Amino acid dipepetide frequency for Candidatus Ishikawaella capsulata Mpkobe

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.45AlaAla: 4.45 ± 0.18
0.936AlaCys: 0.936 ± 0.076
2.676AlaAsp: 2.676 ± 0.12
3.303AlaGlu: 3.303 ± 0.163
2.176AlaPhe: 2.176 ± 0.111
3.911AlaGly: 3.911 ± 0.152
1.328AlaHis: 1.328 ± 0.079
6.567AlaIle: 6.567 ± 0.19
4.259AlaLys: 4.259 ± 0.141
6.131AlaLeu: 6.131 ± 0.193
1.759AlaMet: 1.759 ± 0.106
3.288AlaAsn: 3.288 ± 0.123
1.47AlaPro: 1.47 ± 0.08
1.98AlaGln: 1.98 ± 0.108
2.94AlaArg: 2.94 ± 0.117
3.283AlaSer: 3.283 ± 0.124
3.073AlaThr: 3.073 ± 0.121
3.475AlaVal: 3.475 ± 0.112
0.573AlaTrp: 0.573 ± 0.049
1.95AlaTyr: 1.95 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.789CysAla: 0.789 ± 0.062
0.255CysCys: 0.255 ± 0.038
0.706CysAsp: 0.706 ± 0.061
0.706CysGlu: 0.706 ± 0.061
0.637CysPhe: 0.637 ± 0.054
1.088CysGly: 1.088 ± 0.081
0.392CysHis: 0.392 ± 0.046
1.436CysIle: 1.436 ± 0.097
0.872CysLys: 0.872 ± 0.063
1.284CysLeu: 1.284 ± 0.071
0.343CysMet: 0.343 ± 0.038
0.853CysAsn: 0.853 ± 0.071
0.534CysPro: 0.534 ± 0.053
0.519CysGln: 0.519 ± 0.055
0.603CysArg: 0.603 ± 0.049
1.059CysSer: 1.059 ± 0.076
0.647CysThr: 0.647 ± 0.066
0.745CysVal: 0.745 ± 0.066
0.172CysTrp: 0.172 ± 0.029
0.564CysTyr: 0.564 ± 0.054
0.0CysXaa: 0.0 ± 0.0
Asp
2.725AspAla: 2.725 ± 0.115
0.554AspCys: 0.554 ± 0.046
1.701AspAsp: 1.701 ± 0.111
2.293AspGlu: 2.293 ± 0.103
2.093AspPhe: 2.093 ± 0.105
2.406AspGly: 2.406 ± 0.111
1.034AspHis: 1.034 ± 0.075
5.94AspIle: 5.94 ± 0.192
3.377AspLys: 3.377 ± 0.134
4.744AspLeu: 4.744 ± 0.155
1.201AspMet: 1.201 ± 0.078
2.896AspAsn: 2.896 ± 0.129
1.544AspPro: 1.544 ± 0.082
1.47AspGln: 1.47 ± 0.075
1.936AspArg: 1.936 ± 0.103
2.47AspSer: 2.47 ± 0.106
2.186AspThr: 2.186 ± 0.1
2.455AspVal: 2.455 ± 0.118
0.515AspTrp: 0.515 ± 0.051
1.803AspTyr: 1.803 ± 0.088
0.0AspXaa: 0.0 ± 0.0
Glu
3.44GluAla: 3.44 ± 0.14
0.539GluCys: 0.539 ± 0.046
2.328GluAsp: 2.328 ± 0.114
3.313GluGlu: 3.313 ± 0.131
1.887GluPhe: 1.887 ± 0.088
2.754GluGly: 2.754 ± 0.136
1.22GluHis: 1.22 ± 0.086
6.033GluIle: 6.033 ± 0.177
4.592GluLys: 4.592 ± 0.161
5.508GluLeu: 5.508 ± 0.142
1.549GluMet: 1.549 ± 0.085
3.298GluAsn: 3.298 ± 0.172
1.372GluPro: 1.372 ± 0.086
2.235GluGln: 2.235 ± 0.111
2.519GluArg: 2.519 ± 0.125
2.96GluSer: 2.96 ± 0.123
2.298GluThr: 2.298 ± 0.114
3.308GluVal: 3.308 ± 0.139
