Amino acid dipepetide frequency for Streptococcus phage Javan7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.658AlaAla: 2.658 ± 0.695
0.275AlaCys: 0.275 ± 0.194
4.766AlaAsp: 4.766 ± 0.617
3.849AlaGlu: 3.849 ± 0.657
2.75AlaPhe: 2.75 ± 0.472
4.491AlaGly: 4.491 ± 1.024
0.917AlaHis: 0.917 ± 0.296
5.682AlaIle: 5.682 ± 0.987
6.507AlaLys: 6.507 ± 0.91
5.682AlaLeu: 5.682 ± 0.676
1.283AlaMet: 1.283 ± 0.325
4.857AlaAsn: 4.857 ± 0.651
1.191AlaPro: 1.191 ± 0.302
2.108AlaGln: 2.108 ± 0.386
2.75AlaArg: 2.75 ± 0.467
3.758AlaSer: 3.758 ± 0.501
4.216AlaThr: 4.216 ± 0.648
2.933AlaVal: 2.933 ± 0.475
0.917AlaTrp: 0.917 ± 0.266
2.658AlaTyr: 2.658 ± 0.531
0.0AlaXaa: 0.0 ± 0.0
Cys
0.183CysAla: 0.183 ± 0.134
0.183CysCys: 0.183 ± 0.124
0.733CysAsp: 0.733 ± 0.337
0.458CysGlu: 0.458 ± 0.167
0.092CysPhe: 0.092 ± 0.085
0.275CysGly: 0.275 ± 0.173
0.183CysHis: 0.183 ± 0.125
0.367CysIle: 0.367 ± 0.207
0.367CysLys: 0.367 ± 0.181
0.458CysLeu: 0.458 ± 0.225
0.183CysMet: 0.183 ± 0.13
0.367CysAsn: 0.367 ± 0.198
0.183CysPro: 0.183 ± 0.11
0.367CysGln: 0.367 ± 0.189
0.367CysArg: 0.367 ± 0.171
0.458CysSer: 0.458 ± 0.196
0.275CysThr: 0.275 ± 0.182
0.275CysVal: 0.275 ± 0.151
0.183CysTrp: 0.183 ± 0.147
0.55CysTyr: 0.55 ± 0.273
0.0CysXaa: 0.0 ± 0.0
Asp
3.024AspAla: 3.024 ± 0.494
0.55AspCys: 0.55 ± 0.172
3.116AspAsp: 3.116 ± 0.646
4.491AspGlu: 4.491 ± 0.54
2.841AspPhe: 2.841 ± 0.407
5.866AspGly: 5.866 ± 0.958
0.825AspHis: 0.825 ± 0.263
5.774AspIle: 5.774 ± 0.837
5.682AspLys: 5.682 ± 0.871
4.308AspLeu: 4.308 ± 0.54
1.65AspMet: 1.65 ± 0.347
4.399AspAsn: 4.399 ± 0.569
1.191AspPro: 1.191 ± 0.278
1.1AspGln: 1.1 ± 0.258
2.475AspArg: 2.475 ± 0.36
4.216AspSer: 4.216 ± 0.858
3.666AspThr: 3.666 ± 0.637
3.849AspVal: 3.849 ± 0.63
1.375AspTrp: 1.375 ± 0.279
3.483AspTyr: 3.483 ± 0.775
0.0AspXaa: 0.0 ± 0.0
Glu
5.132GluAla: 5.132 ± 0.65
0.275GluCys: 0.275 ± 0.147
3.666GluAsp: 3.666 ± 0.492
4.491GluGlu: 4.491 ± 0.733
3.116GluPhe: 3.116 ± 0.45
2.291GluGly: 2.291 ± 0.441
1.1GluHis: 1.1 ± 0.383
5.224GluIle: 5.224 ± 0.76
5.407GluLys: 5.407 ± 0.775
6.049GluLeu: 6.049 ± 0.918
2.75GluMet: 2.75 ± 0.638
3.483GluAsn: 3.483 ± 0.574
1.283GluPro: 1.283 ± 0.391
3.299GluGln: 3.299 ± 0.726
3.758GluArg: 3.758 ± 0.657
3.758GluSer: 3.758 ± 0.688
3.666GluThr: 3.666 ± 0.586
4.216GluVal: 4.216 ± 0.696
1.191GluTrp: 1.191 ± 0.302
2.658GluTyr: 2.658 ± 0.371
0.0GluXaa: 0.0 ± 0.0
Phe
2.383PheAla: 2.383 ± 0.372
0.183PheCys: 0.183 ± 0.136
3.391PheAsp: 3.391 ± 0.525
3.299PheGlu: 3.299 ± 0.624
1.375PhePhe: 1.375 ± 0.378
3.024PheGly: 3.024 ± 0.482
0.275PheHis: 0.275 ± 0.172
3.116PheIle: 3.116 ± 0.526
4.308PheLys: 4.308 ± 0.695
2.566PheLeu: 2.566 ± 0.415
1.008PheMet: 1.008 ± 0.376
2.016PheAsn: 2.016 ± 0.477
1.008PhePro: 1.008 ± 0.362
0.733PheGln: 0.733 ± 0.272
1.925PheArg: 1.925 ± 0.401
2.2PheSer: 2.2 ± 0.399
3.024PheThr: 3.024 ± 0.471
3.299PheVal: 3.299 ± 0.663
0.183PheTrp: 0.183 ± 0.106
1.925PheTyr: 1.925 ± 0.48
0.0PheXaa: 0.0 ± 0.0
Gly
3.941GlyAla: 3.941 ± 0.88
0.275GlyCys: 0.275 ± 0.156
3.483GlyAsp: 3.483 ± 0.497
2.933GlyGlu: 2.933 ± 0.627
3.849GlyPhe: 3.849 ± 0.753
4.308GlyGly: 4.308 ± 0.71
0.917GlyHis: 0.917 ± 0.259
5.957GlyIle: 5.957 ± 0.882
7.057GlyLys: 7.057 ± 1.058
4.308GlyLeu: 4.308 ± 0.596
1.833GlyMet: 1.833 ± 0.488
3.849GlyAsn: 3.849 ± 0.429
1.008GlyPro: 1.008 ± 0.493
2.383GlyGln: 2.383 ± 0.359
2.841GlyArg: 2.841 ± 0.495
3.483GlySer: 3.483 ± 0.782
4.766GlyThr: 4.766 ± 0.848
3.574GlyVal: 3.574 ± 0.543
1.466GlyTrp: 1.466 ± 0.281
4.124GlyTyr: 4.124 ± 0.701
0.0GlyXaa: 0.0 ± 0.0
His
0.917HisAla: 0.917 ± 0.221
0.183HisCys: 0.183 ± 0.136
0.917HisAsp: 0.917 ± 0.326
1.283HisGlu: 1.283 ± 0.373
0.55HisPhe: 0.55 ± 0.228
0.917HisGly: 0.917 ± 0.329
0.458HisHis: 0.458 ± 0.241
1.558HisIle: 1.558 ± 0.44
1.1HisLys: 1.1 ± 0.246
1.375HisLeu: 1.375 ± 0.554
0.458HisMet: 0.458 ± 0.202
0.917HisAsn: 0.917 ± 0.337
0.642HisPro: 0.642 ± 0.267
0.733HisGln: 0.733 ± 0.264
0.642HisArg: 0.642 ± 0.208
0.55HisSer: 0.55 ± 0.222
0.642HisThr: 0.642 ± 0.267
1.008HisVal: 1.008 ± 0.293
0.275HisTrp: 0.275 ± 0.145
0.825HisTyr: 0.825 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
5.224IleAla: 5.224 ± 0.673
0.367IleCys: 0.367 ± 0.217
7.332IleAsp: 7.332 ± 0.808
4.949IleGlu: 4.949 ± 0.839
2.566IlePhe: 2.566 ± 0.634
4.399IleGly: 4.399 ± 0.674
1.375IleHis: 1.375 ± 0.312
4.766IleIle: 4.766 ± 0.708
6.69IleLys: 6.69 ± 0.681
5.774IleLeu: 5.774 ± 0.722
1.925IleMet: 1.925 ± 0.474
4.491IleAsn: 4.491 ± 0.689
2.841IlePro: 2.841 ± 0.51
2.75IleGln: 2.75 ± 0.552
2.841IleArg: 2.841 ± 0.557
5.591IleSer: 5.591 ± 1.166
3.758IleThr: 3.758 ± 0.689
4.033IleVal: 4.033 ± 0.709
0.733IleTrp: 0.733 ± 0.284
2.658IleTyr: 2.658 ± 0.582
0.0IleXaa: 0.0 ± 0.0
Lys
6.69LysAla: 6.69 ± 0.944
0.367LysCys: 0.367 ± 0.193
5.132LysAsp: 5.132 ± 0.714
5.316LysGlu: 5.316 ± 0.763
2.475LysPhe: 2.475 ± 0.5
4.308LysGly: 4.308 ± 0.508
0.642LysHis: 0.642 ± 0.219
5.774LysIle: 5.774 ± 0.71
7.057LysLys: 7.057 ± 1.091
6.965LysLeu: 6.965 ± 0.664
2.291LysMet: 2.291 ± 0.528
5.407LysAsn: 5.407 ± 0.709
2.841LysPro: 2.841 ± 0.583
3.483LysGln: 3.483 ± 0.649
3.666LysArg: 3.666 ± 0.554
4.857LysSer: 4.857 ± 0.858
7.057LysThr: 7.057 ± 0.849
5.224LysVal: 5.224 ± 0.651
1.375LysTrp: 1.375 ± 0.305
4.491LysTyr: 4.491 ± 0.621
0.0LysXaa: 0.0 ± 0.0
Leu
5.224LeuAla: 5.224 ± 0.568
0.642LeuCys: 0.642 ± 0.298
4.308LeuAsp: 4.308 ± 0.621
4.857LeuGlu: 4.857 ± 0.81
3.483LeuPhe: 3.483 ± 0.548
5.316LeuGly: 5.316 ± 0.98
0.733LeuHis: 0.733 ± 0.365
5.591LeuIle: 5.591 ± 0.764
7.24LeuLys: 7.24 ± 0.747
6.599LeuLeu: 6.599 ± 1.077
2.108LeuMet: 2.108 ± 0.33
5.316LeuAsn: 5.316 ± 0.761
3.116LeuPro: 3.116 ± 0.504
3.574LeuGln: 3.574 ± 0.622
2.566LeuArg: 2.566 ± 0.483
6.416LeuSer: 6.416 ± 0.813
5.224LeuThr: 5.224 ± 0.623
4.399LeuVal: 4.399 ± 0.68
1.191LeuTrp: 1.191 ± 0.322
2.108LeuTyr: 2.108 ± 0.39
0.0LeuXaa: 0.0 ± 0.0
Met
2.016MetAla: 2.016 ± 0.54
0.092MetCys: 0.092 ± 0.093
1.65MetAsp: 1.65 ± 0.535
1.375MetGlu: 1.375 ± 0.481
0.733MetPhe: 0.733 ± 0.283
1.008MetGly: 1.008 ± 0.278
0.367MetHis: 0.367 ± 0.173
2.108MetIle: 2.108 ± 0.45
1.741MetLys: 1.741 ± 0.375
1.741MetLeu: 1.741 ± 0.387
0.458MetMet: 0.458 ± 0.194
1.283MetAsn: 1.283 ± 0.304
0.733MetPro: 0.733 ± 0.221
1.191MetGln: 1.191 ± 0.392
1.1MetArg: 1.1 ± 0.363
1.466MetSer: 1.466 ± 0.334
1.925MetThr: 1.925 ± 0.416
1.925MetVal: 1.925 ± 0.312
0.367MetTrp: 0.367 ± 0.185
1.008MetTyr: 1.008 ± 0.324
0.0MetXaa: 0.0 ± 0.0
Asn
3.116AsnAla: 3.116 ± 0.579
0.458AsnCys: 0.458 ± 0.193
2.933AsnAsp: 2.933 ± 0.623
4.216AsnGlu: 4.216 ± 0.539
3.208AsnPhe: 3.208 ± 0.499
6.049AsnGly: 6.049 ± 0.739
1.283AsnHis: 1.283 ± 0.442
3.941AsnIle: 3.941 ± 0.68
4.949AsnLys: 4.949 ± 0.797
5.041AsnLeu: 5.041 ± 0.949
1.191AsnMet: 1.191 ± 0.383
3.208AsnAsn: 3.208 ± 0.423
2.475AsnPro: 2.475 ± 0.495
2.108AsnGln: 2.108 ± 0.536
2.658AsnArg: 2.658 ± 0.608
3.024AsnSer: 3.024 ± 0.601
2.658AsnThr: 2.658 ± 0.656
3.391AsnVal: 3.391 ± 0.483
0.917AsnTrp: 0.917 ± 0.373
2.75AsnTyr: 2.75 ± 0.338
0.0AsnXaa: 0.0 ± 0.0
Pro
1.558ProAla: 1.558 ± 0.389
0.0ProCys: 0.0 ± 0.0
2.016ProAsp: 2.016 ± 0.418
1.65ProGlu: 1.65 ± 0.446
1.375ProPhe: 1.375 ± 0.345
1.65ProGly: 1.65 ± 0.369
0.367ProHis: 0.367 ± 0.168
2.2ProIle: 2.2 ± 0.451
3.758ProLys: 3.758 ± 0.512
2.291ProLeu: 2.291 ± 0.4
0.642ProMet: 0.642 ± 0.261
1.283ProAsn: 1.283 ± 0.344
1.008ProPro: 1.008 ± 0.267
1.283ProGln: 1.283 ± 0.292
1.008ProArg: 1.008 ± 0.381
2.75ProSer: 2.75 ± 0.457
1.65ProThr: 1.65 ± 0.426
1.1ProVal: 1.1 ± 0.227
0.092ProTrp: 0.092 ± 0.085
1.558ProTyr: 1.558 ± 0.455
0.0ProXaa: 0.0 ± 0.0
Gln
3.666GlnAla: 3.666 ± 0.654
0.367GlnCys: 0.367 ± 0.166
1.558GlnAsp: 1.558 ± 0.403
2.75GlnGlu: 2.75 ± 0.681
1.375GlnPhe: 1.375 ± 0.315
2.475GlnGly: 2.475 ± 0.649
0.275GlnHis: 0.275 ± 0.172
3.208GlnIle: 3.208 ± 0.743
3.208GlnLys: 3.208 ± 0.396
3.483GlnLeu: 3.483 ± 0.674
0.55GlnMet: 0.55 ± 0.224
1.65GlnAsn: 1.65 ± 0.401
1.1GlnPro: 1.1 ± 0.287
1.833GlnGln: 1.833 ± 0.517
1.833GlnArg: 1.833 ± 0.481
2.566GlnSer: 2.566 ± 0.563
2.016GlnThr: 2.016 ± 0.476
1.925GlnVal: 1.925 ± 0.48
0.458GlnTrp: 0.458 ± 0.177
1.1GlnTyr: 1.1 ± 0.3
0.0GlnXaa: 0.0 ± 0.0
Arg
2.016ArgAla: 2.016 ± 0.403
0.183ArgCys: 0.183 ± 0.127
2.475ArgAsp: 2.475 ± 0.479
3.391ArgGlu: 3.391 ± 0.57
1.283ArgPhe: 1.283 ± 0.335
2.016ArgGly: 2.016 ± 0.459
1.008ArgHis: 1.008 ± 0.419
3.391ArgIle: 3.391 ± 0.553
3.758ArgLys: 3.758 ± 0.684
3.574ArgLeu: 3.574 ± 0.607
0.55ArgMet: 0.55 ± 0.198
2.291ArgAsn: 2.291 ± 0.535
1.833ArgPro: 1.833 ± 0.282
1.008ArgGln: 1.008 ± 0.367
1.833ArgArg: 1.833 ± 0.448
1.558ArgSer: 1.558 ± 0.469
2.658ArgThr: 2.658 ± 0.461
2.566ArgVal: 2.566 ± 0.531
0.367ArgTrp: 0.367 ± 0.137
2.291ArgTyr: 2.291 ± 0.448
0.0ArgXaa: 0.0 ± 0.0
Ser
3.666SerAla: 3.666 ± 1.104
0.275SerCys: 0.275 ± 0.187
5.224SerAsp: 5.224 ± 0.73
4.216SerGlu: 4.216 ± 0.602
3.758SerPhe: 3.758 ± 0.548
5.132SerGly: 5.132 ± 0.703
1.191SerHis: 1.191 ± 0.277
4.308SerIle: 4.308 ± 0.547
4.124SerLys: 4.124 ± 0.763
4.766SerLeu: 4.766 ± 0.741
1.466SerMet: 1.466 ± 0.412
4.583SerAsn: 4.583 ± 0.647
0.917SerPro: 0.917 ± 0.269
1.833SerGln: 1.833 ± 0.46
1.65SerArg: 1.65 ± 0.348
4.949SerSer: 4.949 ± 0.703
3.299SerThr: 3.299 ± 0.547
4.216SerVal: 4.216 ± 0.559
0.733SerTrp: 0.733 ± 0.279
2.658SerTyr: 2.658 ± 0.362
0.0SerXaa: 0.0 ± 0.0
Thr
4.124ThrAla: 4.124 ± 0.522
0.458ThrCys: 0.458 ± 0.21
4.308ThrAsp: 4.308 ± 0.516
4.033ThrGlu: 4.033 ± 0.69
1.925ThrPhe: 1.925 ± 0.347
5.499ThrGly: 5.499 ± 0.709
1.466ThrHis: 1.466 ± 0.356
3.666ThrIle: 3.666 ± 0.63
4.216ThrLys: 4.216 ± 0.548
5.499ThrLeu: 5.499 ± 0.771
1.008ThrMet: 1.008 ± 0.328
3.941ThrAsn: 3.941 ± 0.601
2.2ThrPro: 2.2 ± 0.392
2.108ThrGln: 2.108 ± 0.401
1.65ThrArg: 1.65 ± 0.387
3.849ThrSer: 3.849 ± 0.824
4.033ThrThr: 4.033 ± 0.462
5.957ThrVal: 5.957 ± 0.842
0.367ThrTrp: 0.367 ± 0.218
3.024ThrTyr: 3.024 ± 0.57
0.0ThrXaa: 0.0 ± 0.0
Val
3.941ValAla: 3.941 ± 0.478
0.642ValCys: 0.642 ± 0.267
3.666ValAsp: 3.666 ± 0.606
4.583ValGlu: 4.583 ± 0.749
1.833ValPhe: 1.833 ± 0.409
4.033ValGly: 4.033 ± 0.419
0.917ValHis: 0.917 ± 0.318
4.674ValIle: 4.674 ± 0.635
4.308ValLys: 4.308 ± 0.514
5.132ValLeu: 5.132 ± 0.622
1.375ValMet: 1.375 ± 0.363
3.483ValAsn: 3.483 ± 0.792
2.016ValPro: 2.016 ± 0.395
2.475ValGln: 2.475 ± 0.569
2.566ValArg: 2.566 ± 0.6
4.399ValSer: 4.399 ± 0.529
5.224ValThr: 5.224 ± 0.588
4.583ValVal: 4.583 ± 0.664
0.275ValTrp: 0.275 ± 0.179
1.191ValTyr: 1.191 ± 0.281
0.0ValXaa: 0.0 ± 0.0
Trp
1.008TrpAla: 1.008 ± 0.322
0.183TrpCys: 0.183 ± 0.151
0.183TrpAsp: 0.183 ± 0.137
1.283TrpGlu: 1.283 ± 0.372
0.458TrpPhe: 0.458 ± 0.171
1.191TrpGly: 1.191 ± 0.39
0.183TrpHis: 0.183 ± 0.125
1.283TrpIle: 1.283 ± 0.296
0.917TrpLys: 0.917 ± 0.273
0.825TrpLeu: 0.825 ± 0.318
0.275TrpMet: 0.275 ± 0.164
0.367TrpAsn: 0.367 ± 0.168
0.183TrpPro: 0.183 ± 0.118
0.917TrpGln: 0.917 ± 0.217
0.55TrpArg: 0.55 ± 0.232
1.008TrpSer: 1.008 ± 0.29
0.917TrpThr: 0.917 ± 0.237
0.55TrpVal: 0.55 ± 0.208
0.275TrpTrp: 0.275 ± 0.15
0.458TrpTyr: 0.458 ± 0.177
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.758TyrAla: 3.758 ± 0.621
0.55TyrCys: 0.55 ± 0.192
3.024TyrAsp: 3.024 ± 0.439
3.483TyrGlu: 3.483 ± 0.615
2.2TyrPhe: 2.2 ± 0.447
2.108TyrGly: 2.108 ± 0.395
1.466TyrHis: 1.466 ± 0.415
2.475TyrIle: 2.475 ± 0.472
3.024TyrLys: 3.024 ± 0.577
3.574TyrLeu: 3.574 ± 0.541
1.191TyrMet: 1.191 ± 0.283
2.383TyrAsn: 2.383 ± 0.434
1.466TyrPro: 1.466 ± 0.407
2.108TyrGln: 2.108 ± 0.435
1.375TyrArg: 1.375 ± 0.394
2.108TyrSer: 2.108 ± 0.434
2.658TyrThr: 2.658 ± 0.521
2.291TyrVal: 2.291 ± 0.331
0.275TyrTrp: 0.275 ± 0.126
1.833TyrTyr: 1.833 ± 0.476
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (10912 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski