Amino acid dipepetide frequency for Trypanosoma congolense (strain IL3000)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.576AlaAla: 8.576 ± 0.116	1.751AlaCys: 1.751 ± 0.036	3.609AlaAsp: 3.609 ± 0.09	5.164AlaGlu: 5.164 ± 0.099	2.811AlaPhe: 2.811 ± 0.135	4.728AlaGly: 4.728 ± 0.064	1.993AlaHis: 1.993 ± 0.066	2.944AlaIle: 2.944 ± 0.043	3.578AlaLys: 3.578 ± 0.062	8.348AlaLeu: 8.348 ± 0.133	1.855AlaMet: 1.855 ± 0.032	2.487AlaAsn: 2.487 ± 0.066	3.93AlaPro: 3.93 ± 0.081	3.036AlaGln: 3.036 ± 0.187	4.822AlaArg: 4.822 ± 0.096	6.172AlaSer: 6.172 ± 0.079	4.786AlaThr: 4.786 ± 0.072	6.338AlaVal: 6.338 ± 0.093	0.897AlaTrp: 0.897 ± 0.027	1.84AlaTyr: 1.84 ± 0.041	0.003AlaXaa: 0.003 ± 0.001
Cys	1.766CysAla: 1.766 ± 0.031	0.781CysCys: 0.781 ± 0.025	1.318CysAsp: 1.318 ± 0.027	1.876CysGlu: 1.876 ± 0.185	1.18CysPhe: 1.18 ± 0.027	2.497CysGly: 2.497 ± 0.047	0.592CysHis: 0.592 ± 0.017	1.195CysIle: 1.195 ± 0.192	0.867CysLys: 0.867 ± 0.027	2.258CysLeu: 2.258 ± 0.044	0.444CysMet: 0.444 ± 0.016	1.175CysAsn: 1.175 ± 0.184	0.943CysPro: 0.943 ± 0.022	0.622CysGln: 0.622 ± 0.02	1.592CysArg: 1.592 ± 0.029	1.906CysSer: 1.906 ± 0.035	1.438CysThr: 1.438 ± 0.026	2.059CysVal: 2.059 ± 0.035	0.275CysTrp: 0.275 ± 0.013	0.601CysTyr: 0.601 ± 0.019	0.002CysXaa: 0.002 ± 0.001
Asp	4.503AspAla: 4.503 ± 0.073	0.901AspCys: 0.901 ± 0.026	2.995AspAsp: 2.995 ± 0.05	3.705AspGlu: 3.705 ± 0.061	1.761AspPhe: 1.761 ± 0.029	3.916AspGly: 3.916 ± 0.054	1.033AspHis: 1.033 ± 0.031	2.551AspIle: 2.551 ± 0.067	2.084AspLys: 2.084 ± 0.035	3.595AspLeu: 3.595 ± 0.062	1.327AspMet: 1.327 ± 0.098	1.837AspAsn: 1.837 ± 0.044	2.141AspPro: 2.141 ± 0.054	1.053AspGln: 1.053 ± 0.027	2.448AspArg: 2.448 ± 0.043	3.342AspSer: 3.342 ± 0.047	2.883AspThr: 2.883 ± 0.091	4.193AspVal: 4.193 ± 0.063	0.587AspTrp: 0.587 ± 0.017	1.088AspTyr: 1.088 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.022GluAla: 6.022 ± 0.129	1.309GluCys: 1.309 ± 0.035	3.493GluAsp: 3.493 ± 0.057	6.785GluGlu: 6.785 ± 0.153	1.82GluPhe: 1.82 ± 0.029	4.96GluGly: 4.96 ± 0.079	1.534GluHis: 1.534 ± 0.043	2.98GluIle: 2.98 ± 0.166	4.693GluLys: 4.693 ± 0.108	5.322GluLeu: 5.322 ± 0.096	1.581GluMet: 1.581 ± 0.03	2.651GluAsn: 2.651 ± 0.046	2.357GluPro: 2.357 ± 0.097	2.476GluGln: 2.476 ± 0.089	4.674GluArg: 4.674 ± 0.08	4.238GluSer: 4.238 ± 0.063	3.282GluThr: 3.282 ± 0.072	4.777GluVal: 4.777 ± 0.117	0.948GluTrp: 0.948 ± 0.026	1.39GluTyr: 1.39 ± 0.028	0.003GluXaa: 0.003 ± 0.002
Phe	2.547PheAla: 2.547 ± 0.054	1.116PheCys: 1.116 ± 0.026	1.624PheAsp: 1.624 ± 0.041	1.594PheGlu: 1.594 ± 0.046	2.201PhePhe: 2.201 ± 0.061	2.364PheGly: 2.364 ± 0.044	1.144PheHis: 1.144 ± 0.035	1.67PheIle: 1.67 ± 0.029	1.28PheLys: 1.28 ± 0.027	4.094PheLeu: 4.094 ± 0.066	1.04PheMet: 1.04 ± 0.029	1.244PheAsn: 1.244 ± 0.027	2.021PhePro: 2.021 ± 0.05	0.995PheGln: 0.995 ± 0.019	2.039PheArg: 2.039 ± 0.037	3.18PheSer: 3.18 ± 0.052	2.018PheThr: 2.018 ± 0.048	2.936PheVal: 2.936 ± 0.114	0.429PheTrp: 0.429 ± 0.014	0.978PheTyr: 0.978 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	5.154GlyAla: 5.154 ± 0.07	1.571GlyCys: 1.571 ± 0.029	3.844GlyAsp: 3.844 ± 0.056	4.585GlyGlu: 4.585 ± 0.054	2.502GlyPhe: 2.502 ± 0.109	5.941GlyGly: 5.941 ± 0.089	1.433GlyHis: 1.433 ± 0.026	2.872GlyIle: 2.872 ± 0.062	4.189GlyLys: 4.189 ± 0.061	4.568GlyLeu: 4.568 ± 0.076	1.638GlyMet: 1.638 ± 0.037	3.066GlyAsn: 3.066 ± 0.077	2.561GlyPro: 2.561 ± 0.049	1.914GlyGln: 1.914 ± 0.046	4.106GlyArg: 4.106 ± 0.056	5.817GlySer: 5.817 ± 0.072	4.016GlyThr: 4.016 ± 0.061	5.452GlyVal: 5.452 ± 0.078	1.098GlyTrp: 1.098 ± 0.025	1.692GlyTyr: 1.692 ± 0.029	0.003GlyXaa: 0.003 ± 0.001
His	1.839HisAla: 1.839 ± 0.037	0.886HisCys: 0.886 ± 0.183	1.257HisAsp: 1.257 ± 0.028	1.414HisGlu: 1.414 ± 0.051	1.14HisPhe: 1.14 ± 0.022	1.769HisGly: 1.769 ± 0.031	1.109HisHis: 1.109 ± 0.042	1.457HisIle: 1.457 ± 0.076	1.231HisLys: 1.231 ± 0.1	2.525HisLeu: 2.525 ± 0.126	0.71HisMet: 0.71 ± 0.045	1.22HisAsn: 1.22 ± 0.135	1.586HisPro: 1.586 ± 0.031	0.922HisGln: 0.922 ± 0.024	1.783HisArg: 1.783 ± 0.031	2.016HisSer: 2.016 ± 0.04	1.773HisThr: 1.773 ± 0.069	1.898HisVal: 1.898 ± 0.041	0.411HisTrp: 0.411 ± 0.014	0.842HisTyr: 0.842 ± 0.04	0.003HisXaa: 0.003 ± 0.001
Ile	3.429IleAla: 3.429 ± 0.16	0.951IleCys: 0.951 ± 0.022	1.891IleAsp: 1.891 ± 0.035	2.219IleGlu: 2.219 ± 0.032	1.887IlePhe: 1.887 ± 0.035	2.534IleGly: 2.534 ± 0.052	1.029IleHis: 1.029 ± 0.019	1.987IleIle: 1.987 ± 0.063	1.864IleLys: 1.864 ± 0.033	3.55IleLeu: 3.55 ± 0.08	1.248IleMet: 1.248 ± 0.19	1.592IleAsn: 1.592 ± 0.028	2.466IlePro: 2.466 ± 0.04	1.388IleGln: 1.388 ± 0.026	2.477IleArg: 2.477 ± 0.044	3.649IleSer: 3.649 ± 0.09	3.043IleThr: 3.043 ± 0.344	3.432IleVal: 3.432 ± 0.162	0.448IleTrp: 0.448 ± 0.02	1.284IleTyr: 1.284 ± 0.029	0.003IleXaa: 0.003 ± 0.001
Lys	3.906LysAla: 3.906 ± 0.058	1.289LysCys: 1.289 ± 0.183	2.662LysAsp: 2.662 ± 0.066	4.121LysGlu: 4.121 ± 0.067	1.314LysPhe: 1.314 ± 0.032	3.51LysGly: 3.51 ± 0.058	1.433LysHis: 1.433 ± 0.026	2.24LysIle: 2.24 ± 0.063	3.815LysLys: 3.815 ± 0.093	4.251LysLeu: 4.251 ± 0.058	1.245LysMet: 1.245 ± 0.065	2.126LysAsn: 2.126 ± 0.044	2.147LysPro: 2.147 ± 0.105	2.144LysGln: 2.144 ± 0.057	3.497LysArg: 3.497 ± 0.056	3.167LysSer: 3.167 ± 0.048	2.622LysThr: 2.622 ± 0.043	3.185LysVal: 3.185 ± 0.049	0.736LysTrp: 0.736 ± 0.019	1.126LysTyr: 1.126 ± 0.03	0.004LysXaa: 0.004 ± 0.002
Leu	5.969LeuAla: 5.969 ± 0.068	3.088LeuCys: 3.088 ± 0.059	3.739LeuAsp: 3.739 ± 0.069	5.559LeuGlu: 5.559 ± 0.084	3.791LeuPhe: 3.791 ± 0.06	4.869LeuGly: 4.869 ± 0.085	2.903LeuHis: 2.903 ± 0.124	3.225LeuIle: 3.225 ± 0.049	4.753LeuLys: 4.753 ± 0.082	10.695LeuLeu: 10.695 ± 0.117	2.211LeuMet: 2.211 ± 0.039	3.065LeuAsn: 3.065 ± 0.057	4.97LeuPro: 4.97 ± 0.066	4.247LeuGln: 4.247 ± 0.059	6.906LeuArg: 6.906 ± 0.077	7.789LeuSer: 7.789 ± 0.094	4.53LeuThr: 4.53 ± 0.054	5.76LeuVal: 5.76 ± 0.069	1.397LeuTrp: 1.397 ± 0.027	2.494LeuTyr: 2.494 ± 0.116	0.004LeuXaa: 0.004 ± 0.002
Met	1.745MetAla: 1.745 ± 0.046	0.576MetCys: 0.576 ± 0.018	1.021MetAsp: 1.021 ± 0.034	1.893MetGlu: 1.893 ± 0.033	0.719MetPhe: 0.719 ± 0.02	1.574MetGly: 1.574 ± 0.078	0.921MetHis: 0.921 ± 0.156	0.891MetIle: 0.891 ± 0.02	1.524MetLys: 1.524 ± 0.066	2.142MetLeu: 2.142 ± 0.057	0.717MetMet: 0.717 ± 0.025	0.812MetAsn: 0.812 ± 0.02	1.207MetPro: 1.207 ± 0.048	1.305MetGln: 1.305 ± 0.245	1.789MetArg: 1.789 ± 0.029	1.935MetSer: 1.935 ± 0.071	1.265MetThr: 1.265 ± 0.065	1.693MetVal: 1.693 ± 0.056	0.416MetTrp: 0.416 ± 0.015	0.657MetTyr: 0.657 ± 0.023	0.001MetXaa: 0.001 ± 0.001
Asn	3.347AsnAla: 3.347 ± 0.065	0.881AsnCys: 0.881 ± 0.023	1.944AsnAsp: 1.944 ± 0.043	2.727AsnGlu: 2.727 ± 0.06	1.191AsnPhe: 1.191 ± 0.025	2.976AsnGly: 2.976 ± 0.059	0.816AsnHis: 0.816 ± 0.026	2.416AsnIle: 2.416 ± 0.247	1.807AsnLys: 1.807 ± 0.038	2.704AsnLeu: 2.704 ± 0.044	0.811AsnMet: 0.811 ± 0.02	1.716AsnAsn: 1.716 ± 0.038	1.69AsnPro: 1.69 ± 0.037	1.059AsnGln: 1.059 ± 0.021	1.937AsnArg: 1.937 ± 0.035	2.858AsnSer: 2.858 ± 0.042	2.273AsnThr: 2.273 ± 0.041	2.725AsnVal: 2.725 ± 0.043	0.382AsnTrp: 0.382 ± 0.012	0.841AsnTyr: 0.841 ± 0.021	0.003AsnXaa: 0.003 ± 0.001
Pro	3.554ProAla: 3.554 ± 0.085	1.116ProCys: 1.116 ± 0.032	1.869ProAsp: 1.869 ± 0.045	2.982ProGlu: 2.982 ± 0.099	2.024ProPhe: 2.024 ± 0.049	2.976ProGly: 2.976 ± 0.06	1.678ProHis: 1.678 ± 0.028	1.901ProIle: 1.901 ± 0.032	1.904ProLys: 1.904 ± 0.044	4.907ProLeu: 4.907 ± 0.064	1.106ProMet: 1.106 ± 0.07	1.596ProAsn: 1.596 ± 0.03	3.97ProPro: 3.97 ± 0.09	1.955ProGln: 1.955 ± 0.047	3.173ProArg: 3.173 ± 0.047	4.496ProSer: 4.496 ± 0.053	2.999ProThr: 2.999 ± 0.058	3.278ProVal: 3.278 ± 0.086	0.87ProTrp: 0.87 ± 0.021	1.303ProTyr: 1.303 ± 0.024	0.003ProXaa: 0.003 ± 0.001
Gln	2.548GlnAla: 2.548 ± 0.046	0.793GlnCys: 0.793 ± 0.021	1.21GlnAsp: 1.21 ± 0.021	2.431GlnGlu: 2.431 ± 0.071	1.007GlnPhe: 1.007 ± 0.029	1.969GlnGly: 1.969 ± 0.041	1.299GlnHis: 1.299 ± 0.029	1.217GlnIle: 1.217 ± 0.028	2.117GlnLys: 2.117 ± 0.056	3.766GlnLeu: 3.766 ± 0.063	1.288GlnMet: 1.288 ± 0.248	1.274GlnAsn: 1.274 ± 0.038	1.94GlnPro: 1.94 ± 0.048	2.388GlnGln: 2.388 ± 0.078	3.176GlnArg: 3.176 ± 0.057	2.458GlnSer: 2.458 ± 0.047	1.638GlnThr: 1.638 ± 0.032	2.102GlnVal: 2.102 ± 0.039	0.624GlnTrp: 0.624 ± 0.017	1.804GlnTyr: 1.804 ± 0.31	0.002GlnXaa: 0.002 ± 0.001
Arg	4.69ArgAla: 4.69 ± 0.064	1.78ArgCys: 1.78 ± 0.032	3.106ArgAsp: 3.106 ± 0.044	4.905ArgGlu: 4.905 ± 0.099	1.969ArgPhe: 1.969 ± 0.034	4.406ArgGly: 4.406 ± 0.058	2.064ArgHis: 2.064 ± 0.036	2.647ArgIle: 2.647 ± 0.056	3.529ArgLys: 3.529 ± 0.055	5.875ArgLeu: 5.875 ± 0.078	1.575ArgMet: 1.575 ± 0.04	2.484ArgAsn: 2.484 ± 0.038	2.662ArgPro: 2.662 ± 0.048	2.652ArgGln: 2.652 ± 0.054	5.99ArgArg: 5.99 ± 0.082	4.953ArgSer: 4.953 ± 0.074	3.101ArgThr: 3.101 ± 0.046	4.629ArgVal: 4.629 ± 0.098	1.034ArgTrp: 1.034 ± 0.025	1.77ArgTyr: 1.77 ± 0.031	0.002ArgXaa: 0.002 ± 0.001
Ser	6.509SerAla: 6.509 ± 0.092	1.793SerCys: 1.793 ± 0.034	4.053SerAsp: 4.053 ± 0.109	4.519SerGlu: 4.519 ± 0.098	3.059SerPhe: 3.059 ± 0.047	6.211SerGly: 6.211 ± 0.104	2.097SerHis: 2.097 ± 0.033	3.012SerIle: 3.012 ± 0.049	3.227SerLys: 3.227 ± 0.071	7.485SerLeu: 7.485 ± 0.083	1.789SerMet: 1.789 ± 0.078	2.68SerAsn: 2.68 ± 0.042	4.417SerPro: 4.417 ± 0.072	2.51SerGln: 2.51 ± 0.049	4.787SerArg: 4.787 ± 0.071	7.868SerSer: 7.868 ± 0.099	4.723SerThr: 4.723 ± 0.056	5.476SerVal: 5.476 ± 0.067	1.022SerTrp: 1.022 ± 0.025	1.798SerTyr: 1.798 ± 0.044	0.004SerXaa: 0.004 ± 0.001
Thr	5.06ThrAla: 5.06 ± 0.094	1.152ThrCys: 1.152 ± 0.024	2.6ThrAsp: 2.6 ± 0.109	3.246ThrGlu: 3.246 ± 0.05	1.852ThrPhe: 1.852 ± 0.03	3.615ThrGly: 3.615 ± 0.056	1.657ThrHis: 1.657 ± 0.128	2.4ThrIle: 2.4 ± 0.062	2.43ThrLys: 2.43 ± 0.041	5.628ThrLeu: 5.628 ± 0.119	1.227ThrMet: 1.227 ± 0.044	2.008ThrAsn: 2.008 ± 0.042	3.321ThrPro: 3.321 ± 0.049	2.055ThrGln: 2.055 ± 0.047	3.259ThrArg: 3.259 ± 0.054	4.647ThrSer: 4.647 ± 0.061	3.753ThrThr: 3.753 ± 0.071	4.244ThrVal: 4.244 ± 0.097	0.748ThrTrp: 0.748 ± 0.023	1.215ThrTyr: 1.215 ± 0.094	0.003ThrXaa: 0.003 ± 0.001
Val	5.755ValAla: 5.755 ± 0.091	2.095ValCys: 2.095 ± 0.035	3.624ValAsp: 3.624 ± 0.039	4.959ValGlu: 4.959 ± 0.111	2.678ValPhe: 2.678 ± 0.051	4.459ValGly: 4.459 ± 0.049	1.791ValHis: 1.791 ± 0.087	3.092ValIle: 3.092 ± 0.115	3.704ValLys: 3.704 ± 0.098	6.835ValLeu: 6.835 ± 0.073	1.926ValMet: 1.926 ± 0.074	2.41ValAsn: 2.41 ± 0.04	3.613ValPro: 3.613 ± 0.07	2.897ValGln: 2.897 ± 0.176	4.676ValArg: 4.676 ± 0.096	5.616ValSer: 5.616 ± 0.08	4.037ValThr: 4.037 ± 0.066	6.016ValVal: 6.016 ± 0.075	1.024ValTrp: 1.024 ± 0.024	1.631ValTyr: 1.631 ± 0.025	0.002ValXaa: 0.002 ± 0.001
Trp	0.828TrpAla: 0.828 ± 0.023	0.44TrpCys: 0.44 ± 0.014	0.719TrpAsp: 0.719 ± 0.023	1.089TrpGlu: 1.089 ± 0.026	0.398TrpPhe: 0.398 ± 0.014	0.958TrpGly: 0.958 ± 0.021	0.421TrpHis: 0.421 ± 0.015	0.469TrpIle: 0.469 ± 0.016	0.93TrpLys: 0.93 ± 0.022	1.288TrpLeu: 1.288 ± 0.028	0.364TrpMet: 0.364 ± 0.012	0.562TrpAsn: 0.562 ± 0.017	0.6TrpPro: 0.6 ± 0.017	0.535TrpGln: 0.535 ± 0.021	1.142TrpArg: 1.142 ± 0.028	1.136TrpSer: 1.136 ± 0.024	0.719TrpThr: 0.719 ± 0.018	0.749TrpVal: 0.749 ± 0.02	0.385TrpTrp: 0.385 ± 0.016	0.319TrpTyr: 0.319 ± 0.011	0.002TrpXaa: 0.002 ± 0.001
Tyr	1.919TyrAla: 1.919 ± 0.181	1.117TyrCys: 1.117 ± 0.191	1.36TyrAsp: 1.36 ± 0.029	1.516TyrGlu: 1.516 ± 0.076	1.206TyrPhe: 1.206 ± 0.042	1.788TyrGly: 1.788 ± 0.035	0.846TyrHis: 0.846 ± 0.116	1.2TyrIle: 1.2 ± 0.046	1.011TyrLys: 1.011 ± 0.025	2.126TyrLeu: 2.126 ± 0.04	0.695TyrMet: 0.695 ± 0.099	1.099TyrAsn: 1.099 ± 0.025	1.112TyrPro: 1.112 ± 0.028	0.896TyrGln: 0.896 ± 0.02	1.549TyrArg: 1.549 ± 0.026	1.792TyrSer: 1.792 ± 0.034	1.221TyrThr: 1.221 ± 0.024	1.896TyrVal: 1.896 ± 0.036	0.321TyrTrp: 0.321 ± 0.012	1.261TyrTyr: 1.261 ± 0.242	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.003XaaCys: 0.003 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.005XaaGlu: 0.005 ± 0.002	0.004XaaPhe: 0.004 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.005XaaIle: 0.005 ± 0.002	0.005XaaLys: 0.005 ± 0.002	0.003XaaLeu: 0.003 ± 0.002	0.003XaaMet: 0.003 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.005XaaPro: 0.005 ± 0.002	0.002XaaGln: 0.002 ± 0.001	0.0XaaArg: 0.0 ± 0.001	0.004XaaSer: 0.004 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.027XaaXaa: 0.027 ± 0.021

Statistics based on 5906 proteins (2211927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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