Amino acid dipepetide frequency for Devosia sp. I507

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.898AlaAla: 15.898 ± 0.16
0.784AlaCys: 0.784 ± 0.027
7.032AlaAsp: 7.032 ± 0.089
7.925AlaGlu: 7.925 ± 0.101
4.389AlaPhe: 4.389 ± 0.072
10.574AlaGly: 10.574 ± 0.106
2.199AlaHis: 2.199 ± 0.047
7.045AlaIle: 7.045 ± 0.077
3.37AlaLys: 3.37 ± 0.059
14.007AlaLeu: 14.007 ± 0.142
3.888AlaMet: 3.888 ± 0.051
3.273AlaAsn: 3.273 ± 0.062
5.429AlaPro: 5.429 ± 0.082
4.399AlaGln: 4.399 ± 0.075
8.048AlaArg: 8.048 ± 0.117
6.208AlaSer: 6.208 ± 0.083
6.021AlaThr: 6.021 ± 0.075
8.487AlaVal: 8.487 ± 0.085
1.406AlaTrp: 1.406 ± 0.036
2.592AlaTyr: 2.592 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.029
0.095CysCys: 0.095 ± 0.009
0.435CysAsp: 0.435 ± 0.02
0.336CysGlu: 0.336 ± 0.017
0.27CysPhe: 0.27 ± 0.016
0.743CysGly: 0.743 ± 0.028
0.214CysHis: 0.214 ± 0.013
0.322CysIle: 0.322 ± 0.016
0.13CysLys: 0.13 ± 0.011
0.69CysLeu: 0.69 ± 0.025
0.132CysMet: 0.132 ± 0.011
0.175CysAsn: 0.175 ± 0.011
0.361CysPro: 0.361 ± 0.018
0.227CysGln: 0.227 ± 0.014
0.469CysArg: 0.469 ± 0.02
0.385CysSer: 0.385 ± 0.02
0.321CysThr: 0.321 ± 0.015
0.499CysVal: 0.499 ± 0.022
0.114CysTrp: 0.114 ± 0.01
0.152CysTyr: 0.152 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.704AspAla: 6.704 ± 0.099
0.426AspCys: 0.426 ± 0.02
3.035AspAsp: 3.035 ± 0.07
3.608AspGlu: 3.608 ± 0.054
2.333AspPhe: 2.333 ± 0.048
5.112AspGly: 5.112 ± 0.077
1.262AspHis: 1.262 ± 0.034
3.418AspIle: 3.418 ± 0.051
1.741AspLys: 1.741 ± 0.039
6.162AspLeu: 6.162 ± 0.074
1.476AspMet: 1.476 ± 0.036
1.603AspAsn: 1.603 ± 0.039
3.458AspPro: 3.458 ± 0.056
1.976AspGln: 1.976 ± 0.04
3.92AspArg: 3.92 ± 0.063
2.248AspSer: 2.248 ± 0.049
2.797AspThr: 2.797 ± 0.057
4.046AspVal: 4.046 ± 0.065
1.082AspTrp: 1.082 ± 0.03
1.555AspTyr: 1.555 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
7.68GluAla: 7.68 ± 0.094
0.296GluCys: 0.296 ± 0.018
2.899GluAsp: 2.899 ± 0.049
3.192GluGlu: 3.192 ± 0.065
1.818GluPhe: 1.818 ± 0.039
4.401GluGly: 4.401 ± 0.076
1.29GluHis: 1.29 ± 0.037
3.554GluIle: 3.554 ± 0.058
2.052GluLys: 2.052 ± 0.044
5.667GluLeu: 5.667 ± 0.066
1.613GluMet: 1.613 ± 0.036
1.664GluAsn: 1.664 ± 0.04
2.763GluPro: 2.763 ± 0.057
2.383GluGln: 2.383 ± 0.049
4.426GluArg: 4.426 ± 0.065
2.333GluSer: 2.333 ± 0.046
3.72GluThr: 3.72 ± 0.06
4.062GluVal: 4.062 ± 0.068
0.704GluTrp: 0.704 ± 0.025
1.007GluTyr: 1.007 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.913PheAla: 4.913 ± 0.074
0.361PheCys: 0.361 ± 0.018
2.729PheAsp: 2.729 ± 0.048
2.326PheGlu: 2.326 ± 0.05
1.568PhePhe: 1.568 ± 0.04
3.877PheGly: 3.877 ± 0.065
0.74PheHis: 0.74 ± 0.026
1.819PheIle: 1.819 ± 0.041
0.953PheLys: 0.953 ± 0.031
3.47PheLeu: 3.47 ± 0.065
0.849PheMet: 0.849 ± 0.03
1.128PheAsn: 1.128 ± 0.034
1.569PhePro: 1.569 ± 0.038
1.056PheGln: 1.056 ± 0.031
2.056PheArg: 2.056 ± 0.038
2.264PheSer: 2.264 ± 0.048
2.053PheThr: 2.053 ± 0.044
3.008PheVal: 3.008 ± 0.055
0.636PheTrp: 0.636 ± 0.026
0.963PheTyr: 0.963 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
9.238GlyAla: 9.238 ± 0.095
0.677GlyCys: 0.677 ± 0.025
4.47GlyAsp: 4.47 ± 0.073
4.862GlyGlu: 4.862 ± 0.068
3.733GlyPhe: 3.733 ± 0.069
6.919GlyGly: 6.919 ± 0.111
1.944GlyHis: 1.944 ± 0.043
4.723GlyIle: 4.723 ± 0.074
3.192GlyLys: 3.192 ± 0.065
9.305GlyLeu: 9.305 ± 0.104
2.374GlyMet: 2.374 ± 0.046
2.388GlyAsn: 2.388 ± 0.068
3.514GlyPro: 3.514 ± 0.055
3.38GlyGln: 3.38 ± 0.059
5.437GlyArg: 5.437 ± 0.073
4.554GlySer: 4.554 ± 0.08
4.746GlyThr: 4.746 ± 0.07
6.259GlyVal: 6.259 ± 0.084
1.401GlyTrp: 1.401 ± 0.036
2.383GlyTyr: 2.383 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.226HisAla: 2.226 ± 0.049
0.191HisCys: 0.191 ± 0.014
1.217HisAsp: 1.217 ± 0.036
1.086HisGlu: 1.086 ± 0.032
0.915HisPhe: 0.915 ± 0.029
1.873HisGly: 1.873 ± 0.049
0.58HisHis: 0.58 ± 0.027
1.077HisIle: 1.077 ± 0.032
0.503HisLys: 0.503 ± 0.022
2.111HisLeu: 2.111 ± 0.052
0.557HisMet: 0.557 ± 0.022
0.559HisAsn: 0.559 ± 0.022
1.222HisPro: 1.222 ± 0.033
0.686HisGln: 0.686 ± 0.024
1.365HisArg: 1.365 ± 0.038
0.943HisSer: 0.943 ± 0.03
0.884HisThr: 0.884 ± 0.026
1.416HisVal: 1.416 ± 0.036
0.332HisTrp: 0.332 ± 0.018
0.536HisTyr: 0.536 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.997IleAla: 7.997 ± 0.083
0.513IleCys: 0.513 ± 0.023
3.775IleAsp: 3.775 ± 0.056
3.71IleGlu: 3.71 ± 0.061
1.9IlePhe: 1.9 ± 0.049
5.351IleGly: 5.351 ± 0.081
0.914IleHis: 0.914 ± 0.028
2.76IleIle: 2.76 ± 0.049
1.434IleLys: 1.434 ± 0.039
4.86IleLeu: 4.86 ± 0.083
1.136IleMet: 1.136 ± 0.03
1.601IleAsn: 1.601 ± 0.04
2.335IlePro: 2.335 ± 0.046
1.23IleGln: 1.23 ± 0.038
2.983IleArg: 2.983 ± 0.047
3.075IleSer: 3.075 ± 0.048
2.986IleThr: 2.986 ± 0.059
4.432IleVal: 4.432 ± 0.063
0.666IleTrp: 0.666 ± 0.025
1.222IleTyr: 1.222 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.926LysAla: 3.926 ± 0.065
0.12LysCys: 0.12 ± 0.01
1.582LysAsp: 1.582 ± 0.045
1.238LysGlu: 1.238 ± 0.04
0.864LysPhe: 0.864 ± 0.029
2.44LysGly: 2.44 ± 0.05
0.567LysHis: 0.567 ± 0.026
1.471LysIle: 1.471 ± 0.04
1.042LysLys: 1.042 ± 0.037
3.102LysLeu: 3.102 ± 0.051
0.677LysMet: 0.677 ± 0.025
0.716LysAsn: 0.716 ± 0.023
1.856LysPro: 1.856 ± 0.044
0.974LysGln: 0.974 ± 0.03
2.118LysArg: 2.118 ± 0.045
1.832LysSer: 1.832 ± 0.035
1.763LysThr: 1.763 ± 0.042
2.29LysVal: 2.29 ± 0.051
0.343LysTrp: 0.343 ± 0.018
0.538LysTyr: 0.538 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.739LeuAla: 13.739 ± 0.132
0.751LeuCys: 0.751 ± 0.026
6.522LeuAsp: 6.522 ± 0.085
5.691LeuGlu: 5.691 ± 0.075
3.83LeuPhe: 3.83 ± 0.061
8.829LeuGly: 8.829 ± 0.103
1.813LeuHis: 1.813 ± 0.039
5.404LeuIle: 5.404 ± 0.075
3.304LeuLys: 3.304 ± 0.066
9.793LeuLeu: 9.793 ± 0.133
2.438LeuMet: 2.438 ± 0.043
2.871LeuAsn: 2.871 ± 0.044
5.552LeuPro: 5.552 ± 0.083
2.633LeuGln: 2.633 ± 0.054
6.381LeuArg: 6.381 ± 0.091
6.641LeuSer: 6.641 ± 0.088
5.858LeuThr: 5.858 ± 0.081
8.284LeuVal: 8.284 ± 0.099
1.169LeuTrp: 1.169 ± 0.035
2.094LeuTyr: 2.094 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.485MetAla: 3.485 ± 0.06
0.118MetCys: 0.118 ± 0.009
1.308MetAsp: 1.308 ± 0.035
1.136MetGlu: 1.136 ± 0.031
0.79MetPhe: 0.79 ± 0.027
2.053MetGly: 2.053 ± 0.045
0.492MetHis: 0.492 ± 0.02
1.395MetIle: 1.395 ± 0.04
0.787MetLys: 0.787 ± 0.028
2.657MetLeu: 2.657 ± 0.05
0.65MetMet: 0.65 ± 0.025
0.742MetAsn: 0.742 ± 0.026
1.505MetPro: 1.505 ± 0.032
0.902MetGln: 0.902 ± 0.026
1.785MetArg: 1.785 ± 0.042
1.831MetSer: 1.831 ± 0.042
1.885MetThr: 1.885 ± 0.038
2.017MetVal: 2.017 ± 0.045
0.21MetTrp: 0.21 ± 0.012
0.315MetTyr: 0.315 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.403AsnAla: 3.403 ± 0.052
0.202AsnCys: 0.202 ± 0.015
1.483AsnAsp: 1.483 ± 0.05
1.313AsnGlu: 1.313 ± 0.031
1.108AsnPhe: 1.108 ± 0.029
2.648AsnGly: 2.648 ± 0.058
0.528AsnHis: 0.528 ± 0.019
1.464AsnIle: 1.464 ± 0.033
0.762AsnLys: 0.762 ± 0.029
2.839AsnLeu: 2.839 ± 0.056
0.663AsnMet: 0.663 ± 0.023
0.781AsnAsn: 0.781 ± 0.029
1.865AsnPro: 1.865 ± 0.044
0.882AsnGln: 0.882 ± 0.031
1.917AsnArg: 1.917 ± 0.042
1.439AsnSer: 1.439 ± 0.046
1.402AsnThr: 1.402 ± 0.038
2.036AsnVal: 2.036 ± 0.045
0.505AsnTrp: 0.505 ± 0.021
0.766AsnTyr: 0.766 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.101ProAla: 6.101 ± 0.095
0.259ProCys: 0.259 ± 0.014
3.709ProAsp: 3.709 ± 0.068
3.737ProGlu: 3.737 ± 0.058
1.929ProPhe: 1.929 ± 0.036
4.329ProGly: 4.329 ± 0.064
1.094ProHis: 1.094 ± 0.036
2.524ProIle: 2.524 ± 0.053
1.464ProLys: 1.464 ± 0.039
4.722ProLeu: 4.722 ± 0.081
1.221ProMet: 1.221 ± 0.029
1.468ProAsn: 1.468 ± 0.033
2.238ProPro: 2.238 ± 0.051
1.729ProGln: 1.729 ± 0.041
2.741ProArg: 2.741 ± 0.052
2.631ProSer: 2.631 ± 0.051
2.485ProThr: 2.485 ± 0.045
4.178ProVal: 4.178 ± 0.064
0.667ProTrp: 0.667 ± 0.024
1.151ProTyr: 1.151 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.301GlnAla: 4.301 ± 0.067
0.197GlnCys: 0.197 ± 0.013
1.622GlnAsp: 1.622 ± 0.034
1.407GlnGlu: 1.407 ± 0.035
1.303GlnPhe: 1.303 ± 0.03
2.497GlnGly: 2.497 ± 0.047
0.691GlnHis: 0.691 ± 0.024
2.017GlnIle: 2.017 ± 0.044
0.979GlnLys: 0.979 ± 0.03
3.251GlnLeu: 3.251 ± 0.054
1.039GlnMet: 1.039 ± 0.027
0.897GlnAsn: 0.897 ± 0.031
1.731GlnPro: 1.731 ± 0.036
1.316GlnGln: 1.316 ± 0.036
2.564GlnArg: 2.564 ± 0.06
2.055GlnSer: 2.055 ± 0.046
1.976GlnThr: 1.976 ± 0.044
2.499GlnVal: 2.499 ± 0.048
0.405GlnTrp: 0.405 ± 0.017
0.653GlnTyr: 0.653 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.191ArgAla: 7.191 ± 0.105
0.37ArgCys: 0.37 ± 0.019
3.817ArgAsp: 3.817 ± 0.063
3.553ArgGlu: 3.553 ± 0.057
2.759ArgPhe: 2.759 ± 0.051
4.264ArgGly: 4.264 ± 0.066
1.57ArgHis: 1.57 ± 0.041
3.814ArgIle: 3.814 ± 0.063
2.092ArgLys: 2.092 ± 0.048
7.397ArgLeu: 7.397 ± 0.1
1.785ArgMet: 1.785 ± 0.04
1.941ArgAsn: 1.941 ± 0.042
3.289ArgPro: 3.289 ± 0.051
2.728ArgGln: 2.728 ± 0.05
4.795ArgArg: 4.795 ± 0.094
3.421ArgSer: 3.421 ± 0.064
3.315ArgThr: 3.315 ± 0.06
4.387ArgVal: 4.387 ± 0.062
0.85ArgTrp: 0.85 ± 0.03
1.58ArgTyr: 1.58 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.387SerAla: 6.387 ± 0.09
0.333SerCys: 0.333 ± 0.017
2.954SerAsp: 2.954 ± 0.054
2.846SerGlu: 2.846 ± 0.053
2.411SerPhe: 2.411 ± 0.05
5.687SerGly: 5.687 ± 0.079
1.095SerHis: 1.095 ± 0.03
3.043SerIle: 3.043 ± 0.052
1.424SerLys: 1.424 ± 0.035
5.371SerLeu: 5.371 ± 0.08
1.442SerMet: 1.442 ± 0.037
1.532SerAsn: 1.532 ± 0.04
2.611SerPro: 2.611 ± 0.054
1.765SerGln: 1.765 ± 0.041
3.374SerArg: 3.374 ± 0.06
2.9SerSer: 2.9 ± 0.064
2.818SerThr: 2.818 ± 0.058
4.214SerVal: 4.214 ± 0.072
0.758SerTrp: 0.758 ± 0.025
1.311SerTyr: 1.311 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.114ThrAla: 6.114 ± 0.074
0.345ThrCys: 0.345 ± 0.02
3.028ThrAsp: 3.028 ± 0.05
2.965ThrGlu: 2.965 ± 0.046
1.982ThrPhe: 1.982 ± 0.046
5.167ThrGly: 5.167 ± 0.075
1.121ThrHis: 1.121 ± 0.034
3.411ThrIle: 3.411 ± 0.057
1.368ThrLys: 1.368 ± 0.033
6.271ThrLeu: 6.271 ± 0.076
1.319ThrMet: 1.319 ± 0.036
1.456ThrAsn: 1.456 ± 0.035
3.239ThrPro: 3.239 ± 0.052
1.62ThrGln: 1.62 ± 0.039
3.249ThrArg: 3.249 ± 0.046
2.884ThrSer: 2.884 ± 0.057
2.993ThrThr: 2.993 ± 0.055
4.201ThrVal: 4.201 ± 0.06
0.649ThrTrp: 0.649 ± 0.024
1.213ThrTyr: 1.213 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
8.929ValAla: 8.929 ± 0.105
0.541ValCys: 0.541 ± 0.021
4.21ValAsp: 4.21 ± 0.073
4.736ValGlu: 4.736 ± 0.066
2.809ValPhe: 2.809 ± 0.054
5.745ValGly: 5.745 ± 0.085
1.363ValHis: 1.363 ± 0.037
4.125ValIle: 4.125 ± 0.063
1.926ValLys: 1.926 ± 0.046
7.997ValLeu: 7.997 ± 0.107
2.009ValMet: 2.009 ± 0.043
2.097ValAsn: 2.097 ± 0.049
3.937ValPro: 3.937 ± 0.063
2.157ValGln: 2.157 ± 0.044
4.63ValArg: 4.63 ± 0.07
4.622ValSer: 4.622 ± 0.064
4.719ValThr: 4.719 ± 0.064
6.065ValVal: 6.065 ± 0.09
0.906ValTrp: 0.906 ± 0.029
1.495ValTyr: 1.495 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.29TrpAla: 1.29 ± 0.035
0.12TrpCys: 0.12 ± 0.01
0.693TrpAsp: 0.693 ± 0.025
0.574TrpGlu: 0.574 ± 0.022
0.577TrpPhe: 0.577 ± 0.021
0.885TrpGly: 0.885 ± 0.031
0.326TrpHis: 0.326 ± 0.016
0.627TrpIle: 0.627 ± 0.022
0.365TrpLys: 0.365 ± 0.019
1.623TrpLeu: 1.623 ± 0.042
0.344TrpMet: 0.344 ± 0.017
0.466TrpAsn: 0.466 ± 0.019
0.748TrpPro: 0.748 ± 0.025
0.638TrpGln: 0.638 ± 0.024
1.034TrpArg: 1.034 ± 0.027
0.842TrpSer: 0.842 ± 0.029
0.837TrpThr: 0.837 ± 0.032
0.909TrpVal: 0.909 ± 0.029
0.243TrpTrp: 0.243 ± 0.015
0.304TrpTyr: 0.304 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.606TyrAla: 2.606 ± 0.052
0.219TyrCys: 0.219 ± 0.014
1.442TyrAsp: 1.442 ± 0.036
1.283TyrGlu: 1.283 ± 0.035
1.049TyrPhe: 1.049 ± 0.03
2.108TyrGly: 2.108 ± 0.043
0.474TyrHis: 0.474 ± 0.019
0.871TyrIle: 0.871 ± 0.023
0.571TyrLys: 0.571 ± 0.024
2.302TyrLeu: 2.302 ± 0.047
0.45TyrMet: 0.45 ± 0.022
0.649TyrAsn: 0.649 ± 0.027
1.154TyrPro: 1.154 ± 0.034
0.719TyrGln: 0.719 ± 0.024
1.624TyrArg: 1.624 ± 0.04
1.165TyrSer: 1.165 ± 0.034
1.018TyrThr: 1.018 ± 0.031
1.727TyrVal: 1.727 ± 0.034
0.399TyrTrp: 0.399 ± 0.016
0.64TyrTyr: 0.64 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3776 proteins (1170282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski