Amino acid dipepetide frequency for Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.027AlaAla: 5.027 ± 1.115
0.794AlaCys: 0.794 ± 0.58
3.969AlaAsp: 3.969 ± 0.586
2.381AlaGlu: 2.381 ± 0.528
3.969AlaPhe: 3.969 ± 0.624
4.763AlaGly: 4.763 ± 1.058
0.926AlaHis: 0.926 ± 0.215
3.44AlaIle: 3.44 ± 0.65
2.249AlaLys: 2.249 ± 0.725
9.128AlaLeu: 9.128 ± 0.801
2.249AlaMet: 2.249 ± 0.466
2.646AlaAsn: 2.646 ± 0.458
2.646AlaPro: 2.646 ± 0.528
2.514AlaGln: 2.514 ± 0.599
4.101AlaArg: 4.101 ± 0.611
4.895AlaSer: 4.895 ± 0.484
5.027AlaThr: 5.027 ± 0.978
8.467AlaVal: 8.467 ± 1.24
0.661AlaTrp: 0.661 ± 0.266
2.381AlaTyr: 2.381 ± 1.113
0.0AlaXaa: 0.0 ± 0.0
Cys
1.191CysAla: 1.191 ± 0.293
0.265CysCys: 0.265 ± 0.33
1.72CysAsp: 1.72 ± 0.413
0.794CysGlu: 0.794 ± 0.195
1.588CysPhe: 1.588 ± 0.506
2.514CysGly: 2.514 ± 0.474
0.397CysHis: 0.397 ± 0.18
0.397CysIle: 0.397 ± 0.224
0.397CysLys: 0.397 ± 0.427
0.794CysLeu: 0.794 ± 0.36
0.661CysMet: 0.661 ± 0.259
0.529CysAsn: 0.529 ± 0.246
0.529CysPro: 0.529 ± 0.178
0.0CysGln: 0.0 ± 0.0
1.588CysArg: 1.588 ± 0.657
1.323CysSer: 1.323 ± 0.394
1.455CysThr: 1.455 ± 0.253
1.191CysVal: 1.191 ± 0.747
0.265CysTrp: 0.265 ± 0.098
1.058CysTyr: 1.058 ± 0.393
0.0CysXaa: 0.0 ± 0.0
Asp
3.704AspAla: 3.704 ± 0.563
1.058AspCys: 1.058 ± 0.429
3.307AspAsp: 3.307 ± 0.608
4.233AspGlu: 4.233 ± 0.599
3.175AspPhe: 3.175 ± 0.628
2.91AspGly: 2.91 ± 0.423
0.661AspHis: 0.661 ± 0.332
4.366AspIle: 4.366 ± 0.67
2.117AspLys: 2.117 ± 0.284
3.043AspLeu: 3.043 ± 0.933
0.926AspMet: 0.926 ± 0.222
2.91AspAsn: 2.91 ± 0.403
1.588AspPro: 1.588 ± 0.447
0.794AspGln: 0.794 ± 0.481
2.778AspArg: 2.778 ± 0.768
4.101AspSer: 4.101 ± 0.722
2.91AspThr: 2.91 ± 1.043
8.599AspVal: 8.599 ± 0.958
0.132AspTrp: 0.132 ± 0.092
2.514AspTyr: 2.514 ± 0.345
0.0AspXaa: 0.0 ± 0.0
Glu
4.101GluAla: 4.101 ± 0.702
0.529GluCys: 0.529 ± 0.237
3.704GluAsp: 3.704 ± 0.742
3.307GluGlu: 3.307 ± 0.658
1.191GluPhe: 1.191 ± 0.607
4.63GluGly: 4.63 ± 0.891
0.265GluHis: 0.265 ± 0.098
1.984GluIle: 1.984 ± 0.457
4.233GluLys: 4.233 ± 0.522
3.969GluLeu: 3.969 ± 0.631
0.529GluMet: 0.529 ± 0.214
1.984GluAsn: 1.984 ± 0.869
1.455GluPro: 1.455 ± 0.545
1.323GluGln: 1.323 ± 0.273
2.91GluArg: 2.91 ± 0.685
3.307GluSer: 3.307 ± 0.486
3.44GluThr: 3.44 ± 0.462
6.482GluVal: 6.482 ± 0.879
0.265GluTrp: 0.265 ± 0.098
1.852GluTyr: 1.852 ± 0.41
0.0GluXaa: 0.0 ± 0.0
Phe
1.984PheAla: 1.984 ± 0.356
0.794PheCys: 0.794 ± 0.35
2.91PheAsp: 2.91 ± 0.326
2.91PheGlu: 2.91 ± 0.536
4.233PhePhe: 4.233 ± 0.729
2.646PheGly: 2.646 ± 0.693
1.72PheHis: 1.72 ± 0.385
3.175PheIle: 3.175 ± 0.715
2.117PheLys: 2.117 ± 0.608
3.175PheLeu: 3.175 ± 0.756
0.529PheMet: 0.529 ± 0.4
2.117PheAsn: 2.117 ± 0.246
1.588PhePro: 1.588 ± 0.329
0.794PheGln: 0.794 ± 0.237
2.646PheArg: 2.646 ± 0.556
8.07PheSer: 8.07 ± 1.055
3.043PheThr: 3.043 ± 0.333
4.763PheVal: 4.763 ± 0.972
0.265PheTrp: 0.265 ± 0.098
1.058PheTyr: 1.058 ± 0.264
0.0PheXaa: 0.0 ± 0.0
Gly
4.895GlyAla: 4.895 ± 0.636
1.588GlyCys: 1.588 ± 0.284
5.027GlyAsp: 5.027 ± 0.863
3.572GlyGlu: 3.572 ± 0.739
3.307GlyPhe: 3.307 ± 0.814
7.408GlyGly: 7.408 ± 1.202
0.265GlyHis: 0.265 ± 0.098
4.101GlyIle: 4.101 ± 0.682
7.276GlyLys: 7.276 ± 0.757
6.218GlyLeu: 6.218 ± 0.651
1.191GlyMet: 1.191 ± 0.646
2.514GlyAsn: 2.514 ± 0.457
0.794GlyPro: 0.794 ± 0.253
0.926GlyGln: 0.926 ± 0.492
3.572GlyArg: 3.572 ± 0.352
6.35GlySer: 6.35 ± 0.538
4.233GlyThr: 4.233 ± 0.871
5.821GlyVal: 5.821 ± 0.932
1.058GlyTrp: 1.058 ± 0.34
1.984GlyTyr: 1.984 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
0.926HisAla: 0.926 ± 0.272
0.529HisCys: 0.529 ± 0.197
0.794HisAsp: 0.794 ± 0.228
1.058HisGlu: 1.058 ± 0.257
0.265HisPhe: 0.265 ± 0.184
0.397HisGly: 0.397 ± 0.286
0.265HisHis: 0.265 ± 0.098
0.397HisIle: 0.397 ± 0.195
0.132HisLys: 0.132 ± 0.181
2.117HisLeu: 2.117 ± 0.634
0.529HisMet: 0.529 ± 0.197
0.397HisAsn: 0.397 ± 0.286
0.397HisPro: 0.397 ± 0.163
0.661HisGln: 0.661 ± 0.194
0.794HisArg: 0.794 ± 0.261
1.72HisSer: 1.72 ± 0.5
0.529HisThr: 0.529 ± 0.196
2.778HisVal: 2.778 ± 0.745
0.265HisTrp: 0.265 ± 0.098
0.794HisTyr: 0.794 ± 0.527
0.0HisXaa: 0.0 ± 0.0
Ile
3.043IleAla: 3.043 ± 0.67
1.058IleCys: 1.058 ± 0.637
2.117IleAsp: 2.117 ± 0.584
1.984IleGlu: 1.984 ± 0.516
3.043IlePhe: 3.043 ± 0.785
3.44IleGly: 3.44 ± 0.575
0.132IleHis: 0.132 ± 0.153
1.191IleIle: 1.191 ± 0.478
2.91IleLys: 2.91 ± 0.931
5.556IleLeu: 5.556 ± 1.541
0.529IleMet: 0.529 ± 0.222
4.101IleAsn: 4.101 ± 0.767
1.852IlePro: 1.852 ± 0.798
1.191IleGln: 1.191 ± 0.863
2.381IleArg: 2.381 ± 0.496
3.44IleSer: 3.44 ± 0.863
3.043IleThr: 3.043 ± 0.612
3.175IleVal: 3.175 ± 0.439
0.794IleTrp: 0.794 ± 0.295
1.72IleTyr: 1.72 ± 0.636
0.0IleXaa: 0.0 ± 0.0
Lys
5.292LysAla: 5.292 ± 0.85
1.191LysCys: 1.191 ± 0.444
3.043LysAsp: 3.043 ± 0.87
2.381LysGlu: 2.381 ± 0.556
1.852LysPhe: 1.852 ± 0.598
6.879LysGly: 6.879 ± 0.846
0.265LysHis: 0.265 ± 0.212
2.249LysIle: 2.249 ± 0.944
3.307LysLys: 3.307 ± 0.489
4.763LysLeu: 4.763 ± 0.469
0.794LysMet: 0.794 ± 0.356
1.058LysAsn: 1.058 ± 0.595
3.043LysPro: 3.043 ± 0.357
2.514LysGln: 2.514 ± 0.435
4.763LysArg: 4.763 ± 0.422
4.895LysSer: 4.895 ± 0.547
2.778LysThr: 2.778 ± 0.568
5.424LysVal: 5.424 ± 0.787
0.132LysTrp: 0.132 ± 0.189
2.91LysTyr: 2.91 ± 0.639
0.0LysXaa: 0.0 ± 0.0
Leu
4.63LeuAla: 4.63 ± 0.794
1.72LeuCys: 1.72 ± 0.324
3.969LeuAsp: 3.969 ± 0.686
4.366LeuGlu: 4.366 ± 0.601
3.969LeuPhe: 3.969 ± 0.705
5.424LeuGly: 5.424 ± 0.594
1.455LeuHis: 1.455 ± 0.31
4.763LeuIle: 4.763 ± 2.428
5.159LeuLys: 5.159 ± 0.749
8.07LeuLeu: 8.07 ± 1.279
2.91LeuMet: 2.91 ± 0.429
2.91LeuAsn: 2.91 ± 0.356
3.704LeuPro: 3.704 ± 0.575
1.455LeuGln: 1.455 ± 0.613
6.218LeuArg: 6.218 ± 1.056
7.673LeuSer: 7.673 ± 1.213
5.556LeuThr: 5.556 ± 0.579
8.996LeuVal: 8.996 ± 1.01
0.265LeuTrp: 0.265 ± 0.098
1.323LeuTyr: 1.323 ± 0.761
0.0LeuXaa: 0.0 ± 0.0
Met
1.984MetAla: 1.984 ± 0.396
0.397MetCys: 0.397 ± 0.178
1.323MetAsp: 1.323 ± 0.325
1.191MetGlu: 1.191 ± 0.565
1.191MetPhe: 1.191 ± 0.369
1.191MetGly: 1.191 ± 0.698
0.529MetHis: 0.529 ± 0.197
0.926MetIle: 0.926 ± 0.423
1.852MetLys: 1.852 ± 0.523
1.455MetLeu: 1.455 ± 0.484
0.397MetMet: 0.397 ± 0.222
0.397MetAsn: 0.397 ± 0.286
0.794MetPro: 0.794 ± 0.295
0.132MetGln: 0.132 ± 0.181
0.926MetArg: 0.926 ± 0.524
0.397MetSer: 0.397 ± 0.237
1.455MetThr: 1.455 ± 0.346
1.191MetVal: 1.191 ± 0.444
0.397MetTrp: 0.397 ± 0.195
0.661MetTyr: 0.661 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
3.836AsnAla: 3.836 ± 0.3
0.794AsnCys: 0.794 ± 0.221
1.72AsnAsp: 1.72 ± 0.738
2.91AsnGlu: 2.91 ± 0.502
2.514AsnPhe: 2.514 ± 0.648
2.117AsnGly: 2.117 ± 0.392
0.132AsnHis: 0.132 ± 0.237
1.588AsnIle: 1.588 ± 0.739
2.381AsnLys: 2.381 ± 1.187
3.043AsnLeu: 3.043 ± 0.556
0.397AsnMet: 0.397 ± 0.18
2.117AsnAsn: 2.117 ± 0.573
1.323AsnPro: 1.323 ± 0.294
1.323AsnGln: 1.323 ± 0.407
1.852AsnArg: 1.852 ± 0.229
2.778AsnSer: 2.778 ± 0.278
3.44AsnThr: 3.44 ± 0.531
4.763AsnVal: 4.763 ± 0.804
0.794AsnTrp: 0.794 ± 0.53
0.397AsnTyr: 0.397 ± 0.388
0.0AsnXaa: 0.0 ± 0.0
Pro
1.72ProAla: 1.72 ± 0.335
0.529ProCys: 0.529 ± 0.196
1.588ProAsp: 1.588 ± 0.689
1.984ProGlu: 1.984 ± 0.52
1.058ProPhe: 1.058 ± 0.239
2.91ProGly: 2.91 ± 0.404
0.661ProHis: 0.661 ± 0.194
2.91ProIle: 2.91 ± 0.486
3.44ProLys: 3.44 ± 0.389
2.381ProLeu: 2.381 ± 0.581
0.265ProMet: 0.265 ± 0.098
1.984ProAsn: 1.984 ± 0.297
1.72ProPro: 1.72 ± 0.567
1.984ProGln: 1.984 ± 0.441
2.381ProArg: 2.381 ± 0.536
3.175ProSer: 3.175 ± 0.474
1.72ProThr: 1.72 ± 0.618
4.366ProVal: 4.366 ± 0.767
0.0ProTrp: 0.0 ± 0.0
1.323ProTyr: 1.323 ± 0.527
0.0ProXaa: 0.0 ± 0.0
Gln
2.117GlnAla: 2.117 ± 0.801
0.397GlnCys: 0.397 ± 0.222
0.926GlnAsp: 0.926 ± 0.222
1.588GlnGlu: 1.588 ± 0.398
0.529GlnPhe: 0.529 ± 0.177
1.455GlnGly: 1.455 ± 0.275
0.661GlnHis: 0.661 ± 0.362
1.058GlnIle: 1.058 ± 0.609
1.72GlnLys: 1.72 ± 0.271
2.249GlnLeu: 2.249 ± 0.376
0.132GlnMet: 0.132 ± 0.189
0.794GlnAsn: 0.794 ± 0.284
1.588GlnPro: 1.588 ± 0.232
1.323GlnGln: 1.323 ± 0.403
1.455GlnArg: 1.455 ± 0.304
2.91GlnSer: 2.91 ± 0.694
0.926GlnThr: 0.926 ± 0.576
2.249GlnVal: 2.249 ± 0.345
0.132GlnTrp: 0.132 ± 0.153
0.794GlnTyr: 0.794 ± 0.237
0.0GlnXaa: 0.0 ± 0.0
Arg
6.085ArgAla: 6.085 ± 1.005
2.249ArgCys: 2.249 ± 0.607
3.043ArgAsp: 3.043 ± 0.616
4.101ArgGlu: 4.101 ± 0.753
0.926ArgPhe: 0.926 ± 0.259
6.615ArgGly: 6.615 ± 0.682
1.058ArgHis: 1.058 ± 0.505
2.514ArgIle: 2.514 ± 0.894
2.117ArgLys: 2.117 ± 0.462
3.836ArgLeu: 3.836 ± 0.782
1.058ArgMet: 1.058 ± 0.344
1.72ArgAsn: 1.72 ± 0.368
1.323ArgPro: 1.323 ± 0.376
1.852ArgGln: 1.852 ± 0.582
4.895ArgArg: 4.895 ± 1.009
5.027ArgSer: 5.027 ± 0.674
4.233ArgThr: 4.233 ± 0.94
4.233ArgVal: 4.233 ± 0.685
0.661ArgTrp: 0.661 ± 0.359
1.984ArgTyr: 1.984 ± 0.8
0.0ArgXaa: 0.0 ± 0.0
Ser
4.895SerAla: 4.895 ± 0.869
0.794SerCys: 0.794 ± 0.28
6.085SerAsp: 6.085 ± 0.512
2.91SerGlu: 2.91 ± 0.522
5.556SerPhe: 5.556 ± 0.645
6.747SerGly: 6.747 ± 1.085
1.72SerHis: 1.72 ± 0.668
3.307SerIle: 3.307 ± 0.837
5.027SerLys: 5.027 ± 0.577
8.202SerLeu: 8.202 ± 1.283
1.588SerMet: 1.588 ± 0.318
3.043SerAsn: 3.043 ± 0.662
3.572SerPro: 3.572 ± 0.449
2.249SerGln: 2.249 ± 0.409
4.101SerArg: 4.101 ± 0.677
8.467SerSer: 8.467 ± 1.246
5.027SerThr: 5.027 ± 0.619
8.599SerVal: 8.599 ± 0.939
0.0SerTrp: 0.0 ± 0.0
4.101SerTyr: 4.101 ± 0.665
0.0SerXaa: 0.0 ± 0.0
Thr
5.292ThrAla: 5.292 ± 0.626
0.397ThrCys: 0.397 ± 0.145
2.381ThrAsp: 2.381 ± 1.194
2.91ThrGlu: 2.91 ± 0.557
4.895ThrPhe: 4.895 ± 1.016
3.043ThrGly: 3.043 ± 0.706
1.191ThrHis: 1.191 ± 0.209
3.572ThrIle: 3.572 ± 0.373
2.778ThrLys: 2.778 ± 0.73
5.424ThrLeu: 5.424 ± 1.135
0.926ThrMet: 0.926 ± 0.298
2.646ThrAsn: 2.646 ± 0.871
2.381ThrPro: 2.381 ± 0.406
2.249ThrGln: 2.249 ± 0.377
3.307ThrArg: 3.307 ± 0.398
5.292ThrSer: 5.292 ± 0.708
4.366ThrThr: 4.366 ± 0.981
4.63ThrVal: 4.63 ± 0.672
0.397ThrTrp: 0.397 ± 0.163
3.043ThrTyr: 3.043 ± 0.372
0.0ThrXaa: 0.0 ± 0.0
Val
7.541ValAla: 7.541 ± 0.91
1.984ValCys: 1.984 ± 0.614
4.895ValAsp: 4.895 ± 0.475
4.763ValGlu: 4.763 ± 1.658
5.689ValPhe: 5.689 ± 0.897
6.085ValGly: 6.085 ± 0.598
2.249ValHis: 2.249 ± 0.687
3.043ValIle: 3.043 ± 1.055
7.408ValLys: 7.408 ± 1.129
6.085ValLeu: 6.085 ± 1.029
2.778ValMet: 2.778 ± 0.864
3.704ValAsn: 3.704 ± 0.443
6.218ValPro: 6.218 ± 0.887
1.72ValGln: 1.72 ± 0.455
6.482ValArg: 6.482 ± 0.971
9.26ValSer: 9.26 ± 0.931
4.895ValThr: 4.895 ± 0.474
9.922ValVal: 9.922 ± 1.019
0.794ValTrp: 0.794 ± 0.205
4.895ValTyr: 4.895 ± 0.748
0.0ValXaa: 0.0 ± 0.0
Trp
1.058TrpAla: 1.058 ± 0.288
0.926TrpCys: 0.926 ± 0.286
0.397TrpAsp: 0.397 ± 0.296
0.397TrpGlu: 0.397 ± 0.369
0.265TrpPhe: 0.265 ± 0.098
0.265TrpGly: 0.265 ± 0.098
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.058TrpLys: 1.058 ± 0.319
0.926TrpLeu: 0.926 ± 0.324
0.0TrpMet: 0.0 ± 0.0
0.265TrpAsn: 0.265 ± 0.316
0.265TrpPro: 0.265 ± 0.098
0.0TrpGln: 0.0 ± 0.0
0.265TrpArg: 0.265 ± 0.098
0.529TrpSer: 0.529 ± 0.197
0.265TrpThr: 0.265 ± 0.212
0.397TrpVal: 0.397 ± 0.361
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.91TyrAla: 2.91 ± 0.64
0.661TyrCys: 0.661 ± 0.441
2.91TyrAsp: 2.91 ± 0.569
1.72TyrGlu: 1.72 ± 0.437
1.323TyrPhe: 1.323 ± 0.48
0.794TyrGly: 0.794 ± 0.392
1.191TyrHis: 1.191 ± 0.49
1.72TyrIle: 1.72 ± 0.443
1.852TyrLys: 1.852 ± 0.244
4.101TyrLeu: 4.101 ± 1.395
0.265TyrMet: 0.265 ± 0.355
2.381TyrAsn: 2.381 ± 0.5
1.323TyrPro: 1.323 ± 0.372
0.0TyrGln: 0.0 ± 0.0
2.117TyrArg: 2.117 ± 0.486
2.381TyrSer: 2.381 ± 0.671
2.778TyrThr: 2.778 ± 0.796
4.366TyrVal: 4.366 ± 0.664
0.0TyrTrp: 0.0 ± 0.0
1.455TyrTyr: 1.455 ± 0.948
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (7560 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski