Amino acid dipepetide frequency for Salmonella phage vB_SalM_SA002

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.007AlaAla: 7.007 ± 0.426
0.668AlaCys: 0.668 ± 0.099
4.422AlaAsp: 4.422 ± 0.194
4.545AlaGlu: 4.545 ± 0.217
2.763AlaPhe: 2.763 ± 0.172
5.436AlaGly: 5.436 ± 0.289
1.225AlaHis: 1.225 ± 0.102
5.046AlaIle: 5.046 ± 0.245
4.378AlaLys: 4.378 ± 0.25
6.828AlaLeu: 6.828 ± 0.303
2.774AlaMet: 2.774 ± 0.176
4.266AlaAsn: 4.266 ± 0.256
2.919AlaPro: 2.919 ± 0.222
2.829AlaGln: 2.829 ± 0.204
3.42AlaArg: 3.42 ± 0.231
4.511AlaSer: 4.511 ± 0.28
5.102AlaThr: 5.102 ± 0.228
5.525AlaVal: 5.525 ± 0.311
1.003AlaTrp: 1.003 ± 0.136
2.718AlaTyr: 2.718 ± 0.156
0.0AlaXaa: 0.0 ± 0.0
Cys
0.724CysAla: 0.724 ± 0.103
0.212CysCys: 0.212 ± 0.044
0.657CysAsp: 0.657 ± 0.085
0.479CysGlu: 0.479 ± 0.076
0.301CysPhe: 0.301 ± 0.056
0.735CysGly: 0.735 ± 0.094
0.212CysHis: 0.212 ± 0.048
0.579CysIle: 0.579 ± 0.077
0.557CysLys: 0.557 ± 0.079
0.802CysLeu: 0.802 ± 0.099
0.245CysMet: 0.245 ± 0.059
0.368CysAsn: 0.368 ± 0.053
0.334CysPro: 0.334 ± 0.06
0.334CysGln: 0.334 ± 0.06
0.624CysArg: 0.624 ± 0.091
0.512CysSer: 0.512 ± 0.076
0.59CysThr: 0.59 ± 0.082
0.735CysVal: 0.735 ± 0.094
0.134CysTrp: 0.134 ± 0.038
0.301CysTyr: 0.301 ± 0.062
0.0CysXaa: 0.0 ± 0.0
Asp
4.422AspAla: 4.422 ± 0.223
0.468AspCys: 0.468 ± 0.07
3.542AspAsp: 3.542 ± 0.198
4.055AspGlu: 4.055 ± 0.227
2.428AspPhe: 2.428 ± 0.17
4.411AspGly: 4.411 ± 0.288
1.337AspHis: 1.337 ± 0.119
3.943AspIle: 3.943 ± 0.201
3.598AspLys: 3.598 ± 0.39
5.759AspLeu: 5.759 ± 0.256
1.493AspMet: 1.493 ± 0.132
3.186AspAsn: 3.186 ± 0.196
2.874AspPro: 2.874 ± 0.183
2.362AspGln: 2.362 ± 0.187
3.164AspArg: 3.164 ± 0.158
2.785AspSer: 2.785 ± 0.149
3.498AspThr: 3.498 ± 0.293
5.191AspVal: 5.191 ± 0.233
1.047AspTrp: 1.047 ± 0.116
2.685AspTyr: 2.685 ± 0.174
0.0AspXaa: 0.0 ± 0.0
Glu
4.355GluAla: 4.355 ± 0.314
0.524GluCys: 0.524 ± 0.08
3.13GluAsp: 3.13 ± 0.194
3.297GluGlu: 3.297 ± 0.241
2.328GluPhe: 2.328 ± 0.145
3.186GluGly: 3.186 ± 0.205
1.381GluHis: 1.381 ± 0.144
3.353GluIle: 3.353 ± 0.225
2.428GluLys: 2.428 ± 0.176
6.528GluLeu: 6.528 ± 0.326
1.749GluMet: 1.749 ± 0.194
2.35GluAsn: 2.35 ± 0.193
1.994GluPro: 1.994 ± 0.161
2.985GluGln: 2.985 ± 0.218
3.052GluArg: 3.052 ± 0.238
3.308GluSer: 3.308 ± 0.188
3.498GluThr: 3.498 ± 0.194
4.166GluVal: 4.166 ± 0.182
1.058GluTrp: 1.058 ± 0.106
2.161GluTyr: 2.161 ± 0.177
0.0GluXaa: 0.0 ± 0.0
Phe
2.373PheAla: 2.373 ± 0.169
0.401PheCys: 0.401 ± 0.063
2.618PheAsp: 2.618 ± 0.176
1.983PheGlu: 1.983 ± 0.141
1.203PhePhe: 1.203 ± 0.136
2.517PheGly: 2.517 ± 0.161
0.746PheHis: 0.746 ± 0.093
2.417PheIle: 2.417 ± 0.145
2.339PheLys: 2.339 ± 0.147
2.629PheLeu: 2.629 ± 0.176
1.203PheMet: 1.203 ± 0.129
2.763PheAsn: 2.763 ± 0.18
1.136PhePro: 1.136 ± 0.099
0.858PheGln: 0.858 ± 0.084
1.66PheArg: 1.66 ± 0.119
2.072PheSer: 2.072 ± 0.143
2.573PheThr: 2.573 ± 0.154
2.662PheVal: 2.662 ± 0.195
0.557PheTrp: 0.557 ± 0.078
1.348PheTyr: 1.348 ± 0.137
0.0PheXaa: 0.0 ± 0.0
Gly
5.013GlyAla: 5.013 ± 0.41
0.646GlyCys: 0.646 ± 0.086
5.068GlyAsp: 5.068 ± 0.85
4.055GlyGlu: 4.055 ± 0.283
2.952GlyPhe: 2.952 ± 0.182
6.182GlyGly: 6.182 ± 0.755
1.203GlyHis: 1.203 ± 0.124
3.832GlyIle: 3.832 ± 0.187
4.222GlyLys: 4.222 ± 0.227
5.804GlyLeu: 5.804 ± 0.305
2.161GlyMet: 2.161 ± 0.147
3.943GlyAsn: 3.943 ± 0.271
2.128GlyPro: 2.128 ± 0.25
2.261GlyGln: 2.261 ± 0.177
2.885GlyArg: 2.885 ± 0.179
4.779GlySer: 4.779 ± 0.299
4.523GlyThr: 4.523 ± 0.293
5.035GlyVal: 5.035 ± 0.265
1.181GlyTrp: 1.181 ± 0.156
3.431GlyTyr: 3.431 ± 0.22
0.0GlyXaa: 0.0 ± 0.0
His
1.348HisAla: 1.348 ± 0.133
0.267HisCys: 0.267 ± 0.056
1.259HisAsp: 1.259 ± 0.104
1.036HisGlu: 1.036 ± 0.116
0.735HisPhe: 0.735 ± 0.091
1.381HisGly: 1.381 ± 0.135
0.557HisHis: 0.557 ± 0.086
1.348HisIle: 1.348 ± 0.113
0.858HisLys: 0.858 ± 0.101
1.727HisLeu: 1.727 ± 0.13
0.635HisMet: 0.635 ± 0.076
1.036HisAsn: 1.036 ± 0.103
1.092HisPro: 1.092 ± 0.114
0.757HisGln: 0.757 ± 0.089
1.069HisArg: 1.069 ± 0.118
0.991HisSer: 0.991 ± 0.104
0.991HisThr: 0.991 ± 0.112
1.47HisVal: 1.47 ± 0.13
0.39HisTrp: 0.39 ± 0.07
1.058HisTyr: 1.058 ± 0.114
0.0HisXaa: 0.0 ± 0.0
Ile
5.28IleAla: 5.28 ± 0.255
0.568IleCys: 0.568 ± 0.078
4.489IleAsp: 4.489 ± 0.179
3.331IleGlu: 3.331 ± 0.212
1.615IlePhe: 1.615 ± 0.138
4.122IleGly: 4.122 ± 0.192
1.136IleHis: 1.136 ± 0.124
3.264IleIle: 3.264 ± 0.179
3.553IleLys: 3.553 ± 0.192
3.876IleLeu: 3.876 ± 0.191
1.537IleMet: 1.537 ± 0.13
3.954IleAsn: 3.954 ± 0.216
2.829IlePro: 2.829 ± 0.191
2.094IleGln: 2.094 ± 0.187
3.264IleArg: 3.264 ± 0.202
3.264IleSer: 3.264 ± 0.207
4.5IleThr: 4.5 ± 0.227
3.988IleVal: 3.988 ± 0.218
0.635IleTrp: 0.635 ± 0.095
2.094IleTyr: 2.094 ± 0.143
0.0IleXaa: 0.0 ± 0.0
Lys
3.966LysAla: 3.966 ± 0.232
0.423LysCys: 0.423 ± 0.072
3.097LysAsp: 3.097 ± 0.205
3.253LysGlu: 3.253 ± 0.23
1.838LysPhe: 1.838 ± 0.15
4.311LysGly: 4.311 ± 0.855
1.225LysHis: 1.225 ± 0.13
2.785LysIle: 2.785 ± 0.177
2.863LysLys: 2.863 ± 0.222
4.957LysLeu: 4.957 ± 0.208
1.604LysMet: 1.604 ± 0.133
2.172LysAsn: 2.172 ± 0.147
2.963LysPro: 2.963 ± 0.177
2.261LysGln: 2.261 ± 0.192
2.807LysArg: 2.807 ± 0.153
2.495LysSer: 2.495 ± 0.186
2.963LysThr: 2.963 ± 0.181
3.42LysVal: 3.42 ± 0.207
0.791LysTrp: 0.791 ± 0.108
1.905LysTyr: 1.905 ± 0.135
0.0LysXaa: 0.0 ± 0.0
Leu
6.583LeuAla: 6.583 ± 0.286
0.824LeuCys: 0.824 ± 0.094
5.191LeuAsp: 5.191 ± 0.255
5.492LeuGlu: 5.492 ± 0.237
2.44LeuPhe: 2.44 ± 0.173
5.28LeuGly: 5.28 ± 0.263
1.448LeuHis: 1.448 ± 0.142
5.024LeuIle: 5.024 ± 0.244
4.467LeuLys: 4.467 ± 0.186
6.951LeuLeu: 6.951 ± 0.323
2.751LeuMet: 2.751 ± 0.16
5.224LeuAsn: 5.224 ± 0.277
4.211LeuPro: 4.211 ± 0.267
3.008LeuGln: 3.008 ± 0.187
4.567LeuArg: 4.567 ± 0.213
5.982LeuSer: 5.982 ± 0.289
6.149LeuThr: 6.149 ± 0.25
6.082LeuVal: 6.082 ± 0.266
1.114LeuTrp: 1.114 ± 0.126
3.242LeuTyr: 3.242 ± 0.213
0.0LeuXaa: 0.0 ± 0.0
Met
2.662MetAla: 2.662 ± 0.179
0.234MetCys: 0.234 ± 0.057
1.404MetAsp: 1.404 ± 0.109
1.637MetGlu: 1.637 ± 0.129
1.203MetPhe: 1.203 ± 0.112
2.027MetGly: 2.027 ± 0.155
0.657MetHis: 0.657 ± 0.094
1.537MetIle: 1.537 ± 0.121
1.392MetLys: 1.392 ± 0.113
2.629MetLeu: 2.629 ± 0.172
1.092MetMet: 1.092 ± 0.156
1.671MetAsn: 1.671 ± 0.13
1.47MetPro: 1.47 ± 0.132
1.493MetGln: 1.493 ± 0.204
1.582MetArg: 1.582 ± 0.142
2.729MetSer: 2.729 ± 0.187
1.994MetThr: 1.994 ± 0.136
2.027MetVal: 2.027 ± 0.14
0.267MetTrp: 0.267 ± 0.057
1.103MetTyr: 1.103 ± 0.105
0.0MetXaa: 0.0 ± 0.0
Asn
4.578AsnAla: 4.578 ± 0.201
0.39AsnCys: 0.39 ± 0.079
3.208AsnAsp: 3.208 ± 0.248
2.774AsnGlu: 2.774 ± 0.188
1.548AsnPhe: 1.548 ± 0.134
4.378AsnGly: 4.378 ± 0.258
1.181AsnHis: 1.181 ± 0.125
3.13AsnIle: 3.13 ± 0.185
2.863AsnLys: 2.863 ± 0.195
4.634AsnLeu: 4.634 ± 0.229
1.459AsnMet: 1.459 ± 0.143
3.498AsnAsn: 3.498 ± 0.205
2.763AsnPro: 2.763 ± 0.184
2.261AsnGln: 2.261 ± 0.157
2.685AsnArg: 2.685 ± 0.173
2.985AsnSer: 2.985 ± 0.185
3.487AsnThr: 3.487 ± 0.18
3.297AsnVal: 3.297 ± 0.182
0.791AsnTrp: 0.791 ± 0.102
2.206AsnTyr: 2.206 ± 0.165
0.0AsnXaa: 0.0 ± 0.0
Pro
3.453ProAla: 3.453 ± 0.227
0.29ProCys: 0.29 ± 0.06
2.941ProAsp: 2.941 ± 0.203
2.796ProGlu: 2.796 ± 0.16
1.437ProPhe: 1.437 ± 0.132
3.13ProGly: 3.13 ± 0.209
0.813ProHis: 0.813 ± 0.105
2.763ProIle: 2.763 ± 0.191
2.362ProLys: 2.362 ± 0.183
3.164ProLeu: 3.164 ± 0.188
1.37ProMet: 1.37 ± 0.159
2.261ProAsn: 2.261 ± 0.165
1.504ProPro: 1.504 ± 0.148
1.86ProGln: 1.86 ± 0.242
1.927ProArg: 1.927 ± 0.153
2.629ProSer: 2.629 ± 0.15
3.052ProThr: 3.052 ± 0.205
3.565ProVal: 3.565 ± 0.221
0.524ProTrp: 0.524 ± 0.079
1.693ProTyr: 1.693 ± 0.151
0.0ProXaa: 0.0 ± 0.0
Gln
2.673GlnAla: 2.673 ± 0.191
0.423GlnCys: 0.423 ± 0.071
1.66GlnAsp: 1.66 ± 0.146
1.927GlnGlu: 1.927 ± 0.149
1.537GlnPhe: 1.537 ± 0.141
2.25GlnGly: 2.25 ± 0.366
0.98GlnHis: 0.98 ± 0.096
2.206GlnIle: 2.206 ± 0.144
1.482GlnLys: 1.482 ± 0.155
3.832GlnLeu: 3.832 ± 0.184
1.437GlnMet: 1.437 ± 0.139
1.615GlnAsn: 1.615 ± 0.157
2.451GlnPro: 2.451 ± 0.417
2.662GlnGln: 2.662 ± 0.379
2.317GlnArg: 2.317 ± 0.176
1.816GlnSer: 1.816 ± 0.131
2.128GlnThr: 2.128 ± 0.176
2.64GlnVal: 2.64 ± 0.175
0.546GlnTrp: 0.546 ± 0.076
1.849GlnTyr: 1.849 ± 0.169
0.0GlnXaa: 0.0 ± 0.0
Arg
3.498ArgAla: 3.498 ± 0.209
0.568ArgCys: 0.568 ± 0.086
3.242ArgAsp: 3.242 ± 0.211
2.841ArgGlu: 2.841 ± 0.176
2.228ArgPhe: 2.228 ± 0.187
2.963ArgGly: 2.963 ± 0.182
1.125ArgHis: 1.125 ± 0.114
3.074ArgIle: 3.074 ± 0.164
2.506ArgLys: 2.506 ± 0.161
4.968ArgLeu: 4.968 ± 0.24
1.66ArgMet: 1.66 ± 0.139
2.618ArgAsn: 2.618 ± 0.168
1.727ArgPro: 1.727 ± 0.13
1.838ArgGln: 1.838 ± 0.157
2.328ArgArg: 2.328 ± 0.171
2.941ArgSer: 2.941 ± 0.167
2.74ArgThr: 2.74 ± 0.176
3.732ArgVal: 3.732 ± 0.257
0.769ArgTrp: 0.769 ± 0.091
2.54ArgTyr: 2.54 ± 0.187
0.0ArgXaa: 0.0 ± 0.0
Ser
4.534SerAla: 4.534 ± 0.276
0.557SerCys: 0.557 ± 0.087
3.721SerAsp: 3.721 ± 0.201
3.42SerGlu: 3.42 ± 0.198
2.428SerPhe: 2.428 ± 0.179
4.834SerGly: 4.834 ± 0.327
1.047SerHis: 1.047 ± 0.115
3.966SerIle: 3.966 ± 0.213
2.941SerLys: 2.941 ± 0.183
4.968SerLeu: 4.968 ± 0.231
1.849SerMet: 1.849 ± 0.158
3.108SerAsn: 3.108 ± 0.194
2.272SerPro: 2.272 ± 0.16
1.972SerGln: 1.972 ± 0.138
3.008SerArg: 3.008 ± 0.185
3.721SerSer: 3.721 ± 0.233
3.954SerThr: 3.954 ± 0.205
4.445SerVal: 4.445 ± 0.21
0.824SerTrp: 0.824 ± 0.095
2.172SerTyr: 2.172 ± 0.142
0.0SerXaa: 0.0 ± 0.0
Thr
5.313ThrAla: 5.313 ± 0.252
0.524ThrCys: 0.524 ± 0.09
4.255ThrAsp: 4.255 ± 0.218
3.13ThrGlu: 3.13 ± 0.185
2.384ThrPhe: 2.384 ± 0.16
5.547ThrGly: 5.547 ± 0.402
1.192ThrHis: 1.192 ± 0.117
4.066ThrIle: 4.066 ± 0.214
2.907ThrLys: 2.907 ± 0.176
5.603ThrLeu: 5.603 ± 0.227
1.894ThrMet: 1.894 ± 0.163
3.409ThrAsn: 3.409 ± 0.215
3.342ThrPro: 3.342 ± 0.218
2.027ThrGln: 2.027 ± 0.144
2.818ThrArg: 2.818 ± 0.173
3.921ThrSer: 3.921 ± 0.258
4.968ThrThr: 4.968 ± 0.28
4.545ThrVal: 4.545 ± 0.235
0.835ThrTrp: 0.835 ± 0.091
2.573ThrTyr: 2.573 ± 0.195
0.0ThrXaa: 0.0 ± 0.0
Val
5.681ValAla: 5.681 ± 0.289
0.813ValCys: 0.813 ± 0.099
4.489ValAsp: 4.489 ± 0.23
4.044ValGlu: 4.044 ± 0.224
2.54ValPhe: 2.54 ± 0.174
4.612ValGly: 4.612 ± 0.276
1.337ValHis: 1.337 ± 0.134
4.244ValIle: 4.244 ± 0.232
3.765ValLys: 3.765 ± 0.207
5.625ValLeu: 5.625 ± 0.256
2.373ValMet: 2.373 ± 0.16
3.943ValAsn: 3.943 ± 0.17
3.23ValPro: 3.23 ± 0.193
2.261ValGln: 2.261 ± 0.201
3.631ValArg: 3.631 ± 0.189
5.057ValSer: 5.057 ± 0.257
5.191ValThr: 5.191 ± 0.224
5.67ValVal: 5.67 ± 0.273
0.869ValTrp: 0.869 ± 0.11
2.919ValTyr: 2.919 ± 0.22
0.0ValXaa: 0.0 ± 0.0
Trp
0.847TrpAla: 0.847 ± 0.099
0.156TrpCys: 0.156 ± 0.041
0.947TrpAsp: 0.947 ± 0.113
0.769TrpGlu: 0.769 ± 0.091
0.702TrpPhe: 0.702 ± 0.087
0.824TrpGly: 0.824 ± 0.116
0.345TrpHis: 0.345 ± 0.061
0.746TrpIle: 0.746 ± 0.086
0.624TrpLys: 0.624 ± 0.081
1.482TrpLeu: 1.482 ± 0.129
0.468TrpMet: 0.468 ± 0.071
0.646TrpAsn: 0.646 ± 0.074
0.423TrpPro: 0.423 ± 0.069
0.59TrpGln: 0.59 ± 0.085
0.791TrpArg: 0.791 ± 0.099
0.958TrpSer: 0.958 ± 0.121
1.025TrpThr: 1.025 ± 0.123
1.058TrpVal: 1.058 ± 0.119
0.223TrpTrp: 0.223 ± 0.052
0.668TrpTyr: 0.668 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.074TyrAla: 3.074 ± 0.205
0.479TyrCys: 0.479 ± 0.07
2.907TyrAsp: 2.907 ± 0.19
1.983TyrGlu: 1.983 ± 0.165
1.448TyrPhe: 1.448 ± 0.142
3.175TyrGly: 3.175 ± 0.213
0.858TyrHis: 0.858 ± 0.1
2.072TyrIle: 2.072 ± 0.185
1.994TyrLys: 1.994 ± 0.136
3.264TyrLeu: 3.264 ± 0.209
1.047TyrMet: 1.047 ± 0.118
2.083TyrAsn: 2.083 ± 0.146
1.871TyrPro: 1.871 ± 0.151
1.715TyrGln: 1.715 ± 0.148
2.306TyrArg: 2.306 ± 0.17
2.284TyrSer: 2.284 ± 0.164
2.328TyrThr: 2.328 ± 0.155
3.041TyrVal: 3.041 ± 0.201
0.735TyrTrp: 0.735 ± 0.091
2.172TyrTyr: 2.172 ± 0.19
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 335 proteins (89773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski