Amino acid dipepetide frequency for Planomonospora sphaerica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.37AlaAla: 23.37 ± 0.177	1.211AlaCys: 1.211 ± 0.024	8.177AlaAsp: 8.177 ± 0.07	9.532AlaGlu: 9.532 ± 0.086	3.749AlaPhe: 3.749 ± 0.043	15.103AlaGly: 15.103 ± 0.104	2.624AlaHis: 2.624 ± 0.036	3.602AlaIle: 3.602 ± 0.05	2.357AlaLys: 2.357 ± 0.043	14.805AlaLeu: 14.805 ± 0.115	2.593AlaMet: 2.593 ± 0.025	1.693AlaAsn: 1.693 ± 0.03	7.258AlaPro: 7.258 ± 0.088	3.287AlaGln: 3.287 ± 0.043	11.135AlaArg: 11.135 ± 0.08	5.951AlaSer: 5.951 ± 0.058	6.335AlaThr: 6.335 ± 0.065	13.257AlaVal: 13.257 ± 0.092	1.982AlaTrp: 1.982 ± 0.031	2.578AlaTyr: 2.578 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.053CysAla: 1.053 ± 0.024	0.101CysCys: 0.101 ± 0.007	0.48CysAsp: 0.48 ± 0.019	0.425CysGlu: 0.425 ± 0.014	0.221CysPhe: 0.221 ± 0.009	0.983CysGly: 0.983 ± 0.025	0.201CysHis: 0.201 ± 0.011	0.134CysIle: 0.134 ± 0.007	0.09CysLys: 0.09 ± 0.006	0.757CysLeu: 0.757 ± 0.02	0.116CysMet: 0.116 ± 0.008	0.115CysAsn: 0.115 ± 0.007	0.496CysPro: 0.496 ± 0.016	0.149CysGln: 0.149 ± 0.007	0.643CysArg: 0.643 ± 0.018	0.42CysSer: 0.42 ± 0.015	0.444CysThr: 0.444 ± 0.015	0.656CysVal: 0.656 ± 0.018	0.108CysTrp: 0.108 ± 0.007	0.162CysTyr: 0.162 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.988AspAla: 6.988 ± 0.061	0.379AspCys: 0.379 ± 0.013	3.406AspAsp: 3.406 ± 0.043	3.571AspGlu: 3.571 ± 0.043	1.514AspPhe: 1.514 ± 0.026	6.318AspGly: 6.318 ± 0.068	1.346AspHis: 1.346 ± 0.025	1.553AspIle: 1.553 ± 0.027	0.857AspLys: 0.857 ± 0.02	6.535AspLeu: 6.535 ± 0.055	0.8AspMet: 0.8 ± 0.018	0.727AspAsn: 0.727 ± 0.018	4.814AspPro: 4.814 ± 0.056	1.286AspGln: 1.286 ± 0.025	5.3AspArg: 5.3 ± 0.051	2.093AspSer: 2.093 ± 0.033	2.444AspThr: 2.444 ± 0.035	4.699AspVal: 4.699 ± 0.051	0.911AspTrp: 0.911 ± 0.018	1.122AspTyr: 1.122 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.75GluAla: 7.75 ± 0.073	0.375GluCys: 0.375 ± 0.012	2.708GluAsp: 2.708 ± 0.034	3.856GluGlu: 3.856 ± 0.047	1.47GluPhe: 1.47 ± 0.024	4.31GluGly: 4.31 ± 0.051	1.568GluHis: 1.568 ± 0.028	2.539GluIle: 2.539 ± 0.035	1.172GluLys: 1.172 ± 0.029	6.784GluLeu: 6.784 ± 0.071	0.979GluMet: 0.979 ± 0.023	0.944GluAsn: 0.944 ± 0.022	3.596GluPro: 3.596 ± 0.048	2.056GluGln: 2.056 ± 0.033	6.061GluArg: 6.061 ± 0.063	2.449GluSer: 2.449 ± 0.034	3.097GluThr: 3.097 ± 0.04	4.81GluVal: 4.81 ± 0.054	0.794GluTrp: 0.794 ± 0.018	1.017GluTyr: 1.017 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.866PheAla: 3.866 ± 0.046	0.273PheCys: 0.273 ± 0.01	1.934PheAsp: 1.934 ± 0.028	1.376PheGlu: 1.376 ± 0.026	0.853PhePhe: 0.853 ± 0.02	2.943PheGly: 2.943 ± 0.044	0.603PheHis: 0.603 ± 0.015	0.673PheIle: 0.673 ± 0.016	0.455PheLys: 0.455 ± 0.014	2.671PheLeu: 2.671 ± 0.041	0.436PheMet: 0.436 ± 0.014	0.518PheAsn: 0.518 ± 0.018	1.402PhePro: 1.402 ± 0.027	0.599PheGln: 0.599 ± 0.017	1.904PheArg: 1.904 ± 0.03	1.422PheSer: 1.422 ± 0.025	2.037PheThr: 2.037 ± 0.029	2.204PheVal: 2.204 ± 0.03	0.408PheTrp: 0.408 ± 0.015	0.59PheTyr: 0.59 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.619GlyAla: 11.619 ± 0.096	0.82GlyCys: 0.82 ± 0.02	5.463GlyAsp: 5.463 ± 0.048	5.671GlyGlu: 5.671 ± 0.051	2.938GlyPhe: 2.938 ± 0.04	10.023GlyGly: 10.023 ± 0.101	2.341GlyHis: 2.341 ± 0.036	3.141GlyIle: 3.141 ± 0.044	1.949GlyLys: 1.949 ± 0.031	10.047GlyLeu: 10.047 ± 0.075	2.109GlyMet: 2.109 ± 0.029	1.554GlyAsn: 1.554 ± 0.032	6.038GlyPro: 6.038 ± 0.064	2.402GlyGln: 2.402 ± 0.039	9.156GlyArg: 9.156 ± 0.066	5.262GlySer: 5.262 ± 0.05	6.176GlyThr: 6.176 ± 0.062	8.008GlyVal: 8.008 ± 0.067	1.724GlyTrp: 1.724 ± 0.029	2.225GlyTyr: 2.225 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.709HisAla: 2.709 ± 0.038	0.192HisCys: 0.192 ± 0.009	1.306HisAsp: 1.306 ± 0.028	1.137HisGlu: 1.137 ± 0.023	0.536HisPhe: 0.536 ± 0.017	2.325HisGly: 2.325 ± 0.034	0.629HisHis: 0.629 ± 0.02	0.555HisIle: 0.555 ± 0.015	0.259HisLys: 0.259 ± 0.011	2.474HisLeu: 2.474 ± 0.036	0.301HisMet: 0.301 ± 0.01	0.33HisAsn: 0.33 ± 0.014	1.781HisPro: 1.781 ± 0.028	0.516HisGln: 0.516 ± 0.016	2.234HisArg: 2.234 ± 0.031	0.856HisSer: 0.856 ± 0.023	0.987HisThr: 0.987 ± 0.02	1.741HisVal: 1.741 ± 0.03	0.325HisTrp: 0.325 ± 0.012	0.43HisTyr: 0.43 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.828IleAla: 4.828 ± 0.052	0.289IleCys: 0.289 ± 0.01	2.177IleAsp: 2.177 ± 0.032	2.109IleGlu: 2.109 ± 0.031	0.691IlePhe: 0.691 ± 0.021	3.555IleGly: 3.555 ± 0.045	0.534IleHis: 0.534 ± 0.015	0.924IleIle: 0.924 ± 0.02	0.651IleLys: 0.651 ± 0.019	2.505IleLeu: 2.505 ± 0.038	0.539IleMet: 0.539 ± 0.017	0.605IleAsn: 0.605 ± 0.015	1.747IlePro: 1.747 ± 0.027	0.668IleGln: 0.668 ± 0.019	2.459IleArg: 2.459 ± 0.032	1.638IleSer: 1.638 ± 0.028	2.276IleThr: 2.276 ± 0.031	2.869IleVal: 2.869 ± 0.036	0.387IleTrp: 0.387 ± 0.013	0.511IleTyr: 0.511 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.371LysAla: 2.371 ± 0.037	0.092LysCys: 0.092 ± 0.006	0.962LysAsp: 0.962 ± 0.026	0.986LysGlu: 0.986 ± 0.022	0.363LysPhe: 0.363 ± 0.014	1.48LysGly: 1.48 ± 0.027	0.358LysHis: 0.358 ± 0.012	0.856LysIle: 0.856 ± 0.022	0.589LysLys: 0.589 ± 0.02	1.641LysLeu: 1.641 ± 0.027	0.346LysMet: 0.346 ± 0.012	0.394LysAsn: 0.394 ± 0.015	1.086LysPro: 1.086 ± 0.028	0.524LysGln: 0.524 ± 0.019	1.262LysArg: 1.262 ± 0.03	0.864LysSer: 0.864 ± 0.021	1.056LysThr: 1.056 ± 0.027	1.658LysVal: 1.658 ± 0.031	0.24LysTrp: 0.24 ± 0.012	0.358LysTyr: 0.358 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.358LeuAla: 16.358 ± 0.099	0.8LeuCys: 0.8 ± 0.02	6.389LeuAsp: 6.389 ± 0.053	5.074LeuGlu: 5.074 ± 0.051	2.592LeuPhe: 2.592 ± 0.039	9.471LeuGly: 9.471 ± 0.08	2.182LeuHis: 2.182 ± 0.032	3.292LeuIle: 3.292 ± 0.041	1.722LeuLys: 1.722 ± 0.032	11.572LeuLeu: 11.572 ± 0.096	1.614LeuMet: 1.614 ± 0.027	1.583LeuAsn: 1.583 ± 0.027	6.716LeuPro: 6.716 ± 0.062	2.068LeuGln: 2.068 ± 0.03	9.212LeuArg: 9.212 ± 0.079	5.514LeuSer: 5.514 ± 0.051	6.622LeuThr: 6.622 ± 0.052	9.143LeuVal: 9.143 ± 0.08	1.282LeuTrp: 1.282 ± 0.027	1.769LeuTyr: 1.769 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.319MetAla: 2.319 ± 0.03	0.123MetCys: 0.123 ± 0.008	0.895MetAsp: 0.895 ± 0.021	0.823MetGlu: 0.823 ± 0.018	0.492MetPhe: 0.492 ± 0.017	1.316MetGly: 1.316 ± 0.027	0.344MetHis: 0.344 ± 0.013	0.817MetIle: 0.817 ± 0.02	0.413MetLys: 0.413 ± 0.015	1.853MetLeu: 1.853 ± 0.025	0.329MetMet: 0.329 ± 0.014	0.437MetAsn: 0.437 ± 0.013	1.109MetPro: 1.109 ± 0.02	0.381MetGln: 0.381 ± 0.012	1.611MetArg: 1.611 ± 0.023	1.32MetSer: 1.32 ± 0.026	1.517MetThr: 1.517 ± 0.026	1.383MetVal: 1.383 ± 0.025	0.202MetTrp: 0.202 ± 0.01	0.29MetTyr: 0.29 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.006AsnAla: 2.006 ± 0.035	0.135AsnCys: 0.135 ± 0.008	0.819AsnAsp: 0.819 ± 0.021	0.729AsnGlu: 0.729 ± 0.018	0.384AsnPhe: 0.384 ± 0.015	1.671AsnGly: 1.671 ± 0.034	0.351AsnHis: 0.351 ± 0.012	0.53AsnIle: 0.53 ± 0.015	0.284AsnLys: 0.284 ± 0.012	1.642AsnLeu: 1.642 ± 0.028	0.27AsnMet: 0.27 ± 0.013	0.304AsnAsn: 0.304 ± 0.011	1.221AsnPro: 1.221 ± 0.028	0.418AsnGln: 0.418 ± 0.014	1.297AsnArg: 1.297 ± 0.024	0.667AsnSer: 0.667 ± 0.021	0.891AsnThr: 0.891 ± 0.023	1.311AsnVal: 1.311 ± 0.025	0.25AsnTrp: 0.25 ± 0.011	0.335AsnTyr: 0.335 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	9.738ProAla: 9.738 ± 0.088	0.337ProCys: 0.337 ± 0.012	4.313ProAsp: 4.313 ± 0.052	4.587ProGlu: 4.587 ± 0.049	1.575ProPhe: 1.575 ± 0.027	7.782ProGly: 7.782 ± 0.08	1.233ProHis: 1.233 ± 0.023	1.532ProIle: 1.532 ± 0.027	0.965ProLys: 0.965 ± 0.024	5.433ProLeu: 5.433 ± 0.049	1.073ProMet: 1.073 ± 0.021	0.746ProAsn: 0.746 ± 0.017	4.216ProPro: 4.216 ± 0.067	1.495ProGln: 1.495 ± 0.031	4.197ProArg: 4.197 ± 0.051	3.207ProSer: 3.207 ± 0.04	2.712ProThr: 2.712 ± 0.05	5.894ProVal: 5.894 ± 0.055	0.913ProTrp: 0.913 ± 0.02	1.425ProTyr: 1.425 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.754GlnAla: 3.754 ± 0.05	0.123GlnCys: 0.123 ± 0.007	1.13GlnAsp: 1.13 ± 0.023	1.418GlnGlu: 1.418 ± 0.025	0.561GlnPhe: 0.561 ± 0.016	1.962GlnGly: 1.962 ± 0.033	0.481GlnHis: 0.481 ± 0.018	1.07GlnIle: 1.07 ± 0.021	0.444GlnLys: 0.444 ± 0.014	2.364GlnLeu: 2.364 ± 0.034	0.416GlnMet: 0.416 ± 0.013	0.406GlnAsn: 0.406 ± 0.014	1.399GlnPro: 1.399 ± 0.034	0.888GlnGln: 0.888 ± 0.034	2.201GlnArg: 2.201 ± 0.039	1.032GlnSer: 1.032 ± 0.021	1.198GlnThr: 1.198 ± 0.025	2.372GlnVal: 2.372 ± 0.035	0.402GlnTrp: 0.402 ± 0.015	0.426GlnTyr: 0.426 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	10.652ArgAla: 10.652 ± 0.088	0.612ArgCys: 0.612 ± 0.017	4.479ArgAsp: 4.479 ± 0.048	5.2ArgGlu: 5.2 ± 0.055	2.631ArgPhe: 2.631 ± 0.035	6.435ArgGly: 6.435 ± 0.065	2.218ArgHis: 2.218 ± 0.03	3.459ArgIle: 3.459 ± 0.038	1.415ArgLys: 1.415 ± 0.024	10.144ArgLeu: 10.144 ± 0.081	2.025ArgMet: 2.025 ± 0.033	1.34ArgAsn: 1.34 ± 0.025	5.613ArgPro: 5.613 ± 0.059	2.265ArgGln: 2.265 ± 0.039	9.211ArgArg: 9.211 ± 0.072	4.341ArgSer: 4.341 ± 0.049	5.175ArgThr: 5.175 ± 0.048	6.422ArgVal: 6.422 ± 0.053	1.534ArgTrp: 1.534 ± 0.026	1.801ArgTyr: 1.801 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.834SerAla: 6.834 ± 0.066	0.398SerCys: 0.398 ± 0.016	2.373SerAsp: 2.373 ± 0.036	2.291SerGlu: 2.291 ± 0.039	1.491SerPhe: 1.491 ± 0.026	6.189SerGly: 6.189 ± 0.063	0.944SerHis: 0.944 ± 0.019	1.485SerIle: 1.485 ± 0.029	0.783SerLys: 0.783 ± 0.023	4.535SerLeu: 4.535 ± 0.046	1.061SerMet: 1.061 ± 0.023	0.694SerAsn: 0.694 ± 0.021	3.392SerPro: 3.392 ± 0.041	1.041SerGln: 1.041 ± 0.024	3.977SerArg: 3.977 ± 0.041	2.639SerSer: 2.639 ± 0.04	2.708SerThr: 2.708 ± 0.039	3.973SerVal: 3.973 ± 0.043	0.896SerTrp: 0.896 ± 0.02	1.051SerTyr: 1.051 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.884ThrAla: 8.884 ± 0.081	0.428ThrCys: 0.428 ± 0.014	2.896ThrAsp: 2.896 ± 0.039	2.83ThrGlu: 2.83 ± 0.036	1.464ThrPhe: 1.464 ± 0.025	6.985ThrGly: 6.985 ± 0.055	0.951ThrHis: 0.951 ± 0.022	1.716ThrIle: 1.716 ± 0.027	0.828ThrLys: 0.828 ± 0.022	5.287ThrLeu: 5.287 ± 0.049	0.941ThrMet: 0.941 ± 0.019	0.763ThrAsn: 0.763 ± 0.02	3.904ThrPro: 3.904 ± 0.052	1.043ThrGln: 1.043 ± 0.023	4.038ThrArg: 4.038 ± 0.047	2.748ThrSer: 2.748 ± 0.042	3.108ThrThr: 3.108 ± 0.042	5.835ThrVal: 5.835 ± 0.061	0.845ThrTrp: 0.845 ± 0.021	1.052ThrTyr: 1.052 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	11.369ValAla: 11.369 ± 0.09	0.747ValCys: 0.747 ± 0.019	4.749ValAsp: 4.749 ± 0.043	4.932ValGlu: 4.932 ± 0.053	2.561ValPhe: 2.561 ± 0.034	6.413ValGly: 6.413 ± 0.056	1.936ValHis: 1.936 ± 0.031	3.039ValIle: 3.039 ± 0.039	1.624ValLys: 1.624 ± 0.03	9.987ValLeu: 9.987 ± 0.08	1.479ValMet: 1.479 ± 0.023	1.619ValAsn: 1.619 ± 0.029	5.722ValPro: 5.722 ± 0.053	1.948ValGln: 1.948 ± 0.035	7.724ValArg: 7.724 ± 0.058	4.513ValSer: 4.513 ± 0.047	5.663ValThr: 5.663 ± 0.057	8.304ValVal: 8.304 ± 0.08	1.155ValTrp: 1.155 ± 0.023	1.596ValTyr: 1.596 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.637TrpAla: 1.637 ± 0.029	0.149TrpCys: 0.149 ± 0.009	0.751TrpAsp: 0.751 ± 0.018	0.734TrpGlu: 0.734 ± 0.02	0.497TrpPhe: 0.497 ± 0.016	1.014TrpGly: 1.014 ± 0.021	0.377TrpHis: 0.377 ± 0.014	0.602TrpIle: 0.602 ± 0.019	0.337TrpLys: 0.337 ± 0.013	1.778TrpLeu: 1.778 ± 0.026	0.295TrpMet: 0.295 ± 0.01	0.389TrpAsn: 0.389 ± 0.013	0.867TrpPro: 0.867 ± 0.021	0.509TrpGln: 0.509 ± 0.016	1.483TrpArg: 1.483 ± 0.026	0.967TrpSer: 0.967 ± 0.021	1.031TrpThr: 1.031 ± 0.022	0.918TrpVal: 0.918 ± 0.022	0.349TrpTrp: 0.349 ± 0.012	0.343TrpTyr: 0.343 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.496TyrAla: 2.496 ± 0.037	0.171TyrCys: 0.171 ± 0.009	1.257TyrAsp: 1.257 ± 0.026	1.057TyrGlu: 1.057 ± 0.021	0.583TyrPhe: 0.583 ± 0.015	2.39TyrGly: 2.39 ± 0.038	0.403TyrHis: 0.403 ± 0.012	0.44TyrIle: 0.44 ± 0.015	0.293TyrLys: 0.293 ± 0.011	2.158TyrLeu: 2.158 ± 0.031	0.249TyrMet: 0.249 ± 0.012	0.354TyrAsn: 0.354 ± 0.013	0.995TyrPro: 0.995 ± 0.021	0.505TyrGln: 0.505 ± 0.015	1.867TyrArg: 1.867 ± 0.032	0.852TyrSer: 0.852 ± 0.019	1.07TyrThr: 1.07 ± 0.023	1.625TyrVal: 1.625 ± 0.029	0.317TyrTrp: 0.317 ± 0.012	0.414TyrTyr: 0.414 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7159 proteins (2355000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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