysCys: 0.338 ± 0.023	2.255LysAsp: 2.255 ± 0.054	4.019LysGlu: 4.019 ± 0.095	1.557LysPhe: 1.557 ± 0.044	3.729LysGly: 3.729 ± 0.069	1.041LysHis: 1.041 ± 0.041	3.762LysIle: 3.762 ± 0.075	4.55LysLys: 4.55 ± 0.106	5.021LysLeu: 5.021 ± 0.098	1.276LysMet: 1.276 ± 0.046	2.647LysAsn: 2.647 ± 0.071	2.469LysPro: 2.469 ± 0.071	2.073LysGln: 2.073 ± 0.057	3.01LysArg: 3.01 ± 0.077	3.51LysSer: 3.51 ± 0.083	3.517LysThr: 3.517 ± 0.083	3.279LysVal: 3.279 ± 0.069	0.455LysTrp: 0.455 ± 0.027	1.538LysTyr: 1.538 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	8.642LeuAla: 8.642 ± 0.128	1.204LeuCys: 1.204 ± 0.043	5.771LeuAsp: 5.771 ± 0.093	6.373LeuGlu: 6.373 ± 0.1	5.149LeuPhe: 5.149 ± 0.103	6.482LeuGly: 6.482 ± 0.111	2.293LeuHis: 2.293 ± 0.057	5.652LeuIle: 5.652 ± 0.098	5.785LeuLys: 5.785 ± 0.112	11.242LeuLeu: 11.242 ± 0.183	2.419LeuMet: 2.419 ± 0.066	3.722LeuAsn: 3.722 ± 0.069	4.643LeuPro: 4.643 ± 0.086	3.971LeuGln: 3.971 ± 0.082	5.655LeuArg: 5.655 ± 0.098	7.672LeuSer: 7.672 ± 0.119	4.72LeuThr: 4.72 ± 0.107	6.615LeuVal: 6.615 ± 0.1	1.0LeuTrp: 1.0 ± 0.045	2.969LeuTyr: 2.969 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.14MetAla: 2.14 ± 0.055	0.158MetCys: 0.158 ± 0.016	1.079MetAsp: 1.079 ± 0.042	1.35MetGlu: 1.35 ± 0.04	0.864MetPhe: 0.864 ± 0.032	1.497MetGly: 1.497 ± 0.044	0.63MetHis: 0.63 ± 0.028	1.63MetIle: 1.63 ± 0.047	1.858MetLys: 1.858 ± 0.05	2.735MetLeu: 2.735 ± 0.057	0.73MetMet: 0.73 ± 0.034	1.203MetAsn: 1.203 ± 0.042	1.316MetPro: 1.316 ± 0.049	1.191MetGln: 1.191 ± 0.039	1.379MetArg: 1.379 ± 0.046	1.487MetSer: 1.487 ± 0.047	1.487MetThr: 1.487 ± 0.044	1.78MetVal: 1.78 ± 0.05	0.155MetTrp: 0.155 ± 0.013	0.502MetTyr: 0.502 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.128AsnAla: 3.128 ± 0.069	0.397AsnCys: 0.397 ± 0.022	1.943AsnAsp: 1.943 ± 0.078	2.168AsnGlu: 2.168 ± 0.062	1.438AsnPhe: 1.438 ± 0.049	2.756AsnGly: 2.756 ± 0.123	0.799AsnHis: 0.799 ± 0.033	2.806AsnIle: 2.806 ± 0.063	1.827AsnLys: 1.827 ± 0.065	3.681AsnLeu: 3.681 ± 0.074	0.891AsnMet: 0.891 ± 0.035	1.788AsnAsn: 1.788 ± 0.072	2.335AsnPro: 2.335 ± 0.061	1.193AsnGln: 1.193 ± 0.047	2.689AsnArg: 2.689 ± 0.066	2.379AsnSer: 2.379 ± 0.088	2.132AsnThr: 2.132 ± 0.078	2.274AsnVal: 2.274 ± 0.063	0.439AsnTrp: 0.439 ± 0.027	1.236AsnTyr: 1.236 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.466ProAla: 3.466 ± 0.075	0.42ProCys: 0.42 ± 0.02	3.168ProAsp: 3.168 ± 0.075	4.105ProGlu: 4.105 ± 0.077	1.981ProPhe: 1.981 ± 0.049	3.146ProGly: 3.146 ± 0.073	0.77ProHis: 0.77 ± 0.032	1.883ProIle: 1.883 ± 0.047	1.902ProLys: 1.902 ± 0.047	4.218ProLeu: 4.218 ± 0.074	0.933ProMet: 0.933 ± 0.036	1.113ProAsn: 1.113 ± 0.034	1.593ProPro: 1.593 ± 0.054	1.168ProGln: 1.168 ± 0.037	1.595ProArg: 1.595 ± 0.048	2.615ProSer: 2.615 ± 0.054	1.533ProThr: 1.533 ± 0.052	3.891ProVal: 3.891 ± 0.071	0.473ProTrp: 0.473 ± 0.025	1.285ProTyr: 1.285 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.823GlnAla: 2.823 ± 0.069	0.344GlnCys: 0.344 ± 0.021	1.451GlnAsp: 1.451 ± 0.047	2.399GlnGlu: 2.399 ± 0.064	1.217GlnPhe: 1.217 ± 0.034	2.023GlnGly: 2.023 ± 0.051	0.769GlnHis: 0.769 ± 0.032	2.025GlnIle: 2.025 ± 0.053	2.215GlnLys: 2.215 ± 0.063	3.341GlnLeu: 3.341 ± 0.067	0.809GlnMet: 0.809 ± 0.03	1.377GlnAsn: 1.377 ± 0.041	1.295GlnPro: 1.295 ± 0.043	1.639GlnGln: 1.639 ± 0.054	1.885GlnArg: 1.885 ± 0.055	2.311GlnSer: 2.311 ± 0.082	1.625GlnThr: 1.625 ± 0.046	1.999GlnVal: 1.999 ± 0.057	0.389GlnTrp: 0.389 ± 0.021	0.959GlnTyr: 0.959 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.687ArgAla: 3.687 ± 0.083	0.6ArgCys: 0.6 ± 0.028	2.97ArgAsp: 2.97 ± 0.065	4.166ArgGlu: 4.166 ± 0.089	2.872ArgPhe: 2.872 ± 0.065	3.119ArgGly: 3.119 ± 0.071	1.385ArgHis: 1.385 ± 0.046	4.056ArgIle: 4.056 ± 0.076	3.769ArgLys: 3.769 ± 0.08	5.794ArgLeu: 5.794 ± 0.106	1.673ArgMet: 1.673 ± 0.042	2.51ArgAsn: 2.51 ± 0.052	1.946ArgPro: 1.946 ± 0.052	2.439ArgGln: 2.439 ± 0.076	3.198ArgArg: 3.198 ± 0.071	3.635ArgSer: 3.635 ± 0.073	2.636ArgThr: 2.636 ± 0.054	3.485ArgVal: 3.485 ± 0.069	0.629ArgTrp: 0.629 ± 0.028	2.359ArgTyr: 2.359 ± 0.071	0.0ArgXaa: 0.0 ± 0.0
Ser	5.439SerAla: 5.439 ± 0.09	0.914SerCys: 0.914 ± 0.043	3.74SerAsp: 3.74 ± 0.094	4.023SerGlu: 4.023 ± 0.075	3.292SerPhe: 3.292 ± 0.067	6.847SerGly: 6.847 ± 0.218	1.276SerHis: 1.276 ± 0.036	4.472SerIle: 4.472 ± 0.087	2.904SerLys: 2.904 ± 0.073	6.907SerLeu: 6.907 ± 0.09	1.811SerMet: 1.811 ± 0.047	2.18SerAsn: 2.18 ± 0.06	2.887SerPro: 2.887 ± 0.064	1.834SerGln: 1.834 ± 0.065	3.979SerArg: 3.979 ± 0.086	4.89SerSer: 4.89 ± 0.078	3.059SerThr: 3.059 ± 0.076	4.833SerVal: 4.833 ± 0.095	0.783SerTrp: 0.783 ± 0.033	1.974SerTyr: 1.974 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.584ThrAla: 4.584 ± 0.095	0.553ThrCys: 0.553 ± 0.031	2.737ThrAsp: 2.737 ± 0.079	3.119ThrGlu: 3.119 ± 0.071	2.148ThrPhe: 2.148 ± 0.061	5.228ThrGly: 5.228 ± 0.136	0.913ThrHis: 0.913 ± 0.032	3.9ThrIle: 3.9 ± 0.081	2.081ThrLys: 2.081 ± 0.056	5.79ThrLeu: 5.79 ± 0.159	1.272ThrMet: 1.272 ± 0.041	1.587ThrAsn: 1.587 ± 0.059	2.493ThrPro: 2.493 ± 0.06	1.156ThrGln: 1.156 ± 0.049	2.613ThrArg: 2.613 ± 0.065	3.12ThrSer: 3.12 ± 0.079	2.834ThrThr: 2.834 ± 0.072	3.981ThrVal: 3.981 ± 0.125	0.522ThrTrp: 0.522 ± 0.03	1.375ThrTyr: 1.375 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.319ValAla: 5.319 ± 0.085	0.774ValCys: 0.774 ± 0.031	3.524ValAsp: 3.524 ± 0.066	4.1ValGlu: 4.1 ± 0.077	3.263ValPhe: 3.263 ± 0.063	3.948ValGly: 3.948 ± 0.116	1.395ValHis: 1.395 ± 0.037	4.738ValIle: 4.738 ± 0.076	3.249ValLys: 3.249 ± 0.072	6.98ValLeu: 6.98 ± 0.111	1.864ValMet: 1.864 ± 0.055	2.574ValAsn: 2.574 ± 0.07	2.784ValPro: 2.784 ± 0.065	2.109ValGln: 2.109 ± 0.052	3.7ValArg: 3.7 ± 0.076	4.996ValSer: 4.996 ± 0.08	4.117ValThr: 4.117 ± 0.112	4.875ValVal: 4.875 ± 0.102	0.653ValTrp: 0.653 ± 0.03	1.946ValTyr: 1.946 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.747TrpAla: 0.747 ± 0.033	0.119TrpCys: 0.119 ± 0.012	0.522TrpAsp: 0.522 ± 0.029	0.587TrpGlu: 0.587 ± 0.027	0.533TrpPhe: 0.533 ± 0.028	0.615TrpGly: 0.615 ± 0.025	0.281TrpHis: 0.281 ± 0.017	0.732TrpIle: 0.732 ± 0.033	0.668TrpLys: 0.668 ± 0.029	1.208TrpLeu: 1.208 ± 0.042	0.335TrpMet: 0.335 ± 0.023	0.522TrpAsn: 0.522 ± 0.031	0.373TrpPro: 0.373 ± 0.026	0.487TrpGln: 0.487 ± 0.027	0.595TrpArg: 0.595 ± 0.03	0.715TrpSer: 0.715 ± 0.031	0.466TrpThr: 0.466 ± 0.028	0.58TrpVal: 0.58 ± 0.028	0.166TrpTrp: 0.166 ± 0.016	0.363TrpTyr: 0.363 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.389TyrAla: 2.389 ± 0.055	0.389TyrCys: 0.389 ± 0.023	1.868TyrAsp: 1.868 ± 0.059	1.883TyrGlu: 1.883 ± 0.067	1.51TyrPhe: 1.51 ± 0.042	2.35TyrGly: 2.35 ± 0.058	0.751TyrHis: 0.751 ± 0.033	1.777TyrIle: 1.777 ± 0.058	1.277TyrLys: 1.277 ± 0.047	3.293TyrLeu: 3.293 ± 0.077	0.617TyrMet: 0.617 ± 0.03	1.284TyrAsn: 1.284 ± 0.044	1.459TyrPro: 1.459 ± 0.045	1.08TyrGln: 1.08 ± 0.038	2.269TyrArg: 2.269 ± 0.058	1.984TyrSer: 1.984 ± 0.062	1.639TyrThr: 1.639 ± 0.051	1.661TyrVal: 1.661 ± 0.052	0.363TyrTrp: 0.363 ± 0.023	1.04TyrTyr: 1.04 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2579 proteins (851888 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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