0.554GluTrp: 0.554 ± 0.06
2.029GluTyr: 2.029 ± 0.096
0.0GluXaa: 0.0 ± 0.0
Phe
2.156PheAla: 2.156 ± 0.113
0.838PheCys: 0.838 ± 0.065
2.053PheAsp: 2.053 ± 0.107
1.705PheGlu: 1.705 ± 0.096
1.975PhePhe: 1.975 ± 0.12
2.49PheGly: 2.49 ± 0.103
1.0PheHis: 1.0 ± 0.075
4.352PheIle: 4.352 ± 0.183
2.48PheLys: 2.48 ± 0.111
4.009PheLeu: 4.009 ± 0.16
1.034PheMet: 1.034 ± 0.073
2.823PheAsn: 2.823 ± 0.11
1.509PhePro: 1.509 ± 0.089
1.23PheGln: 1.23 ± 0.083
1.568PheArg: 1.568 ± 0.093
3.328PheSer: 3.328 ± 0.145
2.195PheThr: 2.195 ± 0.094
1.799PheVal: 1.799 ± 0.099
0.466PheTrp: 0.466 ± 0.057
1.607PheTyr: 1.607 ± 0.092
0.0PheXaa: 0.0 ± 0.0
Gly
3.626GlyAla: 3.626 ± 0.171
1.054GlyCys: 1.054 ± 0.084
2.744GlyAsp: 2.744 ± 0.119
2.955GlyGlu: 2.955 ± 0.156
2.578GlyPhe: 2.578 ± 0.117
3.94GlyGly: 3.94 ± 0.169
1.612GlyHis: 1.612 ± 0.099
7.341GlyIle: 7.341 ± 0.202
4.528GlyLys: 4.528 ± 0.138
5.484GlyLeu: 5.484 ± 0.171
1.642GlyMet: 1.642 ± 0.096
3.205GlyAsn: 3.205 ± 0.115
1.705GlyPro: 1.705 ± 0.088
2.004GlyGln: 2.004 ± 0.117
2.798GlyArg: 2.798 ± 0.113
3.367GlySer: 3.367 ± 0.119
2.999GlyThr: 2.999 ± 0.128
3.622GlyVal: 3.622 ± 0.158
0.647GlyTrp: 0.647 ± 0.06
2.323GlyTyr: 2.323 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
1.289HisAla: 1.289 ± 0.074
0.319HisCys: 0.319 ± 0.036
0.931HisAsp: 0.931 ± 0.068
1.024HisGlu: 1.024 ± 0.077
1.098HisPhe: 1.098 ± 0.065
1.701HisGly: 1.701 ± 0.09
0.75HisHis: 0.75 ± 0.065
2.568HisIle: 2.568 ± 0.105
1.48HisLys: 1.48 ± 0.079
2.46HisLeu: 2.46 ± 0.123
0.603HisMet: 0.603 ± 0.053
1.573HisAsn: 1.573 ± 0.089
1.274HisPro: 1.274 ± 0.075
0.956HisGln: 0.956 ± 0.065
1.171HisArg: 1.171 ± 0.078
1.406HisSer: 1.406 ± 0.071
1.269HisThr: 1.269 ± 0.076
1.083HisVal: 1.083 ± 0.078
0.289HisTrp: 0.289 ± 0.039
1.019HisTyr: 1.019 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
7.091IleAla: 7.091 ± 0.186
1.72IleCys: 1.72 ± 0.087
5.856IleAsp: 5.856 ± 0.156
5.866IleGlu: 5.866 ± 0.176
4.357IlePhe: 4.357 ± 0.176
6.488IleGly: 6.488 ± 0.186
2.333IleHis: 2.333 ± 0.117
10.649IleIle: 10.649 ± 0.306
7.919IleLys: 7.919 ± 0.218
9.934IleLeu: 9.934 ± 0.249
2.455IleMet: 2.455 ± 0.116
7.674IleAsn: 7.674 ± 0.218
4.131IlePro: 4.131 ± 0.143
3.45IleGln: 3.45 ± 0.131
4.474IleArg: 4.474 ± 0.131
7.915IleSer: 7.915 ± 0.214
5.734IleThr: 5.734 ± 0.185
5.298IleVal: 5.298 ± 0.166
1.019IleTrp: 1.019 ± 0.076
3.568IleTyr: 3.568 ± 0.16
0.0IleXaa: 0.0 ± 0.0
Lys
3.484LysAla: 3.484 ± 0.164
0.921LysCys: 0.921 ± 0.077
3.215LysAsp: 3.215 ± 0.132
4.273LysGlu: 4.273 ± 0.169
2.436LysPhe: 2.436 ± 0.11
3.646LysGly: 3.646 ± 0.139
1.598LysHis: 1.598 ± 0.078
8.321LysIle: 8.321 ± 0.209
6.782LysLys: 6.782 ± 0.226
7.513LysLeu: 7.513 ± 0.204
2.068LysMet: 2.068 ± 0.103
5.41LysAsn: 5.41 ± 0.172
2.166LysPro: 2.166 ± 0.101
2.862LysGln: 2.862 ± 0.128
3.234LysArg: 3.234 ± 0.14
4.092LysSer: 4.092 ± 0.162
3.416LysThr: 3.416 ± 0.148
3.867LysVal: 3.867 ± 0.141
0.676LysTrp: 0.676 ± 0.065
3.401LysTyr: 3.401 ± 0.132
0.0LysXaa: 0.0 ± 0.0
Leu
6.464LeuAla: 6.464 ± 0.184
1.22LeuCys: 1.22 ± 0.082
4.602LeuAsp: 4.602 ± 0.152
5.979LeuGlu: 5.979 ± 0.201
3.891LeuPhe: 3.891 ± 0.158
5.685LeuGly: 5.685 ± 0.177
2.578LeuHis: 2.578 ± 0.105
9.615LeuIle: 9.615 ± 0.278
7.096LeuLys: 7.096 ± 0.178
10.747LeuLeu: 10.747 ± 0.332
2.494LeuMet: 2.494 ± 0.117
6.39LeuAsn: 6.39 ± 0.165
4.391LeuPro: 4.391 ± 0.16
3.916LeuGln: 3.916 ± 0.138
4.901LeuArg: 4.901 ± 0.192
6.969LeuSer: 6.969 ± 0.198
5.293LeuThr: 5.293 ± 0.176
5.508LeuVal: 5.508 ± 0.161
0.951LeuTrp: 0.951 ± 0.083
3.009LeuTyr: 3.009 ± 0.11
0.0LeuXaa: 0.0 ± 0.0
Met
1.544MetAla: 1.544 ± 0.088
0.323MetCys: 0.323 ± 0.042
0.921MetAsp: 0.921 ± 0.073
1.161MetGlu: 1.161 ± 0.072
0.818MetPhe: 0.818 ± 0.064
1.701MetGly: 1.701 ± 0.101
0.691MetHis: 0.691 ± 0.055
2.592MetIle: 2.592 ± 0.121
1.803MetLys: 1.803 ± 0.102
2.852MetLeu: 2.852 ± 0.128
0.784MetMet: 0.784 ± 0.063
1.436MetAsn: 1.436 ± 0.079
1.014MetPro: 1.014 ± 0.081
1.21MetGln: 1.21 ± 0.074
1.367MetArg: 1.367 ± 0.086
1.72MetSer: 1.72 ± 0.102
1.186MetThr: 1.186 ± 0.07
1.367MetVal: 1.367 ± 0.08
0.172MetTrp: 0.172 ± 0.029
0.74MetTyr: 0.74 ± 0.055
0.0MetXaa: 0.0 ± 0.0
Asn
2.984AsnAla: 2.984 ± 0.121
0.809AsnCys: 0.809 ± 0.059
2.416AsnAsp: 2.416 ± 0.108
2.989AsnGlu: 2.989 ± 0.13
3.112AsnPhe: 3.112 ± 0.111
2.882AsnGly: 2.882 ± 0.126
1.583AsnHis: 1.583 ± 0.095
8.4AsnIle: 8.4 ± 0.245
5.538AsnLys: 5.538 ± 0.191
5.979AsnLeu: 5.979 ± 0.166
1.578AsnMet: 1.578 ± 0.091
5.087AsnAsn: 5.087 ± 0.18
2.494AsnPro: 2.494 ± 0.133
2.122AsnGln: 2.122 ± 0.104
2.602AsnArg: 2.602 ± 0.102
3.661AsnSer: 3.661 ± 0.146
3.347AsnThr: 3.347 ± 0.174
2.984AsnVal: 2.984 ± 0.122
0.691AsnTrp: 0.691 ± 0.052
2.597AsnTyr: 2.597 ± 0.116
0.0AsnXaa: 0.0 ± 0.0
Pro
