Amino acid dipepetide frequency for Klebsiella pneumoniae subsp. rhinoscleromatis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.955AlaAla: 11.955 ± 0.141	1.277AlaCys: 1.277 ± 0.028	5.364AlaAsp: 5.364 ± 0.058	5.928AlaGlu: 5.928 ± 0.068	3.733AlaPhe: 3.733 ± 0.056	8.711AlaGly: 8.711 ± 0.084	1.983AlaHis: 1.983 ± 0.039	5.991AlaIle: 5.991 ± 0.076	3.732AlaLys: 3.732 ± 0.059	12.561AlaLeu: 12.561 ± 0.115	3.287AlaMet: 3.287 ± 0.047	2.945AlaAsn: 2.945 ± 0.045	4.106AlaPro: 4.106 ± 0.055	4.684AlaGln: 4.684 ± 0.066	6.455AlaArg: 6.455 ± 0.063	5.833AlaSer: 5.833 ± 0.057	4.934AlaThr: 4.934 ± 0.058	7.295AlaVal: 7.295 ± 0.068	1.847AlaTrp: 1.847 ± 0.04	1.931AlaTyr: 1.931 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.187CysAla: 1.187 ± 0.03	0.256CysCys: 0.256 ± 0.014	0.59CysAsp: 0.59 ± 0.02	0.57CysGlu: 0.57 ± 0.021	0.446CysPhe: 0.446 ± 0.016	1.146CysGly: 1.146 ± 0.032	0.336CysHis: 0.336 ± 0.015	0.551CysIle: 0.551 ± 0.021	0.307CysLys: 0.307 ± 0.014	1.087CysLeu: 1.087 ± 0.03	0.299CysMet: 0.299 ± 0.015	0.29CysAsn: 0.29 ± 0.013	0.613CysPro: 0.613 ± 0.02	0.478CysGln: 0.478 ± 0.021	0.921CysArg: 0.921 ± 0.028	0.763CysSer: 0.763 ± 0.022	0.5CysThr: 0.5 ± 0.019	0.752CysVal: 0.752 ± 0.024	0.273CysTrp: 0.273 ± 0.012	0.367CysTyr: 0.367 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.286AspAla: 5.286 ± 0.062	0.501AspCys: 0.501 ± 0.019	2.916AspAsp: 2.916 ± 0.049	3.341AspGlu: 3.341 ± 0.046	1.983AspPhe: 1.983 ± 0.036	3.834AspGly: 3.834 ± 0.048	1.024AspHis: 1.024 ± 0.026	3.159AspIle: 3.159 ± 0.047	2.312AspLys: 2.312 ± 0.039	4.612AspLeu: 4.612 ± 0.051	1.264AspMet: 1.264 ± 0.03	2.127AspAsn: 2.127 ± 0.036	2.419AspPro: 2.419 ± 0.046	1.601AspGln: 1.601 ± 0.031	2.973AspArg: 2.973 ± 0.047	2.734AspSer: 2.734 ± 0.052	2.353AspThr: 2.353 ± 0.04	3.526AspVal: 3.526 ± 0.043	0.841AspTrp: 0.841 ± 0.023	1.788AspTyr: 1.788 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.581GluAla: 5.581 ± 0.063	0.469GluCys: 0.469 ± 0.017	2.109GluAsp: 2.109 ± 0.043	3.18GluGlu: 3.18 ± 0.045	1.686GluPhe: 1.686 ± 0.037	3.54GluGly: 3.54 ± 0.055	1.326GluHis: 1.326 ± 0.028	3.025GluIle: 3.025 ± 0.045	2.944GluLys: 2.944 ± 0.048	5.566GluLeu: 5.566 ± 0.066	1.761GluMet: 1.761 ± 0.037	2.051GluAsn: 2.051 ± 0.039	2.055GluPro: 2.055 ± 0.041	3.172GluGln: 3.172 ± 0.051	3.697GluArg: 3.697 ± 0.055	2.827GluSer: 2.827 ± 0.045	2.747GluThr: 2.747 ± 0.047	3.663GluVal: 3.663 ± 0.057	0.787GluTrp: 0.787 ± 0.024	1.378GluTyr: 1.378 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.955PheAla: 3.955 ± 0.052	0.576PheCys: 0.576 ± 0.018	2.214PheAsp: 2.214 ± 0.042	1.575PheGlu: 1.575 ± 0.032	1.664PhePhe: 1.664 ± 0.043	3.095PheGly: 3.095 ± 0.054	0.84PheHis: 0.84 ± 0.023	2.451PheIle: 2.451 ± 0.044	1.12PheLys: 1.12 ± 0.028	3.205PheLeu: 3.205 ± 0.053	0.98PheMet: 0.98 ± 0.024	1.605PheAsn: 1.605 ± 0.035	1.588PhePro: 1.588 ± 0.032	1.141PheGln: 1.141 ± 0.027	1.989PheArg: 1.989 ± 0.036	3.008PheSer: 3.008 ± 0.047	2.392PheThr: 2.392 ± 0.044	2.488PheVal: 2.488 ± 0.041	0.659PheTrp: 0.659 ± 0.022	1.138PheTyr: 1.138 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.827GlyAla: 6.827 ± 0.082	1.087GlyCys: 1.087 ± 0.029	3.84GlyAsp: 3.84 ± 0.057	4.65GlyGlu: 4.65 ± 0.067	3.226GlyPhe: 3.226 ± 0.051	5.928GlyGly: 5.928 ± 0.083	1.655GlyHis: 1.655 ± 0.035	4.886GlyIle: 4.886 ± 0.057	3.797GlyLys: 3.797 ± 0.058	7.797GlyLeu: 7.797 ± 0.085	2.568GlyMet: 2.568 ± 0.04	2.572GlyAsn: 2.572 ± 0.042	2.241GlyPro: 2.241 ± 0.041	3.07GlyGln: 3.07 ± 0.052	4.379GlyArg: 4.379 ± 0.055	4.24GlySer: 4.24 ± 0.054	3.612GlyThr: 3.612 ± 0.055	5.768GlyVal: 5.768 ± 0.066	1.419GlyTrp: 1.419 ± 0.034	2.682GlyTyr: 2.682 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.988HisAla: 1.988 ± 0.042	0.325HisCys: 0.325 ± 0.014	1.236HisAsp: 1.236 ± 0.029	1.046HisGlu: 1.046 ± 0.027	1.054HisPhe: 1.054 ± 0.027	1.844HisGly: 1.844 ± 0.037	0.847HisHis: 0.847 ± 0.027	1.296HisIle: 1.296 ± 0.029	0.693HisLys: 0.693 ± 0.022	2.316HisLeu: 2.316 ± 0.041	0.545HisMet: 0.545 ± 0.018	0.735HisAsn: 0.735 ± 0.023	1.442HisPro: 1.442 ± 0.029	1.215HisGln: 1.215 ± 0.028	1.549HisArg: 1.549 ± 0.033	1.238HisSer: 1.238 ± 0.028	1.057HisThr: 1.057 ± 0.027	1.281HisVal: 1.281 ± 0.027	0.415HisTrp: 0.415 ± 0.015	0.908HisTyr: 0.908 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.607IleAla: 6.607 ± 0.081	0.734IleCys: 0.734 ± 0.023	3.327IleAsp: 3.327 ± 0.046	2.888IleGlu: 2.888 ± 0.047	2.002IlePhe: 2.002 ± 0.036	4.469IleGly: 4.469 ± 0.063	1.159IleHis: 1.159 ± 0.027	3.052IleIle: 3.052 ± 0.046	2.107IleLys: 2.107 ± 0.04	4.741IleLeu: 4.741 ± 0.063	1.207IleMet: 1.207 ± 0.031	2.313IleAsn: 2.313 ± 0.039	2.712IlePro: 2.712 ± 0.042	1.66IleGln: 1.66 ± 0.033	2.975IleArg: 2.975 ± 0.037	3.553IleSer: 3.553 ± 0.048	3.187IleThr: 3.187 ± 0.052	3.846IleVal: 3.846 ± 0.05	0.699IleTrp: 0.699 ± 0.022	1.436IleTyr: 1.436 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.134LysAla: 4.134 ± 0.059	0.279LysCys: 0.279 ± 0.012	1.788LysAsp: 1.788 ± 0.035	2.095LysGlu: 2.095 ± 0.043	1.005LysPhe: 1.005 ± 0.025	2.685LysGly: 2.685 ± 0.047	0.78LysHis: 0.78 ± 0.028	2.049LysIle: 2.049 ± 0.037	1.976LysLys: 1.976 ± 0.049	3.845LysLeu: 3.845 ± 0.055	1.17LysMet: 1.17 ± 0.03	1.464LysAsn: 1.464 ± 0.027	2.014LysPro: 2.014 ± 0.04	1.828LysGln: 1.828 ± 0.038	2.613LysArg: 2.613 ± 0.043	2.109LysSer: 2.109 ± 0.037	2.425LysThr: 2.425 ± 0.043	2.695LysVal: 2.695 ± 0.048	0.443LysTrp: 0.443 ± 0.019	1.026LysTyr: 1.026 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.468LeuAla: 12.468 ± 0.125	1.353LeuCys: 1.353 ± 0.031	5.16LeuAsp: 5.16 ± 0.061	5.171LeuGlu: 5.171 ± 0.056	4.248LeuPhe: 4.248 ± 0.07	7.347LeuGly: 7.347 ± 0.082	2.314LeuHis: 2.314 ± 0.038	5.543LeuIle: 5.543 ± 0.064	4.069LeuLys: 4.069 ± 0.062	12.185LeuLeu: 12.185 ± 0.129	2.965LeuMet: 2.965 ± 0.046	3.982LeuAsn: 3.982 ± 0.05	6.013LeuPro: 6.013 ± 0.056	4.475LeuGln: 4.475 ± 0.052	6.67LeuArg: 6.67 ± 0.068	7.226LeuSer: 7.226 ± 0.073	6.317LeuThr: 6.317 ± 0.064	6.888LeuVal: 6.888 ± 0.075	1.547LeuTrp: 1.547 ± 0.034	2.537LeuTyr: 2.537 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.205MetAla: 3.205 ± 0.042	0.236MetCys: 0.236 ± 0.012	1.122MetAsp: 1.122 ± 0.027	1.223MetGlu: 1.223 ± 0.025	0.879MetPhe: 0.879 ± 0.025	1.902MetGly: 1.902 ± 0.039	0.556MetHis: 0.556 ± 0.021	1.46MetIle: 1.46 ± 0.031	1.402MetLys: 1.402 ± 0.027	3.287MetLeu: 3.287 ± 0.052	0.913MetMet: 0.913 ± 0.024	1.1MetAsn: 1.1 ± 0.027	1.486MetPro: 1.486 ± 0.032	1.197MetGln: 1.197 ± 0.03	1.652MetArg: 1.652 ± 0.036	1.866MetSer: 1.866 ± 0.036	1.877MetThr: 1.877 ± 0.038	2.034MetVal: 2.034 ± 0.036	0.28MetTrp: 0.28 ± 0.014	0.509MetTyr: 0.509 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.343AsnAla: 3.343 ± 0.054	0.316AsnCys: 0.316 ± 0.015	1.884AsnAsp: 1.884 ± 0.038	1.724AsnGlu: 1.724 ± 0.038	1.15AsnPhe: 1.15 ± 0.028	2.918AsnGly: 2.918 ± 0.045	0.79AsnHis: 0.79 ± 0.023	2.032AsnIle: 2.032 ± 0.039	1.324AsnLys: 1.324 ± 0.031	3.173AsnLeu: 3.173 ± 0.052	0.905AsnMet: 0.905 ± 0.023	1.35AsnAsn: 1.35 ± 0.032	2.043AsnPro: 2.043 ± 0.035	1.43AsnGln: 1.43 ± 0.032	2.0AsnArg: 2.0 ± 0.042	1.804AsnSer: 1.804 ± 0.036	1.814AsnThr: 1.814 ± 0.041	2.39AsnVal: 2.39 ± 0.043	0.521AsnTrp: 0.521 ± 0.017	1.057AsnTyr: 1.057 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.457ProAla: 5.457 ± 0.068	0.452ProCys: 0.452 ± 0.017	2.764ProAsp: 2.764 ± 0.043	3.267ProGlu: 3.267 ± 0.045	1.872ProPhe: 1.872 ± 0.034	3.966ProGly: 3.966 ± 0.059	1.163ProHis: 1.163 ± 0.029	1.745ProIle: 1.745 ± 0.033	1.353ProLys: 1.353 ± 0.031	5.527ProLeu: 5.527 ± 0.075	1.142ProMet: 1.142 ± 0.026	1.166ProAsn: 1.166 ± 0.024	2.059ProPro: 2.059 ± 0.042	2.548ProGln: 2.548 ± 0.048	2.516ProArg: 2.516 ± 0.043	2.289ProSer: 2.289 ± 0.039	2.193ProThr: 2.193 ± 0.038	3.954ProVal: 3.954 ± 0.055	0.883ProTrp: 0.883 ± 0.025	1.198ProTyr: 1.198 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.04GlnAla: 5.04 ± 0.076	0.42GlnCys: 0.42 ± 0.017	1.742GlnAsp: 1.742 ± 0.037	2.097GlnGlu: 2.097 ± 0.04	1.472GlnPhe: 1.472 ± 0.029	3.076GlnGly: 3.076 ± 0.042	1.279GlnHis: 1.279 ± 0.029	2.136GlnIle: 2.136 ± 0.034	1.668GlnLys: 1.668 ± 0.035	4.997GlnLeu: 4.997 ± 0.062	1.227GlnMet: 1.227 ± 0.028	1.268GlnAsn: 1.268 ± 0.03	2.394GlnPro: 2.394 ± 0.053	3.446GlnGln: 3.446 ± 0.066	3.637GlnArg: 3.637 ± 0.054	2.269GlnSer: 2.269 ± 0.04	2.212GlnThr: 2.212 ± 0.039	3.012GlnVal: 3.012 ± 0.045	0.681GlnTrp: 0.681 ± 0.019	1.179GlnTyr: 1.179 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.317ArgAla: 5.317 ± 0.056	0.845ArgCys: 0.845 ± 0.024	3.215ArgAsp: 3.215 ± 0.045	3.904ArgGlu: 3.904 ± 0.051	2.745ArgPhe: 2.745 ± 0.048	3.852ArgGly: 3.852 ± 0.056	1.941ArgHis: 1.941 ± 0.039	3.315ArgIle: 3.315 ± 0.049	2.325ArgLys: 2.325 ± 0.043	7.186ArgLeu: 7.186 ± 0.084	1.907ArgMet: 1.907 ± 0.035	1.968ArgAsn: 1.968 ± 0.038	2.842ArgPro: 2.842 ± 0.043	3.751ArgGln: 3.751 ± 0.057	4.852ArgArg: 4.852 ± 0.07	3.218ArgSer: 3.218 ± 0.048	2.56ArgThr: 2.56 ± 0.043	3.878ArgVal: 3.878 ± 0.047	1.219ArgTrp: 1.219 ± 0.031	2.366ArgTyr: 2.366 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.08SerAla: 6.08 ± 0.081	0.676SerCys: 0.676 ± 0.02	3.049SerAsp: 3.049 ± 0.054	2.949SerGlu: 2.949 ± 0.046	2.281SerPhe: 2.281 ± 0.039	5.369SerGly: 5.369 ± 0.062	1.416SerHis: 1.416 ± 0.031	2.792SerIle: 2.792 ± 0.05	1.794SerLys: 1.794 ± 0.036	6.655SerLeu: 6.655 ± 0.067	1.555SerMet: 1.555 ± 0.032	1.705SerAsn: 1.705 ± 0.037	2.94SerPro: 2.94 ± 0.046	2.476SerGln: 2.476 ± 0.04	3.762SerArg: 3.762 ± 0.049	3.414SerSer: 3.414 ± 0.055	2.852SerThr: 2.852 ± 0.041	4.03SerVal: 4.03 ± 0.057	1.071SerTrp: 1.071 ± 0.027	1.503SerTyr: 1.503 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.132ThrAla: 5.132 ± 0.062	0.558ThrCys: 0.558 ± 0.02	2.42ThrAsp: 2.42 ± 0.044	2.378ThrGlu: 2.378 ± 0.045	2.007ThrPhe: 2.007 ± 0.039	4.461ThrGly: 4.461 ± 0.06	1.147ThrHis: 1.147 ± 0.028	2.829ThrIle: 2.829 ± 0.044	1.292ThrLys: 1.292 ± 0.031	7.274ThrLeu: 7.274 ± 0.069	1.172ThrMet: 1.172 ± 0.029	1.344ThrAsn: 1.344 ± 0.032	3.281ThrPro: 3.281 ± 0.052	1.897ThrGln: 1.897 ± 0.036	3.25ThrArg: 3.25 ± 0.047	2.898ThrSer: 2.898 ± 0.047	2.834ThrThr: 2.834 ± 0.046	3.828ThrVal: 3.828 ± 0.05	0.855ThrTrp: 0.855 ± 0.023	1.079ThrTyr: 1.079 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.402ValAla: 7.402 ± 0.083	0.78ValCys: 0.78 ± 0.024	3.675ValAsp: 3.675 ± 0.053	3.854ValGlu: 3.854 ± 0.056	2.445ValPhe: 2.445 ± 0.051	4.885ValGly: 4.885 ± 0.06	1.257ValHis: 1.257 ± 0.027	4.309ValIle: 4.309 ± 0.059	2.878ValLys: 2.878 ± 0.047	7.034ValLeu: 7.034 ± 0.074	2.219ValMet: 2.219 ± 0.042	2.574ValAsn: 2.574 ± 0.041	3.066ValPro: 3.066 ± 0.051	2.376ValGln: 2.376 ± 0.041	3.823ValArg: 3.823 ± 0.046	4.488ValSer: 4.488 ± 0.058	4.062ValThr: 4.062 ± 0.044	5.448ValVal: 5.448 ± 0.073	1.013ValTrp: 1.013 ± 0.023	1.723ValTyr: 1.723 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.126TrpAla: 1.126 ± 0.027	0.226TrpCys: 0.226 ± 0.012	0.652TrpAsp: 0.652 ± 0.021	0.584TrpGlu: 0.584 ± 0.019	0.693TrpPhe: 0.693 ± 0.021	0.994TrpGly: 0.994 ± 0.029	0.466TrpHis: 0.466 ± 0.019	0.743TrpIle: 0.743 ± 0.022	0.493TrpLys: 0.493 ± 0.017	2.53TrpLeu: 2.53 ± 0.049	0.498TrpMet: 0.498 ± 0.018	0.503TrpAsn: 0.503 ± 0.017	0.792TrpPro: 0.792 ± 0.026	1.263TrpGln: 1.263 ± 0.033	1.43TrpArg: 1.43 ± 0.033	0.904TrpSer: 0.904 ± 0.025	0.626TrpThr: 0.626 ± 0.019	0.948TrpVal: 0.948 ± 0.025	0.266TrpTrp: 0.266 ± 0.015	0.424TrpTyr: 0.424 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.041	0.365TyrCys: 0.365 ± 0.015	1.528TyrAsp: 1.528 ± 0.037	1.139TyrGlu: 1.139 ± 0.027	1.092TyrPhe: 1.092 ± 0.025	2.222TyrGly: 2.222 ± 0.041	0.752TyrHis: 0.752 ± 0.023	1.308TyrIle: 1.308 ± 0.035	0.836TyrLys: 0.836 ± 0.026	2.901TyrLeu: 2.901 ± 0.046	0.604TyrMet: 0.604 ± 0.024	0.902TyrAsn: 0.902 ± 0.027	1.406TyrPro: 1.406 ± 0.034	1.547TyrGln: 1.547 ± 0.034	2.064TyrArg: 2.064 ± 0.035	1.689TyrSer: 1.689 ± 0.039	1.382TyrThr: 1.382 ± 0.032	1.589TyrVal: 1.589 ± 0.032	0.441TyrTrp: 0.441 ± 0.018	0.897TyrTyr: 0.897 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6800 proteins (1505742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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