Amino acid dipepetide frequency for Homoserinibacter sp. GY 40078

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.671AlaAla: 19.671 ± 0.218	0.635AlaCys: 0.635 ± 0.03	8.464AlaAsp: 8.464 ± 0.099	8.656AlaGlu: 8.656 ± 0.111	3.967AlaPhe: 3.967 ± 0.067	11.925AlaGly: 11.925 ± 0.14	2.442AlaHis: 2.442 ± 0.052	6.359AlaIle: 6.359 ± 0.093	2.235AlaLys: 2.235 ± 0.063	14.257AlaLeu: 14.257 ± 0.142	2.513AlaMet: 2.513 ± 0.059	2.254AlaAsn: 2.254 ± 0.052	6.501AlaPro: 6.501 ± 0.107	3.474AlaGln: 3.474 ± 0.059	9.726AlaArg: 9.726 ± 0.132	7.807AlaSer: 7.807 ± 0.095	7.334AlaThr: 7.334 ± 0.108	11.688AlaVal: 11.688 ± 0.138	1.992AlaTrp: 1.992 ± 0.057	2.396AlaTyr: 2.396 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.566CysAla: 0.566 ± 0.027	0.035CysCys: 0.035 ± 0.006	0.296CysAsp: 0.296 ± 0.018	0.234CysGlu: 0.234 ± 0.018	0.143CysPhe: 0.143 ± 0.012	0.506CysGly: 0.506 ± 0.024	0.102CysHis: 0.102 ± 0.011	0.176CysIle: 0.176 ± 0.014	0.054CysLys: 0.054 ± 0.009	0.404CysLeu: 0.404 ± 0.022	0.075CysMet: 0.075 ± 0.008	0.09CysAsn: 0.09 ± 0.011	0.248CysPro: 0.248 ± 0.017	0.101CysGln: 0.101 ± 0.011	0.296CysArg: 0.296 ± 0.017	0.32CysSer: 0.32 ± 0.02	0.315CysThr: 0.315 ± 0.018	0.405CysVal: 0.405 ± 0.024	0.07CysTrp: 0.07 ± 0.009	0.101CysTyr: 0.101 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	9.535AspAla: 9.535 ± 0.12	0.222AspCys: 0.222 ± 0.014	4.603AspAsp: 4.603 ± 0.068	4.614AspGlu: 4.614 ± 0.074	1.774AspPhe: 1.774 ± 0.047	6.368AspGly: 6.368 ± 0.118	1.181AspHis: 1.181 ± 0.043	2.401AspIle: 2.401 ± 0.052	0.808AspLys: 0.808 ± 0.038	6.018AspLeu: 6.018 ± 0.083	0.716AspMet: 0.716 ± 0.028	0.878AspAsn: 0.878 ± 0.036	4.739AspPro: 4.739 ± 0.063	1.491AspGln: 1.491 ± 0.039	4.689AspArg: 4.689 ± 0.086	2.716AspSer: 2.716 ± 0.06	2.909AspThr: 2.909 ± 0.065	5.106AspVal: 5.106 ± 0.09	1.019AspTrp: 1.019 ± 0.03	1.393AspTyr: 1.393 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.16GluAla: 7.16 ± 0.105	0.22GluCys: 0.22 ± 0.016	2.472GluAsp: 2.472 ± 0.056	3.037GluGlu: 3.037 ± 0.074	1.891GluPhe: 1.891 ± 0.052	4.33GluGly: 4.33 ± 0.081	1.457GluHis: 1.457 ± 0.043	2.845GluIle: 2.845 ± 0.062	1.287GluLys: 1.287 ± 0.046	7.826GluLeu: 7.826 ± 0.103	0.87GluMet: 0.87 ± 0.033	1.168GluAsn: 1.168 ± 0.035	3.189GluPro: 3.189 ± 0.067	2.02GluGln: 2.02 ± 0.048	5.567GluArg: 5.567 ± 0.108	3.054GluSer: 3.054 ± 0.058	3.035GluThr: 3.035 ± 0.053	5.33GluVal: 5.33 ± 0.081	0.889GluTrp: 0.889 ± 0.034	1.144GluTyr: 1.144 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.405PheAla: 4.405 ± 0.077	0.151PheCys: 0.151 ± 0.013	2.34PheAsp: 2.34 ± 0.052	1.766PheGlu: 1.766 ± 0.041	1.052PhePhe: 1.052 ± 0.036	3.391PheGly: 3.391 ± 0.072	0.546PheHis: 0.546 ± 0.026	1.105PheIle: 1.105 ± 0.036	0.385PheLys: 0.385 ± 0.022	2.846PheLeu: 2.846 ± 0.058	0.424PheMet: 0.424 ± 0.022	0.543PheAsn: 0.543 ± 0.028	1.457PhePro: 1.457 ± 0.042	0.775PheGln: 0.775 ± 0.029	1.994PheArg: 1.994 ± 0.051	1.855PheSer: 1.855 ± 0.048	2.024PheThr: 2.024 ± 0.049	2.86PheVal: 2.86 ± 0.066	0.466PheTrp: 0.466 ± 0.022	0.607PheTyr: 0.607 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.72GlyAla: 10.72 ± 0.129	0.547GlyCys: 0.547 ± 0.027	5.376GlyAsp: 5.376 ± 0.095	5.308GlyGlu: 5.308 ± 0.089	3.291GlyPhe: 3.291 ± 0.069	7.848GlyGly: 7.848 ± 0.128	1.768GlyHis: 1.768 ± 0.052	4.989GlyIle: 4.989 ± 0.076	1.818GlyLys: 1.818 ± 0.048	8.922GlyLeu: 8.922 ± 0.102	1.849GlyMet: 1.849 ± 0.04	1.568GlyAsn: 1.568 ± 0.048	3.722GlyPro: 3.722 ± 0.067	2.185GlyGln: 2.185 ± 0.054	6.579GlyArg: 6.579 ± 0.089	5.778GlySer: 5.778 ± 0.108	5.503GlyThr: 5.503 ± 0.112	8.411GlyVal: 8.411 ± 0.102	1.717GlyTrp: 1.717 ± 0.046	2.389GlyTyr: 2.389 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.324HisAla: 2.324 ± 0.053	0.091HisCys: 0.091 ± 0.01	1.297HisAsp: 1.297 ± 0.033	1.174HisGlu: 1.174 ± 0.036	0.48HisPhe: 0.48 ± 0.025	1.921HisGly: 1.921 ± 0.052	0.518HisHis: 0.518 ± 0.027	0.681HisIle: 0.681 ± 0.024	0.216HisLys: 0.216 ± 0.015	1.987HisLeu: 1.987 ± 0.048	0.27HisMet: 0.27 ± 0.018	0.341HisAsn: 0.341 ± 0.016	1.5HisPro: 1.5 ± 0.041	0.465HisGln: 0.465 ± 0.024	1.56HisArg: 1.56 ± 0.05	0.89HisSer: 0.89 ± 0.031	0.935HisThr: 0.935 ± 0.031	1.569HisVal: 1.569 ± 0.045	0.298HisTrp: 0.298 ± 0.019	0.439HisTyr: 0.439 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.309IleAla: 7.309 ± 0.085	0.201IleCys: 0.201 ± 0.016	3.626IleAsp: 3.626 ± 0.071	2.975IleGlu: 2.975 ± 0.058	1.147IlePhe: 1.147 ± 0.038	4.51IleGly: 4.51 ± 0.08	0.685IleHis: 0.685 ± 0.028	1.662IleIle: 1.662 ± 0.049	0.682IleLys: 0.682 ± 0.034	3.627IleLeu: 3.627 ± 0.07	0.531IleMet: 0.531 ± 0.023	0.767IleAsn: 0.767 ± 0.031	2.564IlePro: 2.564 ± 0.052	0.997IleGln: 0.997 ± 0.039	3.3IleArg: 3.3 ± 0.064	2.45IleSer: 2.45 ± 0.062	2.651IleThr: 2.651 ± 0.054	4.924IleVal: 4.924 ± 0.083	0.55IleTrp: 0.55 ± 0.027	0.725IleTyr: 0.725 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.023LysAla: 2.023 ± 0.058	0.061LysCys: 0.061 ± 0.008	0.877LysAsp: 0.877 ± 0.035	0.796LysGlu: 0.796 ± 0.037	0.434LysPhe: 0.434 ± 0.023	1.265LysGly: 1.265 ± 0.05	0.36LysHis: 0.36 ± 0.02	0.805LysIle: 0.805 ± 0.032	0.618LysLys: 0.618 ± 0.036	1.713LysLeu: 1.713 ± 0.048	0.304LysMet: 0.304 ± 0.018	0.438LysAsn: 0.438 ± 0.024	1.01LysPro: 1.01 ± 0.038	0.525LysGln: 0.525 ± 0.025	1.352LysArg: 1.352 ± 0.053	1.083LysSer: 1.083 ± 0.037	1.098LysThr: 1.098 ± 0.042	1.559LysVal: 1.559 ± 0.056	0.204LysTrp: 0.204 ± 0.012	0.404LysTyr: 0.404 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.508LeuAla: 15.508 ± 0.168	0.427LeuCys: 0.427 ± 0.021	7.183LeuAsp: 7.183 ± 0.09	5.536LeuGlu: 5.536 ± 0.094	2.739LeuPhe: 2.739 ± 0.063	9.714LeuGly: 9.714 ± 0.101	1.747LeuHis: 1.747 ± 0.041	4.288LeuIle: 4.288 ± 0.093	1.505LeuLys: 1.505 ± 0.058	10.448LeuLeu: 10.448 ± 0.152	1.509LeuMet: 1.509 ± 0.044	1.63LeuAsn: 1.63 ± 0.046	5.738LeuPro: 5.738 ± 0.076	2.36LeuGln: 2.36 ± 0.055	7.422LeuArg: 7.422 ± 0.099	5.404LeuSer: 5.404 ± 0.075	6.01LeuThr: 6.01 ± 0.083	10.331LeuVal: 10.331 ± 0.123	1.263LeuTrp: 1.263 ± 0.039	1.706LeuTyr: 1.706 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.921MetAla: 1.921 ± 0.046	0.098MetCys: 0.098 ± 0.01	0.712MetAsp: 0.712 ± 0.028	0.578MetGlu: 0.578 ± 0.029	0.486MetPhe: 0.486 ± 0.022	1.213MetGly: 1.213 ± 0.033	0.329MetHis: 0.329 ± 0.021	0.783MetIle: 0.783 ± 0.027	0.314MetLys: 0.314 ± 0.018	1.858MetLeu: 1.858 ± 0.047	0.231MetMet: 0.231 ± 0.015	0.445MetAsn: 0.445 ± 0.019	1.153MetPro: 1.153 ± 0.035	0.49MetGln: 0.49 ± 0.022	1.435MetArg: 1.435 ± 0.04	1.445MetSer: 1.445 ± 0.04	1.508MetThr: 1.508 ± 0.039	1.271MetVal: 1.271 ± 0.038	0.216MetTrp: 0.216 ± 0.015	0.277MetTyr: 0.277 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.247AsnAla: 2.247 ± 0.048	0.101AsnCys: 0.101 ± 0.011	1.006AsnAsp: 1.006 ± 0.034	0.903AsnGlu: 0.903 ± 0.033	0.61AsnPhe: 0.61 ± 0.026	1.741AsnGly: 1.741 ± 0.048	0.334AsnHis: 0.334 ± 0.023	0.773AsnIle: 0.773 ± 0.031	0.318AsnLys: 0.318 ± 0.02	1.777AsnLeu: 1.777 ± 0.044	0.281AsnMet: 0.281 ± 0.019	0.424AsnAsn: 0.424 ± 0.025	1.465AsnPro: 1.465 ± 0.042	0.489AsnGln: 0.489 ± 0.023	1.211AsnArg: 1.211 ± 0.037	0.963AsnSer: 0.963 ± 0.038	1.063AsnThr: 1.063 ± 0.039	1.602AsnVal: 1.602 ± 0.046	0.323AsnTrp: 0.323 ± 0.02	0.466AsnTyr: 0.466 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.998ProAla: 6.998 ± 0.112	0.187ProCys: 0.187 ± 0.013	4.141ProAsp: 4.141 ± 0.061	4.193ProGlu: 4.193 ± 0.073	1.723ProPhe: 1.723 ± 0.043	5.207ProGly: 5.207 ± 0.084	1.077ProHis: 1.077 ± 0.034	2.203ProIle: 2.203 ± 0.059	0.894ProLys: 0.894 ± 0.037	4.955ProLeu: 4.955 ± 0.075	0.855ProMet: 0.855 ± 0.036	0.999ProAsn: 0.999 ± 0.034	2.435ProPro: 2.435 ± 0.069	1.422ProGln: 1.422 ± 0.04	3.725ProArg: 3.725 ± 0.079	3.332ProSer: 3.332 ± 0.06	3.382ProThr: 3.382 ± 0.074	4.969ProVal: 4.969 ± 0.075	0.912ProTrp: 0.912 ± 0.032	1.088ProTyr: 1.088 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.097GlnAla: 3.097 ± 0.063	0.108GlnCys: 0.108 ± 0.01	1.124GlnAsp: 1.124 ± 0.036	1.266GlnGlu: 1.266 ± 0.042	0.808GlnPhe: 0.808 ± 0.029	1.81GlnGly: 1.81 ± 0.047	0.525GlnHis: 0.525 ± 0.023	1.228GlnIle: 1.228 ± 0.034	0.567GlnLys: 0.567 ± 0.025	3.428GlnLeu: 3.428 ± 0.062	0.412GlnMet: 0.412 ± 0.022	0.612GlnAsn: 0.612 ± 0.027	1.383GlnPro: 1.383 ± 0.04	0.997GlnGln: 0.997 ± 0.033	2.182GlnArg: 2.182 ± 0.053	1.376GlnSer: 1.376 ± 0.046	1.387GlnThr: 1.387 ± 0.04	2.361GlnVal: 2.361 ± 0.052	0.397GlnTrp: 0.397 ± 0.024	0.546GlnTyr: 0.546 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.481ArgAla: 9.481 ± 0.152	0.313ArgCys: 0.313 ± 0.021	4.5ArgAsp: 4.5 ± 0.072	4.751ArgGlu: 4.751 ± 0.085	2.496ArgPhe: 2.496 ± 0.049	5.88ArgGly: 5.88 ± 0.094	1.577ArgHis: 1.577 ± 0.048	4.26ArgIle: 4.26 ± 0.076	1.191ArgLys: 1.191 ± 0.042	7.499ArgLeu: 7.499 ± 0.1	1.809ArgMet: 1.809 ± 0.044	1.277ArgAsn: 1.277 ± 0.034	3.784ArgPro: 3.784 ± 0.076	1.835ArgGln: 1.835 ± 0.047	7.129ArgArg: 7.129 ± 0.12	4.114ArgSer: 4.114 ± 0.075	4.378ArgThr: 4.378 ± 0.069	6.406ArgVal: 6.406 ± 0.093	1.254ArgTrp: 1.254 ± 0.04	1.643ArgTyr: 1.643 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.385SerAla: 7.385 ± 0.097	0.271SerCys: 0.271 ± 0.015	3.496SerAsp: 3.496 ± 0.069	2.893SerGlu: 2.893 ± 0.058	1.895SerPhe: 1.895 ± 0.044	6.221SerGly: 6.221 ± 0.097	1.02SerHis: 1.02 ± 0.037	2.605SerIle: 2.605 ± 0.055	0.972SerLys: 0.972 ± 0.037	5.209SerLeu: 5.209 ± 0.077	1.142SerMet: 1.142 ± 0.037	1.012SerAsn: 1.012 ± 0.04	3.134SerPro: 3.134 ± 0.067	1.282SerGln: 1.282 ± 0.039	3.935SerArg: 3.935 ± 0.072	3.725SerSer: 3.725 ± 0.088	3.777SerThr: 3.777 ± 0.082	4.77SerVal: 4.77 ± 0.076	1.086SerTrp: 1.086 ± 0.039	1.336SerTyr: 1.336 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.55ThrAla: 7.55 ± 0.096	0.218ThrCys: 0.218 ± 0.016	3.472ThrAsp: 3.472 ± 0.063	2.93ThrGlu: 2.93 ± 0.058	1.829ThrPhe: 1.829 ± 0.045	5.803ThrGly: 5.803 ± 0.09	1.052ThrHis: 1.052 ± 0.031	2.909ThrIle: 2.909 ± 0.062	0.989ThrLys: 0.989 ± 0.043	5.787ThrLeu: 5.787 ± 0.092	0.877ThrMet: 0.877 ± 0.028	1.071ThrAsn: 1.071 ± 0.041	3.979ThrPro: 3.979 ± 0.075	1.392ThrGln: 1.392 ± 0.039	4.06ThrArg: 4.06 ± 0.073	3.698ThrSer: 3.698 ± 0.086	3.791ThrThr: 3.791 ± 0.087	5.538ThrVal: 5.538 ± 0.099	0.919ThrTrp: 0.919 ± 0.034	0.984ThrTyr: 0.984 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	12.229ValAla: 12.229 ± 0.123	0.441ValCys: 0.441 ± 0.024	6.002ValAsp: 6.002 ± 0.085	5.35ValGlu: 5.35 ± 0.073	2.978ValPhe: 2.978 ± 0.064	7.487ValGly: 7.487 ± 0.094	1.63ValHis: 1.63 ± 0.044	4.377ValIle: 4.377 ± 0.069	1.474ValLys: 1.474 ± 0.05	9.86ValLeu: 9.86 ± 0.116	1.456ValMet: 1.456 ± 0.041	1.696ValAsn: 1.696 ± 0.051	4.825ValPro: 4.825 ± 0.073	2.212ValGln: 2.212 ± 0.056	6.422ValArg: 6.422 ± 0.1	5.064ValSer: 5.064 ± 0.076	5.616ValThr: 5.616 ± 0.087	9.505ValVal: 9.505 ± 0.123	1.212ValTrp: 1.212 ± 0.042	1.568ValTyr: 1.568 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.705TrpAla: 1.705 ± 0.048	0.099TrpCys: 0.099 ± 0.009	0.897TrpAsp: 0.897 ± 0.032	0.69TrpGlu: 0.69 ± 0.028	0.569TrpPhe: 0.569 ± 0.022	1.195TrpGly: 1.195 ± 0.036	0.321TrpHis: 0.321 ± 0.019	0.795TrpIle: 0.795 ± 0.032	0.282TrpLys: 0.282 ± 0.021	1.666TrpLeu: 1.666 ± 0.05	0.37TrpMet: 0.37 ± 0.02	0.466TrpAsn: 0.466 ± 0.025	0.799TrpPro: 0.799 ± 0.031	0.536TrpGln: 0.536 ± 0.025	1.281TrpArg: 1.281 ± 0.043	0.98TrpSer: 0.98 ± 0.036	0.961TrpThr: 0.961 ± 0.036	1.199TrpVal: 1.199 ± 0.037	0.418TrpTrp: 0.418 ± 0.025	0.311TrpTyr: 0.311 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.053	0.113TyrCys: 0.113 ± 0.011	1.295TyrAsp: 1.295 ± 0.042	1.143TyrGlu: 1.143 ± 0.035	0.683TyrPhe: 0.683 ± 0.026	1.953TyrGly: 1.953 ± 0.056	0.284TyrHis: 0.284 ± 0.017	0.639TyrIle: 0.639 ± 0.029	0.319TyrLys: 0.319 ± 0.021	2.379TyrLeu: 2.379 ± 0.053	0.267TyrMet: 0.267 ± 0.015	0.417TyrAsn: 0.417 ± 0.024	1.071TyrPro: 1.071 ± 0.036	0.567TyrGln: 0.567 ± 0.027	1.71TyrArg: 1.71 ± 0.043	1.112TyrSer: 1.112 ± 0.033	1.171TyrThr: 1.171 ± 0.043	1.602TyrVal: 1.602 ± 0.044	0.336TyrTrp: 0.336 ± 0.021	0.45TyrTyr: 0.45 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2789 proteins (918376 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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