Amino acid dipepetide frequency for Hydrocarboniphaga effusa AP103

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.068AlaAla: 16.068 ± 0.15	1.194AlaCys: 1.194 ± 0.025	6.897AlaAsp: 6.897 ± 0.072	7.224AlaGlu: 7.224 ± 0.078	3.819AlaPhe: 3.819 ± 0.049	9.964AlaGly: 9.964 ± 0.102	2.276AlaHis: 2.276 ± 0.039	5.605AlaIle: 5.605 ± 0.063	3.732AlaLys: 3.732 ± 0.065	13.618AlaLeu: 13.618 ± 0.141	2.914AlaMet: 2.914 ± 0.048	2.99AlaAsn: 2.99 ± 0.055	5.807AlaPro: 5.807 ± 0.075	5.221AlaGln: 5.221 ± 0.076	8.619AlaArg: 8.619 ± 0.093	7.43AlaSer: 7.43 ± 0.085	5.645AlaThr: 5.645 ± 0.07	8.124AlaVal: 8.124 ± 0.074	1.583AlaTrp: 1.583 ± 0.035	2.714AlaTyr: 2.714 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.114CysAla: 1.114 ± 0.032	0.149CysCys: 0.149 ± 0.011	0.479CysAsp: 0.479 ± 0.017	0.517CysGlu: 0.517 ± 0.021	0.307CysPhe: 0.307 ± 0.014	0.94CysGly: 0.94 ± 0.027	0.249CysHis: 0.249 ± 0.014	0.365CysIle: 0.365 ± 0.016	0.242CysLys: 0.242 ± 0.014	0.803CysLeu: 0.803 ± 0.025	0.164CysMet: 0.164 ± 0.011	0.235CysAsn: 0.235 ± 0.012	0.445CysPro: 0.445 ± 0.021	0.214CysGln: 0.214 ± 0.014	0.584CysArg: 0.584 ± 0.022	0.559CysSer: 0.559 ± 0.019	0.421CysThr: 0.421 ± 0.017	0.698CysVal: 0.698 ± 0.02	0.129CysTrp: 0.129 ± 0.008	0.201CysTyr: 0.201 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.183AspAla: 7.183 ± 0.077	0.491AspCys: 0.491 ± 0.019	3.166AspAsp: 3.166 ± 0.053	3.622AspGlu: 3.622 ± 0.05	2.237AspPhe: 2.237 ± 0.035	5.172AspGly: 5.172 ± 0.071	1.164AspHis: 1.164 ± 0.031	2.505AspIle: 2.505 ± 0.048	1.692AspLys: 1.692 ± 0.042	5.709AspLeu: 5.709 ± 0.064	0.943AspMet: 0.943 ± 0.023	1.311AspAsn: 1.311 ± 0.035	3.002AspPro: 3.002 ± 0.041	1.763AspGln: 1.763 ± 0.032	4.192AspArg: 4.192 ± 0.052	2.798AspSer: 2.798 ± 0.046	2.525AspThr: 2.525 ± 0.044	3.836AspVal: 3.836 ± 0.057	1.052AspTrp: 1.052 ± 0.026	1.716AspTyr: 1.716 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.405GluAla: 7.405 ± 0.088	0.395GluCys: 0.395 ± 0.016	2.462GluAsp: 2.462 ± 0.042	2.468GluGlu: 2.468 ± 0.048	1.887GluPhe: 1.887 ± 0.033	3.752GluGly: 3.752 ± 0.05	1.409GluHis: 1.409 ± 0.032	2.996GluIle: 2.996 ± 0.043	1.921GluLys: 1.921 ± 0.038	6.648GluLeu: 6.648 ± 0.073	1.066GluMet: 1.066 ± 0.028	1.415GluAsn: 1.415 ± 0.039	2.783GluPro: 2.783 ± 0.049	2.688GluGln: 2.688 ± 0.048	5.217GluArg: 5.217 ± 0.067	3.265GluSer: 3.265 ± 0.043	2.859GluThr: 2.859 ± 0.048	3.79GluVal: 3.79 ± 0.053	0.701GluTrp: 0.701 ± 0.022	1.177GluTyr: 1.177 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.069PheAla: 4.069 ± 0.056	0.385PheCys: 0.385 ± 0.016	2.724PheAsp: 2.724 ± 0.047	2.21PheGlu: 2.21 ± 0.041	1.307PhePhe: 1.307 ± 0.041	3.481PheGly: 3.481 ± 0.053	0.723PheHis: 0.723 ± 0.024	1.424PheIle: 1.424 ± 0.033	1.14PheLys: 1.14 ± 0.029	2.794PheLeu: 2.794 ± 0.05	0.766PheMet: 0.766 ± 0.021	1.125PheAsn: 1.125 ± 0.032	1.434PhePro: 1.434 ± 0.029	0.952PheGln: 0.952 ± 0.026	2.098PheArg: 2.098 ± 0.037	2.237PheSer: 2.237 ± 0.041	1.937PheThr: 1.937 ± 0.039	2.83PheVal: 2.83 ± 0.039	0.489PheTrp: 0.489 ± 0.02	0.93PheTyr: 0.93 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.693GlyAla: 8.693 ± 0.085	0.814GlyCys: 0.814 ± 0.023	4.575GlyAsp: 4.575 ± 0.062	4.73GlyGlu: 4.73 ± 0.062	3.372GlyPhe: 3.372 ± 0.056	7.275GlyGly: 7.275 ± 0.105	1.763GlyHis: 1.763 ± 0.036	4.166GlyIle: 4.166 ± 0.056	3.144GlyLys: 3.144 ± 0.065	9.024GlyLeu: 9.024 ± 0.086	1.901GlyMet: 1.901 ± 0.041	2.266GlyAsn: 2.266 ± 0.052	2.998GlyPro: 2.998 ± 0.053	2.984GlyGln: 2.984 ± 0.048	5.892GlyArg: 5.892 ± 0.065	5.324GlySer: 5.324 ± 0.084	4.085GlyThr: 4.085 ± 0.063	6.251GlyVal: 6.251 ± 0.07	1.428GlyTrp: 1.428 ± 0.032	2.479GlyTyr: 2.479 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.412HisAla: 2.412 ± 0.044	0.262HisCys: 0.262 ± 0.013	1.15HisAsp: 1.15 ± 0.029	1.281HisGlu: 1.281 ± 0.032	0.858HisPhe: 0.858 ± 0.028	1.893HisGly: 1.893 ± 0.034	0.611HisHis: 0.611 ± 0.026	0.741HisIle: 0.741 ± 0.021	0.497HisLys: 0.497 ± 0.02	2.179HisLeu: 2.179 ± 0.039	0.394HisMet: 0.394 ± 0.015	0.433HisAsn: 0.433 ± 0.018	1.274HisPro: 1.274 ± 0.03	0.701HisGln: 0.701 ± 0.02	1.675HisArg: 1.675 ± 0.04	1.034HisSer: 1.034 ± 0.028	0.812HisThr: 0.812 ± 0.022	1.356HisVal: 1.356 ± 0.029	0.385HisTrp: 0.385 ± 0.014	0.686HisTyr: 0.686 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.684IleAla: 6.684 ± 0.065	0.387IleCys: 0.387 ± 0.017	3.503IleAsp: 3.503 ± 0.054	3.761IleGlu: 3.761 ± 0.054	1.312IlePhe: 1.312 ± 0.036	4.819IleGly: 4.819 ± 0.061	0.803IleHis: 0.803 ± 0.023	1.573IleIle: 1.573 ± 0.035	1.529IleLys: 1.529 ± 0.035	3.149IleLeu: 3.149 ± 0.054	0.677IleMet: 0.677 ± 0.022	1.401IleAsn: 1.401 ± 0.035	2.053IlePro: 2.053 ± 0.042	1.291IleGln: 1.291 ± 0.031	2.911IleArg: 2.911 ± 0.04	2.573IleSer: 2.573 ± 0.048	2.388IleThr: 2.388 ± 0.041	3.946IleVal: 3.946 ± 0.051	0.545IleTrp: 0.545 ± 0.016	1.058IleTyr: 1.058 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.974LysAla: 3.974 ± 0.069	0.176LysCys: 0.176 ± 0.011	1.449LysAsp: 1.449 ± 0.036	1.326LysGlu: 1.326 ± 0.036	0.867LysPhe: 0.867 ± 0.026	2.262LysGly: 2.262 ± 0.051	0.603LysHis: 0.603 ± 0.019	1.469LysIle: 1.469 ± 0.036	1.306LysLys: 1.306 ± 0.045	4.153LysLeu: 4.153 ± 0.057	0.634LysMet: 0.634 ± 0.022	0.878LysAsn: 0.878 ± 0.029	2.476LysPro: 2.476 ± 0.049	1.319LysGln: 1.319 ± 0.031	2.421LysArg: 2.421 ± 0.042	1.86LysSer: 1.86 ± 0.036	1.924LysThr: 1.924 ± 0.043	2.205LysVal: 2.205 ± 0.047	0.306LysTrp: 0.306 ± 0.016	0.582LysTyr: 0.582 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.571LeuAla: 13.571 ± 0.138	1.014LeuCys: 1.014 ± 0.023	6.522LeuAsp: 6.522 ± 0.071	5.35LeuGlu: 5.35 ± 0.071	3.574LeuPhe: 3.574 ± 0.046	8.534LeuGly: 8.534 ± 0.08	2.28LeuHis: 2.28 ± 0.043	4.828LeuIle: 4.828 ± 0.069	3.63LeuLys: 3.63 ± 0.062	11.616LeuLeu: 11.616 ± 0.141	2.256LeuMet: 2.256 ± 0.043	2.669LeuAsn: 2.669 ± 0.049	6.126LeuPro: 6.126 ± 0.067	4.139LeuGln: 4.139 ± 0.051	8.785LeuArg: 8.785 ± 0.098	7.065LeuSer: 7.065 ± 0.077	5.095LeuThr: 5.095 ± 0.066	7.427LeuVal: 7.427 ± 0.08	1.263LeuTrp: 1.263 ± 0.037	2.348LeuTyr: 2.348 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.35MetAla: 2.35 ± 0.041	0.144MetCys: 0.144 ± 0.01	0.844MetAsp: 0.844 ± 0.025	0.915MetGlu: 0.915 ± 0.025	0.648MetPhe: 0.648 ± 0.019	1.504MetGly: 1.504 ± 0.036	0.431MetHis: 0.431 ± 0.017	1.041MetIle: 1.041 ± 0.03	0.913MetLys: 0.913 ± 0.02	2.407MetLeu: 2.407 ± 0.041	0.468MetMet: 0.468 ± 0.018	0.707MetAsn: 0.707 ± 0.022	1.346MetPro: 1.346 ± 0.035	0.932MetGln: 0.932 ± 0.024	1.686MetArg: 1.686 ± 0.036	1.678MetSer: 1.678 ± 0.033	1.277MetThr: 1.277 ± 0.027	1.254MetVal: 1.254 ± 0.03	0.182MetTrp: 0.182 ± 0.012	0.295MetTyr: 0.295 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.26AsnAla: 3.26 ± 0.059	0.277AsnCys: 0.277 ± 0.014	1.398AsnAsp: 1.398 ± 0.034	1.389AsnGlu: 1.389 ± 0.033	1.016AsnPhe: 1.016 ± 0.031	2.507AsnGly: 2.507 ± 0.053	0.5AsnHis: 0.5 ± 0.017	1.141AsnIle: 1.141 ± 0.03	0.755AsnLys: 0.755 ± 0.022	2.905AsnLeu: 2.905 ± 0.053	0.442AsnMet: 0.442 ± 0.02	0.752AsnAsn: 0.752 ± 0.026	1.811AsnPro: 1.811 ± 0.04	0.887AsnGln: 0.887 ± 0.025	1.846AsnArg: 1.846 ± 0.041	1.375AsnSer: 1.375 ± 0.037	1.404AsnThr: 1.404 ± 0.035	1.974AsnVal: 1.974 ± 0.041	0.446AsnTrp: 0.446 ± 0.019	0.762AsnTyr: 0.762 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.577ProAla: 6.577 ± 0.093	0.309ProCys: 0.309 ± 0.015	3.17ProAsp: 3.17 ± 0.046	3.43ProGlu: 3.43 ± 0.045	1.665ProPhe: 1.665 ± 0.038	4.329ProGly: 4.329 ± 0.059	0.944ProHis: 0.944 ± 0.024	2.222ProIle: 2.222 ± 0.041	1.704ProLys: 1.704 ± 0.039	5.176ProLeu: 5.176 ± 0.058	1.302ProMet: 1.302 ± 0.031	1.447ProAsn: 1.447 ± 0.032	2.647ProPro: 2.647 ± 0.068	2.179ProGln: 2.179 ± 0.039	3.103ProArg: 3.103 ± 0.05	2.889ProSer: 2.889 ± 0.047	2.592ProThr: 2.592 ± 0.041	3.882ProVal: 3.882 ± 0.056	0.686ProTrp: 0.686 ± 0.023	1.191ProTyr: 1.191 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.105GlnAla: 5.105 ± 0.067	0.251GlnCys: 0.251 ± 0.014	1.541GlnAsp: 1.541 ± 0.036	1.461GlnGlu: 1.461 ± 0.034	1.256GlnPhe: 1.256 ± 0.027	2.712GlnGly: 2.712 ± 0.044	0.843GlnHis: 0.843 ± 0.024	1.99GlnIle: 1.99 ± 0.04	1.236GlnLys: 1.236 ± 0.026	4.395GlnLeu: 4.395 ± 0.064	0.851GlnMet: 0.851 ± 0.027	0.952GlnAsn: 0.952 ± 0.024	2.091GlnPro: 2.091 ± 0.042	1.96GlnGln: 1.96 ± 0.042	3.412GlnArg: 3.412 ± 0.06	2.184GlnSer: 2.184 ± 0.039	1.916GlnThr: 1.916 ± 0.038	2.563GlnVal: 2.563 ± 0.046	0.584GlnTrp: 0.584 ± 0.019	0.906GlnTyr: 0.906 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.473ArgAla: 7.473 ± 0.079	0.667ArgCys: 0.667 ± 0.023	4.087ArgAsp: 4.087 ± 0.058	4.748ArgGlu: 4.748 ± 0.071	3.038ArgPhe: 3.038 ± 0.047	5.026ArgGly: 5.026 ± 0.059	1.782ArgHis: 1.782 ± 0.04	4.004ArgIle: 4.004 ± 0.061	2.404ArgLys: 2.404 ± 0.043	8.784ArgLeu: 8.784 ± 0.092	1.664ArgMet: 1.664 ± 0.033	2.015ArgAsn: 2.015 ± 0.038	3.296ArgPro: 3.296 ± 0.053	2.866ArgGln: 2.866 ± 0.049	5.943ArgArg: 5.943 ± 0.083	4.55ArgSer: 4.55 ± 0.062	3.091ArgThr: 3.091 ± 0.05	5.128ArgVal: 5.128 ± 0.066	1.275ArgTrp: 1.275 ± 0.034	2.471ArgTyr: 2.471 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	7.338SerAla: 7.338 ± 0.085	0.53SerCys: 0.53 ± 0.021	3.115SerAsp: 3.115 ± 0.044	3.095SerGlu: 3.095 ± 0.044	2.332SerPhe: 2.332 ± 0.041	5.818SerGly: 5.818 ± 0.086	1.035SerHis: 1.035 ± 0.027	2.811SerIle: 2.811 ± 0.047	1.761SerLys: 1.761 ± 0.033	6.583SerLeu: 6.583 ± 0.091	1.335SerMet: 1.335 ± 0.028	1.623SerAsn: 1.623 ± 0.034	3.086SerPro: 3.086 ± 0.049	2.059SerGln: 2.059 ± 0.04	4.168SerArg: 4.168 ± 0.065	3.68SerSer: 3.68 ± 0.058	3.148SerThr: 3.148 ± 0.052	4.329SerVal: 4.329 ± 0.062	0.906SerTrp: 0.906 ± 0.024	1.488SerTyr: 1.488 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.832ThrAla: 5.832 ± 0.073	0.337ThrCys: 0.337 ± 0.018	2.483ThrAsp: 2.483 ± 0.044	2.407ThrGlu: 2.407 ± 0.044	1.507ThrPhe: 1.507 ± 0.032	4.361ThrGly: 4.361 ± 0.067	1.049ThrHis: 1.049 ± 0.027	2.253ThrIle: 2.253 ± 0.042	1.183ThrLys: 1.183 ± 0.031	6.155ThrLeu: 6.155 ± 0.073	0.929ThrMet: 0.929 ± 0.024	1.189ThrAsn: 1.189 ± 0.032	3.351ThrPro: 3.351 ± 0.045	2.041ThrGln: 2.041 ± 0.038	3.576ThrArg: 3.576 ± 0.049	2.778ThrSer: 2.778 ± 0.051	2.622ThrThr: 2.622 ± 0.053	3.72ThrVal: 3.72 ± 0.055	0.607ThrTrp: 0.607 ± 0.026	1.151ThrTyr: 1.151 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.259ValAla: 8.259 ± 0.081	0.679ValCys: 0.679 ± 0.021	4.294ValAsp: 4.294 ± 0.065	4.391ValGlu: 4.391 ± 0.054	2.509ValPhe: 2.509 ± 0.042	5.581ValGly: 5.581 ± 0.068	1.406ValHis: 1.406 ± 0.032	3.677ValIle: 3.677 ± 0.056	2.174ValLys: 2.174 ± 0.041	7.608ValLeu: 7.608 ± 0.083	1.565ValMet: 1.565 ± 0.03	2.129ValAsn: 2.129 ± 0.042	3.597ValPro: 3.597 ± 0.053	2.468ValGln: 2.468 ± 0.044	4.884ValArg: 4.884 ± 0.061	4.519ValSer: 4.519 ± 0.06	3.748ValThr: 3.748 ± 0.055	5.433ValVal: 5.433 ± 0.074	0.855ValTrp: 0.855 ± 0.028	1.606ValTyr: 1.606 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.242TrpAla: 1.242 ± 0.031	0.129TrpCys: 0.129 ± 0.01	0.638TrpAsp: 0.638 ± 0.023	0.553TrpGlu: 0.553 ± 0.023	0.581TrpPhe: 0.581 ± 0.022	0.888TrpGly: 0.888 ± 0.022	0.309TrpHis: 0.309 ± 0.014	0.727TrpIle: 0.727 ± 0.025	0.514TrpLys: 0.514 ± 0.021	1.895TrpLeu: 1.895 ± 0.042	0.355TrpMet: 0.355 ± 0.015	0.545TrpAsn: 0.545 ± 0.023	0.704TrpPro: 0.704 ± 0.022	0.638TrpGln: 0.638 ± 0.023	1.178TrpArg: 1.178 ± 0.029	0.972TrpSer: 0.972 ± 0.028	0.754TrpThr: 0.754 ± 0.024	0.877TrpVal: 0.877 ± 0.028	0.231TrpTrp: 0.231 ± 0.013	0.323TrpTyr: 0.323 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.833TyrAla: 2.833 ± 0.046	0.227TyrCys: 0.227 ± 0.011	1.583TyrAsp: 1.583 ± 0.038	1.429TyrGlu: 1.429 ± 0.032	0.963TyrPhe: 0.963 ± 0.026	2.345TyrGly: 2.345 ± 0.047	0.451TyrHis: 0.451 ± 0.019	0.821TyrIle: 0.821 ± 0.025	0.712TyrLys: 0.712 ± 0.021	2.491TyrLeu: 2.491 ± 0.048	0.396TyrMet: 0.396 ± 0.016	0.763TyrAsn: 0.763 ± 0.028	1.12TyrPro: 1.12 ± 0.035	0.911TyrGln: 0.911 ± 0.027	2.121TyrArg: 2.121 ± 0.037	1.469TyrSer: 1.469 ± 0.035	1.289TyrThr: 1.289 ± 0.035	1.76TyrVal: 1.76 ± 0.037	0.399TyrTrp: 0.399 ± 0.017	0.739TyrTyr: 0.739 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4474 proteins (1483553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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