Amino acid dipepetide frequency for Haloplasma contractile SSD-17B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.977AlaAla: 2.977 ± 0.069	0.544AlaCys: 0.544 ± 0.024	2.473AlaAsp: 2.473 ± 0.054	2.799AlaGlu: 2.799 ± 0.059	2.612AlaPhe: 2.612 ± 0.054	3.307AlaGly: 3.307 ± 0.08	0.917AlaHis: 0.917 ± 0.034	5.321AlaIle: 5.321 ± 0.078	3.83AlaLys: 3.83 ± 0.075	5.423AlaLeu: 5.423 ± 0.09	1.384AlaMet: 1.384 ± 0.04	2.688AlaAsn: 2.688 ± 0.056	1.352AlaPro: 1.352 ± 0.043	1.134AlaGln: 1.134 ± 0.038	1.781AlaArg: 1.781 ± 0.043	3.104AlaSer: 3.104 ± 0.054	2.912AlaThr: 2.912 ± 0.068	3.445AlaVal: 3.445 ± 0.068	0.397AlaTrp: 0.397 ± 0.022	2.218AlaTyr: 2.218 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.413CysAla: 0.413 ± 0.02	0.107CysCys: 0.107 ± 0.011	0.554CysAsp: 0.554 ± 0.025	0.557CysGlu: 0.557 ± 0.024	0.33CysPhe: 0.33 ± 0.017	0.752CysGly: 0.752 ± 0.031	0.198CysHis: 0.198 ± 0.017	0.742CysIle: 0.742 ± 0.032	0.692CysLys: 0.692 ± 0.034	0.653CysLeu: 0.653 ± 0.028	0.193CysMet: 0.193 ± 0.013	0.551CysAsn: 0.551 ± 0.026	0.375CysPro: 0.375 ± 0.027	0.215CysGln: 0.215 ± 0.016	0.287CysArg: 0.287 ± 0.018	0.534CysSer: 0.534 ± 0.023	0.438CysThr: 0.438 ± 0.024	0.465CysVal: 0.465 ± 0.026	0.054CysTrp: 0.054 ± 0.008	0.359CysTyr: 0.359 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.976AspAla: 2.976 ± 0.065	0.515AspCys: 0.515 ± 0.028	3.756AspAsp: 3.756 ± 0.081	5.334AspGlu: 5.334 ± 0.1	2.92AspPhe: 2.92 ± 0.057	3.557AspGly: 3.557 ± 0.081	1.628AspHis: 1.628 ± 0.04	5.055AspIle: 5.055 ± 0.078	3.382AspLys: 3.382 ± 0.067	6.298AspLeu: 6.298 ± 0.083	1.278AspMet: 1.278 ± 0.047	2.531AspAsn: 2.531 ± 0.068	1.705AspPro: 1.705 ± 0.044	2.571AspGln: 2.571 ± 0.058	2.145AspArg: 2.145 ± 0.053	3.131AspSer: 3.131 ± 0.061	3.147AspThr: 3.147 ± 0.076	4.33AspVal: 4.33 ± 0.083	0.548AspTrp: 0.548 ± 0.026	3.648AspTyr: 3.648 ± 0.078	0.0AspXaa: 0.0 ± 0.0
Glu	3.714GluAla: 3.714 ± 0.078	0.522GluCys: 0.522 ± 0.026	4.168GluAsp: 4.168 ± 0.072	5.952GluGlu: 5.952 ± 0.102	3.131GluPhe: 3.131 ± 0.069	3.721GluGly: 3.721 ± 0.065	1.688GluHis: 1.688 ± 0.044	6.189GluIle: 6.189 ± 0.096	5.272GluLys: 5.272 ± 0.099	7.506GluLeu: 7.506 ± 0.101	1.882GluMet: 1.882 ± 0.044	3.886GluAsn: 3.886 ± 0.065	1.689GluPro: 1.689 ± 0.051	3.01GluGln: 3.01 ± 0.064	3.019GluArg: 3.019 ± 0.065	3.729GluSer: 3.729 ± 0.066	3.97GluThr: 3.97 ± 0.068	4.678GluVal: 4.678 ± 0.075	0.57GluTrp: 0.57 ± 0.023	3.103GluTyr: 3.103 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.267PheAla: 2.267 ± 0.054	0.375PheCys: 0.375 ± 0.021	2.919PheAsp: 2.919 ± 0.059	2.982PheGlu: 2.982 ± 0.06	2.18PhePhe: 2.18 ± 0.06	2.86PheGly: 2.86 ± 0.061	0.741PheHis: 0.741 ± 0.028	4.991PheIle: 4.991 ± 0.096	3.898PheLys: 3.898 ± 0.066	4.158PheLeu: 4.158 ± 0.083	1.211PheMet: 1.211 ± 0.038	3.384PheAsn: 3.384 ± 0.067	1.134PhePro: 1.134 ± 0.035	0.931PheGln: 0.931 ± 0.032	1.501PheArg: 1.501 ± 0.038	3.003PheSer: 3.003 ± 0.062	2.691PheThr: 2.691 ± 0.058	2.919PheVal: 2.919 ± 0.07	0.331PheTrp: 0.331 ± 0.021	2.112PheTyr: 2.112 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	3.414GlyAla: 3.414 ± 0.078	0.66GlyCys: 0.66 ± 0.033	3.249GlyAsp: 3.249 ± 0.071	3.655GlyGlu: 3.655 ± 0.064	3.153GlyPhe: 3.153 ± 0.061	3.809GlyGly: 3.809 ± 0.088	1.249GlyHis: 1.249 ± 0.04	5.804GlyIle: 5.804 ± 0.084	4.324GlyLys: 4.324 ± 0.072	5.627GlyLeu: 5.627 ± 0.09	1.574GlyMet: 1.574 ± 0.047	3.086GlyAsn: 3.086 ± 0.076	1.256GlyPro: 1.256 ± 0.043	1.604GlyGln: 1.604 ± 0.047	2.126GlyArg: 2.126 ± 0.056	3.354GlySer: 3.354 ± 0.065	3.706GlyThr: 3.706 ± 0.084	4.242GlyVal: 4.242 ± 0.076	0.511GlyTrp: 0.511 ± 0.021	3.103GlyTyr: 3.103 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.012HisAla: 1.012 ± 0.034	0.195HisCys: 0.195 ± 0.017	1.248HisAsp: 1.248 ± 0.042	1.33HisGlu: 1.33 ± 0.033	0.986HisPhe: 0.986 ± 0.031	1.153HisGly: 1.153 ± 0.041	0.553HisHis: 0.553 ± 0.03	1.797HisIle: 1.797 ± 0.042	1.443HisLys: 1.443 ± 0.046	1.925HisLeu: 1.925 ± 0.046	0.443HisMet: 0.443 ± 0.024	1.241HisAsn: 1.241 ± 0.04	0.826HisPro: 0.826 ± 0.028	0.638HisGln: 0.638 ± 0.025	0.722HisArg: 0.722 ± 0.029	1.106HisSer: 1.106 ± 0.035	1.084HisThr: 1.084 ± 0.036	1.357HisVal: 1.357 ± 0.04	0.129HisTrp: 0.129 ± 0.011	1.215HisTyr: 1.215 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	5.116IleAla: 5.116 ± 0.078	0.708IleCys: 0.708 ± 0.033	6.156IleAsp: 6.156 ± 0.082	6.746IleGlu: 6.746 ± 0.086	3.753IlePhe: 3.753 ± 0.086	5.805IleGly: 5.805 ± 0.107	1.635IleHis: 1.635 ± 0.046	8.51IleIle: 8.51 ± 0.134	7.612IleLys: 7.612 ± 0.101	8.192IleLeu: 8.192 ± 0.145	2.037IleMet: 2.037 ± 0.049	5.95IleAsn: 5.95 ± 0.083	3.199IlePro: 3.199 ± 0.08	2.338IleGln: 2.338 ± 0.052	3.188IleArg: 3.188 ± 0.063	5.673IleSer: 5.673 ± 0.081	5.485IleThr: 5.485 ± 0.094	5.895IleVal: 5.895 ± 0.084	0.567IleTrp: 0.567 ± 0.029	3.709IleTyr: 3.709 ± 0.078	0.0IleXaa: 0.0 ± 0.0
Lys	3.515LysAla: 3.515 ± 0.065	0.551LysCys: 0.551 ± 0.028	4.858LysAsp: 4.858 ± 0.078	7.06LysGlu: 7.06 ± 0.118	2.487LysPhe: 2.487 ± 0.051	4.091LysGly: 4.091 ± 0.075	1.778LysHis: 1.778 ± 0.045	6.038LysIle: 6.038 ± 0.094	6.857LysLys: 6.857 ± 0.109	6.766LysLeu: 6.766 ± 0.1	2.118LysMet: 2.118 ± 0.053	4.562LysAsn: 4.562 ± 0.076	2.043LysPro: 2.043 ± 0.057	3.369LysGln: 3.369 ± 0.072	3.668LysArg: 3.668 ± 0.06	4.243LysSer: 4.243 ± 0.071	4.246LysThr: 4.246 ± 0.062	4.801LysVal: 4.801 ± 0.074	0.583LysTrp: 0.583 ± 0.025	3.214LysTyr: 3.214 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.127LeuAla: 5.127 ± 0.093	0.736LeuCys: 0.736 ± 0.027	5.553LeuAsp: 5.553 ± 0.081	6.407LeuGlu: 6.407 ± 0.091	5.115LeuPhe: 5.115 ± 0.112	5.59LeuGly: 5.59 ± 0.076	1.574LeuHis: 1.574 ± 0.041	9.001LeuIle: 9.001 ± 0.137	7.614LeuLys: 7.614 ± 0.092	9.324LeuLeu: 9.324 ± 0.137	2.336LeuMet: 2.336 ± 0.052	6.266LeuAsn: 6.266 ± 0.1	2.912LeuPro: 2.912 ± 0.059	2.254LeuGln: 2.254 ± 0.048	3.194LeuArg: 3.194 ± 0.063	6.689LeuSer: 6.689 ± 0.112	5.693LeuThr: 5.693 ± 0.101	6.144LeuVal: 6.144 ± 0.087	0.58LeuTrp: 0.58 ± 0.032	4.156LeuTyr: 4.156 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	1.381MetAla: 1.381 ± 0.04	0.188MetCys: 0.188 ± 0.013	1.344MetAsp: 1.344 ± 0.039	1.357MetGlu: 1.357 ± 0.044	1.034MetPhe: 1.034 ± 0.037	1.403MetGly: 1.403 ± 0.038	0.386MetHis: 0.386 ± 0.022	2.333MetIle: 2.333 ± 0.053	2.232MetLys: 2.232 ± 0.051	2.231MetLeu: 2.231 ± 0.05	0.721MetMet: 0.721 ± 0.029	1.961MetAsn: 1.961 ± 0.05	0.777MetPro: 0.777 ± 0.033	0.611MetGln: 0.611 ± 0.024	0.903MetArg: 0.903 ± 0.034	1.541MetSer: 1.541 ± 0.043	1.401MetThr: 1.401 ± 0.042	1.54MetVal: 1.54 ± 0.04	0.146MetTrp: 0.146 ± 0.011	0.863MetTyr: 0.863 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.68AsnAla: 2.68 ± 0.067	0.483AsnCys: 0.483 ± 0.022	3.655AsnAsp: 3.655 ± 0.066	4.791AsnGlu: 4.791 ± 0.08	2.244AsnPhe: 2.244 ± 0.045	3.362AsnGly: 3.362 ± 0.063	1.523AsnHis: 1.523 ± 0.042	4.96AsnIle: 4.96 ± 0.087	5.079AsnLys: 5.079 ± 0.091	5.217AsnLeu: 5.217 ± 0.082	1.398AsnMet: 1.398 ± 0.037	3.961AsnAsn: 3.961 ± 0.091	2.071AsnPro: 2.071 ± 0.047	2.518AsnGln: 2.518 ± 0.057	2.48AsnArg: 2.48 ± 0.053	3.24AsnSer: 3.24 ± 0.074	3.173AsnThr: 3.173 ± 0.078	3.565AsnVal: 3.565 ± 0.071	0.483AsnTrp: 0.483 ± 0.029	3.056AsnTyr: 3.056 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.195ProAla: 1.195 ± 0.039	0.266ProCys: 0.266 ± 0.017	1.678ProAsp: 1.678 ± 0.052	2.158ProGlu: 2.158 ± 0.046	1.56ProPhe: 1.56 ± 0.047	1.669ProGly: 1.669 ± 0.048	0.611ProHis: 0.611 ± 0.027	2.613ProIle: 2.613 ± 0.056	2.013ProLys: 2.013 ± 0.047	2.681ProLeu: 2.681 ± 0.053	0.585ProMet: 0.585 ± 0.025	1.734ProAsn: 1.734 ± 0.049	0.566ProPro: 0.566 ± 0.025	0.741ProGln: 0.741 ± 0.028	0.913ProArg: 0.913 ± 0.034	1.765ProSer: 1.765 ± 0.045	1.81ProThr: 1.81 ± 0.047	2.086ProVal: 2.086 ± 0.046	0.266ProTrp: 0.266 ± 0.019	1.537ProTyr: 1.537 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.644GlnAla: 1.644 ± 0.04	0.196GlnCys: 0.196 ± 0.014	1.828GlnAsp: 1.828 ± 0.044	2.086GlnGlu: 2.086 ± 0.056	1.62GlnPhe: 1.62 ± 0.041	1.609GlnGly: 1.609 ± 0.048	0.604GlnHis: 0.604 ± 0.023	2.627GlnIle: 2.627 ± 0.058	2.108GlnLys: 2.108 ± 0.051	3.156GlnLeu: 3.156 ± 0.066	0.82GlnMet: 0.82 ± 0.029	1.754GlnAsn: 1.754 ± 0.046	0.782GlnPro: 0.782 ± 0.031	0.962GlnGln: 0.962 ± 0.042	0.958GlnArg: 0.958 ± 0.03	1.838GlnSer: 1.838 ± 0.046	1.733GlnThr: 1.733 ± 0.042	2.212GlnVal: 2.212 ± 0.048	0.193GlnTrp: 0.193 ± 0.016	1.566GlnTyr: 1.566 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.693ArgAla: 1.693 ± 0.041	0.333ArgCys: 0.333 ± 0.02	2.184ArgAsp: 2.184 ± 0.045	2.66ArgGlu: 2.66 ± 0.058	1.739ArgPhe: 1.739 ± 0.045	1.933ArgGly: 1.933 ± 0.047	0.758ArgHis: 0.758 ± 0.029	3.324ArgIle: 3.324 ± 0.062	2.932ArgLys: 2.932 ± 0.062	3.714ArgLeu: 3.714 ± 0.074	0.898ArgMet: 0.898 ± 0.034	2.228ArgAsn: 2.228 ± 0.046	0.98ArgPro: 0.98 ± 0.032	1.271ArgGln: 1.271 ± 0.039	1.526ArgArg: 1.526 ± 0.044	1.947ArgSer: 1.947 ± 0.048	1.966ArgThr: 1.966 ± 0.042	2.529ArgVal: 2.529 ± 0.058	0.263ArgTrp: 0.263 ± 0.019	1.894ArgTyr: 1.894 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	2.656SerAla: 2.656 ± 0.058	0.537SerCys: 0.537 ± 0.023	3.437SerAsp: 3.437 ± 0.074	3.809SerGlu: 3.809 ± 0.064	3.131SerPhe: 3.131 ± 0.055	3.919SerGly: 3.919 ± 0.075	1.213SerHis: 1.213 ± 0.035	5.993SerIle: 5.993 ± 0.086	4.596SerLys: 4.596 ± 0.07	6.157SerLeu: 6.157 ± 0.094	1.427SerMet: 1.427 ± 0.039	3.476SerAsn: 3.476 ± 0.071	1.461SerPro: 1.461 ± 0.043	1.69SerGln: 1.69 ± 0.039	2.224SerArg: 2.224 ± 0.051	3.668SerSer: 3.668 ± 0.068	3.104SerThr: 3.104 ± 0.062	3.91SerVal: 3.91 ± 0.076	0.404SerTrp: 0.404 ± 0.022	2.824SerTyr: 2.824 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	2.807ThrAla: 2.807 ± 0.066	0.458ThrCys: 0.458 ± 0.024	3.495ThrAsp: 3.495 ± 0.084	3.61ThrGlu: 3.61 ± 0.071	2.763ThrPhe: 2.763 ± 0.055	3.693ThrGly: 3.693 ± 0.074	1.221ThrHis: 1.221 ± 0.038	5.952ThrIle: 5.952 ± 0.115	3.896ThrLys: 3.896 ± 0.074	5.751ThrLeu: 5.751 ± 0.085	1.145ThrMet: 1.145 ± 0.036	3.224ThrAsn: 3.224 ± 0.065	1.893ThrPro: 1.893 ± 0.05	1.255ThrGln: 1.255 ± 0.035	1.756ThrArg: 1.756 ± 0.05	3.418ThrSer: 3.418 ± 0.063	3.417ThrThr: 3.417 ± 0.1	4.242ThrVal: 4.242 ± 0.103	0.409ThrTrp: 0.409 ± 0.021	2.853ThrTyr: 2.853 ± 0.078	0.0ThrXaa: 0.0 ± 0.0
Val	3.628ValAla: 3.628 ± 0.073	0.603ValCys: 0.603 ± 0.028	4.178ValAsp: 4.178 ± 0.08	4.386ValGlu: 4.386 ± 0.086	3.037ValPhe: 3.037 ± 0.055	4.044ValGly: 4.044 ± 0.076	1.07ValHis: 1.07 ± 0.035	6.318ValIle: 6.318 ± 0.077	4.843ValLys: 4.843 ± 0.078	6.309ValLeu: 6.309 ± 0.096	1.669ValMet: 1.669 ± 0.049	3.844ValAsn: 3.844 ± 0.078	1.937ValPro: 1.937 ± 0.051	1.471ValGln: 1.471 ± 0.041	2.265ValArg: 2.265 ± 0.05	4.32ValSer: 4.32 ± 0.073	4.301ValThr: 4.301 ± 0.114	4.443ValVal: 4.443 ± 0.096	0.481ValTrp: 0.481 ± 0.022	2.877ValTyr: 2.877 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.341TrpAla: 0.341 ± 0.022	0.078TrpCys: 0.078 ± 0.009	0.455TrpAsp: 0.455 ± 0.023	0.409TrpGlu: 0.409 ± 0.022	0.456TrpPhe: 0.456 ± 0.026	0.485TrpGly: 0.485 ± 0.023	0.149TrpHis: 0.149 ± 0.013	0.67TrpIle: 0.67 ± 0.027	0.451TrpLys: 0.451 ± 0.022	0.769TrpLeu: 0.769 ± 0.036	0.206TrpMet: 0.206 ± 0.013	0.487TrpAsn: 0.487 ± 0.023	0.185TrpPro: 0.185 ± 0.015	0.238TrpGln: 0.238 ± 0.015	0.261TrpArg: 0.261 ± 0.015	0.456TrpSer: 0.456 ± 0.026	0.326TrpThr: 0.326 ± 0.019	0.431TrpVal: 0.431 ± 0.024	0.101TrpTrp: 0.101 ± 0.011	0.344TrpTyr: 0.344 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.063TyrAla: 2.063 ± 0.053	0.413TyrCys: 0.413 ± 0.021	3.266TyrAsp: 3.266 ± 0.092	3.31TyrGlu: 3.31 ± 0.066	2.334TyrPhe: 2.334 ± 0.061	2.74TyrGly: 2.74 ± 0.059	0.91TyrHis: 0.91 ± 0.035	4.04TyrIle: 4.04 ± 0.065	3.774TyrLys: 3.774 ± 0.075	4.405TyrLeu: 4.405 ± 0.077	1.028TyrMet: 1.028 ± 0.036	3.126TyrAsn: 3.126 ± 0.062	1.305TyrPro: 1.305 ± 0.042	1.477TyrGln: 1.477 ± 0.043	1.855TyrArg: 1.855 ± 0.051	2.879TyrSer: 2.879 ± 0.058	2.655TyrThr: 2.655 ± 0.07	2.791TyrVal: 2.791 ± 0.059	0.281TyrTrp: 0.281 ± 0.019	2.491TyrTyr: 2.491 ± 0.076	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3019 proteins (927687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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