Amino acid dipepetide frequency for Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.688AlaAla: 6.688 ± 0.143	0.71AlaCys: 0.71 ± 0.039	3.084AlaAsp: 3.084 ± 0.073	5.584AlaGlu: 5.584 ± 0.097	3.367AlaPhe: 3.367 ± 0.068	6.644AlaGly: 6.644 ± 0.127	1.129AlaHis: 1.129 ± 0.045	5.362AlaIle: 5.362 ± 0.102	5.882AlaLys: 5.882 ± 0.09	8.985AlaLeu: 8.985 ± 0.121	1.602AlaMet: 1.602 ± 0.048	2.477AlaAsn: 2.477 ± 0.065	2.201AlaPro: 2.201 ± 0.057	2.455AlaGln: 2.455 ± 0.057	4.192AlaArg: 4.192 ± 0.085	3.08AlaSer: 3.08 ± 0.07	3.396AlaThr: 3.396 ± 0.073	6.554AlaVal: 6.554 ± 0.106	0.539AlaTrp: 0.539 ± 0.029	2.521AlaTyr: 2.521 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.591CysAla: 0.591 ± 0.028	0.149CysCys: 0.149 ± 0.018	0.353CysAsp: 0.353 ± 0.022	0.496CysGlu: 0.496 ± 0.027	0.361CysPhe: 0.361 ± 0.025	1.014CysGly: 1.014 ± 0.036	0.451CysHis: 0.451 ± 0.062	0.418CysIle: 0.418 ± 0.023	0.396CysLys: 0.396 ± 0.028	0.859CysLeu: 0.859 ± 0.036	0.187CysMet: 0.187 ± 0.017	0.303CysAsn: 0.303 ± 0.022	0.728CysPro: 0.728 ± 0.044	0.382CysGln: 0.382 ± 0.023	0.518CysArg: 0.518 ± 0.028	0.461CysSer: 0.461 ± 0.025	0.458CysThr: 0.458 ± 0.026	0.462CysVal: 0.462 ± 0.03	0.086CysTrp: 0.086 ± 0.012	0.317CysTyr: 0.317 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.714AspAla: 2.714 ± 0.057	0.458AspCys: 0.458 ± 0.022	1.776AspAsp: 1.776 ± 0.052	3.554AspGlu: 3.554 ± 0.085	2.337AspPhe: 2.337 ± 0.063	3.066AspGly: 3.066 ± 0.077	0.596AspHis: 0.596 ± 0.03	3.364AspIle: 3.364 ± 0.082	2.927AspLys: 2.927 ± 0.066	5.464AspLeu: 5.464 ± 0.095	0.832AspMet: 0.832 ± 0.033	1.443AspAsn: 1.443 ± 0.05	2.095AspPro: 2.095 ± 0.063	0.965AspGln: 0.965 ± 0.039	2.097AspArg: 2.097 ± 0.057	1.711AspSer: 1.711 ± 0.05	1.791AspThr: 1.791 ± 0.045	3.063AspVal: 3.063 ± 0.07	0.397AspTrp: 0.397 ± 0.024	1.924AspTyr: 1.924 ± 0.055	0.001AspXaa: 0.001 ± 0.001
Glu	5.822GluAla: 5.822 ± 0.105	0.403GluCys: 0.403 ± 0.027	2.998GluAsp: 2.998 ± 0.076	7.956GluGlu: 7.956 ± 0.143	2.982GluPhe: 2.982 ± 0.061	4.901GluGly: 4.901 ± 0.085	0.966GluHis: 0.966 ± 0.036	7.577GluIle: 7.577 ± 0.108	8.461GluLys: 8.461 ± 0.13	8.288GluLeu: 8.288 ± 0.133	1.965GluMet: 1.965 ± 0.048	3.724GluAsn: 3.724 ± 0.078	2.158GluPro: 2.158 ± 0.05	2.465GluGln: 2.465 ± 0.058	3.922GluArg: 3.922 ± 0.078	2.516GluSer: 2.516 ± 0.056	2.888GluThr: 2.888 ± 0.065	6.71GluVal: 6.71 ± 0.103	0.503GluTrp: 0.503 ± 0.03	2.247GluTyr: 2.247 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.509PheAla: 3.509 ± 0.079	0.515PheCys: 0.515 ± 0.03	1.887PheAsp: 1.887 ± 0.052	2.448PheGlu: 2.448 ± 0.064	2.456PhePhe: 2.456 ± 0.075	3.686PheGly: 3.686 ± 0.081	0.651PheHis: 0.651 ± 0.033	3.334PheIle: 3.334 ± 0.079	3.071PheLys: 3.071 ± 0.074	5.75PheLeu: 5.75 ± 0.136	0.905PheMet: 0.905 ± 0.034	2.066PheAsn: 2.066 ± 0.061	1.813PhePro: 1.813 ± 0.052	1.125PheGln: 1.125 ± 0.039	1.784PheArg: 1.784 ± 0.052	2.905PheSer: 2.905 ± 0.08	2.669PheThr: 2.669 ± 0.06	2.598PheVal: 2.598 ± 0.065	0.668PheTrp: 0.668 ± 0.031	2.006PheTyr: 2.006 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	5.412GlyAla: 5.412 ± 0.099	0.833GlyCys: 0.833 ± 0.037	3.062GlyAsp: 3.062 ± 0.068	5.815GlyGlu: 5.815 ± 0.095	3.71GlyPhe: 3.71 ± 0.068	5.443GlyGly: 5.443 ± 0.083	1.237GlyHis: 1.237 ± 0.042	6.645GlyIle: 6.645 ± 0.103	5.968GlyLys: 5.968 ± 0.098	7.603GlyLeu: 7.603 ± 0.125	1.942GlyMet: 1.942 ± 0.048	2.634GlyAsn: 2.634 ± 0.067	2.159GlyPro: 2.159 ± 0.062	2.34GlyGln: 2.34 ± 0.055	3.538GlyArg: 3.538 ± 0.078	3.627GlySer: 3.627 ± 0.07	3.478GlyThr: 3.478 ± 0.079	6.173GlyVal: 6.173 ± 0.099	0.583GlyTrp: 0.583 ± 0.031	3.034GlyTyr: 3.034 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.973HisAla: 0.973 ± 0.035	0.182HisCys: 0.182 ± 0.016	0.665HisAsp: 0.665 ± 0.029	0.948HisGlu: 0.948 ± 0.039	0.739HisPhe: 0.739 ± 0.031	1.266HisGly: 1.266 ± 0.049	0.38HisHis: 0.38 ± 0.028	0.921HisIle: 0.921 ± 0.041	0.773HisLys: 0.773 ± 0.033	1.762HisLeu: 1.762 ± 0.049	0.272HisMet: 0.272 ± 0.022	0.6HisAsn: 0.6 ± 0.03	1.091HisPro: 1.091 ± 0.045	0.537HisGln: 0.537 ± 0.03	0.855HisArg: 0.855 ± 0.035	0.711HisSer: 0.711 ± 0.034	0.75HisThr: 0.75 ± 0.04	0.862HisVal: 0.862 ± 0.035	0.142HisTrp: 0.142 ± 0.015	0.643HisTyr: 0.643 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.391IleAla: 6.391 ± 0.094	0.566IleCys: 0.566 ± 0.028	3.581IleAsp: 3.581 ± 0.072	5.3IleGlu: 5.3 ± 0.083	3.38IlePhe: 3.38 ± 0.081	5.283IleGly: 5.283 ± 0.098	0.993IleHis: 0.993 ± 0.035	6.007IleIle: 6.007 ± 0.11	6.062IleLys: 6.062 ± 0.096	7.92IleLeu: 7.92 ± 0.111	1.436IleMet: 1.436 ± 0.049	3.48IleAsn: 3.48 ± 0.077	3.525IlePro: 3.525 ± 0.068	1.416IleGln: 1.416 ± 0.041	3.005IleArg: 3.005 ± 0.079	4.079IleSer: 4.079 ± 0.079	4.289IleThr: 4.289 ± 0.071	5.072IleVal: 5.072 ± 0.083	0.521IleTrp: 0.521 ± 0.029	2.58IleTyr: 2.58 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	6.055LysAla: 6.055 ± 0.104	0.478LysCys: 0.478 ± 0.033	3.478LysAsp: 3.478 ± 0.072	7.299LysGlu: 7.299 ± 0.11	2.745LysPhe: 2.745 ± 0.059	4.899LysGly: 4.899 ± 0.075	0.965LysHis: 0.965 ± 0.036	7.112LysIle: 7.112 ± 0.094	6.82LysLys: 6.82 ± 0.11	7.514LysLeu: 7.514 ± 0.107	1.844LysMet: 1.844 ± 0.051	4.039LysAsn: 4.039 ± 0.094	2.999LysPro: 2.999 ± 0.07	1.827LysGln: 1.827 ± 0.056	3.331LysArg: 3.331 ± 0.067	3.142LysSer: 3.142 ± 0.06	4.129LysThr: 4.129 ± 0.082	6.348LysVal: 6.348 ± 0.105	0.507LysTrp: 0.507 ± 0.028	2.923LysTyr: 2.923 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	9.458LeuAla: 9.458 ± 0.129	0.765LeuCys: 0.765 ± 0.034	4.3LeuAsp: 4.3 ± 0.09	8.036LeuGlu: 8.036 ± 0.117	4.593LeuPhe: 4.593 ± 0.101	8.291LeuGly: 8.291 ± 0.132	1.354LeuHis: 1.354 ± 0.041	7.645LeuIle: 7.645 ± 0.113	10.411LeuLys: 10.411 ± 0.133	11.603LeuLeu: 11.603 ± 0.187	2.331LeuMet: 2.331 ± 0.054	5.108LeuAsn: 5.108 ± 0.098	5.293LeuPro: 5.293 ± 0.088	2.655LeuGln: 2.655 ± 0.067	4.622LeuArg: 4.622 ± 0.083	5.85LeuSer: 5.85 ± 0.105	6.324LeuThr: 6.324 ± 0.098	6.916LeuVal: 6.916 ± 0.102	0.976LeuTrp: 0.976 ± 0.036	3.416LeuTyr: 3.416 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.091MetAla: 2.091 ± 0.054	0.158MetCys: 0.158 ± 0.017	0.971MetAsp: 0.971 ± 0.036	1.836MetGlu: 1.836 ± 0.052	0.741MetPhe: 0.741 ± 0.034	1.722MetGly: 1.722 ± 0.052	0.294MetHis: 0.294 ± 0.023	1.282MetIle: 1.282 ± 0.045	1.487MetLys: 1.487 ± 0.048	2.192MetLeu: 2.192 ± 0.054	0.437MetMet: 0.437 ± 0.023	0.791MetAsn: 0.791 ± 0.032	1.011MetPro: 1.011 ± 0.043	0.603MetGln: 0.603 ± 0.034	0.972MetArg: 0.972 ± 0.038	0.984MetSer: 0.984 ± 0.034	0.912MetThr: 0.912 ± 0.036	1.974MetVal: 1.974 ± 0.053	0.126MetTrp: 0.126 ± 0.014	0.547MetTyr: 0.547 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.435AsnAla: 2.435 ± 0.066	0.505AsnCys: 0.505 ± 0.029	1.523AsnAsp: 1.523 ± 0.05	2.52AsnGlu: 2.52 ± 0.066	2.387AsnPhe: 2.387 ± 0.07	2.57AsnGly: 2.57 ± 0.06	0.657AsnHis: 0.657 ± 0.028	3.17AsnIle: 3.17 ± 0.068	2.676AsnLys: 2.676 ± 0.066	5.596AsnLeu: 5.596 ± 0.099	0.828AsnMet: 0.828 ± 0.033	1.774AsnAsn: 1.774 ± 0.061	2.624AsnPro: 2.624 ± 0.063	1.302AsnGln: 1.302 ± 0.049	1.949AsnArg: 1.949 ± 0.052	1.93AsnSer: 1.93 ± 0.055	1.819AsnThr: 1.819 ± 0.054	2.512AsnVal: 2.512 ± 0.061	0.451AsnTrp: 0.451 ± 0.027	1.861AsnTyr: 1.861 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	3.064ProAla: 3.064 ± 0.07	0.33ProCys: 0.33 ± 0.019	2.092ProAsp: 2.092 ± 0.061	4.646ProGlu: 4.646 ± 0.09	1.927ProPhe: 1.927 ± 0.052	3.711ProGly: 3.711 ± 0.074	0.743ProHis: 0.743 ± 0.033	2.119ProIle: 2.119 ± 0.058	2.578ProLys: 2.578 ± 0.063	4.157ProLeu: 4.157 ± 0.08	0.69ProMet: 0.69 ± 0.034	1.483ProAsn: 1.483 ± 0.042	1.626ProPro: 1.626 ± 0.048	1.368ProGln: 1.368 ± 0.042	1.845ProArg: 1.845 ± 0.055	1.608ProSer: 1.608 ± 0.052	1.801ProThr: 1.801 ± 0.054	4.05ProVal: 4.05 ± 0.07	0.448ProTrp: 0.448 ± 0.026	1.637ProTyr: 1.637 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	2.091GlnAla: 2.091 ± 0.062	0.208GlnCys: 0.208 ± 0.02	1.129GlnAsp: 1.129 ± 0.04	2.67GlnGlu: 2.67 ± 0.063	0.929GlnPhe: 0.929 ± 0.037	1.941GlnGly: 1.941 ± 0.048	0.411GlnHis: 0.411 ± 0.022	2.124GlnIle: 2.124 ± 0.055	3.335GlnLys: 3.335 ± 0.072	2.441GlnLeu: 2.441 ± 0.071	0.718GlnMet: 0.718 ± 0.031	1.58GlnAsn: 1.58 ± 0.049	0.819GlnPro: 0.819 ± 0.036	0.896GlnGln: 0.896 ± 0.043	1.47GlnArg: 1.47 ± 0.04	1.066GlnSer: 1.066 ± 0.039	1.225GlnThr: 1.225 ± 0.05	2.022GlnVal: 2.022 ± 0.057	0.215GlnTrp: 0.215 ± 0.017	0.883GlnTyr: 0.883 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.163ArgAla: 3.163 ± 0.079	0.447ArgCys: 0.447 ± 0.029	2.12ArgAsp: 2.12 ± 0.057	5.436ArgGlu: 5.436 ± 0.093	2.097ArgPhe: 2.097 ± 0.057	3.367ArgGly: 3.367 ± 0.068	0.722ArgHis: 0.722 ± 0.032	3.26ArgIle: 3.26 ± 0.075	3.613ArgLys: 3.613 ± 0.083	4.835ArgLeu: 4.835 ± 0.093	1.077ArgMet: 1.077 ± 0.041	1.636ArgAsn: 1.636 ± 0.054	1.818ArgPro: 1.818 ± 0.052	1.704ArgGln: 1.704 ± 0.049	2.433ArgArg: 2.433 ± 0.064	1.629ArgSer: 1.629 ± 0.044	1.808ArgThr: 1.808 ± 0.05	3.546ArgVal: 3.546 ± 0.074	0.464ArgTrp: 0.464 ± 0.023	1.867ArgTyr: 1.867 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	2.975SerAla: 2.975 ± 0.071	0.54SerCys: 0.54 ± 0.037	1.826SerAsp: 1.826 ± 0.059	2.969SerGlu: 2.969 ± 0.069	2.895SerPhe: 2.895 ± 0.073	4.074SerGly: 4.074 ± 0.071	0.796SerHis: 0.796 ± 0.035	2.92SerIle: 2.92 ± 0.068	2.691SerLys: 2.691 ± 0.059	5.882SerLeu: 5.882 ± 0.097	0.982SerMet: 0.982 ± 0.036	1.48SerAsn: 1.48 ± 0.048	2.241SerPro: 2.241 ± 0.055	1.498SerGln: 1.498 ± 0.051	2.501SerArg: 2.501 ± 0.062	2.451SerSer: 2.451 ± 0.066	2.083SerThr: 2.083 ± 0.053	2.667SerVal: 2.667 ± 0.059	0.451SerTrp: 0.451 ± 0.025	1.865SerTyr: 1.865 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.949ThrAla: 3.949 ± 0.08	0.544ThrCys: 0.544 ± 0.04	2.017ThrAsp: 2.017 ± 0.056	3.042ThrGlu: 3.042 ± 0.056	2.169ThrPhe: 2.169 ± 0.059	4.84ThrGly: 4.84 ± 0.08	0.798ThrHis: 0.798 ± 0.037	3.306ThrIle: 3.306 ± 0.065	2.899ThrLys: 2.899 ± 0.055	5.043ThrLeu: 5.043 ± 0.085	0.89ThrMet: 0.89 ± 0.034	1.691ThrAsn: 1.691 ± 0.052	2.603ThrPro: 2.603 ± 0.068	1.043ThrGln: 1.043 ± 0.039	2.156ThrArg: 2.156 ± 0.055	2.333ThrSer: 2.333 ± 0.063	2.483ThrThr: 2.483 ± 0.065	4.224ThrVal: 4.224 ± 0.085	0.41ThrTrp: 0.41 ± 0.022	1.638ThrTyr: 1.638 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	6.161ValAla: 6.161 ± 0.112	0.694ValCys: 0.694 ± 0.033	3.664ValAsp: 3.664 ± 0.076	5.764ValGlu: 5.764 ± 0.094	3.395ValPhe: 3.395 ± 0.069	4.983ValGly: 4.983 ± 0.091	1.044ValHis: 1.044 ± 0.038	5.825ValIle: 5.825 ± 0.085	5.875ValLys: 5.875 ± 0.091	8.045ValLeu: 8.045 ± 0.098	1.458ValMet: 1.458 ± 0.044	3.042ValAsn: 3.042 ± 0.078	2.982ValPro: 2.982 ± 0.063	1.629ValGln: 1.629 ± 0.047	3.257ValArg: 3.257 ± 0.074	3.722ValSer: 3.722 ± 0.083	3.814ValThr: 3.814 ± 0.075	6.498ValVal: 6.498 ± 0.119	0.517ValTrp: 0.517 ± 0.025	2.569ValTyr: 2.569 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.654TrpAla: 0.654 ± 0.033	0.096TrpCys: 0.096 ± 0.013	0.411TrpAsp: 0.411 ± 0.022	0.805TrpGlu: 0.805 ± 0.031	0.38TrpPhe: 0.38 ± 0.024	0.697TrpGly: 0.697 ± 0.03	0.21TrpHis: 0.21 ± 0.02	0.417TrpIle: 0.417 ± 0.026	0.448TrpLys: 0.448 ± 0.024	0.972TrpLeu: 0.972 ± 0.033	0.182TrpMet: 0.182 ± 0.017	0.314TrpAsn: 0.314 ± 0.021	0.335TrpPro: 0.335 ± 0.025	0.482TrpGln: 0.482 ± 0.026	0.408TrpArg: 0.408 ± 0.025	0.387TrpSer: 0.387 ± 0.022	0.29TrpThr: 0.29 ± 0.02	0.555TrpVal: 0.555 ± 0.023	0.136TrpTrp: 0.136 ± 0.014	0.329TrpTyr: 0.329 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.064	0.407TyrCys: 0.407 ± 0.024	1.638TyrAsp: 1.638 ± 0.048	2.327TyrGlu: 2.327 ± 0.057	2.256TyrPhe: 2.256 ± 0.063	2.838TyrGly: 2.838 ± 0.065	0.676TyrHis: 0.676 ± 0.027	2.079TyrIle: 2.079 ± 0.053	2.081TyrLys: 2.081 ± 0.056	5.037TyrLeu: 5.037 ± 0.097	0.553TyrMet: 0.553 ± 0.028	1.425TyrAsn: 1.425 ± 0.043	1.804TyrPro: 1.804 ± 0.058	1.484TyrGln: 1.484 ± 0.043	2.184TyrArg: 2.184 ± 0.066	1.595TyrSer: 1.595 ± 0.048	1.67TyrThr: 1.67 ± 0.05	2.13TyrVal: 2.13 ± 0.058	0.369TyrTrp: 0.369 ± 0.022	1.619TyrTyr: 1.619 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2615 proteins (720219 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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