Amino acid dipepetide frequency for Glomus cerebriforme

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.759AlaAla: 2.759 ± 0.029	0.685AlaCys: 0.685 ± 0.011	2.237AlaAsp: 2.237 ± 0.02	2.995AlaGlu: 2.995 ± 0.028	2.244AlaPhe: 2.244 ± 0.023	2.052AlaGly: 2.052 ± 0.025	0.933AlaHis: 0.933 ± 0.013	3.839AlaIle: 3.839 ± 0.027	3.543AlaLys: 3.543 ± 0.023	4.307AlaLeu: 4.307 ± 0.035	0.948AlaMet: 0.948 ± 0.012	2.683AlaAsn: 2.683 ± 0.022	1.711AlaPro: 1.711 ± 0.018	1.757AlaGln: 1.757 ± 0.02	2.024AlaArg: 2.024 ± 0.022	3.406AlaSer: 3.406 ± 0.026	2.604AlaThr: 2.604 ± 0.021	2.347AlaVal: 2.347 ± 0.023	0.446AlaTrp: 0.446 ± 0.009	1.533AlaTyr: 1.533 ± 0.017	0.018AlaXaa: 0.018 ± 0.002
Cys	0.622CysAla: 0.622 ± 0.01	0.304CysCys: 0.304 ± 0.008	0.822CysAsp: 0.822 ± 0.012	0.936CysGlu: 0.936 ± 0.012	0.728CysPhe: 0.728 ± 0.01	0.925CysGly: 0.925 ± 0.015	0.382CysHis: 0.382 ± 0.008	1.091CysIle: 1.091 ± 0.013	1.236CysLys: 1.236 ± 0.016	1.532CysLeu: 1.532 ± 0.015	0.28CysMet: 0.28 ± 0.008	0.978CysAsn: 0.978 ± 0.014	0.657CysPro: 0.657 ± 0.012	0.641CysGln: 0.641 ± 0.011	0.645CysArg: 0.645 ± 0.01	1.063CysSer: 1.063 ± 0.013	0.658CysThr: 0.658 ± 0.011	0.701CysVal: 0.701 ± 0.011	0.28CysTrp: 0.28 ± 0.006	0.823CysTyr: 0.823 ± 0.018	0.005CysXaa: 0.005 ± 0.001
Asp	2.32AspAla: 2.32 ± 0.019	0.774AspCys: 0.774 ± 0.012	4.667AspAsp: 4.667 ± 0.038	4.62AspGlu: 4.62 ± 0.032	2.845AspPhe: 2.845 ± 0.024	2.589AspGly: 2.589 ± 0.023	1.133AspHis: 1.133 ± 0.013	5.024AspIle: 5.024 ± 0.031	4.133AspLys: 4.133 ± 0.028	5.242AspLeu: 5.242 ± 0.03	1.112AspMet: 1.112 ± 0.013	4.002AspAsn: 4.002 ± 0.026	2.268AspPro: 2.268 ± 0.023	1.831AspGln: 1.831 ± 0.016	1.986AspArg: 1.986 ± 0.021	3.931AspSer: 3.931 ± 0.028	2.609AspThr: 2.609 ± 0.02	2.987AspVal: 2.987 ± 0.021	0.682AspTrp: 0.682 ± 0.011	2.444AspTyr: 2.444 ± 0.023	0.025AspXaa: 0.025 ± 0.002
Glu	2.972GluAla: 2.972 ± 0.025	0.946GluCys: 0.946 ± 0.012	3.834GluAsp: 3.834 ± 0.028	6.041GluGlu: 6.041 ± 0.042	3.272GluPhe: 3.272 ± 0.024	2.603GluGly: 2.603 ± 0.021	1.26GluHis: 1.26 ± 0.015	6.495GluIle: 6.495 ± 0.034	6.198GluLys: 6.198 ± 0.04	6.596GluLeu: 6.596 ± 0.037	1.506GluMet: 1.506 ± 0.017	5.319GluAsn: 5.319 ± 0.034	1.833GluPro: 1.833 ± 0.018	2.523GluGln: 2.523 ± 0.021	2.994GluArg: 2.994 ± 0.023	4.478GluSer: 4.478 ± 0.028	3.398GluThr: 3.398 ± 0.026	3.495GluVal: 3.495 ± 0.026	0.96GluTrp: 0.96 ± 0.015	2.762GluTyr: 2.762 ± 0.023	0.028GluXaa: 0.028 ± 0.002
Phe	2.109PheAla: 2.109 ± 0.019	0.833PheCys: 0.833 ± 0.011	2.809PheAsp: 2.809 ± 0.021	3.166PheGlu: 3.166 ± 0.025	2.277PhePhe: 2.277 ± 0.023	2.64PheGly: 2.64 ± 0.024	1.132PheHis: 1.132 ± 0.013	3.883PheIle: 3.883 ± 0.029	3.188PheLys: 3.188 ± 0.026	4.31PheLeu: 4.31 ± 0.027	0.981PheMet: 0.981 ± 0.012	3.197PheAsn: 3.197 ± 0.024	1.698PhePro: 1.698 ± 0.017	1.677PheGln: 1.677 ± 0.018	1.788PheArg: 1.788 ± 0.016	3.775PheSer: 3.775 ± 0.028	2.522PheThr: 2.522 ± 0.019	2.351PheVal: 2.351 ± 0.02	0.568PheTrp: 0.568 ± 0.011	1.979PheTyr: 1.979 ± 0.018	0.02PheXaa: 0.02 ± 0.002
Gly	1.951GlyAla: 1.951 ± 0.023	0.748GlyCys: 0.748 ± 0.013	2.332GlyAsp: 2.332 ± 0.02	2.593GlyGlu: 2.593 ± 0.021	2.249GlyPhe: 2.249 ± 0.02	3.035GlyGly: 3.035 ± 0.038	1.043GlyHis: 1.043 ± 0.016	4.115GlyIle: 4.115 ± 0.033	3.542GlyLys: 3.542 ± 0.025	3.923GlyLeu: 3.923 ± 0.028	0.967GlyMet: 0.967 ± 0.014	2.965GlyAsn: 2.965 ± 0.024	1.421GlyPro: 1.421 ± 0.017	1.553GlyGln: 1.553 ± 0.017	2.051GlyArg: 2.051 ± 0.019	3.296GlySer: 3.296 ± 0.025	2.549GlyThr: 2.549 ± 0.021	2.519GlyVal: 2.519 ± 0.022	0.583GlyTrp: 0.583 ± 0.009	1.974GlyTyr: 1.974 ± 0.019	0.016GlyXaa: 0.016 ± 0.001
His	0.942HisAla: 0.942 ± 0.012	0.35HisCys: 0.35 ± 0.007	1.223HisAsp: 1.223 ± 0.015	1.323HisGlu: 1.323 ± 0.015	1.035HisPhe: 1.035 ± 0.011	0.983HisGly: 0.983 ± 0.011	0.733HisHis: 0.733 ± 0.014	1.706HisIle: 1.706 ± 0.019	1.418HisLys: 1.418 ± 0.015	2.112HisLeu: 2.112 ± 0.019	0.418HisMet: 0.418 ± 0.008	1.366HisAsn: 1.366 ± 0.016	1.04HisPro: 1.04 ± 0.015	0.905HisGln: 0.905 ± 0.011	0.969HisArg: 0.969 ± 0.012	1.771HisSer: 1.771 ± 0.019	1.001HisThr: 1.001 ± 0.014	1.106HisVal: 1.106 ± 0.012	0.229HisTrp: 0.229 ± 0.006	0.879HisTyr: 0.879 ± 0.011	0.007HisXaa: 0.007 ± 0.001
Ile	3.67IleAla: 3.67 ± 0.026	1.353IleCys: 1.353 ± 0.016	4.664IleAsp: 4.664 ± 0.027	5.325IleGlu: 5.325 ± 0.028	3.811IlePhe: 3.811 ± 0.033	3.57IleGly: 3.57 ± 0.03	1.822IleHis: 1.822 ± 0.016	7.175IleIle: 7.175 ± 0.044	6.395IleLys: 6.395 ± 0.041	7.707IleLeu: 7.707 ± 0.037	1.702IleMet: 1.702 ± 0.015	5.672IleAsn: 5.672 ± 0.035	3.796IlePro: 3.796 ± 0.027	3.02IleGln: 3.02 ± 0.022	3.306IleArg: 3.306 ± 0.023	6.689IleSer: 6.689 ± 0.036	4.505IleThr: 4.505 ± 0.027	4.047IleVal: 4.047 ± 0.026	0.91IleTrp: 0.91 ± 0.012	3.326IleTyr: 3.326 ± 0.027	0.035IleXaa: 0.035 ± 0.003
Lys	3.727LysAla: 3.727 ± 0.033	1.235LysCys: 1.235 ± 0.016	4.457LysAsp: 4.457 ± 0.029	6.204LysGlu: 6.204 ± 0.041	3.569LysPhe: 3.569 ± 0.026	3.001LysGly: 3.001 ± 0.024	1.532LysHis: 1.532 ± 0.015	6.463LysIle: 6.463 ± 0.036	7.374LysLys: 7.374 ± 0.047	7.223LysLeu: 7.223 ± 0.037	1.577LysMet: 1.577 ± 0.015	5.776LysAsn: 5.776 ± 0.036	2.546LysPro: 2.546 ± 0.021	2.875LysGln: 2.875 ± 0.022	3.901LysArg: 3.901 ± 0.032	5.706LysSer: 5.706 ± 0.034	3.636LysThr: 3.636 ± 0.025	3.847LysVal: 3.847 ± 0.024	0.964LysTrp: 0.964 ± 0.012	3.315LysTyr: 3.315 ± 0.023	0.032LysXaa: 0.032 ± 0.002
Leu	4.483LeuAla: 4.483 ± 0.028	1.445LeuCys: 1.445 ± 0.018	4.978LeuAsp: 4.978 ± 0.029	6.528LeuGlu: 6.528 ± 0.038	4.252LeuPhe: 4.252 ± 0.029	4.068LeuGly: 4.068 ± 0.032	2.063LeuHis: 2.063 ± 0.017	6.933LeuIle: 6.933 ± 0.041	7.692LeuLys: 7.692 ± 0.041	8.428LeuLeu: 8.428 ± 0.048	1.878LeuMet: 1.878 ± 0.016	5.982LeuAsn: 5.982 ± 0.03	4.02LeuPro: 4.02 ± 0.027	3.786LeuGln: 3.786 ± 0.028	4.273LeuArg: 4.273 ± 0.025	7.37LeuSer: 7.37 ± 0.037	4.709LeuThr: 4.709 ± 0.029	4.41LeuVal: 4.41 ± 0.026	1.05LeuTrp: 1.05 ± 0.013	3.484LeuTyr: 3.484 ± 0.026	0.033LeuXaa: 0.033 ± 0.002
Met	1.124MetAla: 1.124 ± 0.013	0.244MetCys: 0.244 ± 0.007	1.192MetAsp: 1.192 ± 0.014	1.522MetGlu: 1.522 ± 0.015	0.819MetPhe: 0.819 ± 0.01	0.879MetGly: 0.879 ± 0.013	0.367MetHis: 0.367 ± 0.007	1.607MetIle: 1.607 ± 0.017	1.691MetLys: 1.691 ± 0.019	1.609MetLeu: 1.609 ± 0.018	0.515MetMet: 0.515 ± 0.009	1.358MetAsn: 1.358 ± 0.015	0.724MetPro: 0.724 ± 0.011	0.702MetGln: 0.702 ± 0.011	0.841MetArg: 0.841 ± 0.012	1.758MetSer: 1.758 ± 0.016	1.132MetThr: 1.132 ± 0.012	1.101MetVal: 1.101 ± 0.013	0.234MetTrp: 0.234 ± 0.006	0.64MetTyr: 0.64 ± 0.01	0.009MetXaa: 0.009 ± 0.001
Asn	2.73AsnAla: 2.73 ± 0.023	1.016AsnCys: 1.016 ± 0.013	4.373AsnAsp: 4.373 ± 0.027	4.957AsnGlu: 4.957 ± 0.03	3.227AsnPhe: 3.227 ± 0.025	3.212AsnGly: 3.212 ± 0.027	1.436AsnHis: 1.436 ± 0.015	6.236AsnIle: 6.236 ± 0.037	5.194AsnLys: 5.194 ± 0.033	6.557AsnLeu: 6.557 ± 0.039	1.308AsnMet: 1.308 ± 0.013	6.69AsnAsn: 6.69 ± 0.053	2.7AsnPro: 2.7 ± 0.022	2.533AsnGln: 2.533 ± 0.02	2.514AsnArg: 2.514 ± 0.022	5.507AsnSer: 5.507 ± 0.034	3.464AsnThr: 3.464 ± 0.025	3.48AsnVal: 3.48 ± 0.025	0.798AsnTrp: 0.798 ± 0.011	2.93AsnTyr: 2.93 ± 0.024	0.029AsnXaa: 0.029 ± 0.002
Pro	1.725ProAla: 1.725 ± 0.019	0.422ProCys: 0.422 ± 0.008	2.142ProAsp: 2.142 ± 0.02	2.818ProGlu: 2.818 ± 0.019	1.887ProPhe: 1.887 ± 0.021	1.63ProGly: 1.63 ± 0.021	0.802ProHis: 0.802 ± 0.012	3.156ProIle: 3.156 ± 0.02	2.913ProLys: 2.913 ± 0.023	3.395ProLeu: 3.395 ± 0.024	0.666ProMet: 0.666 ± 0.011	2.877ProAsn: 2.877 ± 0.026	2.767ProPro: 2.767 ± 0.048	1.577ProGln: 1.577 ± 0.02	1.532ProArg: 1.532 ± 0.018	3.678ProSer: 3.678 ± 0.03	2.575ProThr: 2.575 ± 0.024	2.033ProVal: 2.033 ± 0.02	0.364ProTrp: 0.364 ± 0.007	1.625ProTyr: 1.625 ± 0.019	0.015ProXaa: 0.015 ± 0.002
Gln	1.593GlnAla: 1.593 ± 0.018	0.541GlnCys: 0.541 ± 0.009	1.908GlnAsp: 1.908 ± 0.018	2.762GlnGlu: 2.762 ± 0.024	1.611GlnPhe: 1.611 ± 0.016	1.363GlnGly: 1.363 ± 0.016	0.929GlnHis: 0.929 ± 0.013	3.035GlnIle: 3.035 ± 0.019	3.171GlnLys: 3.171 ± 0.026	3.505GlnLeu: 3.505 ± 0.023	0.775GlnMet: 0.775 ± 0.012	2.937GlnAsn: 2.937 ± 0.023	1.557GlnPro: 1.557 ± 0.019	2.402GlnGln: 2.402 ± 0.039	1.727GlnArg: 1.727 ± 0.018	2.69GlnSer: 2.69 ± 0.026	1.936GlnThr: 1.936 ± 0.02	1.835GlnVal: 1.835 ± 0.017	0.386GlnTrp: 0.386 ± 0.008	1.562GlnTyr: 1.562 ± 0.019	0.014GlnXaa: 0.014 ± 0.001
Arg	1.954ArgAla: 1.954 ± 0.016	0.633ArgCys: 0.633 ± 0.009	2.37ArgAsp: 2.37 ± 0.024	2.868ArgGlu: 2.868 ± 0.027	1.887ArgPhe: 1.887 ± 0.017	1.888ArgGly: 1.888 ± 0.019	0.942ArgHis: 0.942 ± 0.011	3.385ArgIle: 3.385 ± 0.021	3.802ArgLys: 3.802 ± 0.025	3.773ArgLeu: 3.773 ± 0.026	0.896ArgMet: 0.896 ± 0.013	2.908ArgAsn: 2.908 ± 0.022	1.87ArgPro: 1.87 ± 0.019	1.643ArgGln: 1.643 ± 0.018	2.501ArgArg: 2.501 ± 0.027	3.078ArgSer: 3.078 ± 0.027	2.085ArgThr: 2.085 ± 0.019	2.085ArgVal: 2.085 ± 0.02	0.488ArgTrp: 0.488 ± 0.008	1.574ArgTyr: 1.574 ± 0.017	0.013ArgXaa: 0.013 ± 0.002
Ser	3.281SerAla: 3.281 ± 0.029	1.093SerCys: 1.093 ± 0.016	4.464SerAsp: 4.464 ± 0.033	4.919SerGlu: 4.919 ± 0.03	3.804SerPhe: 3.804 ± 0.027	3.515SerGly: 3.515 ± 0.024	1.641SerHis: 1.641 ± 0.016	5.928SerIle: 5.928 ± 0.034	5.777SerLys: 5.777 ± 0.03	7.31SerLeu: 7.31 ± 0.035	1.394SerMet: 1.394 ± 0.015	5.592SerAsn: 5.592 ± 0.033	3.434SerPro: 3.434 ± 0.04	3.199SerGln: 3.199 ± 0.026	3.302SerArg: 3.302 ± 0.026	8.444SerSer: 8.444 ± 0.066	4.704SerThr: 4.704 ± 0.035	3.539SerVal: 3.539 ± 0.024	0.798SerTrp: 0.798 ± 0.011	2.673SerTyr: 2.673 ± 0.022	0.025SerXaa: 0.025 ± 0.002
Thr	2.445ThrAla: 2.445 ± 0.021	0.773ThrCys: 0.773 ± 0.011	2.61ThrAsp: 2.61 ± 0.02	3.16ThrGlu: 3.16 ± 0.025	2.619ThrPhe: 2.619 ± 0.02	2.465ThrGly: 2.465 ± 0.021	1.033ThrHis: 1.033 ± 0.014	4.317ThrIle: 4.317 ± 0.025	3.909ThrLys: 3.909 ± 0.029	4.932ThrLeu: 4.932 ± 0.031	0.949ThrMet: 0.949 ± 0.01	3.593ThrAsn: 3.593 ± 0.031	2.675ThrPro: 2.675 ± 0.027	1.825ThrGln: 1.825 ± 0.018	2.087ThrArg: 2.087 ± 0.016	4.978ThrSer: 4.978 ± 0.034	3.555ThrThr: 3.555 ± 0.035	2.553ThrVal: 2.553 ± 0.023	0.603ThrTrp: 0.603 ± 0.008	1.855ThrTyr: 1.855 ± 0.016	0.019ThrXaa: 0.019 ± 0.002
Val	2.599ValAla: 2.599 ± 0.027	0.731ValCys: 0.731 ± 0.011	2.965ValAsp: 2.965 ± 0.019	3.382ValGlu: 3.382 ± 0.026	2.205ValPhe: 2.205 ± 0.02	2.391ValGly: 2.391 ± 0.025	1.072ValHis: 1.072 ± 0.014	4.087ValIle: 4.087 ± 0.028	3.874ValLys: 3.874 ± 0.026	4.528ValLeu: 4.528 ± 0.026	1.084ValMet: 1.084 ± 0.012	3.218ValAsn: 3.218 ± 0.022	2.148ValPro: 2.148 ± 0.021	1.792ValGln: 1.792 ± 0.017	2.051ValArg: 2.051 ± 0.02	3.557ValSer: 3.557 ± 0.025	2.78ValThr: 2.78 ± 0.023	2.844ValVal: 2.844 ± 0.029	0.527ValTrp: 0.527 ± 0.008	1.856ValTyr: 1.856 ± 0.017	0.019ValXaa: 0.019 ± 0.002
Trp	0.471TrpAla: 0.471 ± 0.009	0.318TrpCys: 0.318 ± 0.007	0.762TrpAsp: 0.762 ± 0.012	0.779TrpGlu: 0.779 ± 0.011	0.499TrpPhe: 0.499 ± 0.01	0.476TrpGly: 0.476 ± 0.009	0.249TrpHis: 0.249 ± 0.006	0.999TrpIle: 0.999 ± 0.013	1.115TrpLys: 1.115 ± 0.011	0.907TrpLeu: 0.907 ± 0.011	0.263TrpMet: 0.263 ± 0.006	0.889TrpAsn: 0.889 ± 0.012	0.303TrpPro: 0.303 ± 0.007	0.373TrpGln: 0.373 ± 0.007	0.525TrpArg: 0.525 ± 0.01	0.765TrpSer: 0.765 ± 0.012	0.621TrpThr: 0.621 ± 0.009	0.524TrpVal: 0.524 ± 0.009	0.164TrpTrp: 0.164 ± 0.005	0.571TrpTyr: 0.571 ± 0.013	0.005TrpXaa: 0.005 ± 0.001
Tyr	1.58TyrAla: 1.58 ± 0.016	0.856TyrCys: 0.856 ± 0.013	2.393TyrAsp: 2.393 ± 0.021	2.586TyrGlu: 2.586 ± 0.021	2.043TyrPhe: 2.043 ± 0.02	2.116TyrGly: 2.116 ± 0.023	1.004TyrHis: 1.004 ± 0.014	2.996TyrIle: 2.996 ± 0.026	2.764TyrLys: 2.764 ± 0.026	3.938TyrLeu: 3.938 ± 0.025	0.842TyrMet: 0.842 ± 0.013	2.857TyrAsn: 2.857 ± 0.025	1.414TyrPro: 1.414 ± 0.016	1.607TyrGln: 1.607 ± 0.019	1.611TyrArg: 1.611 ± 0.014	2.87TyrSer: 2.87 ± 0.023	1.895TyrThr: 1.895 ± 0.016	1.89TyrVal: 1.89 ± 0.017	0.541TyrTrp: 0.541 ± 0.01	1.984TyrTyr: 1.984 ± 0.023	0.019TyrXaa: 0.019 ± 0.002
Xaa	0.014XaaAla: 0.014 ± 0.002	0.005XaaCys: 0.005 ± 0.001	0.024XaaAsp: 0.024 ± 0.002	0.028XaaGlu: 0.028 ± 0.002	0.019XaaPhe: 0.019 ± 0.002	0.019XaaGly: 0.019 ± 0.002	0.01XaaHis: 0.01 ± 0.001	0.031XaaIle: 0.031 ± 0.002	0.032XaaLys: 0.032 ± 0.003	0.033XaaLeu: 0.033 ± 0.002	0.009XaaMet: 0.009 ± 0.001	0.033XaaAsn: 0.033 ± 0.003	0.016XaaPro: 0.016 ± 0.002	0.017XaaGln: 0.017 ± 0.002	0.013XaaArg: 0.013 ± 0.001	0.027XaaSer: 0.027 ± 0.002	0.018XaaThr: 0.018 ± 0.002	0.017XaaVal: 0.017 ± 0.001	0.004XaaTrp: 0.004 ± 0.001	0.017XaaTyr: 0.017 ± 0.002	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 20972 proteins (6808095 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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