Amino acid dipepetide frequency for Thiogranum longum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.111AlaAla: 10.111 ± 0.155	1.202AlaCys: 1.202 ± 0.038	5.516AlaAsp: 5.516 ± 0.08	5.985AlaGlu: 5.985 ± 0.09	3.318AlaPhe: 3.318 ± 0.062	8.568AlaGly: 8.568 ± 0.114	1.952AlaHis: 1.952 ± 0.049	5.292AlaIle: 5.292 ± 0.083	2.961AlaLys: 2.961 ± 0.066	11.007AlaLeu: 11.007 ± 0.126	2.786AlaMet: 2.786 ± 0.062	2.774AlaAsn: 2.774 ± 0.068	3.59AlaPro: 3.59 ± 0.07	3.629AlaGln: 3.629 ± 0.071	6.669AlaArg: 6.669 ± 0.106	5.692AlaSer: 5.692 ± 0.077	4.68AlaThr: 4.68 ± 0.082	7.0AlaVal: 7.0 ± 0.108	1.267AlaTrp: 1.267 ± 0.042	2.257AlaTyr: 2.257 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.944CysAla: 0.944 ± 0.037	0.149CysCys: 0.149 ± 0.015	0.579CysAsp: 0.579 ± 0.028	0.601CysGlu: 0.601 ± 0.027	0.329CysPhe: 0.329 ± 0.019	0.994CysGly: 0.994 ± 0.038	0.465CysHis: 0.465 ± 0.041	0.554CysIle: 0.554 ± 0.027	0.34CysLys: 0.34 ± 0.019	0.874CysLeu: 0.874 ± 0.033	0.203CysMet: 0.203 ± 0.013	0.36CysAsn: 0.36 ± 0.021	0.578CysPro: 0.578 ± 0.03	0.392CysGln: 0.392 ± 0.022	0.712CysArg: 0.712 ± 0.028	0.647CysSer: 0.647 ± 0.032	0.467CysThr: 0.467 ± 0.025	0.635CysVal: 0.635 ± 0.029	0.103CysTrp: 0.103 ± 0.012	0.28CysTyr: 0.28 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	5.811AspAla: 5.811 ± 0.097	0.623AspCys: 0.623 ± 0.033	3.566AspAsp: 3.566 ± 0.069	4.216AspGlu: 4.216 ± 0.076	2.356AspPhe: 2.356 ± 0.056	4.42AspGly: 4.42 ± 0.081	1.234AspHis: 1.234 ± 0.04	3.74AspIle: 3.74 ± 0.061	2.428AspLys: 2.428 ± 0.057	5.652AspLeu: 5.652 ± 0.07	1.526AspMet: 1.526 ± 0.046	2.136AspAsn: 2.136 ± 0.053	3.069AspPro: 3.069 ± 0.067	1.944AspGln: 1.944 ± 0.047	3.689AspArg: 3.689 ± 0.068	3.326AspSer: 3.326 ± 0.066	3.205AspThr: 3.205 ± 0.06	4.183AspVal: 4.183 ± 0.082	0.953AspTrp: 0.953 ± 0.033	1.927AspTyr: 1.927 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.302GluAla: 6.302 ± 0.091	0.497GluCys: 0.497 ± 0.029	3.151GluAsp: 3.151 ± 0.063	3.62GluGlu: 3.62 ± 0.089	1.986GluPhe: 1.986 ± 0.049	4.164GluGly: 4.164 ± 0.067	1.664GluHis: 1.664 ± 0.05	3.736GluIle: 3.736 ± 0.068	3.085GluLys: 3.085 ± 0.07	6.653GluLeu: 6.653 ± 0.094	1.581GluMet: 1.581 ± 0.046	2.299GluAsn: 2.299 ± 0.048	2.661GluPro: 2.661 ± 0.061	3.677GluGln: 3.677 ± 0.079	4.507GluArg: 4.507 ± 0.073	3.294GluSer: 3.294 ± 0.06	3.569GluThr: 3.569 ± 0.066	4.3GluVal: 4.3 ± 0.083	0.777GluTrp: 0.777 ± 0.028	1.567GluTyr: 1.567 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.106PheAla: 3.106 ± 0.059	0.398PheCys: 0.398 ± 0.021	2.519PheAsp: 2.519 ± 0.05	2.275PheGlu: 2.275 ± 0.051	1.512PhePhe: 1.512 ± 0.049	3.04PheGly: 3.04 ± 0.062	0.847PheHis: 0.847 ± 0.029	1.989PheIle: 1.989 ± 0.052	1.066PheLys: 1.066 ± 0.04	3.51PheLeu: 3.51 ± 0.07	0.877PheMet: 0.877 ± 0.03	1.406PheAsn: 1.406 ± 0.042	1.549PhePro: 1.549 ± 0.046	1.142PheGln: 1.142 ± 0.035	2.277PheArg: 2.277 ± 0.052	2.766PheSer: 2.766 ± 0.062	2.08PheThr: 2.08 ± 0.057	2.596PheVal: 2.596 ± 0.05	0.521PheTrp: 0.521 ± 0.026	1.068PheTyr: 1.068 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.568GlyAla: 6.568 ± 0.105	0.913GlyCys: 0.913 ± 0.034	4.485GlyAsp: 4.485 ± 0.084	4.997GlyGlu: 4.997 ± 0.078	3.25GlyPhe: 3.25 ± 0.067	5.93GlyGly: 5.93 ± 0.105	1.858GlyHis: 1.858 ± 0.044	4.684GlyIle: 4.684 ± 0.075	3.896GlyLys: 3.896 ± 0.076	7.888GlyLeu: 7.888 ± 0.112	2.332GlyMet: 2.332 ± 0.047	2.785GlyAsn: 2.785 ± 0.06	2.486GlyPro: 2.486 ± 0.056	2.913GlyGln: 2.913 ± 0.055	4.681GlyArg: 4.681 ± 0.085	4.481GlySer: 4.481 ± 0.072	3.77GlyThr: 3.77 ± 0.076	5.887GlyVal: 5.887 ± 0.087	1.307GlyTrp: 1.307 ± 0.037	2.522GlyTyr: 2.522 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.18HisAla: 2.18 ± 0.052	0.306HisCys: 0.306 ± 0.02	1.248HisAsp: 1.248 ± 0.037	1.289HisGlu: 1.289 ± 0.038	0.987HisPhe: 0.987 ± 0.034	1.857HisGly: 1.857 ± 0.054	0.698HisHis: 0.698 ± 0.026	1.351HisIle: 1.351 ± 0.042	0.843HisLys: 0.843 ± 0.034	2.3HisLeu: 2.3 ± 0.052	0.587HisMet: 0.587 ± 0.024	0.788HisAsn: 0.788 ± 0.032	1.407HisPro: 1.407 ± 0.038	0.871HisGln: 0.871 ± 0.032	1.543HisArg: 1.543 ± 0.041	1.258HisSer: 1.258 ± 0.035	1.23HisThr: 1.23 ± 0.038	1.431HisVal: 1.431 ± 0.039	0.424HisTrp: 0.424 ± 0.022	0.849HisTyr: 0.849 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.561IleAla: 5.561 ± 0.095	0.535IleCys: 0.535 ± 0.026	4.069IleAsp: 4.069 ± 0.069	4.03IleGlu: 4.03 ± 0.072	1.663IlePhe: 1.663 ± 0.05	4.307IleGly: 4.307 ± 0.086	1.274IleHis: 1.274 ± 0.039	2.825IleIle: 2.825 ± 0.064	2.009IleLys: 2.009 ± 0.058	4.892IleLeu: 4.892 ± 0.083	1.047IleMet: 1.047 ± 0.036	2.109IleAsn: 2.109 ± 0.047	2.623IlePro: 2.623 ± 0.058	1.876IleGln: 1.876 ± 0.047	3.641IleArg: 3.641 ± 0.066	3.431IleSer: 3.431 ± 0.06	3.053IleThr: 3.053 ± 0.066	3.555IleVal: 3.555 ± 0.07	0.486IleTrp: 0.486 ± 0.024	1.283IleTyr: 1.283 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.777LysAla: 3.777 ± 0.08	0.263LysCys: 0.263 ± 0.021	2.123LysAsp: 2.123 ± 0.052	2.043LysGlu: 2.043 ± 0.062	0.977LysPhe: 0.977 ± 0.03	2.769LysGly: 2.769 ± 0.072	0.915LysHis: 0.915 ± 0.033	2.014LysIle: 2.014 ± 0.049	2.112LysLys: 2.112 ± 0.102	4.019LysLeu: 4.019 ± 0.073	0.897LysMet: 0.897 ± 0.033	1.238LysAsn: 1.238 ± 0.036	2.23LysPro: 2.23 ± 0.052	1.911LysGln: 1.911 ± 0.051	2.782LysArg: 2.782 ± 0.06	2.07LysSer: 2.07 ± 0.047	2.235LysThr: 2.235 ± 0.062	2.712LysVal: 2.712 ± 0.053	0.4LysTrp: 0.4 ± 0.025	0.883LysTyr: 0.883 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.041LeuAla: 11.041 ± 0.149	0.978LeuCys: 0.978 ± 0.039	6.736LeuAsp: 6.736 ± 0.107	6.9LeuGlu: 6.9 ± 0.113	4.13LeuPhe: 4.13 ± 0.074	7.738LeuGly: 7.738 ± 0.109	2.374LeuHis: 2.374 ± 0.056	5.119LeuIle: 5.119 ± 0.096	4.185LeuLys: 4.185 ± 0.081	11.714LeuLeu: 11.714 ± 0.203	2.631LeuMet: 2.631 ± 0.063	3.227LeuAsn: 3.227 ± 0.058	5.428LeuPro: 5.428 ± 0.08	4.113LeuGln: 4.113 ± 0.087	6.713LeuArg: 6.713 ± 0.099	6.643LeuSer: 6.643 ± 0.095	5.26LeuThr: 5.26 ± 0.074	8.102LeuVal: 8.102 ± 0.118	1.164LeuTrp: 1.164 ± 0.039	2.732LeuTyr: 2.732 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.52MetAla: 2.52 ± 0.055	0.184MetCys: 0.184 ± 0.015	1.376MetAsp: 1.376 ± 0.04	1.462MetGlu: 1.462 ± 0.044	0.772MetPhe: 0.772 ± 0.036	1.715MetGly: 1.715 ± 0.045	0.612MetHis: 0.612 ± 0.023	1.25MetIle: 1.25 ± 0.038	1.269MetLys: 1.269 ± 0.038	2.697MetLeu: 2.697 ± 0.053	0.629MetMet: 0.629 ± 0.027	0.974MetAsn: 0.974 ± 0.034	1.395MetPro: 1.395 ± 0.049	1.069MetGln: 1.069 ± 0.036	1.581MetArg: 1.581 ± 0.036	1.692MetSer: 1.692 ± 0.045	1.403MetThr: 1.403 ± 0.036	1.709MetVal: 1.709 ± 0.044	0.178MetTrp: 0.178 ± 0.014	0.46MetTyr: 0.46 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.069AsnAla: 3.069 ± 0.064	0.367AsnCys: 0.367 ± 0.019	1.85AsnAsp: 1.85 ± 0.049	1.826AsnGlu: 1.826 ± 0.044	1.109AsnPhe: 1.109 ± 0.038	2.598AsnGly: 2.598 ± 0.073	0.711AsnHis: 0.711 ± 0.027	1.948AsnIle: 1.948 ± 0.047	1.131AsnLys: 1.131 ± 0.04	3.294AsnLeu: 3.294 ± 0.062	0.781AsnMet: 0.781 ± 0.03	1.261AsnAsn: 1.261 ± 0.044	2.189AsnPro: 2.189 ± 0.05	1.19AsnGln: 1.19 ± 0.039	2.337AsnArg: 2.337 ± 0.05	1.794AsnSer: 1.794 ± 0.057	1.917AsnThr: 1.917 ± 0.056	2.148AsnVal: 2.148 ± 0.059	0.478AsnTrp: 0.478 ± 0.022	0.902AsnTyr: 0.902 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.911ProAla: 4.911 ± 0.085	0.389ProCys: 0.389 ± 0.024	3.765ProAsp: 3.765 ± 0.075	3.886ProGlu: 3.886 ± 0.068	1.772ProPhe: 1.772 ± 0.052	4.43ProGly: 4.43 ± 0.069	0.968ProHis: 0.968 ± 0.029	1.785ProIle: 1.785 ± 0.05	1.308ProLys: 1.308 ± 0.039	4.733ProLeu: 4.733 ± 0.075	1.078ProMet: 1.078 ± 0.031	1.166ProAsn: 1.166 ± 0.038	2.048ProPro: 2.048 ± 0.065	1.638ProGln: 1.638 ± 0.047	2.352ProArg: 2.352 ± 0.06	2.164ProSer: 2.164 ± 0.055	1.884ProThr: 1.884 ± 0.043	4.903ProVal: 4.903 ± 0.082	0.66ProTrp: 0.66 ± 0.031	1.135ProTyr: 1.135 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.351GlnAla: 4.351 ± 0.085	0.353GlnCys: 0.353 ± 0.022	1.887GlnAsp: 1.887 ± 0.046	2.106GlnGlu: 2.106 ± 0.053	1.2GlnPhe: 1.2 ± 0.031	2.802GlnGly: 2.802 ± 0.057	1.114GlnHis: 1.114 ± 0.035	1.938GlnIle: 1.938 ± 0.049	1.448GlnLys: 1.448 ± 0.042	4.641GlnLeu: 4.641 ± 0.086	0.909GlnMet: 0.909 ± 0.035	1.011GlnAsn: 1.011 ± 0.033	2.077GlnPro: 2.077 ± 0.049	2.441GlnGln: 2.441 ± 0.058	3.068GlnArg: 3.068 ± 0.065	2.057GlnSer: 2.057 ± 0.055	1.925GlnThr: 1.925 ± 0.052	3.02GlnVal: 3.02 ± 0.063	0.501GlnTrp: 0.501 ± 0.023	1.012GlnTyr: 1.012 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	5.459ArgAla: 5.459 ± 0.085	0.681ArgCys: 0.681 ± 0.032	3.898ArgAsp: 3.898 ± 0.062	4.678ArgGlu: 4.678 ± 0.083	2.808ArgPhe: 2.808 ± 0.052	3.879ArgGly: 3.879 ± 0.074	1.802ArgHis: 1.802 ± 0.043	4.054ArgIle: 4.054 ± 0.072	3.098ArgLys: 3.098 ± 0.062	7.587ArgLeu: 7.587 ± 0.106	1.746ArgMet: 1.746 ± 0.044	2.36ArgAsn: 2.36 ± 0.051	2.565ArgPro: 2.565 ± 0.053	2.825ArgGln: 2.825 ± 0.062	4.401ArgArg: 4.401 ± 0.084	3.448ArgSer: 3.448 ± 0.064	2.917ArgThr: 2.917 ± 0.061	4.573ArgVal: 4.573 ± 0.066	0.956ArgTrp: 0.956 ± 0.031	2.291ArgTyr: 2.291 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.48SerAla: 5.48 ± 0.088	0.639SerCys: 0.639 ± 0.03	3.429SerAsp: 3.429 ± 0.073	3.401SerGlu: 3.401 ± 0.065	2.096SerPhe: 2.096 ± 0.06	5.72SerGly: 5.72 ± 0.093	1.342SerHis: 1.342 ± 0.042	3.113SerIle: 3.113 ± 0.064	1.933SerLys: 1.933 ± 0.048	6.235SerLeu: 6.235 ± 0.091	1.539SerMet: 1.539 ± 0.043	1.819SerAsn: 1.819 ± 0.055	2.632SerPro: 2.632 ± 0.054	2.099SerGln: 2.099 ± 0.049	3.793SerArg: 3.793 ± 0.074	3.46SerSer: 3.46 ± 0.086	2.921SerThr: 2.921 ± 0.065	4.185SerVal: 4.185 ± 0.071	0.744SerTrp: 0.744 ± 0.028	1.378SerTyr: 1.378 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.76ThrAla: 4.76 ± 0.082	0.52ThrCys: 0.52 ± 0.025	3.133ThrAsp: 3.133 ± 0.064	2.784ThrGlu: 2.784 ± 0.054	1.77ThrPhe: 1.77 ± 0.044	5.155ThrGly: 5.155 ± 0.101	1.185ThrHis: 1.185 ± 0.038	2.544ThrIle: 2.544 ± 0.054	1.178ThrLys: 1.178 ± 0.04	6.493ThrLeu: 6.493 ± 0.099	0.942ThrMet: 0.942 ± 0.035	1.393ThrAsn: 1.393 ± 0.046	3.091ThrPro: 3.091 ± 0.068	1.632ThrGln: 1.632 ± 0.044	3.591ThrArg: 3.591 ± 0.061	2.781ThrSer: 2.781 ± 0.057	2.875ThrThr: 2.875 ± 0.073	3.993ThrVal: 3.993 ± 0.086	0.572ThrTrp: 0.572 ± 0.028	1.187ThrTyr: 1.187 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	7.079ValAla: 7.079 ± 0.092	0.761ValCys: 0.761 ± 0.034	4.534ValAsp: 4.534 ± 0.089	4.852ValGlu: 4.852 ± 0.073	2.858ValPhe: 2.858 ± 0.056	4.737ValGly: 4.737 ± 0.069	1.496ValHis: 1.496 ± 0.05	4.398ValIle: 4.398 ± 0.087	2.588ValLys: 2.588 ± 0.052	7.806ValLeu: 7.806 ± 0.113	1.92ValMet: 1.92 ± 0.047	2.512ValAsn: 2.512 ± 0.057	3.425ValPro: 3.425 ± 0.068	2.563ValGln: 2.563 ± 0.062	4.495ValArg: 4.495 ± 0.076	4.631ValSer: 4.631 ± 0.081	4.201ValThr: 4.201 ± 0.085	5.779ValVal: 5.779 ± 0.097	0.88ValTrp: 0.88 ± 0.035	1.736ValTyr: 1.736 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.911TrpAla: 0.911 ± 0.032	0.145TrpCys: 0.145 ± 0.013	0.625TrpAsp: 0.625 ± 0.027	0.671TrpGlu: 0.671 ± 0.027	0.571TrpPhe: 0.571 ± 0.023	0.803TrpGly: 0.803 ± 0.032	0.288TrpHis: 0.288 ± 0.019	0.689TrpIle: 0.689 ± 0.028	0.565TrpLys: 0.565 ± 0.022	1.927TrpLeu: 1.927 ± 0.057	0.374TrpMet: 0.374 ± 0.019	0.4TrpAsn: 0.4 ± 0.022	0.591TrpPro: 0.591 ± 0.03	0.705TrpGln: 0.705 ± 0.029	0.9TrpArg: 0.9 ± 0.031	0.758TrpSer: 0.758 ± 0.031	0.527TrpThr: 0.527 ± 0.023	0.936TrpVal: 0.936 ± 0.032	0.228TrpTrp: 0.228 ± 0.02	0.392TrpTyr: 0.392 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.314TyrAla: 2.314 ± 0.061	0.305TyrCys: 0.305 ± 0.017	1.513TyrAsp: 1.513 ± 0.057	1.466TyrGlu: 1.466 ± 0.04	1.08TyrPhe: 1.08 ± 0.034	2.006TyrGly: 2.006 ± 0.056	0.647TyrHis: 0.647 ± 0.028	1.244TyrIle: 1.244 ± 0.038	0.928TyrLys: 0.928 ± 0.035	3.007TyrLeu: 3.007 ± 0.063	0.561TyrMet: 0.561 ± 0.025	0.883TyrAsn: 0.883 ± 0.033	1.342TyrPro: 1.342 ± 0.046	1.231TyrGln: 1.231 ± 0.038	2.297TyrArg: 2.297 ± 0.051	1.564TyrSer: 1.564 ± 0.049	1.46TyrThr: 1.46 ± 0.043	1.605TyrVal: 1.605 ± 0.048	0.407TyrTrp: 0.407 ± 0.023	0.875TyrTyr: 0.875 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2795 proteins (882141 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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