Amino acid dipepetide frequency for Corynebacterium glyciniphilum AJ 3170

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.179AlaAla: 16.179 ± 0.175	0.855AlaCys: 0.855 ± 0.031	8.145AlaAsp: 8.145 ± 0.104	7.753AlaGlu: 7.753 ± 0.093	3.204AlaPhe: 3.204 ± 0.058	11.42AlaGly: 11.42 ± 0.114	2.207AlaHis: 2.207 ± 0.051	3.843AlaIle: 3.843 ± 0.073	2.361AlaLys: 2.361 ± 0.061	11.477AlaLeu: 11.477 ± 0.131	2.572AlaMet: 2.572 ± 0.048	2.159AlaAsn: 2.159 ± 0.05	5.407AlaPro: 5.407 ± 0.074	3.268AlaGln: 3.268 ± 0.058	7.235AlaArg: 7.235 ± 0.106	6.255AlaSer: 6.255 ± 0.077	7.411AlaThr: 7.411 ± 0.095	11.84AlaVal: 11.84 ± 0.133	1.58AlaTrp: 1.58 ± 0.044	2.059AlaTyr: 2.059 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.812CysAla: 0.812 ± 0.028	0.077CysCys: 0.077 ± 0.009	0.455CysAsp: 0.455 ± 0.022	0.343CysGlu: 0.343 ± 0.017	0.229CysPhe: 0.229 ± 0.015	0.801CysGly: 0.801 ± 0.029	0.16CysHis: 0.16 ± 0.013	0.277CysIle: 0.277 ± 0.017	0.075CysLys: 0.075 ± 0.009	0.673CysLeu: 0.673 ± 0.025	0.134CysMet: 0.134 ± 0.011	0.142CysAsn: 0.142 ± 0.011	0.366CysPro: 0.366 ± 0.022	0.166CysGln: 0.166 ± 0.013	0.524CysArg: 0.524 ± 0.023	0.484CysSer: 0.484 ± 0.023	0.516CysThr: 0.516 ± 0.022	0.569CysVal: 0.569 ± 0.022	0.101CysTrp: 0.101 ± 0.01	0.144CysTyr: 0.144 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.022AspAla: 8.022 ± 0.094	0.407AspCys: 0.407 ± 0.018	4.974AspAsp: 4.974 ± 0.092	4.442AspGlu: 4.442 ± 0.078	1.765AspPhe: 1.765 ± 0.045	7.079AspGly: 7.079 ± 0.107	1.509AspHis: 1.509 ± 0.042	3.09AspIle: 3.09 ± 0.051	1.371AspLys: 1.371 ± 0.038	6.472AspLeu: 6.472 ± 0.085	1.185AspMet: 1.185 ± 0.035	1.777AspAsn: 1.777 ± 0.049	4.077AspPro: 4.077 ± 0.069	1.843AspGln: 1.843 ± 0.049	4.806AspArg: 4.806 ± 0.081	3.698AspSer: 3.698 ± 0.056	4.048AspThr: 4.048 ± 0.065	5.638AspVal: 5.638 ± 0.093	0.929AspTrp: 0.929 ± 0.033	1.423AspTyr: 1.423 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.116GluAla: 6.116 ± 0.085	0.313GluCys: 0.313 ± 0.018	3.751GluAsp: 3.751 ± 0.066	3.514GluGlu: 3.514 ± 0.071	1.764GluPhe: 1.764 ± 0.042	4.093GluGly: 4.093 ± 0.07	1.451GluHis: 1.451 ± 0.034	2.898GluIle: 2.898 ± 0.064	1.847GluLys: 1.847 ± 0.046	5.955GluLeu: 5.955 ± 0.086	1.219GluMet: 1.219 ± 0.033	1.698GluAsn: 1.698 ± 0.044	2.808GluPro: 2.808 ± 0.062	2.272GluGln: 2.272 ± 0.049	4.116GluArg: 4.116 ± 0.065	3.181GluSer: 3.181 ± 0.056	3.454GluThr: 3.454 ± 0.056	4.555GluVal: 4.555 ± 0.073	0.755GluTrp: 0.755 ± 0.029	1.191GluTyr: 1.191 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.537PheAla: 3.537 ± 0.063	0.245PheCys: 0.245 ± 0.016	2.061PheAsp: 2.061 ± 0.043	1.336PheGlu: 1.336 ± 0.037	1.075PhePhe: 1.075 ± 0.036	3.309PheGly: 3.309 ± 0.062	0.633PheHis: 0.633 ± 0.026	1.495PheIle: 1.495 ± 0.043	0.418PheLys: 0.418 ± 0.023	2.903PheLeu: 2.903 ± 0.069	0.607PheMet: 0.607 ± 0.025	0.782PheAsn: 0.782 ± 0.028	1.495PhePro: 1.495 ± 0.033	0.692PheGln: 0.692 ± 0.024	1.859PheArg: 1.859 ± 0.045	1.936PheSer: 1.936 ± 0.05	2.272PheThr: 2.272 ± 0.049	2.212PheVal: 2.212 ± 0.046	0.419PheTrp: 0.419 ± 0.024	0.67PheTyr: 0.67 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.84GlyAla: 9.84 ± 0.118	0.661GlyCys: 0.661 ± 0.025	5.743GlyAsp: 5.743 ± 0.07	5.288GlyGlu: 5.288 ± 0.072	2.969GlyPhe: 2.969 ± 0.057	7.92GlyGly: 7.92 ± 0.107	2.068GlyHis: 2.068 ± 0.051	4.65GlyIle: 4.65 ± 0.075	2.212GlyLys: 2.212 ± 0.054	8.688GlyLeu: 8.688 ± 0.089	2.444GlyMet: 2.444 ± 0.05	2.174GlyAsn: 2.174 ± 0.047	3.899GlyPro: 3.899 ± 0.061	2.704GlyGln: 2.704 ± 0.048	6.356GlyArg: 6.356 ± 0.071	5.546GlySer: 5.546 ± 0.071	6.344GlyThr: 6.344 ± 0.083	8.168GlyVal: 8.168 ± 0.101	1.539GlyTrp: 1.539 ± 0.04	2.223GlyTyr: 2.223 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.135HisAla: 2.135 ± 0.042	0.183HisCys: 0.183 ± 0.014	1.375HisAsp: 1.375 ± 0.04	0.984HisGlu: 0.984 ± 0.026	0.58HisPhe: 0.58 ± 0.023	2.086HisGly: 2.086 ± 0.054	0.661HisHis: 0.661 ± 0.025	0.819HisIle: 0.819 ± 0.027	0.339HisLys: 0.339 ± 0.018	2.106HisLeu: 2.106 ± 0.05	0.394HisMet: 0.394 ± 0.02	0.488HisAsn: 0.488 ± 0.018	1.514HisPro: 1.514 ± 0.04	0.602HisGln: 0.602 ± 0.026	1.808HisArg: 1.808 ± 0.04	1.176HisSer: 1.176 ± 0.032	1.257HisThr: 1.257 ± 0.033	1.693HisVal: 1.693 ± 0.039	0.351HisTrp: 0.351 ± 0.019	0.508HisTyr: 0.508 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.779IleAla: 5.779 ± 0.082	0.345IleCys: 0.345 ± 0.016	3.341IleAsp: 3.341 ± 0.044	2.266IleGlu: 2.266 ± 0.05	1.25IlePhe: 1.25 ± 0.035	4.426IleGly: 4.426 ± 0.077	0.845IleHis: 0.845 ± 0.026	2.217IleIle: 2.217 ± 0.062	0.745IleLys: 0.745 ± 0.027	4.113IleLeu: 4.113 ± 0.08	0.8IleMet: 0.8 ± 0.03	1.128IleAsn: 1.128 ± 0.033	2.358IlePro: 2.358 ± 0.055	0.967IleGln: 0.967 ± 0.032	2.661IleArg: 2.661 ± 0.046	2.541IleSer: 2.541 ± 0.047	2.965IleThr: 2.965 ± 0.052	3.911IleVal: 3.911 ± 0.068	0.47IleTrp: 0.47 ± 0.023	0.849IleTyr: 0.849 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.372LysAla: 2.372 ± 0.058	0.096LysCys: 0.096 ± 0.01	1.417LysAsp: 1.417 ± 0.039	1.238LysGlu: 1.238 ± 0.035	0.542LysPhe: 0.542 ± 0.022	1.63LysGly: 1.63 ± 0.049	0.401LysHis: 0.401 ± 0.02	1.07LysIle: 1.07 ± 0.032	1.05LysLys: 1.05 ± 0.046	1.842LysLeu: 1.842 ± 0.047	0.524LysMet: 0.524 ± 0.021	0.71LysAsn: 0.71 ± 0.029	1.013LysPro: 1.013 ± 0.036	0.65LysGln: 0.65 ± 0.027	1.418LysArg: 1.418 ± 0.043	1.251LysSer: 1.251 ± 0.038	1.388LysThr: 1.388 ± 0.041	1.8LysVal: 1.8 ± 0.053	0.23LysTrp: 0.23 ± 0.015	0.44LysTyr: 0.44 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.948LeuAla: 11.948 ± 0.129	0.778LeuCys: 0.778 ± 0.033	6.531LeuAsp: 6.531 ± 0.087	4.638LeuGlu: 4.638 ± 0.074	2.788LeuPhe: 2.788 ± 0.064	8.74LeuGly: 8.74 ± 0.098	1.927LeuHis: 1.927 ± 0.043	4.306LeuIle: 4.306 ± 0.085	1.815LeuLys: 1.815 ± 0.046	9.27LeuLeu: 9.27 ± 0.139	1.926LeuMet: 1.926 ± 0.048	2.155LeuAsn: 2.155 ± 0.046	5.332LeuPro: 5.332 ± 0.066	2.5LeuGln: 2.5 ± 0.054	6.643LeuArg: 6.643 ± 0.078	6.518LeuSer: 6.518 ± 0.083	6.575LeuThr: 6.575 ± 0.084	8.705LeuVal: 8.705 ± 0.107	1.227LeuTrp: 1.227 ± 0.034	1.63LeuTyr: 1.63 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.407MetAla: 2.407 ± 0.049	0.156MetCys: 0.156 ± 0.012	1.136MetAsp: 1.136 ± 0.034	0.92MetGlu: 0.92 ± 0.03	0.69MetPhe: 0.69 ± 0.027	1.56MetGly: 1.56 ± 0.039	0.404MetHis: 0.404 ± 0.019	1.139MetIle: 1.139 ± 0.039	0.555MetLys: 0.555 ± 0.023	2.054MetLeu: 2.054 ± 0.047	0.572MetMet: 0.572 ± 0.027	0.675MetAsn: 0.675 ± 0.022	1.231MetPro: 1.231 ± 0.037	0.594MetGln: 0.594 ± 0.024	1.27MetArg: 1.27 ± 0.031	1.807MetSer: 1.807 ± 0.041	2.102MetThr: 2.102 ± 0.039	1.745MetVal: 1.745 ± 0.042	0.254MetTrp: 0.254 ± 0.017	0.373MetTyr: 0.373 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.526AsnAla: 2.526 ± 0.055	0.159AsnCys: 0.159 ± 0.01	1.48AsnAsp: 1.48 ± 0.037	1.194AsnGlu: 1.194 ± 0.033	0.728AsnPhe: 0.728 ± 0.03	2.098AsnGly: 2.098 ± 0.052	0.548AsnHis: 0.548 ± 0.023	1.117AsnIle: 1.117 ± 0.035	0.501AsnLys: 0.501 ± 0.022	2.263AsnLeu: 2.263 ± 0.047	0.48AsnMet: 0.48 ± 0.023	0.682AsnAsn: 0.682 ± 0.03	1.709AsnPro: 1.709 ± 0.04	0.729AsnGln: 0.729 ± 0.028	1.584AsnArg: 1.584 ± 0.04	1.361AsnSer: 1.361 ± 0.039	1.459AsnThr: 1.459 ± 0.041	1.867AsnVal: 1.867 ± 0.039	0.363AsnTrp: 0.363 ± 0.02	0.588AsnTyr: 0.588 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.003ProAla: 6.003 ± 0.079	0.239ProCys: 0.239 ± 0.016	4.404ProAsp: 4.404 ± 0.07	4.196ProGlu: 4.196 ± 0.074	1.481ProPhe: 1.481 ± 0.04	5.393ProGly: 5.393 ± 0.084	1.142ProHis: 1.142 ± 0.034	1.374ProIle: 1.374 ± 0.038	0.993ProLys: 0.993 ± 0.032	4.4ProLeu: 4.4 ± 0.063	1.019ProMet: 1.019 ± 0.031	1.006ProAsn: 1.006 ± 0.029	1.968ProPro: 1.968 ± 0.039	1.486ProGln: 1.486 ± 0.037	3.039ProArg: 3.039 ± 0.056	3.336ProSer: 3.336 ± 0.057	3.462ProThr: 3.462 ± 0.061	5.417ProVal: 5.417 ± 0.075	0.849ProTrp: 0.849 ± 0.032	1.006ProTyr: 1.006 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.117GlnAla: 3.117 ± 0.07	0.203GlnCys: 0.203 ± 0.013	1.799GlnAsp: 1.799 ± 0.042	1.581GlnGlu: 1.581 ± 0.042	0.885GlnPhe: 0.885 ± 0.027	2.154GlnGly: 2.154 ± 0.047	0.633GlnHis: 0.633 ± 0.027	1.49GlnIle: 1.49 ± 0.04	0.743GlnLys: 0.743 ± 0.028	2.868GlnLeu: 2.868 ± 0.058	0.725GlnMet: 0.725 ± 0.028	0.729GlnAsn: 0.729 ± 0.027	1.273GlnPro: 1.273 ± 0.036	1.167GlnGln: 1.167 ± 0.039	2.244GlnArg: 2.244 ± 0.044	1.539GlnSer: 1.539 ± 0.039	1.484GlnThr: 1.484 ± 0.037	2.583GlnVal: 2.583 ± 0.047	0.519GlnTrp: 0.519 ± 0.024	0.59GlnTyr: 0.59 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.898ArgAla: 6.898 ± 0.094	0.404ArgCys: 0.404 ± 0.023	4.572ArgAsp: 4.572 ± 0.076	4.072ArgGlu: 4.072 ± 0.063	2.117ArgPhe: 2.117 ± 0.049	5.057ArgGly: 5.057 ± 0.07	1.622ArgHis: 1.622 ± 0.04	3.425ArgIle: 3.425 ± 0.063	1.552ArgLys: 1.552 ± 0.044	6.238ArgLeu: 6.238 ± 0.072	1.809ArgMet: 1.809 ± 0.043	1.645ArgAsn: 1.645 ± 0.042	3.484ArgPro: 3.484 ± 0.056	2.333ArgGln: 2.333 ± 0.049	6.437ArgArg: 6.437 ± 0.088	4.121ArgSer: 4.121 ± 0.064	4.509ArgThr: 4.509 ± 0.067	5.121ArgVal: 5.121 ± 0.072	1.164ArgTrp: 1.164 ± 0.034	1.644ArgTyr: 1.644 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.982SerAla: 6.982 ± 0.099	0.428SerCys: 0.428 ± 0.022	4.017SerAsp: 4.017 ± 0.071	3.134SerGlu: 3.134 ± 0.049	1.95SerPhe: 1.95 ± 0.043	6.409SerGly: 6.409 ± 0.073	1.202SerHis: 1.202 ± 0.033	2.2SerIle: 2.2 ± 0.05	1.088SerLys: 1.088 ± 0.035	5.66SerLeu: 5.66 ± 0.066	1.457SerMet: 1.457 ± 0.037	1.183SerAsn: 1.183 ± 0.034	3.431SerPro: 3.431 ± 0.058	1.691SerGln: 1.691 ± 0.046	4.117SerArg: 4.117 ± 0.063	4.044SerSer: 4.044 ± 0.068	4.288SerThr: 4.288 ± 0.064	5.253SerVal: 5.253 ± 0.071	1.028SerTrp: 1.028 ± 0.03	1.314SerTyr: 1.314 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	8.368ThrAla: 8.368 ± 0.09	0.46ThrCys: 0.46 ± 0.021	4.678ThrAsp: 4.678 ± 0.067	3.453ThrGlu: 3.453 ± 0.062	1.885ThrPhe: 1.885 ± 0.048	6.864ThrGly: 6.864 ± 0.085	1.191ThrHis: 1.191 ± 0.031	2.579ThrIle: 2.579 ± 0.052	1.093ThrLys: 1.093 ± 0.031	6.031ThrLeu: 6.031 ± 0.08	1.302ThrMet: 1.302 ± 0.035	1.292ThrAsn: 1.292 ± 0.041	4.181ThrPro: 4.181 ± 0.08	1.445ThrGln: 1.445 ± 0.042	3.859ThrArg: 3.859 ± 0.059	4.102ThrSer: 4.102 ± 0.059	4.869ThrThr: 4.869 ± 0.083	7.458ThrVal: 7.458 ± 0.088	0.945ThrTrp: 0.945 ± 0.03	1.313ThrTyr: 1.313 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.532ValAla: 10.532 ± 0.119	0.736ValCys: 0.736 ± 0.026	6.506ValAsp: 6.506 ± 0.084	4.851ValGlu: 4.851 ± 0.077	2.743ValPhe: 2.743 ± 0.052	7.319ValGly: 7.319 ± 0.095	1.808ValHis: 1.808 ± 0.041	4.404ValIle: 4.404 ± 0.079	1.631ValLys: 1.631 ± 0.047	9.148ValLeu: 9.148 ± 0.104	1.742ValMet: 1.742 ± 0.041	2.133ValAsn: 2.133 ± 0.047	4.899ValPro: 4.899 ± 0.067	2.165ValGln: 2.165 ± 0.045	5.47ValArg: 5.47 ± 0.069	5.695ValSer: 5.695 ± 0.073	6.793ValThr: 6.793 ± 0.094	8.687ValVal: 8.687 ± 0.114	1.159ValTrp: 1.159 ± 0.035	1.506ValTyr: 1.506 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.484TrpAla: 1.484 ± 0.04	0.129TrpCys: 0.129 ± 0.01	0.807TrpAsp: 0.807 ± 0.026	0.691TrpGlu: 0.691 ± 0.023	0.618TrpPhe: 0.618 ± 0.026	1.09TrpGly: 1.09 ± 0.032	0.288TrpHis: 0.288 ± 0.017	0.766TrpIle: 0.766 ± 0.029	0.359TrpLys: 0.359 ± 0.02	1.58TrpLeu: 1.58 ± 0.043	0.383TrpMet: 0.383 ± 0.018	0.416TrpAsn: 0.416 ± 0.02	0.648TrpPro: 0.648 ± 0.026	0.517TrpGln: 0.517 ± 0.022	1.097TrpArg: 1.097 ± 0.036	0.962TrpSer: 0.962 ± 0.03	0.912TrpThr: 0.912 ± 0.029	1.15TrpVal: 1.15 ± 0.036	0.334TrpTrp: 0.334 ± 0.018	0.302TrpTyr: 0.302 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.174TyrAla: 2.174 ± 0.047	0.175TyrCys: 0.175 ± 0.012	1.362TyrAsp: 1.362 ± 0.035	1.055TyrGlu: 1.055 ± 0.033	0.694TyrPhe: 0.694 ± 0.025	1.99TyrGly: 1.99 ± 0.047	0.36TyrHis: 0.36 ± 0.021	0.816TyrIle: 0.816 ± 0.031	0.332TyrLys: 0.332 ± 0.016	2.211TyrLeu: 2.211 ± 0.051	0.35TyrMet: 0.35 ± 0.021	0.461TyrAsn: 0.461 ± 0.021	1.12TyrPro: 1.12 ± 0.029	0.535TyrGln: 0.535 ± 0.024	1.679TyrArg: 1.679 ± 0.042	1.326TyrSer: 1.326 ± 0.037	1.26TyrThr: 1.26 ± 0.03	1.553TyrVal: 1.553 ± 0.04	0.315TyrTrp: 0.315 ± 0.015	0.438TyrTyr: 0.438 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3270 proteins (1073090 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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