Amino acid dipepetide frequency for Caulobacter vibrioides (Caulobacter crescentus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.205AlaAla: 22.205 ± 0.192	1.14AlaCys: 1.14 ± 0.034	7.916AlaAsp: 7.916 ± 0.088	7.437AlaGlu: 7.437 ± 0.092	5.061AlaPhe: 5.061 ± 0.07	12.912AlaGly: 12.912 ± 0.112	2.167AlaHis: 2.167 ± 0.04	5.488AlaIle: 5.488 ± 0.059	4.656AlaLys: 4.656 ± 0.078	14.921AlaLeu: 14.921 ± 0.127	3.28AlaMet: 3.28 ± 0.053	2.877AlaAsn: 2.877 ± 0.06	8.016AlaPro: 8.016 ± 0.095	4.846AlaGln: 4.846 ± 0.068	10.181AlaArg: 10.181 ± 0.119	7.128AlaSer: 7.128 ± 0.083	6.244AlaThr: 6.244 ± 0.087	10.203AlaVal: 10.203 ± 0.093	2.183AlaTrp: 2.183 ± 0.04	3.026AlaTyr: 3.026 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.97CysAla: 0.97 ± 0.028	0.071CysCys: 0.071 ± 0.007	0.431CysAsp: 0.431 ± 0.017	0.383CysGlu: 0.383 ± 0.018	0.229CysPhe: 0.229 ± 0.012	0.755CysGly: 0.755 ± 0.024	0.135CysHis: 0.135 ± 0.009	0.264CysIle: 0.264 ± 0.013	0.17CysLys: 0.17 ± 0.011	0.635CysLeu: 0.635 ± 0.021	0.112CysMet: 0.112 ± 0.009	0.152CysAsn: 0.152 ± 0.009	0.35CysPro: 0.35 ± 0.018	0.176CysGln: 0.176 ± 0.01	0.451CysArg: 0.451 ± 0.017	0.314CysSer: 0.314 ± 0.016	0.297CysThr: 0.297 ± 0.015	0.56CysVal: 0.56 ± 0.021	0.098CysTrp: 0.098 ± 0.008	0.166CysTyr: 0.166 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.888AspAla: 7.888 ± 0.085	0.376AspCys: 0.376 ± 0.017	3.269AspAsp: 3.269 ± 0.058	3.322AspGlu: 3.322 ± 0.05	2.224AspPhe: 2.224 ± 0.043	5.98AspGly: 5.98 ± 0.084	1.147AspHis: 1.147 ± 0.026	2.356AspIle: 2.356 ± 0.045	1.867AspLys: 1.867 ± 0.036	6.518AspLeu: 6.518 ± 0.077	1.094AspMet: 1.094 ± 0.031	1.261AspAsn: 1.261 ± 0.03	3.922AspPro: 3.922 ± 0.055	1.928AspGln: 1.928 ± 0.042	4.334AspArg: 4.334 ± 0.064	2.011AspSer: 2.011 ± 0.04	2.402AspThr: 2.402 ± 0.043	4.257AspVal: 4.257 ± 0.054	1.08AspTrp: 1.08 ± 0.025	1.606AspTyr: 1.606 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.617GluAla: 8.617 ± 0.1	0.219GluCys: 0.219 ± 0.013	2.721GluAsp: 2.721 ± 0.052	2.446GluGlu: 2.446 ± 0.045	1.462GluPhe: 1.462 ± 0.03	4.78GluGly: 4.78 ± 0.064	1.018GluHis: 1.018 ± 0.028	2.843GluIle: 2.843 ± 0.048	1.95GluLys: 1.95 ± 0.044	4.669GluLeu: 4.669 ± 0.059	1.092GluMet: 1.092 ± 0.029	1.188GluAsn: 1.188 ± 0.031	2.691GluPro: 2.691 ± 0.047	1.84GluGln: 1.84 ± 0.032	4.705GluArg: 4.705 ± 0.072	2.031GluSer: 2.031 ± 0.039	3.544GluThr: 3.544 ± 0.049	3.779GluVal: 3.779 ± 0.052	0.591GluTrp: 0.591 ± 0.018	0.895GluTyr: 0.895 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.537PheAla: 4.537 ± 0.062	0.276PheCys: 0.276 ± 0.013	2.855PheAsp: 2.855 ± 0.041	2.202PheGlu: 2.202 ± 0.039	1.182PhePhe: 1.182 ± 0.032	3.604PheGly: 3.604 ± 0.052	0.665PheHis: 0.665 ± 0.025	1.199PheIle: 1.199 ± 0.031	1.141PheLys: 1.141 ± 0.028	2.954PheLeu: 2.954 ± 0.046	0.743PheMet: 0.743 ± 0.023	1.095PheAsn: 1.095 ± 0.034	1.472PhePro: 1.472 ± 0.034	1.052PheGln: 1.052 ± 0.025	1.944PheArg: 1.944 ± 0.035	2.137PheSer: 2.137 ± 0.045	2.112PheThr: 2.112 ± 0.041	2.846PheVal: 2.846 ± 0.048	0.532PheTrp: 0.532 ± 0.021	0.835PheTyr: 0.835 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.969GlyAla: 11.969 ± 0.113	0.685GlyCys: 0.685 ± 0.023	5.114GlyAsp: 5.114 ± 0.077	5.304GlyGlu: 5.304 ± 0.054	3.757GlyPhe: 3.757 ± 0.057	9.319GlyGly: 9.319 ± 0.228	1.572GlyHis: 1.572 ± 0.038	2.702GlyIle: 2.702 ± 0.042	3.523GlyLys: 3.523 ± 0.058	9.976GlyLeu: 9.976 ± 0.102	2.001GlyMet: 2.001 ± 0.037	1.69GlyAsn: 1.69 ± 0.048	4.246GlyPro: 4.246 ± 0.058	3.353GlyGln: 3.353 ± 0.049	6.642GlyArg: 6.642 ± 0.079	4.545GlySer: 4.545 ± 0.089	3.567GlyThr: 3.567 ± 0.08	8.257GlyVal: 8.257 ± 0.075	1.631GlyTrp: 1.631 ± 0.034	2.385GlyTyr: 2.385 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.187HisAla: 2.187 ± 0.038	0.139HisCys: 0.139 ± 0.008	1.085HisAsp: 1.085 ± 0.026	0.881HisGlu: 0.881 ± 0.024	0.625HisPhe: 0.625 ± 0.022	1.79HisGly: 1.79 ± 0.035	0.446HisHis: 0.446 ± 0.019	0.605HisIle: 0.605 ± 0.019	0.429HisLys: 0.429 ± 0.016	1.661HisLeu: 1.661 ± 0.037	0.378HisMet: 0.378 ± 0.016	0.359HisAsn: 0.359 ± 0.015	1.153HisPro: 1.153 ± 0.026	0.522HisGln: 0.522 ± 0.02	1.175HisArg: 1.175 ± 0.032	0.68HisSer: 0.68 ± 0.018	0.663HisThr: 0.663 ± 0.019	1.306HisVal: 1.306 ± 0.027	0.282HisTrp: 0.282 ± 0.013	0.461HisTyr: 0.461 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.118IleAla: 6.118 ± 0.068	0.34IleCys: 0.34 ± 0.016	3.191IleAsp: 3.191 ± 0.043	2.878IleGlu: 2.878 ± 0.046	1.178IlePhe: 1.178 ± 0.03	4.077IleGly: 4.077 ± 0.067	0.683IleHis: 0.683 ± 0.021	1.383IleIle: 1.383 ± 0.034	1.259IleLys: 1.259 ± 0.03	3.589IleLeu: 3.589 ± 0.053	0.634IleMet: 0.634 ± 0.021	1.158IleAsn: 1.158 ± 0.032	1.825IlePro: 1.825 ± 0.035	1.12IleGln: 1.12 ± 0.03	2.516IleArg: 2.516 ± 0.045	2.182IleSer: 2.182 ± 0.047	2.286IleThr: 2.286 ± 0.056	3.48IleVal: 3.48 ± 0.047	0.524IleTrp: 0.524 ± 0.018	0.837IleTyr: 0.837 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	5.42LysAla: 5.42 ± 0.081	0.109LysCys: 0.109 ± 0.009	1.85LysAsp: 1.85 ± 0.04	1.269LysGlu: 1.269 ± 0.039	0.917LysPhe: 0.917 ± 0.027	3.056LysGly: 3.056 ± 0.056	0.506LysHis: 0.506 ± 0.017	1.528LysIle: 1.528 ± 0.032	1.127LysLys: 1.127 ± 0.035	3.098LysLeu: 3.098 ± 0.044	0.601LysMet: 0.601 ± 0.021	0.754LysAsn: 0.754 ± 0.026	2.359LysPro: 2.359 ± 0.045	0.828LysGln: 0.828 ± 0.023	2.154LysArg: 2.154 ± 0.038	1.695LysSer: 1.695 ± 0.036	2.236LysThr: 2.236 ± 0.044	2.675LysVal: 2.675 ± 0.048	0.328LysTrp: 0.328 ± 0.014	0.55LysTyr: 0.55 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.613LeuAla: 15.613 ± 0.143	0.68LeuCys: 0.68 ± 0.021	6.316LeuAsp: 6.316 ± 0.069	5.14LeuGlu: 5.14 ± 0.072	3.317LeuPhe: 3.317 ± 0.058	8.31LeuGly: 8.31 ± 0.075	1.613LeuHis: 1.613 ± 0.032	4.232LeuIle: 4.232 ± 0.055	3.896LeuLys: 3.896 ± 0.055	8.905LeuLeu: 8.905 ± 0.115	1.939LeuMet: 1.939 ± 0.042	2.577LeuAsn: 2.577 ± 0.048	5.344LeuPro: 5.344 ± 0.068	2.53LeuGln: 2.53 ± 0.04	6.581LeuArg: 6.581 ± 0.084	6.509LeuSer: 6.509 ± 0.075	6.053LeuThr: 6.053 ± 0.066	7.468LeuVal: 7.468 ± 0.073	1.197LeuTrp: 1.197 ± 0.032	1.988LeuTyr: 1.988 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.903MetAla: 2.903 ± 0.049	0.106MetCys: 0.106 ± 0.008	1.004MetAsp: 1.004 ± 0.026	0.84MetGlu: 0.84 ± 0.022	0.59MetPhe: 0.59 ± 0.021	1.678MetGly: 1.678 ± 0.034	0.319MetHis: 0.319 ± 0.016	1.022MetIle: 1.022 ± 0.025	0.788MetLys: 0.788 ± 0.021	1.983MetLeu: 1.983 ± 0.035	0.455MetMet: 0.455 ± 0.017	0.6MetAsn: 0.6 ± 0.02	1.041MetPro: 1.041 ± 0.026	0.592MetGln: 0.592 ± 0.022	1.486MetArg: 1.486 ± 0.028	1.517MetSer: 1.517 ± 0.028	1.692MetThr: 1.692 ± 0.032	1.408MetVal: 1.408 ± 0.03	0.178MetTrp: 0.178 ± 0.011	0.231MetTyr: 0.231 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.055	0.195AsnCys: 0.195 ± 0.012	1.278AsnAsp: 1.278 ± 0.032	0.988AsnGlu: 0.988 ± 0.026	0.845AsnPhe: 0.845 ± 0.027	2.422AsnGly: 2.422 ± 0.058	0.402AsnHis: 0.402 ± 0.019	1.058AsnIle: 1.058 ± 0.03	0.57AsnLys: 0.57 ± 0.021	2.601AsnLeu: 2.601 ± 0.046	0.429AsnMet: 0.429 ± 0.015	0.655AsnAsn: 0.655 ± 0.027	1.653AsnPro: 1.653 ± 0.039	0.72AsnGln: 0.72 ± 0.024	1.52AsnArg: 1.52 ± 0.035	1.12AsnSer: 1.12 ± 0.036	1.26AsnThr: 1.26 ± 0.04	1.857AsnVal: 1.857 ± 0.044	0.373AsnTrp: 0.373 ± 0.018	0.708AsnTyr: 0.708 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.882ProAla: 7.882 ± 0.087	0.286ProCys: 0.286 ± 0.014	3.587ProAsp: 3.587 ± 0.049	3.495ProGlu: 3.495 ± 0.054	1.993ProPhe: 1.993 ± 0.037	5.094ProGly: 5.094 ± 0.064	0.897ProHis: 0.897 ± 0.024	2.177ProIle: 2.177 ± 0.034	1.863ProLys: 1.863 ± 0.039	4.836ProLeu: 4.836 ± 0.064	1.138ProMet: 1.138 ± 0.027	1.274ProAsn: 1.274 ± 0.033	3.241ProPro: 3.241 ± 0.071	1.736ProGln: 1.736 ± 0.037	3.272ProArg: 3.272 ± 0.048	2.919ProSer: 2.919 ± 0.044	2.879ProThr: 2.879 ± 0.053	4.303ProVal: 4.303 ± 0.056	0.773ProTrp: 0.773 ± 0.024	1.179ProTyr: 1.179 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.214GlnAla: 5.214 ± 0.065	0.142GlnCys: 0.142 ± 0.011	1.529GlnAsp: 1.529 ± 0.033	1.272GlnGlu: 1.272 ± 0.027	0.984GlnPhe: 0.984 ± 0.025	2.765GlnGly: 2.765 ± 0.046	0.476GlnHis: 0.476 ± 0.02	1.527GlnIle: 1.527 ± 0.034	0.954GlnLys: 0.954 ± 0.025	2.765GlnLeu: 2.765 ± 0.046	0.667GlnMet: 0.667 ± 0.023	0.761GlnAsn: 0.761 ± 0.024	1.712GlnPro: 1.712 ± 0.033	1.039GlnGln: 1.039 ± 0.034	2.244GlnArg: 2.244 ± 0.04	1.596GlnSer: 1.596 ± 0.041	1.918GlnThr: 1.918 ± 0.043	2.579GlnVal: 2.579 ± 0.04	0.391GlnTrp: 0.391 ± 0.016	0.558GlnTyr: 0.558 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.741ArgAla: 8.741 ± 0.095	0.405ArgCys: 0.405 ± 0.018	4.061ArgAsp: 4.061 ± 0.054	3.82ArgGlu: 3.82 ± 0.06	2.846ArgPhe: 2.846 ± 0.039	5.18ArgGly: 5.18 ± 0.068	1.282ArgHis: 1.282 ± 0.031	3.367ArgIle: 3.367 ± 0.047	2.283ArgLys: 2.283 ± 0.041	8.59ArgLeu: 8.59 ± 0.11	1.683ArgMet: 1.683 ± 0.03	1.552ArgAsn: 1.552 ± 0.029	3.994ArgPro: 3.994 ± 0.06	2.374ArgGln: 2.374 ± 0.042	6.002ArgArg: 6.002 ± 0.089	3.28ArgSer: 3.28 ± 0.055	3.483ArgThr: 3.483 ± 0.045	4.813ArgVal: 4.813 ± 0.066	1.172ArgTrp: 1.172 ± 0.028	1.771ArgTyr: 1.771 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.865SerAla: 6.865 ± 0.084	0.32SerCys: 0.32 ± 0.014	2.855SerAsp: 2.855 ± 0.042	2.325SerGlu: 2.325 ± 0.038	1.979SerPhe: 1.979 ± 0.039	5.359SerGly: 5.359 ± 0.08	0.849SerHis: 0.849 ± 0.023	2.253SerIle: 2.253 ± 0.043	1.499SerLys: 1.499 ± 0.037	5.492SerLeu: 5.492 ± 0.068	0.998SerMet: 0.998 ± 0.027	1.374SerAsn: 1.374 ± 0.04	3.12SerPro: 3.12 ± 0.051	1.637SerGln: 1.637 ± 0.037	3.491SerArg: 3.491 ± 0.057	2.757SerSer: 2.757 ± 0.06	2.841SerThr: 2.841 ± 0.059	3.908SerVal: 3.908 ± 0.063	0.778SerTrp: 0.778 ± 0.024	1.309SerTyr: 1.309 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.114ThrAla: 7.114 ± 0.083	0.34ThrCys: 0.34 ± 0.016	2.801ThrAsp: 2.801 ± 0.052	2.177ThrGlu: 2.177 ± 0.031	2.056ThrPhe: 2.056 ± 0.039	5.429ThrGly: 5.429 ± 0.094	0.835ThrHis: 0.835 ± 0.025	2.445ThrIle: 2.445 ± 0.05	1.445ThrLys: 1.445 ± 0.031	5.766ThrLeu: 5.766 ± 0.055	0.853ThrMet: 0.853 ± 0.024	1.289ThrAsn: 1.289 ± 0.041	3.869ThrPro: 3.869 ± 0.053	1.483ThrGln: 1.483 ± 0.035	3.239ThrArg: 3.239 ± 0.053	2.712ThrSer: 2.712 ± 0.059	3.07ThrThr: 3.07 ± 0.072	4.504ThrVal: 4.504 ± 0.075	0.769ThrTrp: 0.769 ± 0.025	1.347ThrTyr: 1.347 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	10.213ValAla: 10.213 ± 0.086	0.6ValCys: 0.6 ± 0.023	4.623ValAsp: 4.623 ± 0.059	5.087ValGlu: 5.087 ± 0.059	2.752ValPhe: 2.752 ± 0.047	6.329ValGly: 6.329 ± 0.074	1.234ValHis: 1.234 ± 0.036	3.424ValIle: 3.424 ± 0.05	2.406ValLys: 2.406 ± 0.045	7.611ValLeu: 7.611 ± 0.082	1.637ValMet: 1.637 ± 0.035	1.985ValAsn: 1.985 ± 0.044	3.127ValPro: 3.127 ± 0.05	2.196ValGln: 2.196 ± 0.041	5.499ValArg: 5.499 ± 0.068	4.718ValSer: 4.718 ± 0.064	4.758ValThr: 4.758 ± 0.084	6.578ValVal: 6.578 ± 0.074	1.037ValTrp: 1.037 ± 0.026	1.567ValTyr: 1.567 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.51TrpAla: 1.51 ± 0.034	0.112TrpCys: 0.112 ± 0.009	0.674TrpAsp: 0.674 ± 0.024	0.569TrpGlu: 0.569 ± 0.022	0.551TrpPhe: 0.551 ± 0.019	1.096TrpGly: 1.096 ± 0.029	0.197TrpHis: 0.197 ± 0.011	0.688TrpIle: 0.688 ± 0.021	0.577TrpLys: 0.577 ± 0.021	1.679TrpLeu: 1.679 ± 0.04	0.323TrpMet: 0.323 ± 0.015	0.489TrpAsn: 0.489 ± 0.02	0.698TrpPro: 0.698 ± 0.022	0.394TrpGln: 0.394 ± 0.017	1.528TrpArg: 1.528 ± 0.033	0.986TrpSer: 0.986 ± 0.027	1.116TrpThr: 1.116 ± 0.028	0.785TrpVal: 0.785 ± 0.023	0.253TrpTrp: 0.253 ± 0.012	0.274TrpTyr: 0.274 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.867TyrAla: 2.867 ± 0.05	0.178TyrCys: 0.178 ± 0.011	1.683TyrAsp: 1.683 ± 0.063	1.247TyrGlu: 1.247 ± 0.029	0.834TyrPhe: 0.834 ± 0.024	2.305TyrGly: 2.305 ± 0.042	0.386TyrHis: 0.386 ± 0.018	0.693TyrIle: 0.693 ± 0.023	0.657TyrLys: 0.657 ± 0.024	1.959TyrLeu: 1.959 ± 0.039	0.377TyrMet: 0.377 ± 0.013	0.619TyrAsn: 0.619 ± 0.028	0.991TyrPro: 0.991 ± 0.03	0.727TyrGln: 0.727 ± 0.025	1.734TyrArg: 1.734 ± 0.031	1.173TyrSer: 1.173 ± 0.034	1.122TyrThr: 1.122 ± 0.046	1.813TyrVal: 1.813 ± 0.036	0.329TyrTrp: 0.329 ± 0.017	0.614TyrTyr: 0.614 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4642 proteins (1543440 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---