Amino acid dipepetide frequency for Streptococcus phage 109751

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.381AlaAla: 4.381 ± 1.33
0.331AlaCys: 0.331 ± 0.208
3.554AlaAsp: 3.554 ± 0.455
6.777AlaGlu: 6.777 ± 0.804
2.066AlaPhe: 2.066 ± 0.539
4.546AlaGly: 4.546 ± 1.736
0.909AlaHis: 0.909 ± 0.285
4.876AlaIle: 4.876 ± 0.88
6.116AlaLys: 6.116 ± 0.701
6.695AlaLeu: 6.695 ± 1.337
2.48AlaMet: 2.48 ± 0.414
3.554AlaAsn: 3.554 ± 0.549
1.818AlaPro: 1.818 ± 0.334
3.058AlaGln: 3.058 ± 0.623
2.48AlaArg: 2.48 ± 0.531
3.885AlaSer: 3.885 ± 0.901
3.471AlaThr: 3.471 ± 0.741
5.042AlaVal: 5.042 ± 0.944
0.579AlaTrp: 0.579 ± 0.243
2.149AlaTyr: 2.149 ± 0.41
0.0AlaXaa: 0.0 ± 0.0
Cys
0.331CysAla: 0.331 ± 0.139
0.0CysCys: 0.0 ± 0.0
0.413CysAsp: 0.413 ± 0.162
0.331CysGlu: 0.331 ± 0.18
0.083CysPhe: 0.083 ± 0.081
0.248CysGly: 0.248 ± 0.14
0.083CysHis: 0.083 ± 0.089
0.413CysIle: 0.413 ± 0.207
0.744CysLys: 0.744 ± 0.272
0.661CysLeu: 0.661 ± 0.247
0.083CysMet: 0.083 ± 0.128
0.165CysAsn: 0.165 ± 0.113
0.331CysPro: 0.331 ± 0.168
0.083CysGln: 0.083 ± 0.081
0.165CysArg: 0.165 ± 0.111
0.413CysSer: 0.413 ± 0.193
0.165CysThr: 0.165 ± 0.165
0.248CysVal: 0.248 ± 0.152
0.0CysTrp: 0.0 ± 0.0
0.248CysTyr: 0.248 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
3.554AspAla: 3.554 ± 0.597
0.413AspCys: 0.413 ± 0.216
3.885AspAsp: 3.885 ± 0.626
5.124AspGlu: 5.124 ± 0.574
3.306AspPhe: 3.306 ± 0.621
5.29AspGly: 5.29 ± 0.824
1.157AspHis: 1.157 ± 0.303
5.372AspIle: 5.372 ± 0.649
5.29AspLys: 5.29 ± 0.638
4.794AspLeu: 4.794 ± 0.648
1.901AspMet: 1.901 ± 0.316
3.058AspAsn: 3.058 ± 0.549
1.818AspPro: 1.818 ± 0.429
0.827AspGln: 0.827 ± 0.253
2.727AspArg: 2.727 ± 0.564
3.223AspSer: 3.223 ± 0.493
3.389AspThr: 3.389 ± 0.498
3.719AspVal: 3.719 ± 0.529
0.992AspTrp: 0.992 ± 0.294
3.141AspTyr: 3.141 ± 0.477
0.0AspXaa: 0.0 ± 0.0
Glu
4.876GluAla: 4.876 ± 0.658
0.248GluCys: 0.248 ± 0.151
4.876GluAsp: 4.876 ± 0.82
5.538GluGlu: 5.538 ± 0.886
3.223GluPhe: 3.223 ± 0.577
3.471GluGly: 3.471 ± 0.435
1.157GluHis: 1.157 ± 0.315
5.29GluIle: 5.29 ± 0.825
8.182GluLys: 8.182 ± 1.253
7.273GluLeu: 7.273 ± 0.902
2.975GluMet: 2.975 ± 0.542
3.554GluAsn: 3.554 ± 0.511
1.736GluPro: 1.736 ± 0.479
3.223GluGln: 3.223 ± 0.506
3.885GluArg: 3.885 ± 0.676
3.719GluSer: 3.719 ± 0.619
3.554GluThr: 3.554 ± 0.589
6.034GluVal: 6.034 ± 0.906
0.827GluTrp: 0.827 ± 0.275
2.81GluTyr: 2.81 ± 0.573
0.0GluXaa: 0.0 ± 0.0
Phe
2.562PheAla: 2.562 ± 0.553
0.248PheCys: 0.248 ± 0.166
4.381PheAsp: 4.381 ± 0.831
3.967PheGlu: 3.967 ± 0.624
2.066PhePhe: 2.066 ± 0.528
2.727PheGly: 2.727 ± 0.668
0.331PheHis: 0.331 ± 0.173
2.562PheIle: 2.562 ± 0.665
2.727PheLys: 2.727 ± 0.423
3.058PheLeu: 3.058 ± 0.451
0.992PheMet: 0.992 ± 0.254
1.653PheAsn: 1.653 ± 0.46
0.331PhePro: 0.331 ± 0.146
1.157PheGln: 1.157 ± 0.291
2.232PheArg: 2.232 ± 0.453
2.893PheSer: 2.893 ± 0.461
1.488PheThr: 1.488 ± 0.36
2.81PheVal: 2.81 ± 0.385
0.579PheTrp: 0.579 ± 0.214
1.24PheTyr: 1.24 ± 0.36
0.0PheXaa: 0.0 ± 0.0
Gly
5.124GlyAla: 5.124 ± 1.943
0.331GlyCys: 0.331 ± 0.189
4.05GlyAsp: 4.05 ± 0.594
3.471GlyGlu: 3.471 ± 0.457
3.471GlyPhe: 3.471 ± 0.562
3.885GlyGly: 3.885 ± 0.579
0.992GlyHis: 0.992 ± 0.287
4.463GlyIle: 4.463 ± 0.888
4.876GlyLys: 4.876 ± 0.55
5.786GlyLeu: 5.786 ± 0.985
1.57GlyMet: 1.57 ± 0.398
3.967GlyAsn: 3.967 ± 0.565
0.827GlyPro: 0.827 ± 0.326
3.306GlyGln: 3.306 ± 0.518
3.058GlyArg: 3.058 ± 0.444
3.058GlySer: 3.058 ± 0.586
3.389GlyThr: 3.389 ± 0.713
4.711GlyVal: 4.711 ± 1.01
1.157GlyTrp: 1.157 ± 0.545
2.727GlyTyr: 2.727 ± 0.504
0.0GlyXaa: 0.0 ± 0.0
His
0.744HisAla: 0.744 ± 0.24
0.0HisCys: 0.0 ± 0.0
0.992HisAsp: 0.992 ± 0.288
1.24HisGlu: 1.24 ± 0.373
0.579HisPhe: 0.579 ± 0.209
0.992HisGly: 0.992 ± 0.295
0.165HisHis: 0.165 ± 0.113
0.992HisIle: 0.992 ± 0.295
0.992HisLys: 0.992 ± 0.328
1.157HisLeu: 1.157 ± 0.348
0.165HisMet: 0.165 ± 0.152
0.744HisAsn: 0.744 ± 0.287
0.992HisPro: 0.992 ± 0.254
0.661HisGln: 0.661 ± 0.249
0.496HisArg: 0.496 ± 0.181
1.488HisSer: 1.488 ± 0.451
0.909HisThr: 0.909 ± 0.322
0.909HisVal: 0.909 ± 0.295
0.248HisTrp: 0.248 ± 0.133
0.827HisTyr: 0.827 ± 0.341
0.0HisXaa: 0.0 ± 0.0
Ile
5.62IleAla: 5.62 ± 0.587
0.992IleCys: 0.992 ± 0.295
5.207IleAsp: 5.207 ± 0.615
6.034IleGlu: 6.034 ± 0.886
1.57IlePhe: 1.57 ± 0.337
4.711IleGly: 4.711 ± 0.696
0.579IleHis: 0.579 ± 0.176
4.215IleIle: 4.215 ± 0.678
6.86IleLys: 6.86 ± 0.736
4.298IleLeu: 4.298 ± 0.699
1.653IleMet: 1.653 ± 0.378
3.471IleAsn: 3.471 ± 0.756
2.314IlePro: 2.314 ± 0.404
3.306IleGln: 3.306 ± 0.585
2.232IleArg: 2.232 ± 0.526
4.711IleSer: 4.711 ± 1.142
4.215IleThr: 4.215 ± 0.69
3.967IleVal: 3.967 ± 0.523
0.909IleTrp: 0.909 ± 0.395
2.893IleTyr: 2.893 ± 0.421
0.0IleXaa: 0.0 ± 0.0
Lys
5.786LysAla: 5.786 ± 0.661
0.331LysCys: 0.331 ± 0.287
4.546LysAsp: 4.546 ± 0.558
7.273LysGlu: 7.273 ± 1.221
3.471LysPhe: 3.471 ± 0.563
5.042LysGly: 5.042 ± 0.643
1.901LysHis: 1.901 ± 0.422
6.364LysIle: 6.364 ± 0.696
9.092LysLys: 9.092 ± 1.345
6.529LysLeu: 6.529 ± 0.769
2.314LysMet: 2.314 ± 0.378
4.546LysAsn: 4.546 ± 0.625
3.141LysPro: 3.141 ± 0.634
3.802LysGln: 3.802 ± 0.609
3.885LysArg: 3.885 ± 0.587
4.711LysSer: 4.711 ± 0.575
6.116LysThr: 6.116 ± 0.822
4.876LysVal: 4.876 ± 0.71
1.322LysTrp: 1.322 ± 0.333
3.637LysTyr: 3.637 ± 0.589
0.0LysXaa: 0.0 ± 0.0
Leu
7.356LeuAla: 7.356 ± 0.89
0.165LeuCys: 0.165 ± 0.114
5.62LeuAsp: 5.62 ± 0.709
6.364LeuGlu: 6.364 ± 1.015
3.058LeuPhe: 3.058 ± 0.473
6.612LeuGly: 6.612 ± 1.197
1.24LeuHis: 1.24 ± 0.326
5.29LeuIle: 5.29 ± 0.627
7.687LeuLys: 7.687 ± 0.795
5.951LeuLeu: 5.951 ± 0.77
1.736LeuMet: 1.736 ± 0.469
3.802LeuAsn: 3.802 ± 0.573
3.141LeuPro: 3.141 ± 0.463
3.141LeuGln: 3.141 ± 0.514
2.893LeuArg: 2.893 ± 0.464
5.372LeuSer: 5.372 ± 0.797
5.372LeuThr: 5.372 ± 0.814
4.959LeuVal: 4.959 ± 0.813
0.331LeuTrp: 0.331 ± 0.175
3.058LeuTyr: 3.058 ± 0.488
0.0LeuXaa: 0.0 ± 0.0
Met
2.397MetAla: 2.397 ± 0.672
0.165MetCys: 0.165 ± 0.109
2.066MetAsp: 2.066 ± 0.413
1.901MetGlu: 1.901 ± 0.472
0.661MetPhe: 0.661 ± 0.224
0.744MetGly: 0.744 ± 0.266
0.331MetHis: 0.331 ± 0.17
1.653MetIle: 1.653 ± 0.424
2.149MetLys: 2.149 ± 0.335
1.984MetLeu: 1.984 ± 0.35
0.579MetMet: 0.579 ± 0.228
1.818MetAsn: 1.818 ± 0.409
0.744MetPro: 0.744 ± 0.303
1.24MetGln: 1.24 ± 0.323
1.405MetArg: 1.405 ± 0.383
1.818MetSer: 1.818 ± 0.354
1.653MetThr: 1.653 ± 0.395
1.818MetVal: 1.818 ± 0.623
0.496MetTrp: 0.496 ± 0.189
0.579MetTyr: 0.579 ± 0.211
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.434
0.248AsnCys: 0.248 ± 0.14
2.975AsnAsp: 2.975 ± 0.528
3.223AsnGlu: 3.223 ± 0.581
2.397AsnPhe: 2.397 ± 0.446
4.133AsnGly: 4.133 ± 0.662
1.074AsnHis: 1.074 ± 0.36
3.802AsnIle: 3.802 ± 0.607
3.389AsnLys: 3.389 ± 0.557
4.628AsnLeu: 4.628 ± 0.565
1.24AsnMet: 1.24 ± 0.252
3.141AsnAsn: 3.141 ± 0.535
1.736AsnPro: 1.736 ± 0.427
2.232AsnGln: 2.232 ± 0.423
2.397AsnArg: 2.397 ± 0.466
3.802AsnSer: 3.802 ± 0.66
2.727AsnThr: 2.727 ± 0.402
2.975AsnVal: 2.975 ± 0.437
1.074AsnTrp: 1.074 ± 0.302
2.232AsnTyr: 2.232 ± 0.497
0.0AsnXaa: 0.0 ± 0.0
Pro
1.818ProAla: 1.818 ± 0.446
0.248ProCys: 0.248 ± 0.142
2.314ProAsp: 2.314 ± 0.496
2.066ProGlu: 2.066 ± 0.544
1.24ProPhe: 1.24 ± 0.378
1.157ProGly: 1.157 ± 0.285
0.165ProHis: 0.165 ± 0.112
2.314ProIle: 2.314 ± 0.443
2.645ProLys: 2.645 ± 0.557
1.736ProLeu: 1.736 ± 0.424
0.413ProMet: 0.413 ± 0.162
1.488ProAsn: 1.488 ± 0.463
0.744ProPro: 0.744 ± 0.255
1.653ProGln: 1.653 ± 0.436
0.992ProArg: 0.992 ± 0.299
2.314ProSer: 2.314 ± 0.548
0.909ProThr: 0.909 ± 0.335
2.232ProVal: 2.232 ± 0.343
0.165ProTrp: 0.165 ± 0.117
1.984ProTyr: 1.984 ± 0.452
0.0ProXaa: 0.0 ± 0.0
Gln
3.306GlnAla: 3.306 ± 0.522
0.165GlnCys: 0.165 ± 0.138
1.322GlnAsp: 1.322 ± 0.314
3.141GlnGlu: 3.141 ± 0.586
1.57GlnPhe: 1.57 ± 0.291
2.397GlnGly: 2.397 ± 0.511
0.827GlnHis: 0.827 ± 0.263
3.058GlnIle: 3.058 ± 0.584
3.967GlnLys: 3.967 ± 0.811
4.133GlnLeu: 4.133 ± 0.514
1.157GlnMet: 1.157 ± 0.272
2.562GlnAsn: 2.562 ± 0.411
1.074GlnPro: 1.074 ± 0.34
1.24GlnGln: 1.24 ± 0.346
1.322GlnArg: 1.322 ± 0.416
3.471GlnSer: 3.471 ± 0.603
1.736GlnThr: 1.736 ± 0.389
2.81GlnVal: 2.81 ± 0.537
0.248GlnTrp: 0.248 ± 0.155
1.074GlnTyr: 1.074 ± 0.343
0.0GlnXaa: 0.0 ± 0.0
Arg
1.984ArgAla: 1.984 ± 0.479
0.165ArgCys: 0.165 ± 0.096
1.736ArgAsp: 1.736 ± 0.44
3.306ArgGlu: 3.306 ± 0.638
1.24ArgPhe: 1.24 ± 0.407
2.81ArgGly: 2.81 ± 0.517
0.579ArgHis: 0.579 ± 0.191
1.984ArgIle: 1.984 ± 0.462
4.298ArgLys: 4.298 ± 0.789
3.885ArgLeu: 3.885 ± 0.551
1.984ArgMet: 1.984 ± 0.485
2.893ArgAsn: 2.893 ± 0.497
1.074ArgPro: 1.074 ± 0.299
1.57ArgGln: 1.57 ± 0.305
1.984ArgArg: 1.984 ± 0.395
2.81ArgSer: 2.81 ± 0.494
2.48ArgThr: 2.48 ± 0.499
2.149ArgVal: 2.149 ± 0.501
0.496ArgTrp: 0.496 ± 0.18
2.149ArgTyr: 2.149 ± 0.616
0.0ArgXaa: 0.0 ± 0.0
Ser
3.967SerAla: 3.967 ± 0.882
0.331SerCys: 0.331 ± 0.138
4.215SerAsp: 4.215 ± 0.514
4.794SerGlu: 4.794 ± 0.581
2.727SerPhe: 2.727 ± 0.473
4.463SerGly: 4.463 ± 0.668
1.074SerHis: 1.074 ± 0.407
3.802SerIle: 3.802 ± 0.569
5.29SerLys: 5.29 ± 0.656
6.282SerLeu: 6.282 ± 0.85
1.653SerMet: 1.653 ± 0.369
4.215SerAsn: 4.215 ± 0.773
1.818SerPro: 1.818 ± 0.342
2.727SerGln: 2.727 ± 0.553
2.149SerArg: 2.149 ± 0.348
3.058SerSer: 3.058 ± 0.54
3.306SerThr: 3.306 ± 0.561
4.215SerVal: 4.215 ± 0.675
0.496SerTrp: 0.496 ± 0.187
2.48SerTyr: 2.48 ± 0.427
0.0SerXaa: 0.0 ± 0.0
Thr
3.719ThrAla: 3.719 ± 0.622
0.083ThrCys: 0.083 ± 0.082
3.389ThrAsp: 3.389 ± 0.495
4.381ThrGlu: 4.381 ± 0.579
2.727ThrPhe: 2.727 ± 0.417
4.215ThrGly: 4.215 ± 0.837
1.322ThrHis: 1.322 ± 0.347
4.133ThrIle: 4.133 ± 0.708
4.711ThrLys: 4.711 ± 0.594
4.05ThrLeu: 4.05 ± 0.65
1.157ThrMet: 1.157 ± 0.298
2.81ThrAsn: 2.81 ± 0.462
1.901ThrPro: 1.901 ± 0.401
2.314ThrGln: 2.314 ± 0.497
2.232ThrArg: 2.232 ± 0.506
3.637ThrSer: 3.637 ± 0.657
3.967ThrThr: 3.967 ± 0.594
2.893ThrVal: 2.893 ± 0.463
0.331ThrTrp: 0.331 ± 0.169
2.314ThrTyr: 2.314 ± 0.433
0.0ThrXaa: 0.0 ± 0.0
Val
5.042ValAla: 5.042 ± 0.976
0.331ValCys: 0.331 ± 0.138
3.802ValAsp: 3.802 ± 0.598
4.381ValGlu: 4.381 ± 0.721
1.901ValPhe: 1.901 ± 0.397
4.546ValGly: 4.546 ± 0.977
0.579ValHis: 0.579 ± 0.258
5.786ValIle: 5.786 ± 0.72
5.042ValLys: 5.042 ± 0.743
4.381ValLeu: 4.381 ± 0.629
1.074ValMet: 1.074 ± 0.33
3.223ValAsn: 3.223 ± 0.478
1.57ValPro: 1.57 ± 0.434
2.066ValGln: 2.066 ± 0.387
1.984ValArg: 1.984 ± 0.355
5.786ValSer: 5.786 ± 0.701
4.133ValThr: 4.133 ± 0.569
4.215ValVal: 4.215 ± 0.583
0.827ValTrp: 0.827 ± 0.265
3.141ValTyr: 3.141 ± 0.448
0.0ValXaa: 0.0 ± 0.0
Trp
0.744TrpAla: 0.744 ± 0.224
0.165TrpCys: 0.165 ± 0.117
0.909TrpAsp: 0.909 ± 0.314
0.909TrpGlu: 0.909 ± 0.248
0.661TrpPhe: 0.661 ± 0.197
0.413TrpGly: 0.413 ± 0.189
0.083TrpHis: 0.083 ± 0.128
0.661TrpIle: 0.661 ± 0.234
1.405TrpLys: 1.405 ± 0.335
0.909TrpLeu: 0.909 ± 0.257
0.248TrpMet: 0.248 ± 0.13
0.331TrpAsn: 0.331 ± 0.177
0.0TrpPro: 0.0 ± 0.0
0.992TrpGln: 0.992 ± 0.313
0.331TrpArg: 0.331 ± 0.235
0.413TrpSer: 0.413 ± 0.154
1.157TrpThr: 1.157 ± 0.395
0.579TrpVal: 0.579 ± 0.194
0.083TrpTrp: 0.083 ± 0.096
0.661TrpTyr: 0.661 ± 0.498
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.066TyrAla: 2.066 ± 0.438
0.248TyrCys: 0.248 ± 0.147
2.727TyrAsp: 2.727 ± 0.458
2.232TyrGlu: 2.232 ± 0.528
1.984TyrPhe: 1.984 ± 0.446
1.818TyrGly: 1.818 ± 0.417
0.744TyrHis: 0.744 ± 0.319
2.727TyrIle: 2.727 ± 0.433
3.223TyrLys: 3.223 ± 0.56
4.959TyrLeu: 4.959 ± 0.812
0.744TyrMet: 0.744 ± 0.296
1.818TyrAsn: 1.818 ± 0.514
1.488TyrPro: 1.488 ± 0.38
1.984TyrGln: 1.984 ± 0.355
2.727TyrArg: 2.727 ± 0.57
2.48TyrSer: 2.48 ± 0.553
2.149TyrThr: 2.149 ± 0.416
2.727TyrVal: 2.727 ± 0.527
0.496TyrTrp: 0.496 ± 0.213
1.57TyrTyr: 1.57 ± 0.449
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (12100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski