Amino acid dipepetide frequency for Dishui lake phycodnavirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.734AlaAla: 5.734 ± 1.121
1.36AlaCys: 1.36 ± 0.176
3.134AlaAsp: 3.134 ± 0.229
3.065AlaGlu: 3.065 ± 0.368
2.876AlaPhe: 2.876 ± 0.243
4.425AlaGly: 4.425 ± 1.028
1.36AlaHis: 1.36 ± 0.151
4.081AlaIle: 4.081 ± 0.752
5.028AlaLys: 5.028 ± 0.98
5.872AlaLeu: 5.872 ± 0.275
1.67AlaMet: 1.67 ± 0.183
3.719AlaAsn: 3.719 ± 0.9
2.858AlaPro: 2.858 ± 0.243
2.652AlaGln: 2.652 ± 0.499
4.253AlaArg: 4.253 ± 0.388
4.77AlaSer: 4.77 ± 0.392
3.96AlaThr: 3.96 ± 0.306
4.752AlaVal: 4.752 ± 0.76
0.568AlaTrp: 0.568 ± 0.102
2.376AlaTyr: 2.376 ± 0.293
0.0AlaXaa: 0.0 ± 0.0
Cys
0.981CysAla: 0.981 ± 0.135
0.534CysCys: 0.534 ± 0.098
1.085CysAsp: 1.085 ± 0.169
0.913CysGlu: 0.913 ± 0.145
0.723CysPhe: 0.723 ± 0.124
1.36CysGly: 1.36 ± 0.183
0.327CysHis: 0.327 ± 0.07
0.844CysIle: 0.844 ± 0.147
1.188CysLys: 1.188 ± 0.168
1.274CysLeu: 1.274 ± 0.203
0.775CysMet: 0.775 ± 0.115
0.585CysAsn: 0.585 ± 0.112
0.758CysPro: 0.758 ± 0.136
0.413CysGln: 0.413 ± 0.08
1.154CysArg: 1.154 ± 0.19
0.93CysSer: 0.93 ± 0.151
0.895CysThr: 0.895 ± 0.133
1.36CysVal: 1.36 ± 0.194
0.207CysTrp: 0.207 ± 0.059
0.654CysTyr: 0.654 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
4.701AspAla: 4.701 ± 0.344
1.085AspCys: 1.085 ± 0.151
4.718AspAsp: 4.718 ± 0.407
4.787AspGlu: 4.787 ± 0.379
2.6AspPhe: 2.6 ± 0.24
4.236AspGly: 4.236 ± 0.317
1.739AspHis: 1.739 ± 0.197
3.289AspIle: 3.289 ± 0.328
2.789AspLys: 2.789 ± 0.222
6.078AspLeu: 6.078 ± 0.667
1.601AspMet: 1.601 ± 0.179
2.015AspAsn: 2.015 ± 0.173
2.927AspPro: 2.927 ± 0.255
1.584AspGln: 1.584 ± 0.149
3.065AspArg: 3.065 ± 0.275
3.151AspSer: 3.151 ± 0.261
3.392AspThr: 3.392 ± 0.245
4.563AspVal: 4.563 ± 0.301
0.809AspTrp: 0.809 ± 0.113
2.135AspTyr: 2.135 ± 0.245
0.0AspXaa: 0.0 ± 0.0
Glu
3.702GluAla: 3.702 ± 0.377
1.085GluCys: 1.085 ± 0.146
3.84GluAsp: 3.84 ± 0.324
4.89GluGlu: 4.89 ± 0.586
2.703GluPhe: 2.703 ± 0.209
2.686GluGly: 2.686 ± 0.237
1.515GluHis: 1.515 ± 0.192
4.064GluIle: 4.064 ± 0.279
4.322GluLys: 4.322 ± 0.365
5.2GluLeu: 5.2 ± 0.307
1.722GluMet: 1.722 ± 0.197
3.117GluAsn: 3.117 ± 0.251
2.221GluPro: 2.221 ± 0.237
2.273GluGln: 2.273 ± 0.232
3.668GluArg: 3.668 ± 0.27
3.151GluSer: 3.151 ± 0.223
3.444GluThr: 3.444 ± 0.248
3.857GluVal: 3.857 ± 0.352
0.964GluTrp: 0.964 ± 0.138
2.049GluTyr: 2.049 ± 0.235
0.0GluXaa: 0.0 ± 0.0
Phe
2.755PheAla: 2.755 ± 0.235
0.947PheCys: 0.947 ± 0.155
2.962PheAsp: 2.962 ± 0.3
2.6PheGlu: 2.6 ± 0.227
2.445PhePhe: 2.445 ± 0.278
2.6PheGly: 2.6 ± 0.202
1.154PheHis: 1.154 ± 0.169
2.204PheIle: 2.204 ± 0.206
2.29PheLys: 2.29 ± 0.208
3.461PheLeu: 3.461 ± 0.329
1.395PheMet: 1.395 ± 0.16
1.739PheAsn: 1.739 ± 0.164
1.498PhePro: 1.498 ± 0.206
1.343PheGln: 1.343 ± 0.157
1.911PheArg: 1.911 ± 0.22
2.962PheSer: 2.962 ± 0.226
2.514PheThr: 2.514 ± 0.229
3.616PheVal: 3.616 ± 0.346
0.517PheTrp: 0.517 ± 0.087
1.412PheTyr: 1.412 ± 0.166
0.0PheXaa: 0.0 ± 0.0
Gly
4.322GlyAla: 4.322 ± 0.37
0.93GlyCys: 0.93 ± 0.141
4.029GlyAsp: 4.029 ± 0.349
3.168GlyGlu: 3.168 ± 0.237
2.721GlyPhe: 2.721 ± 0.273
5.166GlyGly: 5.166 ± 0.424
1.67GlyHis: 1.67 ± 0.285
2.979GlyIle: 2.979 ± 0.318
3.513GlyLys: 3.513 ± 0.276
4.925GlyLeu: 4.925 ± 0.367
1.636GlyMet: 1.636 ± 0.157
3.289GlyAsn: 3.289 ± 0.532
1.86GlyPro: 1.86 ± 0.249
2.411GlyGln: 2.411 ± 0.469
3.599GlyArg: 3.599 ± 0.296
4.477GlySer: 4.477 ± 0.523
3.823GlyThr: 3.823 ± 0.392
4.339GlyVal: 4.339 ± 0.346
0.775GlyTrp: 0.775 ± 0.105
2.686GlyTyr: 2.686 ± 0.495
0.0GlyXaa: 0.0 ± 0.0
His
1.774HisAla: 1.774 ± 0.164
0.482HisCys: 0.482 ± 0.094
1.188HisAsp: 1.188 ± 0.14
1.36HisGlu: 1.36 ± 0.208
0.844HisPhe: 0.844 ± 0.148
1.722HisGly: 1.722 ± 0.207
0.603HisHis: 0.603 ± 0.121
1.068HisIle: 1.068 ± 0.153
1.343HisLys: 1.343 ± 0.16
1.946HisLeu: 1.946 ± 0.175
0.517HisMet: 0.517 ± 0.088
0.827HisAsn: 0.827 ± 0.132
1.085HisPro: 1.085 ± 0.142
0.844HisGln: 0.844 ± 0.128
1.481HisArg: 1.481 ± 0.199
1.309HisSer: 1.309 ± 0.184
1.498HisThr: 1.498 ± 0.176
2.256HisVal: 2.256 ± 0.208
0.482HisTrp: 0.482 ± 0.095
1.05HisTyr: 1.05 ± 0.139
0.0HisXaa: 0.0 ± 0.0
Ile
4.167IleAla: 4.167 ± 0.401
0.74IleCys: 0.74 ± 0.105
3.805IleAsp: 3.805 ± 0.276
3.358IleGlu: 3.358 ± 0.24
1.911IlePhe: 1.911 ± 0.206
3.943IleGly: 3.943 ± 0.749
1.55IleHis: 1.55 ± 0.145
2.686IleIle: 2.686 ± 0.242
3.254IleLys: 3.254 ± 0.244
4.529IleLeu: 4.529 ± 0.511
1.24IleMet: 1.24 ± 0.14
2.411IleAsn: 2.411 ± 0.257
2.238IlePro: 2.238 ± 0.21
1.894IleGln: 1.894 ± 0.197
3.616IleArg: 3.616 ± 0.27
2.996IleSer: 2.996 ± 0.238
3.53IleThr: 3.53 ± 0.364
4.081IleVal: 4.081 ± 0.29
0.482IleTrp: 0.482 ± 0.086
1.687IleTyr: 1.687 ± 0.177
0.0IleXaa: 0.0 ± 0.0
Lys
4.081LysAla: 4.081 ± 0.721
1.016LysCys: 1.016 ± 0.17
3.392LysAsp: 3.392 ± 0.274
3.805LysGlu: 3.805 ± 0.374
2.634LysPhe: 2.634 ± 0.222
3.117LysGly: 3.117 ± 0.315
1.532LysHis: 1.532 ± 0.161
4.012LysIle: 4.012 ± 0.287
6.337LysLys: 6.337 ± 0.805
5.028LysLeu: 5.028 ± 0.424
2.015LysMet: 2.015 ± 0.233
3.805LysAsn: 3.805 ± 0.471
2.738LysPro: 2.738 ± 0.26
2.48LysGln: 2.48 ± 0.295
3.702LysArg: 3.702 ± 0.334
4.098LysSer: 4.098 ± 0.325
3.495LysThr: 3.495 ± 0.272
3.736LysVal: 3.736 ± 0.294
0.585LysTrp: 0.585 ± 0.096
2.755LysTyr: 2.755 ± 0.257
0.0LysXaa: 0.0 ± 0.0
Leu
4.701LeuAla: 4.701 ± 0.343
1.429LeuCys: 1.429 ± 0.162
5.355LeuAsp: 5.355 ± 0.348
5.493LeuGlu: 5.493 ± 0.393
3.117LeuPhe: 3.117 ± 0.271
4.408LeuGly: 4.408 ± 0.334
2.015LeuHis: 2.015 ± 0.207
3.943LeuIle: 3.943 ± 0.23
5.097LeuLys: 5.097 ± 0.355
5.906LeuLeu: 5.906 ± 0.377
2.29LeuMet: 2.29 ± 0.208
4.546LeuAsn: 4.546 ± 0.433
2.927LeuPro: 2.927 ± 0.257
3.22LeuGln: 3.22 ± 0.438
5.872LeuArg: 5.872 ± 0.403
6.147LeuSer: 6.147 ± 0.338
5.062LeuThr: 5.062 ± 0.381
5.458LeuVal: 5.458 ± 0.363
0.672LeuTrp: 0.672 ± 0.105
2.755LeuTyr: 2.755 ± 0.248
0.0LeuXaa: 0.0 ± 0.0
Met
1.412MetAla: 1.412 ± 0.166
0.534MetCys: 0.534 ± 0.106
1.343MetAsp: 1.343 ± 0.164
1.257MetGlu: 1.257 ± 0.172
1.326MetPhe: 1.326 ± 0.156
1.291MetGly: 1.291 ± 0.148
0.603MetHis: 0.603 ± 0.092
1.464MetIle: 1.464 ± 0.167
2.015MetLys: 2.015 ± 0.23
2.032MetLeu: 2.032 ± 0.211
1.085MetMet: 1.085 ± 0.155
1.894MetAsn: 1.894 ± 0.226
1.154MetPro: 1.154 ± 0.134
1.016MetGln: 1.016 ± 0.157
1.808MetArg: 1.808 ± 0.179
2.221MetSer: 2.221 ± 0.229
2.083MetThr: 2.083 ± 0.216
1.55MetVal: 1.55 ± 0.168
0.344MetTrp: 0.344 ± 0.077
1.102MetTyr: 1.102 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
5.355AsnAla: 5.355 ± 1.182
0.654AsnCys: 0.654 ± 0.11
2.669AsnAsp: 2.669 ± 0.222
1.842AsnGlu: 1.842 ± 0.192
2.135AsnPhe: 2.135 ± 0.234
3.564AsnGly: 3.564 ± 0.34
0.964AsnHis: 0.964 ± 0.127
3.237AsnIle: 3.237 ± 0.447
2.755AsnLys: 2.755 ± 0.437
4.133AsnLeu: 4.133 ± 0.429
1.395AsnMet: 1.395 ± 0.177
2.721AsnAsn: 2.721 ± 0.37
1.894AsnPro: 1.894 ± 0.23
2.152AsnGln: 2.152 ± 0.333
2.514AsnArg: 2.514 ± 0.265
2.944AsnSer: 2.944 ± 0.296
3.392AsnThr: 3.392 ± 0.348
5.527AsnVal: 5.527 ± 1.323
0.568AsnTrp: 0.568 ± 0.124
1.705AsnTyr: 1.705 ± 0.165
0.0AsnXaa: 0.0 ± 0.0
Pro
2.566ProAla: 2.566 ± 0.258
0.448ProCys: 0.448 ± 0.091
2.359ProAsp: 2.359 ± 0.238
3.117ProGlu: 3.117 ± 0.302
1.774ProPhe: 1.774 ± 0.191
2.359ProGly: 2.359 ± 0.208
0.878ProHis: 0.878 ± 0.136
1.911ProIle: 1.911 ± 0.165
3.151ProLys: 3.151 ± 0.314
2.807ProLeu: 2.807 ± 0.258
0.999ProMet: 0.999 ± 0.169
1.911ProAsn: 1.911 ± 0.162
2.428ProPro: 2.428 ± 0.35
1.498ProGln: 1.498 ± 0.176
1.894ProArg: 1.894 ± 0.221
3.099ProSer: 3.099 ± 0.302
2.893ProThr: 2.893 ± 0.264
2.841ProVal: 2.841 ± 0.266
0.534ProTrp: 0.534 ± 0.098
1.274ProTyr: 1.274 ± 0.158
0.0ProXaa: 0.0 ± 0.0
Gln
2.29GlnAla: 2.29 ± 0.317
0.499GlnCys: 0.499 ± 0.091
1.687GlnAsp: 1.687 ± 0.179
2.29GlnGlu: 2.29 ± 0.283
1.584GlnPhe: 1.584 ± 0.189
2.015GlnGly: 2.015 ± 0.44
0.809GlnHis: 0.809 ± 0.114
1.98GlnIle: 1.98 ± 0.179
2.721GlnLys: 2.721 ± 0.319
2.858GlnLeu: 2.858 ± 0.282
1.171GlnMet: 1.171 ± 0.157
2.634GlnAsn: 2.634 ± 0.378
1.498GlnPro: 1.498 ± 0.154
1.687GlnGln: 1.687 ± 0.23
2.411GlnArg: 2.411 ± 0.22
2.531GlnSer: 2.531 ± 0.345
2.101GlnThr: 2.101 ± 0.205
2.273GlnVal: 2.273 ± 0.215
0.396GlnTrp: 0.396 ± 0.072
1.274GlnTyr: 1.274 ± 0.151
0.0GlnXaa: 0.0 ± 0.0
Arg
4.098ArgAla: 4.098 ± 0.292
1.205ArgCys: 1.205 ± 0.179
3.53ArgAsp: 3.53 ± 0.308
4.15ArgGlu: 4.15 ± 0.337
2.48ArgPhe: 2.48 ± 0.216
2.617ArgGly: 2.617 ± 0.25
1.36ArgHis: 1.36 ± 0.15
3.013ArgIle: 3.013 ± 0.215
3.53ArgLys: 3.53 ± 0.328
5.148ArgLeu: 5.148 ± 0.376
1.481ArgMet: 1.481 ± 0.179
2.6ArgAsn: 2.6 ± 0.308
2.325ArgPro: 2.325 ± 0.193
2.824ArgGln: 2.824 ± 0.268
4.391ArgArg: 4.391 ± 0.426
3.995ArgSer: 3.995 ± 0.315
3.099ArgThr: 3.099 ± 0.294
4.287ArgVal: 4.287 ± 0.337
0.792ArgTrp: 0.792 ± 0.116
2.204ArgTyr: 2.204 ± 0.18
0.0ArgXaa: 0.0 ± 0.0
Ser
4.236SerAla: 4.236 ± 0.361
0.809SerCys: 0.809 ± 0.133
4.563SerAsp: 4.563 ± 0.499
3.668SerGlu: 3.668 ± 0.237
2.858SerPhe: 2.858 ± 0.238
4.752SerGly: 4.752 ± 0.435
1.24SerHis: 1.24 ± 0.161
3.805SerIle: 3.805 ± 0.378
3.771SerLys: 3.771 ± 0.286
4.942SerLeu: 4.942 ± 0.36
1.825SerMet: 1.825 ± 0.168
5.131SerAsn: 5.131 ± 1.376
2.669SerPro: 2.669 ± 0.276
2.307SerGln: 2.307 ± 0.217
3.409SerArg: 3.409 ± 0.277
5.458SerSer: 5.458 ± 0.476
4.787SerThr: 4.787 ± 0.367
4.529SerVal: 4.529 ± 0.367
0.844SerTrp: 0.844 ± 0.129
1.98SerTyr: 1.98 ± 0.221
0.0SerXaa: 0.0 ± 0.0
Thr
4.046ThrAla: 4.046 ± 0.371
1.016ThrCys: 1.016 ± 0.175
3.719ThrAsp: 3.719 ± 0.37
3.547ThrGlu: 3.547 ± 0.278
2.634ThrPhe: 2.634 ± 0.196
4.201ThrGly: 4.201 ± 0.352
1.481ThrHis: 1.481 ± 0.187
3.668ThrIle: 3.668 ± 0.315
3.891ThrLys: 3.891 ± 0.394
4.597ThrLeu: 4.597 ± 0.329
1.584ThrMet: 1.584 ± 0.169
3.237ThrAsn: 3.237 ± 0.368
3.168ThrPro: 3.168 ± 0.22
1.946ThrGln: 1.946 ± 0.219
3.444ThrArg: 3.444 ± 0.261
4.546ThrSer: 4.546 ± 0.395
4.442ThrThr: 4.442 ± 0.386
4.287ThrVal: 4.287 ± 0.332
0.551ThrTrp: 0.551 ± 0.087
2.049ThrTyr: 2.049 ± 0.242
0.0ThrXaa: 0.0 ± 0.0
Val
4.976ValAla: 4.976 ± 0.653
1.205ValCys: 1.205 ± 0.155
4.511ValAsp: 4.511 ± 0.302
4.511ValGlu: 4.511 ± 0.293
2.979ValPhe: 2.979 ± 0.221
4.718ValGly: 4.718 ± 0.646
1.739ValHis: 1.739 ± 0.189
3.53ValIle: 3.53 ± 0.3
4.046ValLys: 4.046 ± 0.292
5.613ValLeu: 5.613 ± 0.384
1.722ValMet: 1.722 ± 0.189
3.306ValAsn: 3.306 ± 0.291
3.099ValPro: 3.099 ± 0.263
2.738ValGln: 2.738 ± 0.21
4.546ValArg: 4.546 ± 0.414
5.372ValSer: 5.372 ± 0.714
4.511ValThr: 4.511 ± 0.42
5.217ValVal: 5.217 ± 0.357
0.827ValTrp: 0.827 ± 0.13
2.876ValTyr: 2.876 ± 0.225
0.0ValXaa: 0.0 ± 0.0
Trp
0.396TrpAla: 0.396 ± 0.074
0.241TrpCys: 0.241 ± 0.065
0.775TrpAsp: 0.775 ± 0.118
0.482TrpGlu: 0.482 ± 0.115
0.689TrpPhe: 0.689 ± 0.12
0.74TrpGly: 0.74 ± 0.126
0.379TrpHis: 0.379 ± 0.083
0.585TrpIle: 0.585 ± 0.116
0.93TrpLys: 0.93 ± 0.126
0.93TrpLeu: 0.93 ± 0.136
0.344TrpMet: 0.344 ± 0.076
0.844TrpAsn: 0.844 ± 0.133
0.155TrpPro: 0.155 ± 0.05
0.344TrpGln: 0.344 ± 0.074
0.723TrpArg: 0.723 ± 0.106
0.895TrpSer: 0.895 ± 0.127
0.654TrpThr: 0.654 ± 0.129
0.93TrpVal: 0.93 ± 0.137
0.207TrpTrp: 0.207 ± 0.058
0.31TrpTyr: 0.31 ± 0.079
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.238TyrAla: 2.238 ± 0.424
0.74TyrCys: 0.74 ± 0.117
2.6TyrAsp: 2.6 ± 0.261
2.17TyrGlu: 2.17 ± 0.206
1.291TyrPhe: 1.291 ± 0.15
2.393TyrGly: 2.393 ± 0.21
0.758TyrHis: 0.758 ± 0.107
1.756TyrIle: 1.756 ± 0.187
2.393TyrLys: 2.393 ± 0.23
3.134TyrLeu: 3.134 ± 0.248
1.05TyrMet: 1.05 ± 0.148
1.791TyrAsn: 1.791 ± 0.24
1.24TyrPro: 1.24 ± 0.164
1.085TyrGln: 1.085 ± 0.172
1.67TyrArg: 1.67 ± 0.167
2.531TyrSer: 2.531 ± 0.267
2.48TyrThr: 2.48 ± 0.204
2.583TyrVal: 2.583 ± 0.216
0.43TyrTrp: 0.43 ± 0.091
1.774TyrTyr: 1.774 ± 0.27
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 227 proteins (58077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski