Amino acid dipepetide frequency for Massilia sp. JS1662

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.987AlaAla: 17.987 ± 0.157	1.243AlaCys: 1.243 ± 0.026	7.137AlaAsp: 7.137 ± 0.072	5.95AlaGlu: 5.95 ± 0.072	4.13AlaPhe: 4.13 ± 0.053	11.384AlaGly: 11.384 ± 0.093	2.769AlaHis: 2.769 ± 0.036	5.596AlaIle: 5.596 ± 0.059	3.801AlaLys: 3.801 ± 0.058	13.965AlaLeu: 13.965 ± 0.114	3.178AlaMet: 3.178 ± 0.043	3.419AlaAsn: 3.419 ± 0.045	6.325AlaPro: 6.325 ± 0.085	5.082AlaGln: 5.082 ± 0.058	9.205AlaArg: 9.205 ± 0.093	6.304AlaSer: 6.304 ± 0.065	6.489AlaThr: 6.489 ± 0.067	8.857AlaVal: 8.857 ± 0.077	1.918AlaTrp: 1.918 ± 0.036	2.882AlaTyr: 2.882 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.225CysAla: 1.225 ± 0.028	0.101CysCys: 0.101 ± 0.008	0.481CysAsp: 0.481 ± 0.016	0.371CysGlu: 0.371 ± 0.013	0.282CysPhe: 0.282 ± 0.012	0.895CysGly: 0.895 ± 0.026	0.215CysHis: 0.215 ± 0.014	0.364CysIle: 0.364 ± 0.013	0.204CysLys: 0.204 ± 0.011	0.748CysLeu: 0.748 ± 0.022	0.179CysMet: 0.179 ± 0.01	0.213CysAsn: 0.213 ± 0.01	0.412CysPro: 0.412 ± 0.016	0.197CysGln: 0.197 ± 0.011	0.539CysArg: 0.539 ± 0.017	0.448CysSer: 0.448 ± 0.014	0.479CysThr: 0.479 ± 0.015	0.651CysVal: 0.651 ± 0.019	0.124CysTrp: 0.124 ± 0.009	0.21CysTyr: 0.21 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.824AspAla: 7.824 ± 0.081	0.442AspCys: 0.442 ± 0.017	3.335AspAsp: 3.335 ± 0.044	3.102AspGlu: 3.102 ± 0.047	2.195AspPhe: 2.195 ± 0.037	5.552AspGly: 5.552 ± 0.081	1.153AspHis: 1.153 ± 0.024	2.713AspIle: 2.713 ± 0.038	2.042AspLys: 2.042 ± 0.038	5.673AspLeu: 5.673 ± 0.058	1.322AspMet: 1.322 ± 0.028	1.544AspAsn: 1.544 ± 0.03	3.318AspPro: 3.318 ± 0.046	1.733AspGln: 1.733 ± 0.033	3.615AspArg: 3.615 ± 0.051	2.235AspSer: 2.235 ± 0.036	3.0AspThr: 3.0 ± 0.05	4.821AspVal: 4.821 ± 0.054	1.073AspTrp: 1.073 ± 0.024	1.743AspTyr: 1.743 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.988GluAla: 5.988 ± 0.071	0.339GluCys: 0.339 ± 0.014	2.31GluAsp: 2.31 ± 0.035	2.517GluGlu: 2.517 ± 0.05	1.735GluPhe: 1.735 ± 0.031	3.477GluGly: 3.477 ± 0.048	1.3GluHis: 1.3 ± 0.029	2.525GluIle: 2.525 ± 0.038	1.844GluLys: 1.844 ± 0.04	5.338GluLeu: 5.338 ± 0.062	1.219GluMet: 1.219 ± 0.028	1.421GluAsn: 1.421 ± 0.029	2.29GluPro: 2.29 ± 0.043	2.426GluGln: 2.426 ± 0.044	4.373GluArg: 4.373 ± 0.06	2.194GluSer: 2.194 ± 0.033	2.648GluThr: 2.648 ± 0.039	3.327GluVal: 3.327 ± 0.047	0.699GluTrp: 0.699 ± 0.02	1.189GluTyr: 1.189 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.304PheAla: 4.304 ± 0.044	0.371PheCys: 0.371 ± 0.014	2.748PheAsp: 2.748 ± 0.043	1.857PheGlu: 1.857 ± 0.029	1.324PhePhe: 1.324 ± 0.03	3.574PheGly: 3.574 ± 0.057	0.745PheHis: 0.745 ± 0.021	1.531PheIle: 1.531 ± 0.035	1.145PheLys: 1.145 ± 0.026	2.987PheLeu: 2.987 ± 0.037	0.85PheMet: 0.85 ± 0.024	1.215PheAsn: 1.215 ± 0.028	1.552PhePro: 1.552 ± 0.031	1.047PheGln: 1.047 ± 0.022	2.051PheArg: 2.051 ± 0.032	2.069PheSer: 2.069 ± 0.034	2.216PheThr: 2.216 ± 0.037	2.769PheVal: 2.769 ± 0.039	0.505PheTrp: 0.505 ± 0.013	1.026PheTyr: 1.026 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.632GlyAla: 9.632 ± 0.085	0.813GlyCys: 0.813 ± 0.021	4.417GlyAsp: 4.417 ± 0.06	4.034GlyGlu: 4.034 ± 0.05	3.385GlyPhe: 3.385 ± 0.045	7.287GlyGly: 7.287 ± 0.095	1.928GlyHis: 1.928 ± 0.032	4.354GlyIle: 4.354 ± 0.053	3.639GlyLys: 3.639 ± 0.054	8.214GlyLeu: 8.214 ± 0.077	2.414GlyMet: 2.414 ± 0.036	2.63GlyAsn: 2.63 ± 0.049	3.312GlyPro: 3.312 ± 0.048	3.068GlyGln: 3.068 ± 0.05	5.554GlyArg: 5.554 ± 0.055	4.534GlySer: 4.534 ± 0.06	5.215GlyThr: 5.215 ± 0.066	6.542GlyVal: 6.542 ± 0.06	1.46GlyTrp: 1.46 ± 0.028	2.531GlyTyr: 2.531 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.972HisAla: 2.972 ± 0.043	0.22HisCys: 0.22 ± 0.011	1.365HisAsp: 1.365 ± 0.029	1.061HisGlu: 1.061 ± 0.026	0.902HisPhe: 0.902 ± 0.021	2.207HisGly: 2.207 ± 0.043	0.578HisHis: 0.578 ± 0.019	0.924HisIle: 0.924 ± 0.021	0.618HisLys: 0.618 ± 0.017	2.14HisLeu: 2.14 ± 0.036	0.523HisMet: 0.523 ± 0.015	0.542HisAsn: 0.542 ± 0.018	1.418HisPro: 1.418 ± 0.03	0.652HisGln: 0.652 ± 0.018	1.341HisArg: 1.341 ± 0.031	0.883HisSer: 0.883 ± 0.017	1.09HisThr: 1.09 ± 0.023	1.74HisVal: 1.74 ± 0.028	0.398HisTrp: 0.398 ± 0.014	0.697HisTyr: 0.697 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.333IleAla: 6.333 ± 0.064	0.336IleCys: 0.336 ± 0.013	3.367IleAsp: 3.367 ± 0.041	2.852IleGlu: 2.852 ± 0.039	1.26IlePhe: 1.26 ± 0.03	4.3IleGly: 4.3 ± 0.051	0.895IleHis: 0.895 ± 0.021	1.593IleIle: 1.593 ± 0.037	1.516IleLys: 1.516 ± 0.03	3.599IleLeu: 3.599 ± 0.054	0.876IleMet: 0.876 ± 0.028	1.452IleAsn: 1.452 ± 0.029	2.173IlePro: 2.173 ± 0.035	1.196IleGln: 1.196 ± 0.025	2.739IleArg: 2.739 ± 0.042	2.236IleSer: 2.236 ± 0.035	2.381IleThr: 2.381 ± 0.037	4.037IleVal: 4.037 ± 0.054	0.459IleTrp: 0.459 ± 0.015	1.005IleTyr: 1.005 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.958LysAla: 3.958 ± 0.054	0.161LysCys: 0.161 ± 0.01	1.883LysAsp: 1.883 ± 0.034	1.604LysGlu: 1.604 ± 0.036	1.012LysPhe: 1.012 ± 0.026	2.51LysGly: 2.51 ± 0.039	0.692LysHis: 0.692 ± 0.019	1.603LysIle: 1.603 ± 0.037	1.4LysLys: 1.4 ± 0.034	3.6LysLeu: 3.6 ± 0.049	0.894LysMet: 0.894 ± 0.022	1.174LysAsn: 1.174 ± 0.028	2.135LysPro: 2.135 ± 0.039	1.229LysGln: 1.229 ± 0.026	2.292LysArg: 2.292 ± 0.036	1.704LysSer: 1.704 ± 0.03	1.987LysThr: 1.987 ± 0.035	2.59LysVal: 2.59 ± 0.039	0.347LysTrp: 0.347 ± 0.012	0.824LysTyr: 0.824 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.738LeuAla: 14.738 ± 0.112	0.938LeuCys: 0.938 ± 0.025	6.368LeuAsp: 6.368 ± 0.068	4.905LeuGlu: 4.905 ± 0.063	3.417LeuPhe: 3.417 ± 0.048	8.136LeuGly: 8.136 ± 0.081	2.231LeuHis: 2.231 ± 0.041	3.822LeuIle: 3.822 ± 0.057	3.483LeuLys: 3.483 ± 0.049	10.189LeuLeu: 10.189 ± 0.1	2.193LeuMet: 2.193 ± 0.034	2.833LeuAsn: 2.833 ± 0.047	5.806LeuPro: 5.806 ± 0.061	3.535LeuGln: 3.535 ± 0.045	7.272LeuArg: 7.272 ± 0.069	5.587LeuSer: 5.587 ± 0.06	5.314LeuThr: 5.314 ± 0.066	7.648LeuVal: 7.648 ± 0.086	1.176LeuTrp: 1.176 ± 0.031	2.32LeuTyr: 2.32 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.826MetAla: 2.826 ± 0.037	0.171MetCys: 0.171 ± 0.009	1.176MetAsp: 1.176 ± 0.026	1.063MetGlu: 1.063 ± 0.023	0.77MetPhe: 0.77 ± 0.023	1.671MetGly: 1.671 ± 0.034	0.563MetHis: 0.563 ± 0.016	1.02MetIle: 1.02 ± 0.025	1.088MetLys: 1.088 ± 0.024	2.674MetLeu: 2.674 ± 0.039	0.635MetMet: 0.635 ± 0.02	0.927MetAsn: 0.927 ± 0.021	1.378MetPro: 1.378 ± 0.027	0.995MetGln: 0.995 ± 0.022	1.792MetArg: 1.792 ± 0.033	1.446MetSer: 1.446 ± 0.029	1.586MetThr: 1.586 ± 0.029	1.629MetVal: 1.629 ± 0.034	0.223MetTrp: 0.223 ± 0.011	0.471MetTyr: 0.471 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.541AsnAla: 3.541 ± 0.051	0.246AsnCys: 0.246 ± 0.012	1.698AsnAsp: 1.698 ± 0.04	1.351AsnGlu: 1.351 ± 0.028	1.104AsnPhe: 1.104 ± 0.03	2.875AsnGly: 2.875 ± 0.052	0.578AsnHis: 0.578 ± 0.016	1.366AsnIle: 1.366 ± 0.029	0.949AsnLys: 0.949 ± 0.024	3.015AsnLeu: 3.015 ± 0.045	0.616AsnMet: 0.616 ± 0.019	1.024AsnAsn: 1.024 ± 0.028	1.934AsnPro: 1.934 ± 0.034	1.001AsnGln: 1.001 ± 0.03	1.823AsnArg: 1.823 ± 0.034	1.331AsnSer: 1.331 ± 0.033	1.659AsnThr: 1.659 ± 0.039	2.509AsnVal: 2.509 ± 0.043	0.491AsnTrp: 0.491 ± 0.017	0.889AsnTyr: 0.889 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.28ProAla: 7.28 ± 0.075	0.331ProCys: 0.331 ± 0.014	3.779ProAsp: 3.779 ± 0.049	3.055ProGlu: 3.055 ± 0.044	1.878ProPhe: 1.878 ± 0.032	4.738ProGly: 4.738 ± 0.05	1.127ProHis: 1.127 ± 0.024	1.855ProIle: 1.855 ± 0.03	1.51ProLys: 1.51 ± 0.029	5.056ProLeu: 5.056 ± 0.054	1.141ProMet: 1.141 ± 0.026	1.5ProAsn: 1.5 ± 0.034	2.467ProPro: 2.467 ± 0.05	1.901ProGln: 1.901 ± 0.03	2.863ProArg: 2.863 ± 0.045	2.525ProSer: 2.525 ± 0.038	2.537ProThr: 2.537 ± 0.035	4.413ProVal: 4.413 ± 0.054	0.721ProTrp: 0.721 ± 0.021	1.259ProTyr: 1.259 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.93GlnAla: 4.93 ± 0.062	0.243GlnCys: 0.243 ± 0.011	1.727GlnAsp: 1.727 ± 0.03	1.511GlnGlu: 1.511 ± 0.034	1.274GlnPhe: 1.274 ± 0.028	2.64GlnGly: 2.64 ± 0.038	0.83GlnHis: 0.83 ± 0.024	1.617GlnIle: 1.617 ± 0.035	1.162GlnLys: 1.162 ± 0.025	3.744GlnLeu: 3.744 ± 0.043	0.993GlnMet: 0.993 ± 0.024	0.977GlnAsn: 0.977 ± 0.022	2.081GlnPro: 2.081 ± 0.033	1.688GlnGln: 1.688 ± 0.035	2.804GlnArg: 2.804 ± 0.04	1.734GlnSer: 1.734 ± 0.032	1.773GlnThr: 1.773 ± 0.033	2.884GlnVal: 2.884 ± 0.043	0.501GlnTrp: 0.501 ± 0.016	0.896GlnTyr: 0.896 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.105ArgAla: 8.105 ± 0.077	0.497ArgCys: 0.497 ± 0.017	4.085ArgAsp: 4.085 ± 0.051	3.638ArgGlu: 3.638 ± 0.048	2.87ArgPhe: 2.87 ± 0.041	4.55ArgGly: 4.55 ± 0.054	1.83ArgHis: 1.83 ± 0.037	3.691ArgIle: 3.691 ± 0.049	2.164ArgLys: 2.164 ± 0.035	7.464ArgLeu: 7.464 ± 0.075	1.915ArgMet: 1.915 ± 0.031	2.04ArgAsn: 2.04 ± 0.031	3.204ArgPro: 3.204 ± 0.046	2.699ArgGln: 2.699 ± 0.043	5.122ArgArg: 5.122 ± 0.064	2.998ArgSer: 2.998 ± 0.038	3.704ArgThr: 3.704 ± 0.044	4.938ArgVal: 4.938 ± 0.052	1.098ArgTrp: 1.098 ± 0.026	2.089ArgTyr: 2.089 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.838SerAla: 5.838 ± 0.067	0.402SerCys: 0.402 ± 0.017	2.622SerAsp: 2.622 ± 0.036	2.159SerGlu: 2.159 ± 0.038	2.025SerPhe: 2.025 ± 0.034	5.021SerGly: 5.021 ± 0.062	1.089SerHis: 1.089 ± 0.027	2.39SerIle: 2.39 ± 0.038	1.555SerLys: 1.555 ± 0.031	5.174SerLeu: 5.174 ± 0.062	1.252SerMet: 1.252 ± 0.029	1.618SerAsn: 1.618 ± 0.032	2.551SerPro: 2.551 ± 0.04	1.619SerGln: 1.619 ± 0.033	3.124SerArg: 3.124 ± 0.046	2.82SerSer: 2.82 ± 0.045	2.956SerThr: 2.956 ± 0.045	3.663SerVal: 3.663 ± 0.048	0.76SerTrp: 0.76 ± 0.021	1.417SerTyr: 1.417 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.152ThrAla: 6.152 ± 0.071	0.41ThrCys: 0.41 ± 0.016	2.912ThrAsp: 2.912 ± 0.043	2.236ThrGlu: 2.236 ± 0.032	2.013ThrPhe: 2.013 ± 0.033	5.145ThrGly: 5.145 ± 0.066	1.191ThrHis: 1.191 ± 0.026	2.699ThrIle: 2.699 ± 0.04	1.466ThrLys: 1.466 ± 0.031	6.128ThrLeu: 6.128 ± 0.069	1.227ThrMet: 1.227 ± 0.029	1.624ThrAsn: 1.624 ± 0.04	3.519ThrPro: 3.519 ± 0.05	1.767ThrGln: 1.767 ± 0.034	3.476ThrArg: 3.476 ± 0.049	2.866ThrSer: 2.866 ± 0.046	3.264ThrThr: 3.264 ± 0.057	4.782ThrVal: 4.782 ± 0.06	0.863ThrTrp: 0.863 ± 0.024	1.511ThrTyr: 1.511 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.703ValAla: 9.703 ± 0.082	0.671ValCys: 0.671 ± 0.02	4.72ValAsp: 4.72 ± 0.051	4.053ValGlu: 4.053 ± 0.049	2.673ValPhe: 2.673 ± 0.043	5.706ValGly: 5.706 ± 0.069	1.59ValHis: 1.59 ± 0.031	3.349ValIle: 3.349 ± 0.043	2.613ValLys: 2.613 ± 0.039	7.955ValLeu: 7.955 ± 0.071	1.707ValMet: 1.707 ± 0.031	2.461ValAsn: 2.461 ± 0.042	4.093ValPro: 4.093 ± 0.048	2.596ValGln: 2.596 ± 0.036	5.415ValArg: 5.415 ± 0.058	4.011ValSer: 4.011 ± 0.055	4.584ValThr: 4.584 ± 0.06	6.131ValVal: 6.131 ± 0.072	0.938ValTrp: 0.938 ± 0.023	1.82ValTyr: 1.82 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.268TrpAla: 1.268 ± 0.027	0.14TrpCys: 0.14 ± 0.009	0.743TrpAsp: 0.743 ± 0.021	0.577TrpGlu: 0.577 ± 0.019	0.573TrpPhe: 0.573 ± 0.018	0.935TrpGly: 0.935 ± 0.024	0.405TrpHis: 0.405 ± 0.015	0.701TrpIle: 0.701 ± 0.02	0.533TrpLys: 0.533 ± 0.017	1.713TrpLeu: 1.713 ± 0.031	0.446TrpMet: 0.446 ± 0.016	0.549TrpAsn: 0.549 ± 0.02	0.656TrpPro: 0.656 ± 0.019	0.659TrpGln: 0.659 ± 0.022	1.224TrpArg: 1.224 ± 0.026	0.808TrpSer: 0.808 ± 0.023	0.915TrpThr: 0.915 ± 0.026	0.913TrpVal: 0.913 ± 0.024	0.252TrpTrp: 0.252 ± 0.013	0.404TrpTyr: 0.404 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.015TyrAla: 3.015 ± 0.044	0.263TyrCys: 0.263 ± 0.013	1.562TyrAsp: 1.562 ± 0.027	1.262TyrGlu: 1.262 ± 0.025	1.065TyrPhe: 1.065 ± 0.027	2.359TyrGly: 2.359 ± 0.039	0.564TyrHis: 0.564 ± 0.017	0.89TyrIle: 0.89 ± 0.021	0.868TyrLys: 0.868 ± 0.023	2.535TyrLeu: 2.535 ± 0.037	0.523TyrMet: 0.523 ± 0.015	0.836TyrAsn: 0.836 ± 0.024	1.312TyrPro: 1.312 ± 0.029	0.919TyrGln: 0.919 ± 0.024	2.078TyrArg: 2.078 ± 0.036	1.322TyrSer: 1.322 ± 0.029	1.455TyrThr: 1.455 ± 0.029	1.946TyrVal: 1.946 ± 0.032	0.408TyrTrp: 0.408 ± 0.016	0.781TyrTyr: 0.781 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5560 proteins (1865432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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