Amino acid dipepetide frequency for Luteimicrobium xylanilyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.474AlaAla: 21.474 ± 0.209	0.821AlaCys: 0.821 ± 0.026	9.066AlaAsp: 9.066 ± 0.096	7.162AlaGlu: 7.162 ± 0.105	3.559AlaPhe: 3.559 ± 0.055	13.364AlaGly: 13.364 ± 0.132	2.815AlaHis: 2.815 ± 0.047	3.733AlaIle: 3.733 ± 0.059	2.601AlaLys: 2.601 ± 0.062	14.686AlaLeu: 14.686 ± 0.156	2.26AlaMet: 2.26 ± 0.044	2.041AlaAsn: 2.041 ± 0.049	7.651AlaPro: 7.651 ± 0.103	3.86AlaGln: 3.86 ± 0.062	11.239AlaArg: 11.239 ± 0.133	7.706AlaSer: 7.706 ± 0.086	8.778AlaThr: 8.778 ± 0.111	13.438AlaVal: 13.438 ± 0.12	2.218AlaTrp: 2.218 ± 0.047	2.564AlaTyr: 2.564 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.695CysAla: 0.695 ± 0.025	0.055CysCys: 0.055 ± 0.007	0.343CysAsp: 0.343 ± 0.018	0.271CysGlu: 0.271 ± 0.014	0.155CysPhe: 0.155 ± 0.012	0.626CysGly: 0.626 ± 0.024	0.122CysHis: 0.122 ± 0.008	0.113CysIle: 0.113 ± 0.01	0.058CysLys: 0.058 ± 0.008	0.503CysLeu: 0.503 ± 0.022	0.06CysMet: 0.06 ± 0.007	0.095CysAsn: 0.095 ± 0.009	0.334CysPro: 0.334 ± 0.02	0.122CysGln: 0.122 ± 0.011	0.369CysArg: 0.369 ± 0.018	0.366CysSer: 0.366 ± 0.017	0.376CysThr: 0.376 ± 0.02	0.496CysVal: 0.496 ± 0.021	0.093CysTrp: 0.093 ± 0.01	0.115CysTyr: 0.115 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	10.4AspAla: 10.4 ± 0.118	0.266AspCys: 0.266 ± 0.016	5.768AspAsp: 5.768 ± 0.078	4.161AspGlu: 4.161 ± 0.073	1.349AspPhe: 1.349 ± 0.033	7.673AspGly: 7.673 ± 0.097	1.365AspHis: 1.365 ± 0.035	1.203AspIle: 1.203 ± 0.035	1.009AspLys: 1.009 ± 0.035	6.716AspLeu: 6.716 ± 0.067	0.628AspMet: 0.628 ± 0.022	0.802AspAsn: 0.802 ± 0.03	4.766AspPro: 4.766 ± 0.075	1.528AspGln: 1.528 ± 0.04	4.68AspArg: 4.68 ± 0.068	2.226AspSer: 2.226 ± 0.055	3.112AspThr: 3.112 ± 0.059	7.597AspVal: 7.597 ± 0.085	0.911AspTrp: 0.911 ± 0.03	1.161AspTyr: 1.161 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.656GluAla: 6.656 ± 0.1	0.21GluCys: 0.21 ± 0.012	2.739GluAsp: 2.739 ± 0.052	2.345GluGlu: 2.345 ± 0.056	1.09GluPhe: 1.09 ± 0.034	3.691GluGly: 3.691 ± 0.056	1.568GluHis: 1.568 ± 0.038	1.965GluIle: 1.965 ± 0.049	1.033GluLys: 1.033 ± 0.036	6.348GluLeu: 6.348 ± 0.095	0.62GluMet: 0.62 ± 0.023	0.873GluAsn: 0.873 ± 0.031	3.373GluPro: 3.373 ± 0.062	1.848GluGln: 1.848 ± 0.041	5.165GluArg: 5.165 ± 0.077	2.22GluSer: 2.22 ± 0.041	2.627GluThr: 2.627 ± 0.043	4.507GluVal: 4.507 ± 0.065	0.587GluTrp: 0.587 ± 0.019	0.864GluTyr: 0.864 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.61PheAla: 3.61 ± 0.056	0.191PheCys: 0.191 ± 0.012	2.084PheAsp: 2.084 ± 0.048	1.406PheGlu: 1.406 ± 0.039	0.806PhePhe: 0.806 ± 0.029	2.765PheGly: 2.765 ± 0.051	0.528PheHis: 0.528 ± 0.021	0.576PheIle: 0.576 ± 0.026	0.42PheLys: 0.42 ± 0.02	2.387PheLeu: 2.387 ± 0.056	0.326PheMet: 0.326 ± 0.017	0.478PheAsn: 0.478 ± 0.019	1.267PhePro: 1.267 ± 0.034	0.687PheGln: 0.687 ± 0.025	1.645PheArg: 1.645 ± 0.036	1.366PheSer: 1.366 ± 0.038	1.854PheThr: 1.854 ± 0.047	2.839PheVal: 2.839 ± 0.051	0.444PheTrp: 0.444 ± 0.021	0.577PheTyr: 0.577 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	12.258GlyAla: 12.258 ± 0.102	0.553GlyCys: 0.553 ± 0.022	5.46GlyAsp: 5.46 ± 0.07	4.577GlyGlu: 4.577 ± 0.078	2.784GlyPhe: 2.784 ± 0.046	8.431GlyGly: 8.431 ± 0.095	2.083GlyHis: 2.083 ± 0.044	3.306GlyIle: 3.306 ± 0.062	2.292GlyLys: 2.292 ± 0.054	9.337GlyLeu: 9.337 ± 0.104	1.692GlyMet: 1.692 ± 0.04	1.496GlyAsn: 1.496 ± 0.042	4.81GlyPro: 4.81 ± 0.062	2.393GlyGln: 2.393 ± 0.043	7.287GlyArg: 7.287 ± 0.106	5.908GlySer: 5.908 ± 0.087	6.893GlyThr: 6.893 ± 0.094	8.717GlyVal: 8.717 ± 0.093	1.752GlyTrp: 1.752 ± 0.041	2.178GlyTyr: 2.178 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.845HisAla: 2.845 ± 0.047	0.11HisCys: 0.11 ± 0.01	1.666HisAsp: 1.666 ± 0.04	1.161HisGlu: 1.161 ± 0.034	0.472HisPhe: 0.472 ± 0.022	2.242HisGly: 2.242 ± 0.046	0.6HisHis: 0.6 ± 0.025	0.357HisIle: 0.357 ± 0.016	0.256HisLys: 0.256 ± 0.014	2.308HisLeu: 2.308 ± 0.042	0.214HisMet: 0.214 ± 0.011	0.334HisAsn: 0.334 ± 0.016	1.564HisPro: 1.564 ± 0.041	0.486HisGln: 0.486 ± 0.02	1.808HisArg: 1.808 ± 0.04	0.74HisSer: 0.74 ± 0.024	1.074HisThr: 1.074 ± 0.03	2.319HisVal: 2.319 ± 0.042	0.292HisTrp: 0.292 ± 0.014	0.414HisTyr: 0.414 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.996IleAla: 3.996 ± 0.063	0.155IleCys: 0.155 ± 0.013	2.109IleAsp: 2.109 ± 0.049	1.698IleGlu: 1.698 ± 0.042	0.698IlePhe: 0.698 ± 0.022	2.892IleGly: 2.892 ± 0.059	0.474IleHis: 0.474 ± 0.018	0.773IleIle: 0.773 ± 0.031	0.606IleLys: 0.606 ± 0.025	2.34IleLeu: 2.34 ± 0.056	0.396IleMet: 0.396 ± 0.016	0.544IleAsn: 0.544 ± 0.023	1.533IlePro: 1.533 ± 0.043	0.653IleGln: 0.653 ± 0.026	1.592IleArg: 1.592 ± 0.035	1.39IleSer: 1.39 ± 0.037	1.932IleThr: 1.932 ± 0.051	2.999IleVal: 2.999 ± 0.056	0.355IleTrp: 0.355 ± 0.02	0.485IleTyr: 0.485 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.492LysAla: 2.492 ± 0.062	0.056LysCys: 0.056 ± 0.007	1.267LysAsp: 1.267 ± 0.039	0.809LysGlu: 0.809 ± 0.027	0.429LysPhe: 0.429 ± 0.02	1.614LysGly: 1.614 ± 0.041	0.429LysHis: 0.429 ± 0.021	0.783LysIle: 0.783 ± 0.033	0.766LysLys: 0.766 ± 0.034	1.55LysLeu: 1.55 ± 0.046	0.28LysMet: 0.28 ± 0.015	0.51LysAsn: 0.51 ± 0.025	1.068LysPro: 1.068 ± 0.035	0.581LysGln: 0.581 ± 0.021	1.128LysArg: 1.128 ± 0.03	1.136LysSer: 1.136 ± 0.036	1.267LysThr: 1.267 ± 0.042	1.882LysVal: 1.882 ± 0.052	0.2LysTrp: 0.2 ± 0.013	0.41LysTyr: 0.41 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	16.063LeuAla: 16.063 ± 0.152	0.574LeuCys: 0.574 ± 0.021	7.6LeuAsp: 7.6 ± 0.093	4.895LeuGlu: 4.895 ± 0.076	2.371LeuPhe: 2.371 ± 0.054	9.454LeuGly: 9.454 ± 0.096	2.024LeuHis: 2.024 ± 0.043	2.058LeuIle: 2.058 ± 0.044	1.456LeuLys: 1.456 ± 0.037	9.834LeuLeu: 9.834 ± 0.131	1.185LeuMet: 1.185 ± 0.032	1.352LeuAsn: 1.352 ± 0.034	5.73LeuPro: 5.73 ± 0.075	2.206LeuGln: 2.206 ± 0.04	7.961LeuArg: 7.961 ± 0.117	4.586LeuSer: 4.586 ± 0.063	6.557LeuThr: 6.557 ± 0.092	11.305LeuVal: 11.305 ± 0.128	1.273LeuTrp: 1.273 ± 0.037	1.577LeuTyr: 1.577 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.74MetAla: 1.74 ± 0.042	0.078MetCys: 0.078 ± 0.007	0.648MetAsp: 0.648 ± 0.022	0.451MetGlu: 0.451 ± 0.019	0.398MetPhe: 0.398 ± 0.018	0.963MetGly: 0.963 ± 0.027	0.281MetHis: 0.281 ± 0.015	0.53MetIle: 0.53 ± 0.023	0.33MetLys: 0.33 ± 0.017	1.442MetLeu: 1.442 ± 0.04	0.196MetMet: 0.196 ± 0.013	0.33MetAsn: 0.33 ± 0.012	0.919MetPro: 0.919 ± 0.025	0.337MetGln: 0.337 ± 0.016	1.078MetArg: 1.078 ± 0.028	1.226MetSer: 1.226 ± 0.028	1.595MetThr: 1.595 ± 0.036	1.097MetVal: 1.097 ± 0.033	0.161MetTrp: 0.161 ± 0.012	0.217MetTyr: 0.217 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.026AsnAla: 2.026 ± 0.051	0.087AsnCys: 0.087 ± 0.008	1.002AsnAsp: 1.002 ± 0.03	0.682AsnGlu: 0.682 ± 0.029	0.458AsnPhe: 0.458 ± 0.02	1.601AsnGly: 1.601 ± 0.047	0.338AsnHis: 0.338 ± 0.018	0.497AsnIle: 0.497 ± 0.021	0.387AsnLys: 0.387 ± 0.021	1.654AsnLeu: 1.654 ± 0.037	0.22AsnMet: 0.22 ± 0.014	0.366AsnAsn: 0.366 ± 0.02	1.337AsnPro: 1.337 ± 0.036	0.49AsnGln: 0.49 ± 0.023	1.029AsnArg: 1.029 ± 0.03	0.685AsnSer: 0.685 ± 0.03	0.977AsnThr: 0.977 ± 0.04	1.558AsnVal: 1.558 ± 0.037	0.234AsnTrp: 0.234 ± 0.015	0.387AsnTyr: 0.387 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.492ProAla: 8.492 ± 0.098	0.211ProCys: 0.211 ± 0.014	5.038ProAsp: 5.038 ± 0.067	3.476ProGlu: 3.476 ± 0.056	1.587ProPhe: 1.587 ± 0.036	6.315ProGly: 6.315 ± 0.09	1.197ProHis: 1.197 ± 0.036	1.229ProIle: 1.229 ± 0.036	0.896ProLys: 0.896 ± 0.029	4.744ProLeu: 4.744 ± 0.062	0.723ProMet: 0.723 ± 0.024	0.84ProAsn: 0.84 ± 0.026	2.838ProPro: 2.838 ± 0.067	1.426ProGln: 1.426 ± 0.032	4.033ProArg: 4.033 ± 0.066	3.597ProSer: 3.597 ± 0.064	4.145ProThr: 4.145 ± 0.067	5.723ProVal: 5.723 ± 0.085	0.914ProTrp: 0.914 ± 0.029	1.096ProTyr: 1.096 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.411GlnAla: 3.411 ± 0.06	0.12GlnCys: 0.12 ± 0.011	1.454GlnAsp: 1.454 ± 0.035	1.116GlnGlu: 1.116 ± 0.029	0.65GlnPhe: 0.65 ± 0.024	2.17GlnGly: 2.17 ± 0.041	0.619GlnHis: 0.619 ± 0.025	0.938GlnIle: 0.938 ± 0.025	0.585GlnLys: 0.585 ± 0.027	2.705GlnLeu: 2.705 ± 0.045	0.383GlnMet: 0.383 ± 0.016	0.47GlnAsn: 0.47 ± 0.025	1.489GlnPro: 1.489 ± 0.042	1.027GlnGln: 1.027 ± 0.035	2.118GlnArg: 2.118 ± 0.045	1.19GlnSer: 1.19 ± 0.031	1.479GlnThr: 1.479 ± 0.041	2.866GlnVal: 2.866 ± 0.051	0.442GlnTrp: 0.442 ± 0.019	0.584GlnTyr: 0.584 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.572ArgAla: 10.572 ± 0.125	0.373ArgCys: 0.373 ± 0.019	4.663ArgAsp: 4.663 ± 0.074	4.194ArgGlu: 4.194 ± 0.07	2.136ArgPhe: 2.136 ± 0.045	5.904ArgGly: 5.904 ± 0.085	1.764ArgHis: 1.764 ± 0.042	2.454ArgIle: 2.454 ± 0.047	1.196ArgLys: 1.196 ± 0.035	7.972ArgLeu: 7.972 ± 0.111	1.364ArgMet: 1.364 ± 0.034	1.108ArgAsn: 1.108 ± 0.032	4.526ArgPro: 4.526 ± 0.066	1.825ArgGln: 1.825 ± 0.036	7.61ArgArg: 7.61 ± 0.121	4.12ArgSer: 4.12 ± 0.063	5.358ArgThr: 5.358 ± 0.068	6.78ArgVal: 6.78 ± 0.088	1.458ArgTrp: 1.458 ± 0.032	1.68ArgTyr: 1.68 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.95SerAla: 6.95 ± 0.09	0.281SerCys: 0.281 ± 0.017	3.281SerAsp: 3.281 ± 0.064	2.183SerGlu: 2.183 ± 0.039	1.652SerPhe: 1.652 ± 0.038	6.08SerGly: 6.08 ± 0.08	0.994SerHis: 0.994 ± 0.029	1.598SerIle: 1.598 ± 0.039	1.113SerLys: 1.113 ± 0.029	4.67SerLeu: 4.67 ± 0.067	0.953SerMet: 0.953 ± 0.028	0.934SerAsn: 0.934 ± 0.032	3.06SerPro: 3.06 ± 0.048	1.317SerGln: 1.317 ± 0.038	3.56SerArg: 3.56 ± 0.06	3.718SerSer: 3.718 ± 0.082	3.892SerThr: 3.892 ± 0.062	4.674SerVal: 4.674 ± 0.057	0.965SerTrp: 0.965 ± 0.028	1.222SerTyr: 1.222 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.528ThrAla: 8.528 ± 0.117	0.408ThrCys: 0.408 ± 0.021	3.988ThrAsp: 3.988 ± 0.066	2.714ThrGlu: 2.714 ± 0.048	2.112ThrPhe: 2.112 ± 0.053	6.498ThrGly: 6.498 ± 0.089	1.278ThrHis: 1.278 ± 0.029	2.218ThrIle: 2.218 ± 0.058	1.362ThrLys: 1.362 ± 0.048	6.262ThrLeu: 6.262 ± 0.082	0.826ThrMet: 0.826 ± 0.028	1.17ThrAsn: 1.17 ± 0.042	4.39ThrPro: 4.39 ± 0.07	1.62ThrGln: 1.62 ± 0.045	4.023ThrArg: 4.023 ± 0.064	4.077ThrSer: 4.077 ± 0.072	5.488ThrThr: 5.488 ± 0.116	6.961ThrVal: 6.961 ± 0.097	1.207ThrTrp: 1.207 ± 0.04	1.49ThrTyr: 1.49 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	14.493ValAla: 14.493 ± 0.15	0.577ValCys: 0.577 ± 0.023	6.81ValAsp: 6.81 ± 0.077	5.357ValGlu: 5.357 ± 0.077	2.419ValPhe: 2.419 ± 0.044	8.83ValGly: 8.83 ± 0.099	2.076ValHis: 2.076 ± 0.044	2.457ValIle: 2.457 ± 0.054	1.627ValLys: 1.627 ± 0.047	10.854ValLeu: 10.854 ± 0.124	1.276ValMet: 1.276 ± 0.032	1.544ValAsn: 1.544 ± 0.037	6.081ValPro: 6.081 ± 0.09	2.281ValGln: 2.281 ± 0.041	7.753ValArg: 7.753 ± 0.105	4.813ValSer: 4.813 ± 0.07	6.851ValThr: 6.851 ± 0.107	12.766ValVal: 12.766 ± 0.15	1.273ValTrp: 1.273 ± 0.028	1.617ValTyr: 1.617 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.786TrpAla: 1.786 ± 0.04	0.132TrpCys: 0.132 ± 0.009	0.937TrpAsp: 0.937 ± 0.027	0.65TrpGlu: 0.65 ± 0.022	0.55TrpPhe: 0.55 ± 0.022	1.122TrpGly: 1.122 ± 0.029	0.373TrpHis: 0.373 ± 0.018	0.469TrpIle: 0.469 ± 0.02	0.319TrpLys: 0.319 ± 0.017	1.72TrpLeu: 1.72 ± 0.043	0.249TrpMet: 0.249 ± 0.013	0.364TrpAsn: 0.364 ± 0.019	0.742TrpPro: 0.742 ± 0.024	0.517TrpGln: 0.517 ± 0.018	1.355TrpArg: 1.355 ± 0.035	1.07TrpSer: 1.07 ± 0.031	1.113TrpThr: 1.113 ± 0.032	1.309TrpVal: 1.309 ± 0.036	0.451TrpTrp: 0.451 ± 0.02	0.326TrpTyr: 0.326 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.053	0.107TyrCys: 0.107 ± 0.01	1.398TyrAsp: 1.398 ± 0.045	1.016TyrGlu: 1.016 ± 0.031	0.578TyrPhe: 0.578 ± 0.022	1.975TyrGly: 1.975 ± 0.043	0.334TyrHis: 0.334 ± 0.014	0.362TyrIle: 0.362 ± 0.02	0.345TyrLys: 0.345 ± 0.021	2.028TyrLeu: 2.028 ± 0.04	0.167TyrMet: 0.167 ± 0.012	0.362TyrAsn: 0.362 ± 0.019	1.045TyrPro: 1.045 ± 0.037	0.611TyrGln: 0.611 ± 0.023	1.627TyrArg: 1.627 ± 0.041	0.956TyrSer: 0.956 ± 0.035	1.253TyrThr: 1.253 ± 0.045	1.921TyrVal: 1.921 ± 0.04	0.327TyrTrp: 0.327 ± 0.017	0.471TyrTyr: 0.471 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3715 proteins (1282968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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