Amino acid dipepetide frequency for Volucribacter psittacicida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.531AlaAla: 5.531 ± 0.132
0.997AlaCys: 0.997 ± 0.042
4.209AlaAsp: 4.209 ± 0.091
5.931AlaGlu: 5.931 ± 0.107
3.324AlaPhe: 3.324 ± 0.087
5.578AlaGly: 5.578 ± 0.113
1.387AlaHis: 1.387 ± 0.05
6.658AlaIle: 6.658 ± 0.125
5.641AlaLys: 5.641 ± 0.117
10.057AlaLeu: 10.057 ± 0.143
2.352AlaMet: 2.352 ± 0.067
4.063AlaAsn: 4.063 ± 0.11
2.423AlaPro: 2.423 ± 0.059
4.809AlaGln: 4.809 ± 0.11
3.334AlaArg: 3.334 ± 0.078
4.289AlaSer: 4.289 ± 0.089
4.283AlaThr: 4.283 ± 0.129
5.477AlaVal: 5.477 ± 0.114
0.908AlaTrp: 0.908 ± 0.04
2.425AlaTyr: 2.425 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.848CysAla: 0.848 ± 0.041
0.177CysCys: 0.177 ± 0.018
0.524CysAsp: 0.524 ± 0.029
0.595CysGlu: 0.595 ± 0.031
0.489CysPhe: 0.489 ± 0.026
0.923CysGly: 0.923 ± 0.042
0.355CysHis: 0.355 ± 0.024
0.585CysIle: 0.585 ± 0.033
0.37CysLys: 0.37 ± 0.024
1.213CysLeu: 1.213 ± 0.046
0.162CysMet: 0.162 ± 0.016
0.31CysAsn: 0.31 ± 0.023
0.5CysPro: 0.5 ± 0.029
0.663CysGln: 0.663 ± 0.033
0.476CysArg: 0.476 ± 0.026
0.613CysSer: 0.613 ± 0.028
0.42CysThr: 0.42 ± 0.026
0.592CysVal: 0.592 ± 0.033
0.15CysTrp: 0.15 ± 0.014
0.435CysTyr: 0.435 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
2.839AspAla: 2.839 ± 0.078
0.601AspCys: 0.601 ± 0.033
2.212AspAsp: 2.212 ± 0.076
3.212AspGlu: 3.212 ± 0.088
2.543AspPhe: 2.543 ± 0.069
2.762AspGly: 2.762 ± 0.092
0.873AspHis: 0.873 ± 0.038
4.07AspIle: 4.07 ± 0.107
3.271AspLys: 3.271 ± 0.073
5.038AspLeu: 5.038 ± 0.092
1.118AspMet: 1.118 ± 0.041
2.692AspAsn: 2.692 ± 0.076
2.245AspPro: 2.245 ± 0.069
2.132AspGln: 2.132 ± 0.061
2.049AspArg: 2.049 ± 0.061
2.441AspSer: 2.441 ± 0.086
2.018AspThr: 2.018 ± 0.065
3.076AspVal: 3.076 ± 0.086
0.79AspTrp: 0.79 ± 0.043
2.384AspTyr: 2.384 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.185GluAla: 4.185 ± 0.103
0.352GluCys: 0.352 ± 0.023
2.42GluAsp: 2.42 ± 0.079
3.227GluGlu: 3.227 ± 0.09
2.102GluPhe: 2.102 ± 0.064
3.076GluGly: 3.076 ± 0.085
1.272GluHis: 1.272 ± 0.049
4.333GluIle: 4.333 ± 0.078
4.327GluLys: 4.327 ± 0.09
6.137GluLeu: 6.137 ± 0.12
1.564GluMet: 1.564 ± 0.046
3.277GluAsn: 3.277 ± 0.084
1.795GluPro: 1.795 ± 0.054
5.844GluGln: 5.844 ± 0.127
2.951GluArg: 2.951 ± 0.076
2.606GluSer: 2.606 ± 0.071
2.585GluThr: 2.585 ± 0.079
3.742GluVal: 3.742 ± 0.09
0.598GluTrp: 0.598 ± 0.031
1.668GluTyr: 1.668 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.984PheAla: 3.984 ± 0.083
0.597PheCys: 0.597 ± 0.03
2.523PheAsp: 2.523 ± 0.066
2.142PheGlu: 2.142 ± 0.068
1.928PhePhe: 1.928 ± 0.065
3.09PheGly: 3.09 ± 0.074
0.832PheHis: 0.832 ± 0.033
3.378PheIle: 3.378 ± 0.09
2.029PheLys: 2.029 ± 0.058
3.807PheLeu: 3.807 ± 0.091
1.073PheMet: 1.073 ± 0.045
2.379PheAsn: 2.379 ± 0.061
1.45PhePro: 1.45 ± 0.051
1.481PheGln: 1.481 ± 0.05
1.533PheArg: 1.533 ± 0.044
3.201PheSer: 3.201 ± 0.086
2.263PheThr: 2.263 ± 0.061
2.747PheVal: 2.747 ± 0.073
0.567PheTrp: 0.567 ± 0.035
1.603PheTyr: 1.603 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.838GlyAla: 4.838 ± 0.099
0.786GlyCys: 0.786 ± 0.034
3.035GlyAsp: 3.035 ± 0.079
4.248GlyGlu: 4.248 ± 0.097
3.085GlyPhe: 3.085 ± 0.076
4.495GlyGly: 4.495 ± 0.119
1.257GlyHis: 1.257 ± 0.045
5.322GlyIle: 5.322 ± 0.106
4.635GlyLys: 4.635 ± 0.084
7.045GlyLeu: 7.045 ± 0.13
1.707GlyMet: 1.707 ± 0.052
2.902GlyAsn: 2.902 ± 0.131
1.115GlyPro: 1.115 ± 0.047
2.867GlyGln: 2.867 ± 0.084
2.757GlyArg: 2.757 ± 0.071
3.467GlySer: 3.467 ± 0.096
3.236GlyThr: 3.236 ± 0.095
4.582GlyVal: 4.582 ± 0.098
0.86GlyTrp: 0.86 ± 0.042
2.58GlyTyr: 2.58 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.073HisAla: 1.073 ± 0.039
0.414HisCys: 0.414 ± 0.027
0.742HisAsp: 0.742 ± 0.042
0.687HisGlu: 0.687 ± 0.035
1.322HisPhe: 1.322 ± 0.052
1.124HisGly: 1.124 ± 0.043
0.766HisHis: 0.766 ± 0.04
1.928HisIle: 1.928 ± 0.053
1.201HisLys: 1.201 ± 0.044
2.546HisLeu: 2.546 ± 0.07
0.313HisMet: 0.313 ± 0.021
1.126HisAsn: 1.126 ± 0.047
0.931HisPro: 0.931 ± 0.043
1.713HisGln: 1.713 ± 0.06
1.112HisArg: 1.112 ± 0.04
1.391HisSer: 1.391 ± 0.05
0.982HisThr: 0.982 ± 0.044
0.751HisVal: 0.751 ± 0.039
0.352HisTrp: 0.352 ± 0.028
1.11HisTyr: 1.11 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
7.099IleAla: 7.099 ± 0.134
0.81IleCys: 0.81 ± 0.042
4.183IleAsp: 4.183 ± 0.092
4.85IleGlu: 4.85 ± 0.093
2.889IlePhe: 2.889 ± 0.067
5.264IleGly: 5.264 ± 0.121
1.472IleHis: 1.472 ± 0.056
5.307IleIle: 5.307 ± 0.122
4.149IleLys: 4.149 ± 0.076
6.783IleLeu: 6.783 ± 0.13
1.496IleMet: 1.496 ± 0.048
3.689IleAsn: 3.689 ± 0.084
2.883IlePro: 2.883 ± 0.067
3.297IleGln: 3.297 ± 0.075
2.97IleArg: 2.97 ± 0.066
4.693IleSer: 4.693 ± 0.095
4.008IleThr: 4.008 ± 0.1
4.263IleVal: 4.263 ± 0.087
0.683IleTrp: 0.683 ± 0.033
2.284IleTyr: 2.284 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.974LysAla: 4.974 ± 0.114
0.381LysCys: 0.381 ± 0.023
2.594LysAsp: 2.594 ± 0.074
3.209LysGlu: 3.209 ± 0.083
1.798LysPhe: 1.798 ± 0.059
3.562LysGly: 3.562 ± 0.085
1.237LysHis: 1.237 ± 0.043
4.209LysIle: 4.209 ± 0.08
3.414LysLys: 3.414 ± 0.093
5.73LysLeu: 5.73 ± 0.102
1.737LysMet: 1.737 ± 0.056
2.928LysAsn: 2.928 ± 0.076
2.324LysPro: 2.324 ± 0.062
4.049LysGln: 4.049 ± 0.081
2.713LysArg: 2.713 ± 0.067
2.966LysSer: 2.966 ± 0.072
3.2LysThr: 3.2 ± 0.068
3.798LysVal: 3.798 ± 0.083
0.619LysTrp: 0.619 ± 0.038
1.695LysTyr: 1.695 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
10.926LeuAla: 10.926 ± 0.15
1.219LeuCys: 1.219 ± 0.051
5.365LeuAsp: 5.365 ± 0.097
5.687LeuGlu: 5.687 ± 0.115
4.789LeuPhe: 4.789 ± 0.102
7.052LeuGly: 7.052 ± 0.123
2.014LeuHis: 2.014 ± 0.063
7.297LeuIle: 7.297 ± 0.136
5.543LeuLys: 5.543 ± 0.109
12.203LeuLeu: 12.203 ± 0.21
2.472LeuMet: 2.472 ± 0.062
5.202LeuAsn: 5.202 ± 0.103
4.903LeuPro: 4.903 ± 0.115
5.513LeuGln: 5.513 ± 0.12
4.623LeuArg: 4.623 ± 0.092
7.587LeuSer: 7.587 ± 0.135
6.462LeuThr: 6.462 ± 0.101
6.463LeuVal: 6.463 ± 0.116
1.239LeuTrp: 1.239 ± 0.048
2.94LeuTyr: 2.94 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.355MetAla: 2.355 ± 0.065
0.172MetCys: 0.172 ± 0.016
0.932MetAsp: 0.932 ± 0.037
0.999MetGlu: 0.999 ± 0.04
0.766MetPhe: 0.766 ± 0.03
1.589MetGly: 1.589 ± 0.048
0.344MetHis: 0.344 ± 0.023
1.53MetIle: 1.53 ± 0.05
1.437MetLys: 1.437 ± 0.043
2.736MetLeu: 2.736 ± 0.068
0.642MetMet: 0.642 ± 0.038
1.138MetAsn: 1.138 ± 0.043
1.023MetPro: 1.023 ± 0.044
1.393MetGln: 1.393 ± 0.046
1.062MetArg: 1.062 ± 0.048
1.396MetSer: 1.396 ± 0.053
1.499MetThr: 1.499 ± 0.053
1.435MetVal: 1.435 ± 0.047
0.196MetTrp: 0.196 ± 0.019
0.461MetTyr: 0.461 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.866AsnAla: 3.866 ± 0.121
0.352AsnCys: 0.352 ± 0.024
2.266AsnAsp: 2.266 ± 0.064
2.654AsnGlu: 2.654 ± 0.061
1.798AsnPhe: 1.798 ± 0.048
3.109AsnGly: 3.109 ± 0.097
1.112AsnHis: 1.112 ± 0.041
3.839AsnIle: 3.839 ± 0.098
2.964AsnLys: 2.964 ± 0.093
4.821AsnLeu: 4.821 ± 0.099
1.035AsnMet: 1.035 ± 0.041
2.633AsnAsn: 2.633 ± 0.114
2.372AsnPro: 2.372 ± 0.066
3.132AsnGln: 3.132 ± 0.082
2.02AsnArg: 2.02 ± 0.063
2.555AsnSer: 2.555 ± 0.082
2.373AsnThr: 2.373 ± 0.106
2.771AsnVal: 2.771 ± 0.069
0.628AsnTrp: 0.628 ± 0.032
1.691AsnTyr: 1.691 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.821ProAla: 2.821 ± 0.078
0.329ProCys: 0.329 ± 0.022
1.914ProAsp: 1.914 ± 0.059
2.819ProGlu: 2.819 ± 0.076
1.771ProPhe: 1.771 ± 0.059
1.408ProGly: 1.408 ± 0.05
1.061ProHis: 1.061 ± 0.046
2.742ProIle: 2.742 ± 0.068
2.015ProLys: 2.015 ± 0.054
4.294ProLeu: 4.294 ± 0.09
0.894ProMet: 0.894 ± 0.042
1.934ProAsn: 1.934 ± 0.057
1.132ProPro: 1.132 ± 0.043
2.399ProGln: 2.399 ± 0.068
1.366ProArg: 1.366 ± 0.053
1.994ProSer: 1.994 ± 0.049
2.254ProThr: 2.254 ± 0.062
2.481ProVal: 2.481 ± 0.066
0.447ProTrp: 0.447 ± 0.036
1.52ProTyr: 1.52 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
6.153GlnAla: 6.153 ± 0.129
0.483GlnCys: 0.483 ± 0.027
2.766GlnAsp: 2.766 ± 0.065
2.774GlnGlu: 2.774 ± 0.08
2.379GlnPhe: 2.379 ± 0.065
4.18GlnGly: 4.18 ± 0.103
1.749GlnHis: 1.749 ± 0.057
3.791GlnIle: 3.791 ± 0.086
3.023GlnLys: 3.023 ± 0.08
6.901GlnLeu: 6.901 ± 0.161
1.103GlnMet: 1.103 ± 0.039
2.502GlnAsn: 2.502 ± 0.068
2.094GlnPro: 2.094 ± 0.066
7.493GlnGln: 7.493 ± 0.229
3.093GlnArg: 3.093 ± 0.074
3.056GlnSer: 3.056 ± 0.073
2.679GlnThr: 2.679 ± 0.074
3.568GlnVal: 3.568 ± 0.084
0.842GlnTrp: 0.842 ± 0.04
2.245GlnTyr: 2.245 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
3.099ArgAla: 3.099 ± 0.074
0.435ArgCys: 0.435 ± 0.027
2.095ArgAsp: 2.095 ± 0.06
2.756ArgGlu: 2.756 ± 0.065
2.109ArgPhe: 2.109 ± 0.064
2.478ArgGly: 2.478 ± 0.07
1.16ArgHis: 1.16 ± 0.047
3.241ArgIle: 3.241 ± 0.083
2.375ArgLys: 2.375 ± 0.079
5.156ArgLeu: 5.156 ± 0.096
0.994ArgMet: 0.994 ± 0.035
1.931ArgAsn: 1.931 ± 0.055
1.58ArgPro: 1.58 ± 0.053
2.96ArgGln: 2.96 ± 0.065
2.154ArgArg: 2.154 ± 0.065
2.203ArgSer: 2.203 ± 0.06
1.944ArgThr: 1.944 ± 0.056
2.574ArgVal: 2.574 ± 0.069
0.511ArgTrp: 0.511 ± 0.03
1.845ArgTyr: 1.845 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.999SerAla: 4.999 ± 0.094
0.511SerCys: 0.511 ± 0.03
2.564SerAsp: 2.564 ± 0.063
3.204SerGlu: 3.204 ± 0.084
2.633SerPhe: 2.633 ± 0.067
3.967SerGly: 3.967 ± 0.095
1.358SerHis: 1.358 ± 0.044
3.981SerIle: 3.981 ± 0.085
2.828SerLys: 2.828 ± 0.073
6.792SerLeu: 6.792 ± 0.113
1.237SerMet: 1.237 ± 0.046
2.369SerAsn: 2.369 ± 0.085
2.337SerPro: 2.337 ± 0.06
3.633SerGln: 3.633 ± 0.102
2.334SerArg: 2.334 ± 0.064
3.522SerSer: 3.522 ± 0.102
2.783SerThr: 2.783 ± 0.079
3.555SerVal: 3.555 ± 0.089
0.678SerTrp: 0.678 ± 0.038
1.961SerTyr: 1.961 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.64ThrAla: 4.64 ± 0.097
0.452ThrCys: 0.452 ± 0.026
2.591ThrAsp: 2.591 ± 0.114
3.132ThrGlu: 3.132 ± 0.074
2.064ThrPhe: 2.064 ± 0.058
3.957ThrGly: 3.957 ± 0.095
1.148ThrHis: 1.148 ± 0.044
3.351ThrIle: 3.351 ± 0.121
2.392ThrLys: 2.392 ± 0.068
6.217ThrLeu: 6.217 ± 0.103
0.926ThrMet: 0.926 ± 0.04
2.115ThrAsn: 2.115 ± 0.093
2.544ThrPro: 2.544 ± 0.07
2.7ThrGln: 2.7 ± 0.065
1.813ThrArg: 1.813 ± 0.053
2.872ThrSer: 2.872 ± 0.079
2.86ThrThr: 2.86 ± 0.104
3.268ThrVal: 3.268 ± 0.137
0.542ThrTrp: 0.542 ± 0.026
1.357ThrTyr: 1.357 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.974ValAla: 5.974 ± 0.121
0.641ValCys: 0.641 ± 0.03
3.203ValAsp: 3.203 ± 0.086
4.085ValGlu: 4.085 ± 0.093
2.517ValPhe: 2.517 ± 0.068
4.195ValGly: 4.195 ± 0.09
0.976ValHis: 0.976 ± 0.037
4.764ValIle: 4.764 ± 0.089
3.718ValLys: 3.718 ± 0.098
6.261ValLeu: 6.261 ± 0.093
1.517ValMet: 1.517 ± 0.048
3.065ValAsn: 3.065 ± 0.07
2.183ValPro: 2.183 ± 0.058
2.515ValGln: 2.515 ± 0.058
2.733ValArg: 2.733 ± 0.075
3.898ValSer: 3.898 ± 0.091
3.191ValThr: 3.191 ± 0.099
4.334ValVal: 4.334 ± 0.098
0.541ValTrp: 0.541 ± 0.028
1.715ValTyr: 1.715 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.807TrpAla: 0.807 ± 0.035
0.151TrpCys: 0.151 ± 0.016
0.539TrpAsp: 0.539 ± 0.033
0.429TrpGlu: 0.429 ± 0.026
0.603TrpPhe: 0.603 ± 0.031
0.731TrpGly: 0.731 ± 0.036
0.308TrpHis: 0.308 ± 0.02
0.742TrpIle: 0.742 ± 0.041
0.508TrpLys: 0.508 ± 0.03
1.926TrpLeu: 1.926 ± 0.069
0.15TrpMet: 0.15 ± 0.014
0.458TrpAsn: 0.458 ± 0.029
0.175TrpPro: 0.175 ± 0.016
1.425TrpGln: 1.425 ± 0.056
0.686TrpArg: 0.686 ± 0.038
0.533TrpSer: 0.533 ± 0.033
0.437TrpThr: 0.437 ± 0.022
0.725TrpVal: 0.725 ± 0.034
0.175TrpTrp: 0.175 ± 0.019
0.357TrpTyr: 0.357 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.668TyrAla: 2.668 ± 0.07
0.541TyrCys: 0.541 ± 0.026
1.688TyrAsp: 1.688 ± 0.053
1.419TyrGlu: 1.419 ± 0.049
1.7TyrPhe: 1.7 ± 0.065
2.28TyrGly: 2.28 ± 0.062
0.9TyrHis: 0.9 ± 0.04
2.003TyrIle: 2.003 ± 0.059
1.298TyrLys: 1.298 ± 0.055
3.833TyrLeu: 3.833 ± 0.069
0.613TyrMet: 0.613 ± 0.03
1.28TyrAsn: 1.28 ± 0.053
1.586TyrPro: 1.586 ± 0.057
2.858TyrGln: 2.858 ± 0.08
1.82TyrArg: 1.82 ± 0.054
1.966TyrSer: 1.966 ± 0.065
1.462TyrThr: 1.462 ± 0.048
1.822TyrVal: 1.822 ± 0.056
0.538TyrTrp: 0.538 ± 0.032
1.262TyrTyr: 1.262 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2076 proteins (661908 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski