Amino acid dipepetide frequency for Rubrimonas cliftonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	30.928AlaAla: 30.928 ± 0.306	1.427AlaCys: 1.427 ± 0.034	8.381AlaAsp: 8.381 ± 0.089	10.212AlaGlu: 10.212 ± 0.108	5.355AlaPhe: 5.355 ± 0.065	14.201AlaGly: 14.201 ± 0.123	2.7AlaHis: 2.7 ± 0.048	5.614AlaIle: 5.614 ± 0.066	2.744AlaLys: 2.744 ± 0.058	20.029AlaLeu: 20.029 ± 0.171	4.511AlaMet: 4.511 ± 0.066	2.323AlaAsn: 2.323 ± 0.045	10.305AlaPro: 10.305 ± 0.116	4.659AlaGln: 4.659 ± 0.075	13.808AlaArg: 13.808 ± 0.13	6.452AlaSer: 6.452 ± 0.065	6.979AlaThr: 6.979 ± 0.066	11.004AlaVal: 11.004 ± 0.103	2.042AlaTrp: 2.042 ± 0.039	2.493AlaTyr: 2.493 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.52CysAla: 1.52 ± 0.039	0.123CysCys: 0.123 ± 0.01	0.612CysAsp: 0.612 ± 0.021	0.446CysGlu: 0.446 ± 0.017	0.33CysPhe: 0.33 ± 0.015	1.087CysGly: 1.087 ± 0.028	0.199CysHis: 0.199 ± 0.012	0.246CysIle: 0.246 ± 0.014	0.119CysLys: 0.119 ± 0.01	0.769CysLeu: 0.769 ± 0.023	0.156CysMet: 0.156 ± 0.011	0.161CysAsn: 0.161 ± 0.011	0.481CysPro: 0.481 ± 0.017	0.135CysGln: 0.135 ± 0.009	0.591CysArg: 0.591 ± 0.021	0.396CysSer: 0.396 ± 0.018	0.306CysThr: 0.306 ± 0.017	0.717CysVal: 0.717 ± 0.023	0.125CysTrp: 0.125 ± 0.009	0.163CysTyr: 0.163 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	10.534AspAla: 10.534 ± 0.111	0.47AspCys: 0.47 ± 0.019	3.39AspAsp: 3.39 ± 0.087	3.054AspGlu: 3.054 ± 0.056	2.118AspPhe: 2.118 ± 0.038	6.323AspGly: 6.323 ± 0.105	1.14AspHis: 1.14 ± 0.03	2.313AspIle: 2.313 ± 0.042	0.863AspLys: 0.863 ± 0.029	5.549AspLeu: 5.549 ± 0.069	1.27AspMet: 1.27 ± 0.029	0.899AspAsn: 0.899 ± 0.027	4.026AspPro: 4.026 ± 0.058	1.161AspGln: 1.161 ± 0.028	4.686AspArg: 4.686 ± 0.059	1.715AspSer: 1.715 ± 0.041	1.934AspThr: 1.934 ± 0.06	4.473AspVal: 4.473 ± 0.071	1.089AspTrp: 1.089 ± 0.027	1.268AspTyr: 1.268 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	10.479GluAla: 10.479 ± 0.118	0.301GluCys: 0.301 ± 0.015	2.835GluAsp: 2.835 ± 0.052	2.706GluGlu: 2.706 ± 0.055	1.534GluPhe: 1.534 ± 0.041	5.394GluGly: 5.394 ± 0.066	1.001GluHis: 1.001 ± 0.029	3.294GluIle: 3.294 ± 0.05	1.496GluLys: 1.496 ± 0.034	4.416GluLeu: 4.416 ± 0.067	1.463GluMet: 1.463 ± 0.032	1.237GluAsn: 1.237 ± 0.034	2.932GluPro: 2.932 ± 0.047	1.509GluGln: 1.509 ± 0.033	5.275GluArg: 5.275 ± 0.064	2.037GluSer: 2.037 ± 0.039	4.12GluThr: 4.12 ± 0.053	3.591GluVal: 3.591 ± 0.053	0.632GluTrp: 0.632 ± 0.022	0.721GluTyr: 0.721 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	5.22PheAla: 5.22 ± 0.069	0.388PheCys: 0.388 ± 0.016	2.73PheAsp: 2.73 ± 0.05	2.225PheGlu: 2.225 ± 0.035	1.289PhePhe: 1.289 ± 0.033	3.721PheGly: 3.721 ± 0.055	0.668PheHis: 0.668 ± 0.025	1.329PheIle: 1.329 ± 0.033	0.553PheLys: 0.553 ± 0.02	3.1PheLeu: 3.1 ± 0.063	0.732PheMet: 0.732 ± 0.027	0.752PheAsn: 0.752 ± 0.027	1.505PhePro: 1.505 ± 0.032	0.793PheGln: 0.793 ± 0.023	2.345PheArg: 2.345 ± 0.038	1.87PheSer: 1.87 ± 0.04	1.84PheThr: 1.84 ± 0.04	2.569PheVal: 2.569 ± 0.045	0.536PheTrp: 0.536 ± 0.022	0.721PheTyr: 0.721 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	16.069GlyAla: 16.069 ± 0.145	0.931GlyCys: 0.931 ± 0.026	5.544GlyAsp: 5.544 ± 0.107	5.367GlyGlu: 5.367 ± 0.062	3.841GlyPhe: 3.841 ± 0.061	9.371GlyGly: 9.371 ± 0.124	1.659GlyHis: 1.659 ± 0.039	2.144GlyIle: 2.144 ± 0.044	1.932GlyLys: 1.932 ± 0.043	9.73GlyLeu: 9.73 ± 0.113	2.43GlyMet: 2.43 ± 0.041	1.293GlyAsn: 1.293 ± 0.037	4.93GlyPro: 4.93 ± 0.065	2.149GlyGln: 2.149 ± 0.041	7.978GlyArg: 7.978 ± 0.08	3.65GlySer: 3.65 ± 0.059	2.835GlyThr: 2.835 ± 0.05	8.585GlyVal: 8.585 ± 0.09	1.727GlyTrp: 1.727 ± 0.039	1.97GlyTyr: 1.97 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.649HisAla: 2.649 ± 0.049	0.209HisCys: 0.209 ± 0.01	1.184HisAsp: 1.184 ± 0.031	0.923HisGlu: 0.923 ± 0.028	0.618HisPhe: 0.618 ± 0.02	2.007HisGly: 2.007 ± 0.044	0.466HisHis: 0.466 ± 0.02	0.656HisIle: 0.656 ± 0.021	0.236HisLys: 0.236 ± 0.011	1.721HisLeu: 1.721 ± 0.038	0.409HisMet: 0.409 ± 0.017	0.296HisAsn: 0.296 ± 0.015	1.25HisPro: 1.25 ± 0.032	0.388HisGln: 0.388 ± 0.018	1.326HisArg: 1.326 ± 0.03	0.64HisSer: 0.64 ± 0.02	0.589HisThr: 0.589 ± 0.021	1.53HisVal: 1.53 ± 0.033	0.258HisTrp: 0.258 ± 0.014	0.375HisTyr: 0.375 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.702IleAla: 6.702 ± 0.073	0.405IleCys: 0.405 ± 0.018	3.077IleAsp: 3.077 ± 0.052	2.832IleGlu: 2.832 ± 0.045	1.266IlePhe: 1.266 ± 0.03	4.015IleGly: 4.015 ± 0.05	0.68IleHis: 0.68 ± 0.022	1.237IleIle: 1.237 ± 0.035	0.678IleLys: 0.678 ± 0.023	3.466IleLeu: 3.466 ± 0.055	0.678IleMet: 0.678 ± 0.024	0.857IleAsn: 0.857 ± 0.026	1.8IlePro: 1.8 ± 0.039	0.735IleGln: 0.735 ± 0.02	2.595IleArg: 2.595 ± 0.046	1.888IleSer: 1.888 ± 0.041	1.772IleThr: 1.772 ± 0.035	3.378IleVal: 3.378 ± 0.053	0.491IleTrp: 0.491 ± 0.018	0.785IleTyr: 0.785 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.035LysAla: 3.035 ± 0.06	0.112LysCys: 0.112 ± 0.007	0.891LysAsp: 0.891 ± 0.024	0.822LysGlu: 0.822 ± 0.027	0.539LysPhe: 0.539 ± 0.021	1.85LysGly: 1.85 ± 0.042	0.362LysHis: 0.362 ± 0.016	0.912LysIle: 0.912 ± 0.026	0.558LysLys: 0.558 ± 0.022	2.116LysLeu: 2.116 ± 0.04	0.453LysMet: 0.453 ± 0.02	0.418LysAsn: 0.418 ± 0.014	1.28LysPro: 1.28 ± 0.032	0.505LysGln: 0.505 ± 0.02	1.536LysArg: 1.536 ± 0.035	1.007LysSer: 1.007 ± 0.028	1.149LysThr: 1.149 ± 0.029	1.355LysVal: 1.355 ± 0.037	0.247LysTrp: 0.247 ± 0.015	0.361LysTyr: 0.361 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	17.61LeuAla: 17.61 ± 0.155	0.987LeuCys: 0.987 ± 0.027	6.489LeuAsp: 6.489 ± 0.065	5.258LeuGlu: 5.258 ± 0.066	3.275LeuPhe: 3.275 ± 0.051	9.282LeuGly: 9.282 ± 0.11	1.684LeuHis: 1.684 ± 0.036	4.29LeuIle: 4.29 ± 0.064	2.293LeuLys: 2.293 ± 0.046	9.141LeuLeu: 9.141 ± 0.116	2.373LeuMet: 2.373 ± 0.045	1.986LeuAsn: 1.986 ± 0.034	5.165LeuPro: 5.165 ± 0.066	2.014LeuGln: 2.014 ± 0.038	8.708LeuArg: 8.708 ± 0.094	6.008LeuSer: 6.008 ± 0.07	5.652LeuThr: 5.652 ± 0.06	6.865LeuVal: 6.865 ± 0.077	1.362LeuTrp: 1.362 ± 0.034	1.743LeuTyr: 1.743 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.852MetAla: 3.852 ± 0.057	0.145MetCys: 0.145 ± 0.01	1.087MetAsp: 1.087 ± 0.027	1.087MetGlu: 1.087 ± 0.026	0.651MetPhe: 0.651 ± 0.022	1.976MetGly: 1.976 ± 0.038	0.364MetHis: 0.364 ± 0.015	1.22MetIle: 1.22 ± 0.027	0.705MetLys: 0.705 ± 0.022	2.518MetLeu: 2.518 ± 0.041	0.572MetMet: 0.572 ± 0.021	0.639MetAsn: 0.639 ± 0.023	1.177MetPro: 1.177 ± 0.03	0.607MetGln: 0.607 ± 0.021	2.115MetArg: 2.115 ± 0.041	1.436MetSer: 1.436 ± 0.033	1.919MetThr: 1.919 ± 0.035	1.591MetVal: 1.591 ± 0.035	0.202MetTrp: 0.202 ± 0.011	0.233MetTyr: 0.233 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.719AsnAla: 2.719 ± 0.047	0.168AsnCys: 0.168 ± 0.01	1.064AsnAsp: 1.064 ± 0.037	0.76AsnGlu: 0.76 ± 0.027	0.709AsnPhe: 0.709 ± 0.023	1.775AsnGly: 1.775 ± 0.044	0.351AsnHis: 0.351 ± 0.014	0.821AsnIle: 0.821 ± 0.024	0.324AsnLys: 0.324 ± 0.017	1.928AsnLeu: 1.928 ± 0.038	0.435AsnMet: 0.435 ± 0.018	0.446AsnAsn: 0.446 ± 0.021	1.458AsnPro: 1.458 ± 0.036	0.419AsnGln: 0.419 ± 0.014	1.403AsnArg: 1.403 ± 0.033	0.733AsnSer: 0.733 ± 0.027	0.846AsnThr: 0.846 ± 0.024	1.442AsnVal: 1.442 ± 0.031	0.327AsnTrp: 0.327 ± 0.017	0.425AsnTyr: 0.425 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.665ProAla: 8.665 ± 0.09	0.453ProCys: 0.453 ± 0.019	3.996ProAsp: 3.996 ± 0.052	4.342ProGlu: 4.342 ± 0.063	2.112ProPhe: 2.112 ± 0.044	5.725ProGly: 5.725 ± 0.074	1.03ProHis: 1.03 ± 0.028	1.874ProIle: 1.874 ± 0.031	1.106ProLys: 1.106 ± 0.03	5.201ProLeu: 5.201 ± 0.063	1.333ProMet: 1.333 ± 0.028	1.029ProAsn: 1.029 ± 0.03	3.551ProPro: 3.551 ± 0.06	1.503ProGln: 1.503 ± 0.036	3.779ProArg: 3.779 ± 0.051	2.578ProSer: 2.578 ± 0.046	2.485ProThr: 2.485 ± 0.039	4.062ProVal: 4.062 ± 0.054	0.81ProTrp: 0.81 ± 0.026	1.0ProTyr: 1.0 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.712GlnAla: 3.712 ± 0.06	0.157GlnCys: 0.157 ± 0.011	1.094GlnAsp: 1.094 ± 0.028	1.109GlnGlu: 1.109 ± 0.035	0.815GlnPhe: 0.815 ± 0.027	2.182GlnGly: 2.182 ± 0.042	0.395GlnHis: 0.395 ± 0.017	1.256GlnIle: 1.256 ± 0.027	0.581GlnLys: 0.581 ± 0.021	2.018GlnLeu: 2.018 ± 0.043	0.663GlnMet: 0.663 ± 0.023	0.552GlnAsn: 0.552 ± 0.023	1.392GlnPro: 1.392 ± 0.036	0.678GlnGln: 0.678 ± 0.028	1.887GlnArg: 1.887 ± 0.04	1.203GlnSer: 1.203 ± 0.031	1.432GlnThr: 1.432 ± 0.033	1.637GlnVal: 1.637 ± 0.032	0.301GlnTrp: 0.301 ± 0.015	0.336GlnTyr: 0.336 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	12.652ArgAla: 12.652 ± 0.129	0.609ArgCys: 0.609 ± 0.02	4.705ArgAsp: 4.705 ± 0.062	4.708ArgGlu: 4.708 ± 0.068	2.938ArgPhe: 2.938 ± 0.049	6.193ArgGly: 6.193 ± 0.07	1.565ArgHis: 1.565 ± 0.037	3.719ArgIle: 3.719 ± 0.049	1.507ArgLys: 1.507 ± 0.033	9.752ArgLeu: 9.752 ± 0.092	2.071ArgMet: 2.071 ± 0.034	1.463ArgAsn: 1.463 ± 0.03	4.608ArgPro: 4.608 ± 0.071	1.82ArgGln: 1.82 ± 0.04	8.117ArgArg: 8.117 ± 0.103	3.35ArgSer: 3.35 ± 0.051	3.195ArgThr: 3.195 ± 0.048	5.623ArgVal: 5.623 ± 0.061	1.218ArgTrp: 1.218 ± 0.036	1.403ArgTyr: 1.403 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.414SerAla: 6.414 ± 0.078	0.356SerCys: 0.356 ± 0.019	2.436SerAsp: 2.436 ± 0.041	2.186SerGlu: 2.186 ± 0.047	1.85SerPhe: 1.85 ± 0.038	5.249SerGly: 5.249 ± 0.067	0.873SerHis: 0.873 ± 0.022	1.888SerIle: 1.888 ± 0.04	0.829SerLys: 0.829 ± 0.025	4.581SerLeu: 4.581 ± 0.062	1.03SerMet: 1.03 ± 0.027	0.881SerAsn: 0.881 ± 0.024	2.739SerPro: 2.739 ± 0.048	1.097SerGln: 1.097 ± 0.026	3.374SerArg: 3.374 ± 0.051	1.98SerSer: 1.98 ± 0.04	2.023SerThr: 2.023 ± 0.038	3.473SerVal: 3.473 ± 0.055	0.629SerTrp: 0.629 ± 0.023	0.886SerTyr: 0.886 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.645ThrAla: 6.645 ± 0.076	0.38ThrCys: 0.38 ± 0.015	2.459ThrAsp: 2.459 ± 0.042	2.381ThrGlu: 2.381 ± 0.041	1.607ThrPhe: 1.607 ± 0.038	4.754ThrGly: 4.754 ± 0.07	0.828ThrHis: 0.828 ± 0.024	1.985ThrIle: 1.985 ± 0.052	0.746ThrLys: 0.746 ± 0.024	5.912ThrLeu: 5.912 ± 0.063	1.007ThrMet: 1.007 ± 0.028	0.864ThrAsn: 0.864 ± 0.027	3.791ThrPro: 3.791 ± 0.054	1.075ThrGln: 1.075 ± 0.029	3.303ThrArg: 3.303 ± 0.056	1.978ThrSer: 1.978 ± 0.041	2.333ThrThr: 2.333 ± 0.044	4.045ThrVal: 4.045 ± 0.053	0.567ThrTrp: 0.567 ± 0.022	0.808ThrTyr: 0.808 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	12.363ValAla: 12.363 ± 0.119	0.728ValCys: 0.728 ± 0.023	4.387ValAsp: 4.387 ± 0.061	4.936ValGlu: 4.936 ± 0.055	2.788ValPhe: 2.788 ± 0.045	6.125ValGly: 6.125 ± 0.08	1.187ValHis: 1.187 ± 0.03	3.407ValIle: 3.407 ± 0.052	1.628ValLys: 1.628 ± 0.036	6.7ValLeu: 6.7 ± 0.088	1.821ValMet: 1.821 ± 0.033	1.734ValAsn: 1.734 ± 0.038	2.529ValPro: 2.529 ± 0.041	1.465ValGln: 1.465 ± 0.035	5.119ValArg: 5.119 ± 0.066	4.252ValSer: 4.252 ± 0.062	4.402ValThr: 4.402 ± 0.065	6.048ValVal: 6.048 ± 0.073	1.091ValTrp: 1.091 ± 0.026	1.394ValTyr: 1.394 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.706TrpAla: 1.706 ± 0.037	0.142TrpCys: 0.142 ± 0.009	0.649TrpAsp: 0.649 ± 0.026	0.656TrpGlu: 0.656 ± 0.022	0.565TrpPhe: 0.565 ± 0.022	1.097TrpGly: 1.097 ± 0.027	0.223TrpHis: 0.223 ± 0.012	0.592TrpIle: 0.592 ± 0.02	0.302TrpLys: 0.302 ± 0.015	1.783TrpLeu: 1.783 ± 0.042	0.361TrpMet: 0.361 ± 0.017	0.323TrpAsn: 0.323 ± 0.016	0.829TrpPro: 0.829 ± 0.024	0.262TrpGln: 0.262 ± 0.014	1.842TrpArg: 1.842 ± 0.038	0.832TrpSer: 0.832 ± 0.025	0.85TrpThr: 0.85 ± 0.026	0.746TrpVal: 0.746 ± 0.023	0.244TrpTrp: 0.244 ± 0.013	0.192TrpTyr: 0.192 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.695TyrAla: 2.695 ± 0.039	0.189TyrCys: 0.189 ± 0.011	1.264TyrAsp: 1.264 ± 0.035	0.963TyrGlu: 0.963 ± 0.031	0.687TyrPhe: 0.687 ± 0.02	1.806TyrGly: 1.806 ± 0.035	0.357TyrHis: 0.357 ± 0.012	0.539TyrIle: 0.539 ± 0.022	0.308TyrLys: 0.308 ± 0.015	1.753TyrLeu: 1.753 ± 0.036	0.326TyrMet: 0.326 ± 0.015	0.4TyrAsn: 0.4 ± 0.016	0.884TyrPro: 0.884 ± 0.026	0.424TyrGln: 0.424 ± 0.018	1.43TyrArg: 1.43 ± 0.035	0.773TyrSer: 0.773 ± 0.025	0.809TyrThr: 0.809 ± 0.024	1.37TyrVal: 1.37 ± 0.033	0.298TyrTrp: 0.298 ± 0.016	0.41TyrTyr: 0.41 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4574 proteins (1452153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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