1.852ProAla: 1.852 ± 0.108
0.47ProCys: 0.47 ± 0.048
1.637ProAsp: 1.637 ± 0.09
2.284ProGlu: 2.284 ± 0.101
1.5ProPhe: 1.5 ± 0.1
2.421ProGly: 2.421 ± 0.118
0.965ProHis: 0.965 ± 0.072
3.891ProIle: 3.891 ± 0.149
2.024ProLys: 2.024 ± 0.083
3.867ProLeu: 3.867 ± 0.128
0.745ProMet: 0.745 ± 0.059
1.995ProAsn: 1.995 ± 0.098
1.078ProPro: 1.078 ± 0.074
1.142ProGln: 1.142 ± 0.089
1.22ProArg: 1.22 ± 0.08
1.96ProSer: 1.96 ± 0.103
1.794ProThr: 1.794 ± 0.093
2.225ProVal: 2.225 ± 0.095
0.402ProTrp: 0.402 ± 0.044
1.656ProTyr: 1.656 ± 0.095
0.0ProXaa: 0.0 ± 0.0
Gln
2.504GlnAla: 2.504 ± 0.12
0.392GlnCys: 0.392 ± 0.043
1.519GlnAsp: 1.519 ± 0.08
2.151GlnGlu: 2.151 ± 0.115
1.25GlnPhe: 1.25 ± 0.079
2.254GlnGly: 2.254 ± 0.095
0.774GlnHis: 0.774 ± 0.058
3.896GlnIle: 3.896 ± 0.128
2.882GlnLys: 2.882 ± 0.128
3.876GlnLeu: 3.876 ± 0.138
0.907GlnMet: 0.907 ± 0.056
2.009GlnAsn: 2.009 ± 0.113
1.206GlnPro: 1.206 ± 0.074
1.632GlnGln: 1.632 ± 0.098
1.931GlnArg: 1.931 ± 0.101
1.921GlnSer: 1.921 ± 0.088
1.509GlnThr: 1.509 ± 0.087
1.975GlnVal: 1.975 ± 0.092
0.397GlnTrp: 0.397 ± 0.046
1.49GlnTyr: 1.49 ± 0.085
0.0GlnXaa: 0.0 ± 0.0
Arg
2.563ArgAla: 2.563 ± 0.093
0.632ArgCys: 0.632 ± 0.053
2.176ArgAsp: 2.176 ± 0.096
2.735ArgGlu: 2.735 ± 0.128
2.034ArgPhe: 2.034 ± 0.096
2.651ArgGly: 2.651 ± 0.131
1.049ArgHis: 1.049 ± 0.068
4.651ArgIle: 4.651 ± 0.163
3.156ArgLys: 3.156 ± 0.122
4.675ArgLeu: 4.675 ± 0.168
1.039ArgMet: 1.039 ± 0.074
2.666ArgAsn: 2.666 ± 0.114
1.485ArgPro: 1.485 ± 0.082
1.911ArgGln: 1.911 ± 0.105
2.411ArgArg: 2.411 ± 0.138
2.524ArgSer: 2.524 ± 0.112
1.98ArgThr: 1.98 ± 0.106
2.347ArgVal: 2.347 ± 0.133
0.519ArgTrp: 0.519 ± 0.043
1.867ArgTyr: 1.867 ± 0.099
0.0ArgXaa: 0.0 ± 0.0
Ser
3.788SerAla: 3.788 ± 0.146
0.916SerCys: 0.916 ± 0.071
2.72SerAsp: 2.72 ± 0.112
3.078SerGlu: 3.078 ± 0.114
2.592SerPhe: 2.592 ± 0.11
4.166SerGly: 4.166 ± 0.134
1.514SerHis: 1.514 ± 0.09
6.43SerIle: 6.43 ± 0.182
4.283SerLys: 4.283 ± 0.136
6.871SerLeu: 6.871 ± 0.211
1.627SerMet: 1.627 ± 0.079
3.896SerAsn: 3.896 ± 0.151
1.975SerPro: 1.975 ± 0.09
2.24SerGln: 2.24 ± 0.11
2.847SerArg: 2.847 ± 0.142
4.288SerSer: 4.288 ± 0.165
3.038SerThr: 3.038 ± 0.108
3.386SerVal: 3.386 ± 0.15
0.691SerTrp: 0.691 ± 0.065
2.352SerTyr: 2.352 ± 0.095
0.0SerXaa: 0.0 ± 0.0
Thr
3.156ThrAla: 3.156 ± 0.136
0.74ThrCys: 0.74 ± 0.061
2.254ThrAsp: 2.254 ± 0.116
2.548ThrGlu: 2.548 ± 0.103
1.941ThrPhe: 1.941 ± 0.093
3.876ThrGly: 3.876 ± 0.145
1.245ThrHis: 1.245 ± 0.077
4.754ThrIle: 4.754 ± 0.17
3.185ThrLys: 3.185 ± 0.125
5.204ThrLeu: 5.204 ± 0.172
0.99ThrMet: 0.99 ± 0.069
2.95ThrAsn: 2.95 ± 0.122
2.078ThrPro: 2.078 ± 0.099
1.598ThrGln: 1.598 ± 0.101
2.181ThrArg: 2.181 ± 0.09
3.132ThrSer: 3.132 ± 0.125
2.69ThrThr: 2.69 ± 0.114
3.073ThrVal: 3.073 ± 0.172
0.505ThrTrp: 0.505 ± 0.062
1.47ThrTyr: 1.47 ± 0.083
0.0ThrXaa: 0.0 ± 0.0
Val
3.22ValAla: 3.22 ± 0.147
0.769ValCys: 0.769 ± 0.064
2.632ValAsp: 2.632 ± 0.114
3.161ValGlu: 3.161 ± 0.138
2.058ValPhe: 2.058 ± 0.114
3.45ValGly: 3.45 ± 0.151
1.157ValHis: 1.157 ± 0.078
6.013ValIle: 6.013 ± 0.193
3.867ValLys: 3.867 ± 0.154
5.146ValLeu: 5.146 ± 0.15
1.338ValMet: 1.338 ± 0.081
3.421ValAsn: 3.421 ± 0.129
2.073ValPro: 2.073 ± 0.1
1.671ValGln: 1.671 ± 0.087
2.215ValArg: 2.215 ± 0.118
3.646ValSer: 3.646 ± 0.144
2.872ValThr: 2.872 ± 0.105
3.249ValVal: 3.249 ± 0.148
0.358ValTrp: 0.358 ± 0.041
1.593ValTyr: 1.593 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.446TrpAla: 0.446 ± 0.046
0.181TrpCys: 0.181 ± 0.033
0.431TrpAsp: 0.431 ± 0.044
0.441TrpGlu: 0.441 ± 0.058
0.426TrpPhe: 0.426 ± 0.04
0.461TrpGly: 0.461 ± 0.045
0.392TrpHis: 0.392 ± 0.054
1.054TrpIle: 1.054 ± 0.08
0.662TrpLys: 0.662 ± 0.065
1.377TrpLeu: 1.377 ± 0.093
0.309TrpMet: 0.309 ± 0.042
0.632TrpAsn: 0.632 ± 0.055
0.333TrpPro: 0.333 ± 0.038
0.72TrpGln: 0.72 ± 0.066
0.47TrpArg: 0.47 ± 0.059
0.583TrpSer: 0.583 ± 0.052
0.338TrpThr: 0.338 ± 0.043
0.431TrpVal: 0.431 ± 0.041
0.098TrpTrp: 0.098 ± 0.023
0.377TrpTyr: 0.377 ± 0.044
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.955TyrAla: 1.955 ± 0.102
0.613TyrCys: 0.613 ± 0.052
1.823TyrAsp: 1.823 ± 0.087
1.769TyrGlu: 1.769 ± 0.091
1.759TyrPhe: 1.759 ± 0.105
2.205TyrGly: 2.205 ± 0.089
1.049TyrHis: 1.049 ± 0.075
3.43TyrIle: 3.43 ± 0.147
2.602TyrLys: 2.602 ± 0.116
4.038TyrLeu: 4.038 ± 0.136
0.936TyrMet: 0.936 ± 0.071
2.352TyrAsn: 2.352 ± 0.115
1.294TyrPro: 1.294 ± 0.084
1.607TyrGln: 1.607 ± 0.074
1.681TyrArg: 1.681 ± 0.1
2.416TyrSer: 2.416 ± 0.109
1.705TyrThr: 1.705 ± 0.089
1.71TyrVal: 1.71 ± 0.09
0.47TyrTrp: 0.47 ± 0.059
1.436TyrTyr: 1.436 ± 0.098
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 623 proteins (204056 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski